Article
Pharmacology & Pharmacy
Wencheng Wei, Yunfei Li, Chuanxi Wang, Sanxing Gao, Yan Zhao, Zhenyu Yang, Hao Wang, Ziying Gao, Yanxiang Jiang, Yuan He, Li Zhao, Hao Gao, Xinsheng Yao, Yuhui Hu
Summary: Vinigrol is a natural diterpenoid with a unique chemical structure, and its total synthesis has been a subject of great interest in the past decades. In this study, we conducted a comprehensive functional prediction of Vinigrol using a transcriptome-based strategy and identified its prominent anti-cancer effect. Further investigations revealed the underlying targets and regulatory mechanisms of Vinigrol's anti-cancer function. This study provides insights into the structure-efficacy relationship of Vinigrol and its potential applications in experimental and clinical settings.
PHARMACOLOGICAL RESEARCH
(2022)
Article
Pharmacology & Pharmacy
Yongli Zhang, Luna Ge, Guanhua Song, Ruojia Zhang, Shufeng Li, Haojun Shi, Hongchang Zhang, Yi Li, Jihong Pan, Lin Wang, Jinxiang Han
Summary: Azithromycin, a macrolide antibiotic with anti-inflammatory properties, has shown promising treatment potential in reducing inflammation in rheumatoid arthritis patients. It affects signaling cascades associated with cholesterol and lipid biosynthesis, and targets GRP78, playing a key role in anti-arthritic activity.
BRITISH JOURNAL OF PHARMACOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Anja Batel, Mirjana Polovic, Mateo Glumac, Oliver Suman, Stipislav Jadrijevic, Bernarda Lozic, Marija Petrovic, Bobana Samardzija, Nicholas J. Bradshaw, Karlo Skube, Vinko Palada, Mislav Acman, Ivana Marinovic Terzic
Summary: This study reveals the role of the SPRTN gene in hepatocellular carcinoma (HCC) and its association with endoplasmic reticulum (ER) stress, providing new insights into the pathogenesis of HCC.
CANCER GENE THERAPY
(2023)
Article
Pharmacology & Pharmacy
Wencheng Wei, Yunfei Li, Chuanxi Wang, Yan Zhao, Zhenyu Yang, Hao Wang, Ziying Gao, Yanxiang Jiang, Yuan He, Li Zhao, Hao Gao, Xinsheng Yao, Yuhui Hu
Summary: The study conducted a comprehensive functional prediction of Vinigrol, revealing its broad anti-cancer function and the underlying mechanisms, which provide insights for further exploration of the structure-efficacy relationship of the compound family.
PHARMACOLOGICAL RESEARCH
(2022)
Article
Immunology
Wei Fang, Qiuchi Chen, Jiamin Li, Yongtao Liu, Zengqi Zhao, Yanan Shen, Kangsen Mai, Qinghui Ai
Summary: The study found that ER stress disrupted lipid metabolism and increased inflammation in the intestine and isolated intestinal cells of large yellow croaker, potentially leading to novel therapies for addressing lipid dysregulation and inflammation in the intestines of fish and humans.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Oncology
Mahmoud Aghaei, Ahmad Nasimian, Marveh Rahmati, Philip Kawalec, Filip Machaj, Jakub Rosik, Bhavya Bhushan, S. Zahra Bathaie, Negar Azarpira, Marek J. Los, Afshin Samali, David Perrin, Joseph W. Gordon, Saeid Ghavami
Summary: The study found significant associations of BiP, sXBP1, and IRE1 alpha with RMS in all studied types of RMS tumors, compared to normal skeletal muscle tissues. BiP and sXBP1 were associated with all subtypes, while IRE1 alpha was associated with ARMS, PRMS, and ERMS, and cytosolic XBP1 was associated with ARMS and SRMS. These findings suggest possible new targeted therapeutic strategies for RMS.
Review
Medicine, Research & Experimental
Shengkai Xia, Wenzhe Duan, Wenwen Liu, Xinri Zhang, Qi Wang
Summary: GRP78 is a key protein in the pathological processes of lung cancer, involved in protein folding, cellular stress response to microenvironment stimuli, and closely associated with the progression and poor prognosis of lung cancer.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Oncology
Elia Ranzato, Gregorio Bonsignore, Simona Martinotti
Summary: Malignant mesothelioma is a rare and aggressive cancer strongly linked to asbestos exposure. With limited therapeutic options, novel approaches are urgently needed. Previous studies have shown the importance of GRP78 in MPM survival, and our research suggests that BOLD-100, a specific modulator of GRP78, inhibits MPM cell growth by inducing cellular stress and cell death.
Article
Nutrition & Dietetics
Sindiyan Alshaikh Mubarak, Abeer Al Otaibi, Ali Al Qarni, Ahmed Bakillah, Jahangir Iqbal
Summary: Saturated FFAs, such as palmitate, circulating in the body can cause ER stress and insulin resistance. In this study, it was found that palmitate treatment reduced insulin-mediated glucose uptake and ERK phosphorylation in Huh-7 cells, while AKT phosphorylation remained unchanged. Supplementation of oleate alleviated palmitate-induced ER stress but did not affect insulin-mediated glucose uptake or ERK phosphorylation.
Article
Biology
Anupam Bhoi, Francesca Palladino, Paola Fabrizio
Summary: Auxins are plant growth regulators that influence various aspects of plant development. The development of an AID system allows rapid, conditional protein degradation, which has been successfully implemented in Caenorhabditis elegans. Indole-3-acetic acid functions through the IRE-1/XBP-1 branch of the UPR to promote resistance to ER stress, indicating caution is needed when using the AID system to study related processes.
Article
Oncology
Ankit Patel, Masanori Oshi, Li Yan, Ryusei Matsuyama, Itaru Endo, Kazuaki Takabe
Summary: The study found a correlation between the unfolded protein response (UPR) and hepatocellular carcinoma (HCC) in terms of carcinogenesis, cancer progression, and patient survival. The UPR score can serve as a biomarker for predicting cancer progression and patient prognosis in HCC.
Article
Biotechnology & Applied Microbiology
Preeti Borde, Nicola Cosgrove, Sara Charmsaz, Stephen T. Safrany, Leonie Young
Summary: Therapeutic options and prognostic biomarkers for hormone receptor- or Her2 receptor-negative breast cancers are limited. This study reveals that the sigma-1 receptor is elevated in breast cancer, particularly in the aggressive triple-negative subtype. High SIGMAR1 expression is associated with poor survival outcomes and shorter survival times in ER-Her2- groups. In addition, higher SIGMAR1 levels are related to a higher rate of pathologic complete response in patients receiving neoadjuvant taxane + anthracycline treatment.
CANCER GENE THERAPY
(2023)
Article
Biochemistry & Molecular Biology
Lee-Wen Chen, Shie-Shan Wang, Chien-Hui Hung, Ya-Hui Hung, Chun-Liang Lin, Pey-Jium Chang
Summary: The unfolded protein response (UPR) is crucial for alleviating endoplasmic reticulum (ER) stress and many viruses manipulate the UPR signaling network. In the lytic cycle of Epstein-Barr virus (EBV), the expression of central UPR regulator GRP78 is up-regulated, and knockdown of GRP78 reduces virus particle production. BMLF1 is identified as a key regulator contributing to the activation of the grp78 gene promoter and can trigger the activation of the UPR senor ATF6.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Jing Yong, Vishal S. Parekh, Shannon M. Reilly, Jonamani Nayak, Zhouji Chen, Cynthia Lebeaupin, Insook Jang, Jiangwei Zhang, Thazha P. Prakash, Hong Sun, Sue Murray, Shuling Guo, Julio E. Ayala, Leslie S. Satin, Alan R. Saltiel, Randal J. Kaufman
Summary: The deletion of Chop gene in beta cells alleviates ER stress and delays glucose-stimulated insulin secretion, preventing the development of fatty liver disease. This study suggests that targeting Chop in beta cells could be a potential therapeutic strategy for improving insulin secretion and preventing complications in type 2 diabetes.
SCIENCE TRANSLATIONAL MEDICINE
(2021)
Article
Biochemical Research Methods
Swati Gupta, K. P. Mishra, Bhuvnesh Kumar, S. B. Singh, Lilly Ganju
Summary: The study suggests that andrographolide is a potential remedy for chikungunya virus infection, as it can suppress virus-induced ER stress and apoptosis.
COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING
(2021)
Article
Oncology
Xiaoxiao Liu, Naru Sato, Yuko Shimosato, Teh-Wei Wang, Tamami Denda, Yu-Hsuan Chang, Tomohiro Yabushita, Takeshi Fujino, Shuhei Asada, Yosuke Tanaka, Tomofusa Fukuyama, Yutaka Enomoto, Yasunori Ota, Takeharu Sakamoto, Toshio Kitamura, Susumu Goyama
Summary: The study found that certain mutations in clonal hematopoiesis lead to T-cell dysregulation, exacerbating the development of solid tumors.
Article
Hematology
Tomofusa Fukuyama, Toshio Kitamura, Tomoko Kozu
Summary: The chimeric oncogene AML1-MTG8 interacts with UBC9, suggesting a role in leukemogenesis in (8;21) AML. Overexpression of UBC9 suppressed myeloid differentiation, while UBC9 inhibitor accelerated myeloid differentiation. Therefore, UBC9 may be a promising target for therapy against (8;21) AML.
INTERNATIONAL JOURNAL OF HEMATOLOGY
(2022)
Letter
Pathology
Takumi Kiwaki, Mayumi Akaki Nagayasu, Naoshi Yamada, Yuki Kodama, Yoshiko Umekita, Tsuyoshi Fukushima, Hiroaki Kataoka, Hiroyuki Tanaka
PATHOLOGY INTERNATIONAL
(2022)
Article
Oncology
Aya Izumi, Koji Yamamoto, Makiko Kawaguchi, Fumiki Yamashita, Tsuyoshi Fukushima, Takumi Kiwaki, Hiroyuki Tanaka, Yoshihiro Yamashita, Hiroaki Kataoka
Summary: HAI-1 deficiency enhances pericellular protease activity, leading to the activation of growth factors associated with tumor progression in tongue squamous cell carcinoma.
Article
Cell Biology
Hiroyuki Nunoi, Peiyu Xie, Hideaki Nakamura, Yasuaki Aratani, Jun Fang, Toyoki Nishimura, Hiroaki Kataoka, Hiroshi Maeda, Makoto Matsukura
Summary: This study validates the efficacy of using polyethylene glycol-conjugated recombinant Fusarium spp. D-amino acid oxidase (PEG-fDAO) as a potential therapy for CGD-induced lung inflammation.
Review
Oncology
Reina Takeda, Kazuaki Yokoyama, Tomofusa Fukuyama, Toyotaka Kawamata, Mika Ito, Nozomi Yusa, Rika Kasajima, Eigo Shimizu, Nobuhiro Ohno, Kaoru Uchimaru, Rui Yamaguchi, Seiya Imoto, Satoru Miyano, Arinobu Tojo
Summary: Lineage switches in acute leukemia are rare, and the mechanisms behind them are not well understood. This report describes a case of an elderly patient with leukemia where the leukemia transformed from B-cell acute lymphoblastic leukemia (B-ALL) to B- and T-cell mixed phenotype acute leukemia (MPAL) and acute myeloid leukemia (AML) during consecutive induction chemotherapy treatments. The patient's leukemia did not respond well to standard B-ALL chemotherapy and eventually transformed into AML. The study suggests that this case should be classified as lineage switching leukemia rather than multiple simultaneous cancers.
FRONTIERS IN ONCOLOGY
(2022)
Review
Health Care Sciences & Services
Takumi Kiwaki, Hiroaki Kataoka
Summary: Three-dimensional culture methods and patient-derived organoids play a crucial role in the study of colorectal cancer, aiding in predicting patient sensitivity to chemotherapy and radiotherapy and guiding precision medicine.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Medicine, General & Internal
Mayumi Akaki Nagayasu, Tsuyoshi Fukushima, Fumitaka Matsumoto, Hideo Takeshima, Yuichiro Sato, Hiroaki Kataoka
Summary: Dura-attached supratentorial extra-axial ependymoma is a rare tumor subtype that is often misdiagnosed as a meningioma. This case report highlights the difficulty in accurately diagnosing this rare tumor using intraoperative histological and cytological examinations.
JOURNAL OF MEDICAL CASE REPORTS
(2022)
Article
Medicine, Research & Experimental
Xiaoxiao Liu, Naru Sato, Tomohiro Yabushita, Jingmei Li, Yuhan Jia, Moe Tamura, Shuhei Asada, Takeshi Fujino, Tsuyoshi Fukushima, Taishi Yonezawa, Yosuke Tanaka, Tomofusa Fukuyama, Akiho Tsuchiya, Shiori Shikata, Hiroyuki Iwamura, Chieko Kinouchi, Kensuke Komatsu, Satoshi Yamasaki, Tatsuhiro Shibata, Atsuo T. Sasaki, Janet Schibler, Mark Wunderlich, Eric O'Brien, Benjamin Mizukawa, James C. Mulloy, Yuki Sugiura, Hitoshi Takizawa, Takuma Shibata, Kensuke Miyake, Toshio Kitamura, Susumu Goyama
Summary: Inosine monophosphate dehydrogenase (IMPDH) inhibitors have been widely used as immunosuppressants but their antitumor effects remain unproven in clinical practice. This study demonstrated the susceptibility of acute myeloid leukemias (AMLs) with MLL-fusions to IMPDH inhibitors in vitro. Alternate-day administration of IMPDH inhibitors effectively suppressed the development of MLL-AF9-driven AML without compromising immune function. The antileukemia effect of IMPDH inhibitors was attributed to the overactivation of Toll-like receptor (TLR)-TRAF6-NF-kappa B signaling pathway and upregulation of VCAM1 adhesion molecule. Combined treatment with IMPDH inhibitors and TLR1/2 agonist showed a promising inhibitory effect on MLL-fusion AML. These findings provide a rational basis for clinical testing of IMPDH inhibitors against MLL-fusion AMLs and other aggressive tumors with active TLR signaling.
EMBO MOLECULAR MEDICINE
(2023)
Article
Multidisciplinary Sciences
Takashi Sugiyama, Naoya Murao, Hisae Kadowaki, Hideki Nishitoh
Summary: A study found that chemical chaperones can alleviate brain atrophy and motor dysfunction by improving brain cholesterol biosynthesis, offering a promising therapeutic strategy for neurodegenerative diseases.
SCIENTIFIC REPORTS
(2022)
Article
Dermatology
Mayumi Akaki Nagayasu, Hiroyuki Tanaka, Kyoko Nogami, Yoji Kukita, Harumi Nakamura, Toru Motoi, Toshiaki Manabe, Hiroaki Kataoka
Summary: Cutaneous syncytial myoepithelioma is a rare tumor type characterized by nodular proliferation of oval to spindle-shaped tumor cells. The fusion of genes EWSR1 and PBX3 is commonly found in this type of tumor. We report a case with diagnostic difficulty and atypical immunohistochemical results, which were resolved by fluorescence in situ hybridization study to confirm EWSR1 rearrangement. Differential diagnoses and relevant literature are discussed.
JOURNAL OF CUTANEOUS PATHOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Makiko Kawaguchi, Hiroaki Kataoka, Takumi Kiwaki, Liang Weiting, Sayaka Nagata, Kazuo Kitamura, Tsuyoshi Fukushima
Summary: Adrenomedullin (AM) is a peptide that attenuates intestinal mucosal inflammation and enhances mucosal regeneration by upregulating claudin-4 expression in primary-cultured murine intestinal epithelial cells and a mouse model of colitis. AM also reverses TNF alpha-mediated downregulation of claudin-4 and loss of cell-cell adhesion in a human intestinal epithelial cell line, indicating its potential in enhancing intestinal epithelial integrity.
Article
Medicine, General & Internal
Yoshiko Umekita, Kazumi Umeki, Fumiaki Kawano, Hiroyuki Tanaka, Hiroaki Kataoka
Summary: This article presents a case of papillary thyroid carcinoma with features of hyalinizing trabecular tumor and discusses its histopathological characteristics and diagnostic challenges. Although specific genetic alterations were not detected, this case may indicate a potential relationship between papillary thyroid carcinoma and hyalinizing trabecular tumor.
JOURNAL OF MEDICAL CASE REPORTS
(2023)
Meeting Abstract
Oncology
Emi Sugimoto, Susumu Goyama, Shuhei Asada, Yuta Kaito, Yoichi Imai, Tomofusa Fukuyama, Yosuke Tanaka, Toshio Kitamura
Article
Multidisciplinary Sciences
Yosuke Tanaka, Reina Takeda, Tsuyoshi Fukushima, Keiko Mikami, Shun Tsuchiya, Moe Tamura, Keito Adachi, Terumasa Umemoto, Shuhei Asada, Naoki Watanabe, Soji Morishita, Misa Imai, Masayoshi Nagata, Marito Araki, Hitoshi Takizawa, Tomofusa Fukuyama, Chrystelle Lamagna, Esteban S. Masuda, Ryoji Ito, Susumu Goyama, Norio Komatsu, Tomoiku Takaku, Toshio Kitamura
Summary: Leukemia stem cells in chronic myeloid leukemia are resistant to imatinib, but can be eliminated by combining imatinib with IRAK1/4 inhibitors that inhibit the IRAK1/4-NF-kappa B-PD-L1 signaling pathway.
NATURE COMMUNICATIONS
(2022)
