Enzyme-catalyzed domino reaction: efficient construction of spirocyclic oxindole skeleton using porcine pepsin

Biocatalytic one-pot three-component synthesis of 3,3′-disubstituted oxindoles and spirooxindole pyrans using α-amylase from hog pancreas

(2015) Tao He et al.   RSC Advances

Phosphine-Catalyzed Asymmetric Formal [4+2] Tandem Cyclization of Activated Dienes with Isatylidenemalononitriles: Enantioselective Synthesis of Multistereogenic Spirocyclic Oxindoles

(2014) Fang-Le Hu et al.   ADVANCED SYNTHESIS & CATALYSIS

Organocatalytic Asymmetric Assembly Reactions: Synthesis of Spirooxindoles via Organocascade Strategies

(2014) Daojuan Cheng et al.   ACS Catalysis

Highly efficient Michael-type addition of acetaldehyde to β-nitrostyrenes by whole resting cells of Escherichia coli expressing 4-oxalocrotonate tautomerase

(2013) Tanja Narancic et al.   BIORESOURCE TECHNOLOGY

Biocatalytic Michael-Type Additions of Acetaldehyde to Nitroolefins with the Proline-Based Enzyme 4-Oxalocrotonate Tautomerase Yielding Enantioenriched γ-Nitroaldehydes

(2013) Edzard M. Geertsema et al.   CHEMISTRY-A EUROPEAN JOURNAL

Asymmetric Synthesis of Druglike Six-Membered Spirooxindoles through an Amino Enyne Catalysis

(2013) D. B. Ramachary et al.   ORGANIC LETTERS

Highly efficient and large-scalable glucoamylase-catalyzed Henry reactions

(2013) Na Gao et al.   RSC Advances

Chymopapain-Catalyzed Direct Asymmetric Aldol Reaction

(2012) Yan-Hong He et al.   ADVANCED SYNTHESIS & CATALYSIS

Promiscuous enzyme-catalyzed Michael addition: synthesis of warfarin and derivatives

(2012) Bang-Hua Xie et al.   JOURNAL OF CHEMICAL TECHNOLOGY AND BIOTECHNOLOGY

Trypsin-catalyzed direct asymmetric aldol reaction

(2012) Yan-Li Chen et al.   JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC

The enzymatic asymmetric aldol reaction using acidic protease from Aspergillus usamii

(2012) Bang-Hua Xie et al.   TETRAHEDRON

Biocatalytic promiscuity: lipase-catalyzed asymmetric aldol reaction of heterocyclic ketones with aldehydes

(2012) Zhi Guan et al.   TETRAHEDRON LETTERS

Protease-catalysed Direct Asymmetric Mannich Reaction in Organic Solvent

(2012) Yang Xue et al.   Scientific Reports

One-Pot Synthesis of Spirooxindole Derivatives Catalyzed by Lipase in the Presence of Water

(2011) She-Jie Chai et al.   ADVANCED SYNTHESIS & CATALYSIS

Enantioselective Michael/Cyclization Reaction Sequence: Scaffold-Inspired Synthesis of Spirooxindoles with Multiple Stereocenters

(2011) Yiming Cao et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Enzyme catalytic promiscuity: The papain-catalyzed Knoevenagel reaction

(2011) Wen Hu et al.   BIOCHIMIE

A highly organocatalytic stereoselective double Michael reaction: efficient construction of optically enriched spirocyclic oxindoles

(2011) Liang-Liang Wang et al.   CHEMICAL COMMUNICATIONS

Hydrolases in the Stereoselective Synthesis ofN-Heterocyclic Amines and Amino Acid Derivatives

(2011) Eduardo Busto et al.   CHEMICAL REVIEWS

Biocatalytic domino reaction: synthesis of 2H-1-benzopyran-2-one derivatives using alkaline protease from Bacillus licheniformis

(2011) Chang-Heng Wang et al.   GREEN CHEMISTRY

Enzyme-Catalyzed Direct Three-Component Aza-Diels–Alder Reaction Using Hen Egg White Lysozyme

(2011) Yan-Hong He et al.   JOURNAL OF ORGANIC CHEMISTRY

Chiral Counteranion Synergistic Organocatalysis under High Temperature: Efficient Construction of Optically Pure Spiro[cyclohexanone-oxindole] Backbone

(2011) Yu-Bao Lan et al.   ORGANIC LETTERS

Protease-catalyzed direct aldol reaction

(2010) Hai-Hong Li et al.   CATALYSIS COMMUNICATIONS

Highly organocatalytic asymmetric Michael–ketone aldol–dehydration domino reaction: straightforward approach to construct six-membered spirocyclic oxindoles

(2010) Liang-Liang Wang et al.   CHEMICAL COMMUNICATIONS

Nuclease p1: a new biocatalyst for direct asymmetric aldol reaction under solvent-free conditions

(2010) Hai-Hong Li et al.   GREEN CHEMISTRY

The lipase-catalyzed asymmetric C–C Michael addition

(2010) Jian-Feng Cai et al.   JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC

Organocatalytic Asymmetric Formal [4 + 2] Cycloaddition for the Synthesis of Spiro[4-cyclohexanone-1,3′-oxindoline] Derivatives in High Optical Purity

(2010) Qiang Wei et al.   ORGANIC LETTERS

Targeting Structural and Stereochemical Complexity by Organocascade Catalysis: Construction of Spirocyclic Oxindoles Having Multiple Stereocenters

(2009) Giorgio Bencivenni et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Recombinant prosegment peptide acts as a folding catalyst and inhibitor of native pepsin

(2009) Derek R. Dee et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Organocatalytic Synthesis of Spiro[pyrrolidin-3,3′-oxindoles] with High Enantiopurity and Structural Diversity

(2009) Xiao-Hua Chen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Selected Synthetic Strategies to Spirocyclics

(2009) Sambasivarao Kotha et al.   SYNTHESIS-STUTTGART

Investigation of lipase-catalyzed Michael-type carbon–carbon bond formations

(2009) Gernot A. Strohmeier et al.   TETRAHEDRON

Biocatalytic promiscuity: the first lipase-catalysed asymmetric aldol reaction

(2008) Chao Li et al.   GREEN CHEMISTRY