期刊
ARABIAN JOURNAL OF CHEMISTRY
卷 9, 期 -, 页码 S931-S935出版社
ELSEVIER
DOI: 10.1016/j.arabjc.2011.09.002
关键词
Claisen-Schmidt condensation; Microwave irradiation; Cytotoxic activity; Antioxidant activity
Chalcones are abundant in edible plants and are considered to be the precursors of flavonoids and isoflavonoids. Chalcones belong to an important class of flavonoids, which may be prepared by Claisen-Schmidt condensation. They possess a wide range of biological activities and industrial applications. The cytotoxicity against tumour cell lines may be the result of disruption of the cell cycle, inhibition of angiogenesis, interference with p53-MDM2 interaction, mitochondrial uncoupling or induction of apoptosis. Chalcones are synthesized by conventional and microwave assisted synthesis methods. By microwave assisted synthesis, a considerable increase in the reaction rate has been observed and that too, with better yields. The compounds have been screened for cytotoxic activity and antioxidant activity. (C) 2011 Production and hosting by Elsevier B.V. on behalf of King Saud University.
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