Crosstalk between MSH2–MSH3 and polβ promotes trinucleotide repeat expansion during base excision repair

Cockayne Syndrome B protein antagonizes OGG1 in modulating CAG repeat length in vivo

(2016) Irina V. Kovtun et al.   Aging-US

DNA Triplet Repeat Expansion and Mismatch Repair

(2015) Ravi R. Iyer et al.   Annual Review of Biochemistry

New insights into the mechanism of DNA mismatch repair

(2015) Gloria X. Reyes et al.   CHROMOSOMA

EGFR inhibits DNA mismatch repair

(2015) Peggy Hsieh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Large expansion of CTG•CAG repeats is exacerbated by MutSβ in human cells

(2015) Rie Nakatani et al.   Scientific Reports

Heterozygosity for a Hypomorphic Polβ Mutation Reduces the Expansion Frequency in a Mouse Model of the Fragile X-Related Disorders

(2015) Rachel Adihe Lokanga et al.   PLoS Genetics

Suppression of Somatic Expansion Delays the Onset of Pathophysiology in a Mouse Model of Huntington’s Disease

(2015) Helen Budworth et al.   PLoS Genetics

A 5′, 8-cyclo-2′-deoxypurine lesion induces trinucleotide repeat deletion via a unique lesion bypass by DNA polymerase β

(2014) Meng Xu et al.   NUCLEIC ACIDS RESEARCH

MutLα Heterodimers Modify the Molecular Phenotype of Friedreich Ataxia

(2014) Vahid Ezzatizadeh et al.   PLoS One

Base Excision Repair of Chemotherapeutically-Induced Alkylated DNA Damage Predominantly Causes Contractions of Expanded GAA Repeats Associated with Friedreich's Ataxia

(2014) Yanhao Lai et al.   PLoS One

The Mismatch Repair Protein MSH2 is Rate Limiting for Repeat Expansion in a Fragile X Premutation Mouse Model

(2013) Rachel Adihe Lokanga et al.   HUMAN MUTATION

Gender and Cell-Type-Specific Effects of the Transcription-Coupled Repair Protein, ERCC6/CSB, on Repeat Expansion in a Mouse Model of the Fragile X-Related Disorders

(2013) Xiao-Nan Zhao et al.   HUMAN MUTATION

Instability of CTG Repeats is Governed by the Position of a DNA Base Lesion through Base Excision Repair

(2013) Yanhao Lai et al.   PLoS One

Extrahelical (CAG)/(CTG) triplet repeat elements support proliferating cell nuclear antigen loading and MutL  endonuclease activation

(2013) A. Pluciennik et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mismatch Repair Genes Mlh1 and Mlh3 Modify CAG Instability in Huntington's Disease Mice: Genome-Wide and Candidate Approaches

(2013) Ricardo Mouro Pinto et al.   PLoS Genetics

MSH3 Polymorphisms and Protein Levels Affect CAG Repeat Instability in Huntington's Disease Mice

(2013) Stéphanie Tomé et al.   PLoS Genetics

Neil1 is a genetic modifier of somatic and germline CAG trinucleotide repeat instability in R6/1 mice

(2012) L. Mollersen et al.   HUMAN MOLECULAR GENETICS

DNA Mismatch Repair Complex MutSβ Promotes GAA·TTC Repeat Expansion in Human Cells

(2012) Anasheh Halabi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Noncanonical Mismatch Repair as a Source of Genomic Instability in Human Cells

(2012) Javier Peña-Diaz et al.   MOLECULAR CELL

MutSβ and histone deacetylase complexes promote expansions of trinucleotide repeats in human cells

(2012) Anne-Marie M. Gannon et al.   NUCLEIC ACIDS RESEARCH

Trinucleotide repeat deletion via a unique hairpin bypass by DNA polymerase β and alternate flap cleavage by flap endonuclease 1

(2012) Meng Xu et al.   NUCLEIC ACIDS RESEARCH

Msh2 Acts in Medium-Spiny Striatal Neurons as an Enhancer of CAG Instability and Mutant Huntingtin Phenotypes in Huntington’s Disease Knock-In Mice

(2012) Marina Kovalenko et al.   PLoS One

Pms2 Suppresses Large Expansions of the (GAA·TTC)n Sequence in Neuronal Tissues

(2012) Rebecka L. Bourn et al.   PLoS One

DNA base excision repair: a mechanism of trinucleotide repeat expansion

(2012) Yuan Liu et al.   TRENDS IN BIOCHEMICAL SCIENCES

Msh2-Msh3 Interferes with Okazaki Fragment Processing to Promote Trinucleotide Repeat Expansions

(2012) Athena Kantartzis et al.   Cell Reports

Human Flap Endonuclease Structures, DNA Double-Base Flipping, and a Unified Understanding of the FEN1 Superfamily

(2011) Susan E. Tsutakawa et al.   CELL

Xpa deficiency reduces CAG trinucleotide repeat instability in neuronal tissues in a mouse model of SCA1

(2011) Leroy Hubert et al.   HUMAN MOLECULAR GENETICS

Mechanism of mismatch recognition revealed by human MutSβ bound to unpaired DNA loops

(2011) Shikha Gupta et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Conformational trapping of Mismatch Recognition Complex MSH2/MSH3 on repair-resistant DNA loops

(2011) W. H. Lang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Friedreich's ataxia protein frataxin modulates DNA base excision repair in prokaryotes and mammals

(2010) René Thierbach et al.   BIOCHEMICAL JOURNAL

Mechanisms of trinucleotide repeat instability during human development

(2010) Cynthia T. McMurray   NATURE REVIEWS GENETICS

Mismatch Recognition Protein MutSβ Does Not Hijack (CAG)nHairpin Repairin Vitro

(2009) Lei Tian et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Coordination between Polymerase β and FEN1 Can Modulate CAG Repeat Expansion

(2009) Yuan Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The nucleotide binding dynamics of human MSH2–MSH3 are lesion dependent

(2009) Barbara A L Owen et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Incision-dependent and error-free repair of (CAG) n /(CTG) n hairpins in human cell extracts

(2009) Caixia Hou et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

MSH2 ATPase Domain Mutation Affects CTG•CAG Repeat Instability in Transgenic Mice

(2009) Stéphanie Tomé et al.   PLoS Genetics

Stoichiometry of Base Excision Repair Proteins Correlates with Increased Somatic CAG Instability in Striatum over Cerebellum in Huntington's Disease Transgenic Mice

(2009) Agathi-Vassiliki Goula et al.   PLoS Genetics

Hijacking of the mismatch repair system to cause CAG expansion and cell death in neurodegenerative disease

(2008) Cynthia T. McMurray   DNA REPAIR

Transcription-coupled DNA repair: two decades of progress and surprises

(2008) Philip C. Hanawalt et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Intergenerational and striatal CAG repeat instability in Huntington's disease knock-in mice involve different DNA repair genes

(2008) Ella Dragileva et al.   NEUROBIOLOGY OF DISEASE