Super-complexes of adhesion GPCRs and neural guidance receptors

Attractive and repulsive factors act through multi-subunit receptor complexes to regulate nerve fiber growth

(2015) Nina K. Thiede-Stan et al.   JOURNAL OF CELL SCIENCE

ADHD-associated dopamine transporter, latrophilin and neurofibromin share a dopamine-related locomotor signature in Drosophila

(2015) M van der Voet et al.   MOLECULAR PSYCHIATRY

Repulsive guidance molecule is a structural bridge between neogenin and bone morphogenetic protein

(2015) Eleanor G Healey et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Adhesion G protein-coupled receptors are activated by exposure of a cryptic tethered agonist

(2015) Hannah M. Stoveken et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural Basis of Latrophilin-FLRT-UNC5 Interaction in Cell Adhesion

(2015) Yue C. Lu et al.   STRUCTURE

Structural and Mechanistic Insights into the Latrophilin3-FLRT3 Complex that Mediates Glutamatergic Synapse Development

(2015) Fanomezana M. Ranaivoson et al.   STRUCTURE

Structural Basis of Latrophilin-FLRT Interaction

(2015) Verity A. Jackson et al.   STRUCTURE

Repulsive guidance molecule is a structural bridge between neogenin and bone morphogenetic protein

(2015) Eleanor G Healey et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The Adhesion GPCR Latrophilin/CIRL Shapes Mechanosensation

(2015) Nicole Scholz et al.   Cell Reports

An extracellular biochemical screen reveals that FLRTs and Unc5s mediate neuronal subtype recognition in the retina

(2015) Jasper J Visser et al.   eLife

A rare mutation in UNC5C predisposes to late-onset Alzheimer's disease and increases neuronal cell death

(2014) Monica K Wetzel-Smith et al.   NATURE MEDICINE

LPHN3, a presynaptic adhesion-GPCR implicated in ADHD, regulates the strength of neocortical layer 2/3 synaptic input to layer 5

(2014) Matthew L O’Sullivan et al.   Neural Development

FLRT Structure: Balancing Repulsion and Cell Adhesion in Cortical and Vascular Development

(2014) Elena Seiradake et al.   NEURON

A Tethered Agonist within the Ectodomain Activates the Adhesion G Protein-Coupled Receptors GPR126 and GPR133

(2014) Ines Liebscher et al.   Cell Reports

Decision making inxia2

(2013) Graeme Winter et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Latrophilins Function as Heterophilic Cell-adhesion Molecules by Binding to Teneurins

(2013) Antony A. Boucard et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structurally encoded intraclass differences in EphA clusters drive distinct cell responses

(2013) Elena Seiradake et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Integration of guidance cues: parallel signaling and crosstalk

(2013) Irina Dudanova et al.   TRENDS IN NEUROSCIENCES

Exploiting structure similarity in refinement: automated NCS and target-structure restraints inBUSTER

(2012) Oliver S. Smart et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

A novel evolutionarily conserved domain of cell-adhesion GPCRs mediates autoproteolysis

(2012) Demet Araç et al.   EMBO JOURNAL

High Affinity Neurexin Binding to Cell Adhesion G-protein-coupled Receptor CIRL1/Latrophilin-1 Produces an Intercellular Adhesion Complex

(2012) Antony A. Boucard et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Methionine-aromatic Motif Plays a Unique Role in Stabilizing Protein Structure

(2012) Christopher C. Valley et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Neuropilins lock secreted semaphorins onto plexins in a ternary signaling complex

(2012) Bert J C Janssen et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

FLRT Proteins Are Endogenous Latrophilin Ligands and Regulate Excitatory Synapse Development

(2012) Matthew L. O'Sullivan et al.   NEURON

Linking Crystallographic Model and Data Quality

(2012) P. A. Karplus et al.   SCIENCE

The GPS Motif Is a Molecular Switch for Bimodal Activities of Adhesion Class G Protein-Coupled Receptors

(2012) Simone Prömel et al.   Cell Reports

Overview of theCCP4 suite and current developments

(2011) Martyn D. Winn et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Regulation of the catalytic activity of the EGF receptor

(2011) Nicholas F Endres et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

The fibronectin leucine-rich repeat transmembrane protein Flrt2 is required in the epicardium to promote heart morphogenesis

(2011) Pari-Sima Müller et al.   DEVELOPMENT

Robo4 Maintains Vessel Integrity and Inhibits Angiogenesis by Interacting with UNC5B

(2011) Alexander W. Koch et al.   DEVELOPMENTAL CELL

FLRT2 and FLRT3 act as repulsive guidance cues for Unc5-positive neurons

(2011) Satoru Yamagishi et al.   EMBO JOURNAL

Structural basis for cell surface patterning through NetrinG-NGL interactions

(2011) Elena Seiradake et al.   EMBO JOURNAL

FLRT2 promotes cellular proliferation and inhibits cell adhesion during chondrogenesis

(2011) Y. Xu et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Latrophilin 1 and its endogenous ligand Lasso/teneurin-2 form a high-affinity transsynaptic receptor pair with signaling capabilities

(2011) J.-P. Silva et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A common variant of the latrophilin 3 gene, LPHN3, confers susceptibility to ADHD and predicts effectiveness of stimulant medication

(2010) M Arcos-Burgos et al.   MOLECULAR PSYCHIATRY

Structural basis of semaphorin–plexin signalling

(2010) Bert J. C. Janssen et al.   NATURE

An extracellular steric seeding mechanism for Eph-ephrin signaling platform assembly

(2010) Elena Seiradake et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

ConSurf 2010: calculating evolutionary conservation in sequence and structure of proteins and nucleic acids

(2010) H. Ashkenazy et al.   NUCLEIC ACIDS RESEARCH

Dependence receptors: a new paradigm in cell signaling and cancer therapy

(2010) D Goldschneider et al.   ONCOGENE

Latrophilin Signaling Links Anterior-Posterior Tissue Polarity and Oriented Cell Divisions in the C. elegans Embryo

(2009) Tobias Langenhan et al.   DEVELOPMENTAL CELL

Autoinhibition of UNC5b Revealed by the Cytoplasmic Domain Structure of the Receptor

(2009) Rui Wang et al.   MOLECULAR CELL

Protein structure homology modeling using SWISS-MODEL workspace

(2009) Lorenza Bordoli et al.   Nature Protocols

Unc5B Interacts with FLRT3 and Rnd1 to Modulate Cell Adhesion in Xenopus Embryos

(2009) Emil Karaulanov et al.   PLoS One

Ventral closure, headfold fusion and definitive endoderm migration defects in mouse embryos lacking the fibronectin leucine-rich transmembrane protein FLRT3

(2008) Silvia Maretto et al.   DEVELOPMENTAL BIOLOGY

Genetic ablation of FLRT3 reveals a novel morphogenetic function for the anterior visceral endoderm in suppressing mesoderm differentiation

(2008) J. Egea et al.   GENES & DEVELOPMENT

Determination of Alkali and Halide Monovalent Ion Parameters for Use in Explicitly Solvated Biomolecular Simulations

(2008) In Suk Joung et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Solution Structure and Sugar-Binding Mechanism of Mouse Latrophilin-1 RBL: a 7TM Receptor-Attached Lectin-Like Domain

(2008) Ioannis Vakonakis et al.   STRUCTURE