期刊
JOURNAL OF CELL SCIENCE
卷 128, 期 14, 页码 2403-2414出版社
COMPANY OF BIOLOGISTS LTD
DOI: 10.1242/jcs.165555
关键词
Ephrin; Functional microdomain; Myelin-associated inhibitors; Neurotrophins; Receptor complex
类别
资金
- Swiss National Science Foundation [31003A-149315-1]
- European Research Council [294115]
- National Centre for Competence in Research 'Neural Plasticity and Repair' of the Swiss National Science Foundation
- Christopher and Dana Reeve Foundation, USA
- European Research Council (ERC) [294115] Funding Source: European Research Council (ERC)
- Swiss National Science Foundation (SNF) [31003A_149315] Funding Source: Swiss National Science Foundation (SNF)
In the nervous system, attractive and repulsive factors guide neuronal growth, pathfinding and target innervation during development, learning and regeneration after injury. Repulsive and growth-inhibitory factors, such as some ephrins, semaphorins, netrins and myelin-associated growth inhibitors, restrict nerve fiber growth, whereas neurotrophins, and other ephrins, semaphorins and netrins attract fibers and promote neurite growth. Several of these guidance molecules also play crucial roles in vasculogenesis, and regulate cell migration and tissue formation in different organs. Precise and highly specific signal transduction in space and time is required in all these cases, which primarily depends on the presence and function of specific receptors. Interestingly, many of these ligands act through multi-subunit receptor complexes. In this Commentary, we review the current knowledge of how complexes of the receptors for attractive and repulsive neurite growth regulatory factors are reorganized in a spatial and temporal manner, and reveal the implications that such dynamics have on the signaling events that coordinate neurite fiber growth.
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