mTORC1 and mTORC2 regulate skin morphogenesis and epidermal barrier formation

NuMA-microtubule interactions are critical for spindle orientation and the morphogenesis of diverse epidermal structures

(2016) Lindsey Seldin et al.   eLife

Conditional disruption of rictor demonstrates a direct requirement for mTORC2 in skin tumor development and continued growth of established tumors

(2015) Theresa D. Carr et al.   CARCINOGENESIS

Advances in the therapeutic use of mammalian target of rapamycin (mTOR) inhibitors in dermatology

(2015) Alexander L. Fogel et al.   JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY

mTOR Directs Breast Morphogenesis through the PKC-alpha-Rac1 Signaling Axis

(2015) Meghan M. Morrison et al.   PLoS Genetics

Distinct Functions of Epidermal and Myeloid-Derived VEGF-A in Skin Tumorigenesis Mediated by HPV8

(2014) X. Ding et al.   CANCER RESEARCH

Par3–mInsc and Gαi3 cooperate to promote oriented epidermal cell divisions through LGN

(2014) Scott E. Williams et al.   NATURE CELL BIOLOGY

Making new contacts: the mTOR network in metabolism and signalling crosstalk

(2014) Mitsugu Shimobayashi et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Pten Loss Induces Autocrine FGF Signaling to Promote Skin Tumorigenesis

(2014) Kristina Hertzler-Schaefer et al.   Cell Reports

Insulin/IGF-1 Controls Epidermal Morphogenesis via Regulation of FoxO-Mediated p63 Inhibition

(2013) Christian Günschmann et al.   DEVELOPMENTAL CELL

Ablation of the mTORC2 component rictor in brain or Purkinje cells affects size and neuron morphology

(2013) Venus Thomanetz et al.   JOURNAL OF CELL BIOLOGY

Inhibition of Notch uncouples Akt activation from hepatic lipid accumulation by decreasing mTorc1 stability

(2013) Utpal B Pajvani et al.   NATURE MEDICINE

mTORC2 controls actin polymerization required for consolidation of long-term memory

(2013) Wei Huang et al.   NATURE NEUROSCIENCE

mTOR Signaling in Growth Control and Disease

(2012) Mathieu Laplante et al.   CELL

Hepatic mTORC2 Activates Glycolysis and Lipogenesis through Akt, Glucokinase, and SREBP1c

(2012) Asami Hagiwara et al.   Cell Metabolism

mTOR Inhibition Prevents Epithelial Stem Cell Senescence and Protects from Radiation-Induced Mucositis

(2012) Ramiro Iglesias-Bartolome et al.   Cell Stem Cell

The in vivo function of mammalian cell and tissue polarity regulators - how to shape and maintain the epidermal barrier

(2012) M. T. Niessen et al.   JOURNAL OF CELL SCIENCE

A unifying model for mTORC1-mediated regulation of mRNA translation

(2012) Carson C. Thoreen et al.   NATURE

The translational landscape of mTOR signalling steers cancer initiation and metastasis

(2012) Andrew C. Hsieh et al.   NATURE

Wound Healing Complications and the Use of Mammalian Target of Rapamycin Inhibitors in Kidney Transplantation

(2012) Björn Nashan et al.   TRANSPLANTATION

Asymmetric cell divisions promote Notch-dependent epidermal differentiation

(2011) Scott E. Williams et al.   NATURE

Developmental roles for Srf, cortical cytoskeleton and cell shape in epidermal spindle orientation

(2011) Chen Luxenburg et al.   NATURE CELL BIOLOGY

Mammalian target of rapamycin regulates murine and human cell differentiation through STAT3/p63/Jagged/Notch cascade

(2010) Jianhui Ma et al.   JOURNAL OF CLINICAL INVESTIGATION

A regulatory feedback loop involving p63 and IRF6 links the pathogenesis of 2 genetically different human ectodermal dysplasias

(2010) Francesca Moretti et al.   JOURNAL OF CLINICAL INVESTIGATION

Accelerated Wound Healing by mTOR Activation in Genetically Defined Mouse Models

(2010) Cristiane H. Squarize et al.   PLoS One

mTOR Mediates Wnt-Induced Epidermal Stem Cell Exhaustion and Aging

(2009) Rogerio M. Castilho et al.   Cell Stem Cell

Muscle inactivation of mTOR causes metabolic and dystrophin defects leading to severe myopathy

(2009) Valérie Risson et al.   JOURNAL OF CELL BIOLOGY

Role for Protein Kinase C-α in Keratinocyte Growth Arrest

(2009) Anita Jerome-Morais et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Skeletal Muscle-Specific Ablation of raptor, but Not of rictor, Causes Metabolic Changes and Results in Muscle Dystrophy

(2008) C. Florian Bentzinger et al.   Cell Metabolism

Essential function of TORC2 in PKC and Akt turn motif phosphorylation, maturation and signalling

(2008) Tsuneo Ikenoue et al.   EMBO JOURNAL

Epidermal insulin/IGF-1 signalling control interfollicular morphogenesis and proliferative potential through Rac activation

(2008) Heike Stachelscheid et al.   EMBO JOURNAL