The RNA helicase DHX34 functions as a scaffold for SMG1-mediated UPF1 phosphorylation

Smg6/Est1 licenses embryonic stem cell differentiation via nonsense-mediated mRNA decay

(2015) T. Li et al.   EMBO JOURNAL

RNA degradation drives stem cell differentiation

(2015) C.-H. Lou et al.   EMBO JOURNAL

The conformational plasticity of eukaryotic RNA-dependent ATPases

(2015) Sevim Ozgur et al.   FEBS Journal

A network of SMG-8, SMG-9 and SMG-1 C-terminal insertion domain regulates UPF1 substrate recruitment and phosphorylation

(2015) Aurélien Deniaud et al.   NUCLEIC ACIDS RESEARCH

Regulation of DEAH/RHA Helicases by G-Patch Proteins

(2015) Julien Robert-Paganin et al.   Biomed Research International

Identification and characterization of novel factors that act in the nonsense-mediated mRNA decay pathway in nematodes, flies and mammals

(2014) A. Casadio et al.   EMBO REPORTS

A post-translational regulatory switch on UPF1 controls targeted mRNA degradation

(2014) Tatsuaki Kurosaki et al.   GENES & DEVELOPMENT

Structures of SMG1-UPFs Complexes: SMG1 Contributes to Regulate UPF2-Dependent Activation of UPF1 in NMD

(2014) Roberto Melero et al.   STRUCTURE

The RNA Helicase DHX34 Activates NMD by Promoting a Transition from the Surveillance to the Decay-Inducing Complex

(2014) Nele Hug et al.   Cell Reports

Organizing Principles of Mammalian Nonsense-Mediated mRNA Decay

(2013) Maximilian Wei-Lin Popp et al.   Annual Review of Genetics

Nonsense-mediated mRNA decay — Mechanisms of substrate mRNA recognition and degradation in mammalian cells

(2013) Christoph Schweingruber et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Role of SMG-1-mediated Upf1 phosphorylation in mammalian nonsense-mediated mRNA decay

(2013) Akio Yamashita   GENES TO CELLS

mTOR kinase structure, mechanism and regulation

(2013) Haijuan Yang et al.   NATURE

Identification and functional analysis of novel phosphorylation sites in the RNA surveillance protein Upf1

(2013) Clarivel Lasalde et al.   NUCLEIC ACIDS RESEARCH

DHX34 and NBAS form part of an autoregulatory NMD circuit that regulates endogenous RNA targets in human cells, zebrafish and Caenorhabditis elegans

(2013) Dasa Longman et al.   NUCLEIC ACIDS RESEARCH

Comparison of EJC-enhanced and EJC-independent NMD in human cells reveals two partially redundant degradation pathways

(2013) S. Metze et al.   RNA

NMD: a multifaceted response to premature translational termination

(2012) Stephanie Kervestin et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Tight intramolecular regulation of the human Upf1 helicase by its N- and C-terminal domains

(2012) Francesca Fiorini et al.   NUCLEIC ACIDS RESEARCH

Regulation of nonsense-mediated mRNA decay

(2012) Lulu Huang et al.   Wiley Interdisciplinary Reviews-RNA

Mammalian tissues defective in nonsense-mediated mRNA decay display highly aberrant splicing patterns

(2012) Joachim Weischenfeldt et al.   GENOME BIOLOGY

Integrated regulation of PIKK-mediated stress responses by AAA+ proteins RUVBL1 and RUVBL2

(2012) Natsuko Izumi et al.   Nucleus

The nonsense-mediated mRNA decay SMG-1 kinase is regulated by large-scale conformational changes controlled by SMG-8

(2011) E. Arias-Palomo et al.   GENES & DEVELOPMENT

Molecular Mechanisms for the RNA-Dependent ATPase Activity of Upf1 and Its Regulation by Upf2

(2011) Sutapa Chakrabarti et al.   MOLECULAR CELL

Dhx34 and Nbas function in the NMD pathway and are required for embryonic development in zebrafish

(2011) Corina Anastasaki et al.   NUCLEIC ACIDS RESEARCH

Upf1 ATPase-Dependent mRNP Disassembly Is Required for Completion of Nonsense- Mediated mRNA Decay

(2010) Tobias M. Franks et al.   CELL

Prp43p contains a processive helicase structural architecture with a specific regulatory domain

(2010) Hélène Walbott et al.   EMBO JOURNAL

Structural basis for the function of DEAH helicases

(2010) Yangzi He et al.   EMBO REPORTS

Characterization of SMG-9, an essential component of the nonsense-mediated mRNA decay SMG1C complex

(2010) Israel S. Fernández et al.   NUCLEIC ACIDS RESEARCH

Unusual bipartite mode of interaction between the nonsense-mediated decay factors, UPF1 and UPF2

(2009) Marcello Clerici et al.   EMBO JOURNAL

SMG-8 and SMG-9, two novel subunits of the SMG-1 complex, regulate remodeling of the mRNA surveillance complex during nonsense-mediated mRNA decay

(2009) A. Yamashita et al.   GENES & DEVELOPMENT

Human Proline-Rich Nuclear Receptor Coregulatory Protein 2 Mediates an Interaction between mRNA Surveillance Machinery and Decapping Complex

(2009) Hana Cho et al.   MOLECULAR CELL

Crystal structure of DNA-PKcs reveals a large open-ring cradle comprised of HEAT repeats

(2009) Bancinyane L. Sibanda et al.   NATURE

Protein structure prediction on the Web: a case study using the Phyre server

(2009) Lawrence A Kelley et al.   Nature Protocols

Interactions between UPF1, eRFs, PABP and the exon junction complex suggest an integrated model for mammalian NMD pathways

(2008) Pavel V Ivanov et al.   EMBO JOURNAL