A network of SMG-8, SMG-9 and SMG-1 C-terminal insertion domain regulates UPF1 substrate recruitment and phosphorylation

Structures of SMG1-UPFs Complexes: SMG1 Contributes to Regulate UPF2-Dependent Activation of UPF1 in NMD

(2014) Roberto Melero et al.   STRUCTURE

Organizing Principles of Mammalian Nonsense-Mediated mRNA Decay

(2013) Maximilian Wei-Lin Popp et al.   Annual Review of Genetics

Nonsense-mediated mRNA decay — Mechanisms of substrate mRNA recognition and degradation in mammalian cells

(2013) Christoph Schweingruber et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Role of SMG-1-mediated Upf1 phosphorylation in mammalian nonsense-mediated mRNA decay

(2013) Akio Yamashita   GENES TO CELLS

mTOR kinase structure, mechanism and regulation

(2013) Haijuan Yang et al.   NATURE

Structural and functional analysis of the three MIF4G domains of nonsense-mediated decay factor UPF2

(2013) Marcello Clerici et al.   NUCLEIC ACIDS RESEARCH

Inhibition of SMG-8, a subunit of SMG-1 kinase, ameliorates nonsense-mediated mRNA decay-exacerbated mutant phenotypes without cytotoxicity

(2013) F. Usuki et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

NMD: a multifaceted response to premature translational termination

(2012) Stephanie Kervestin et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The cryo-EM structure of the UPF–EJC complex shows UPF1 poised toward the RNA 3′ end

(2012) Roberto Melero et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Tight intramolecular regulation of the human Upf1 helicase by its N- and C-terminal domains

(2012) Francesca Fiorini et al.   NUCLEIC ACIDS RESEARCH

Genetic Characterization of smg-8 Mutants Reveals No Role in C. elegans Nonsense Mediated Decay

(2012) Jacqueline Rosains et al.   PLoS One

Sense from nonsense: therapies for premature stop codon diseases

(2012) Laure Bidou et al.   TRENDS IN MOLECULAR MEDICINE

The nonsense-mediated mRNA decay SMG-1 kinase is regulated by large-scale conformational changes controlled by SMG-8

(2011) E. Arias-Palomo et al.   GENES & DEVELOPMENT

Molecular Mechanisms for the RNA-Dependent ATPase Activity of Upf1 and Its Regulation by Upf2

(2011) Sutapa Chakrabarti et al.   MOLECULAR CELL

N- and C-terminal Upf1 phosphorylations create binding platforms for SMG-6 and SMG-5:SMG-7 during NMD

(2011) Yukiko Okada-Katsuhata et al.   NUCLEIC ACIDS RESEARCH

Execution of nonsense-mediated mRNA decay: what defines a substrate?

(2009) Indrani Rebbapragada et al.   CURRENT OPINION IN CELL BIOLOGY

Emerging common themes in regulation of PIKKs and PI3Ks

(2009) Harri Lempiäinen et al.   EMBO JOURNAL

Unusual bipartite mode of interaction between the nonsense-mediated decay factors, UPF1 and UPF2

(2009) Marcello Clerici et al.   EMBO JOURNAL

SMG-8 and SMG-9, two novel subunits of the SMG-1 complex, regulate remodeling of the mRNA surveillance complex during nonsense-mediated mRNA decay

(2009) A. Yamashita et al.   GENES & DEVELOPMENT

DoG Picker and TiltPicker: Software tools to facilitate particle selection in single particle electron microscopy

(2009) N.R. Voss et al.   JOURNAL OF STRUCTURAL BIOLOGY

Crystal structure of DNA-PKcs reveals a large open-ring cradle comprised of HEAT repeats

(2009) Bancinyane L. Sibanda et al.   NATURE

Interactions between UPF1, eRFs, PABP and the exon junction complex suggest an integrated model for mammalian NMD pathways

(2008) Pavel V Ivanov et al.   EMBO JOURNAL

Image processing for electron microscopy single-particle analysis using XMIPP

(2008) Sjors H W Scheres et al.   Nature Protocols

Cryo-EM Structure of the DNA-Dependent Protein Kinase Catalytic Subunit at Subnanometer Resolution Reveals α Helices and Insight into DNA Binding

(2008) Dewight R. Williams et al.   STRUCTURE

The meaning of nonsense

(2008) Lukas Stalder et al.   TRENDS IN CELL BIOLOGY