Inductive interactions mediated by interplay of asymmetric signalling underlie development of adult haematopoietic stem cells

Flow-induced protein kinase A–CREB pathway acts via BMP signaling to promote HSC emergence

(2015) Peter Geon Kim et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Adenosine signaling promotes hematopoietic stem and progenitor cell emergence

(2015) Lili Jing et al.   JOURNAL OF EXPERIMENTAL MEDICINE

BMP signalling differentially regulates distinct haematopoietic stem cell types

(2015) Mihaela Crisan et al.   Nature Communications

NACA deficiency reveals the crucial role of somite-derived stromal cells in haematopoietic niche formation

(2015) Emi Murayama et al.   Nature Communications

Endothelial Smad4 restrains the transition to hematopoietic progenitors via suppression of ERK activation

(2014) Y. Lan et al.   BLOOD

Proinflammatory Signaling Regulates Hematopoietic Stem Cell Emergence

(2014) Raquel Espín-Palazón et al.   CELL

Interferon Gamma Signaling Positively Regulates Hematopoietic Stem Cell Emergence

(2014) Suphansa Sawamiphak et al.   DEVELOPMENTAL CELL

Inflammatory signaling regulates embryonic hematopoietic stem and progenitor cell production

(2014) Yan Li et al.   GENES & DEVELOPMENT

Haematopoietic stem cell induction by somite-derived endothelial cells controlled by meox1

(2014) Phong Dang Nguyen et al.   NATURE

FGF signalling restricts haematopoietic stem cell specification via modulation of the BMP pathway

(2014) Claire Pouget et al.   Nature Communications

FGF signalling specifies haematopoietic stem cells through its regulation of somitic Notch signalling

(2014) Yoonsung Lee et al.   Nature Communications

Tracing the Origin of the HSC Hierarchy Reveals an SCF-Dependent, IL-3-Independent CD43− Embryonic Precursor

(2014) Stanislav Rybtsov et al.   Stem Cell Reports

Identification of the Niche and Phenotype of the First Human Hematopoietic Stem Cells

(2014) Andrejs Ivanovs et al.   Stem Cell Reports

Notch and Wnt signaling in the emergence of hematopoietic stem cells

(2013) Anna Bigas et al.   BLOOD CELLS MOLECULES AND DISEASES

Retinoic Acid Signaling Is Essential for Embryonic Hematopoietic Stem Cell Development

(2013) Bhaskar Chanda et al.   CELL

Mathematical model of a gene regulatory network reconciles effects of genetic perturbations on hematopoietic stem cell emergence

(2013) Jatin Narula et al.   DEVELOPMENTAL BIOLOGY

Uncoupling VEGFA Functions in Arteriogenesis and Hematopoietic Stem Cell Specification

(2013) Amy Leung et al.   DEVELOPMENTAL CELL

Hemogenic Endothelial Cell Specification Requires c-Kit, Notch Signaling, and p27-Mediated Cell-Cycle Control

(2013) Kathrina L. Marcelo et al.   DEVELOPMENTAL CELL

Early dynamic fate changes in haemogenic endothelium characterized at the single-cell level

(2013) Gemma Swiers et al.   Nature Communications

Gene Regulatory Logic for Reading the Sonic Hedgehog Signaling Gradient in the Vertebrate Neural Tube

(2012) Nikolaos Balaskas et al.   CELL

Signaling from the Sympathetic Nervous System Regulates Hematopoietic Stem Cell Emergence during Embryogenesis

(2012) Simon R. Fitch et al.   Cell Stem Cell

Dorsal-ventral patterning of the neural tube: A tale of three signals

(2012) Gwenvael Le Dréau et al.   Developmental Neurobiology

Hematopoietic stem cell development requires transient Wnt/β-catenin activity

(2012) Cristina Ruiz-Herguido et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Endothelial and perivascular cells maintain haematopoietic stem cells

(2012) Lei Ding et al.   NATURE

E-Cadherin Promotes Incorporation of Mouse Epiblast Stem Cells into Normal Development

(2012) Satoshi Ohtsuka et al.   PLoS One

Signaling axis involving Hedgehog, Notch, and Scl promotes the embryonic endothelial-to-hematopoietic transition

(2012) P. G. Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Embryonic origin of the adult hematopoietic system: advances and questions

(2011) A. Medvinsky et al.   DEVELOPMENT

Hierarchical organization and early hematopoietic specification of the developing HSC lineage in the AGM region

(2011) Stanislav Rybtsov et al.   JOURNAL OF EXPERIMENTAL MEDICINE

A Runx1-Smad6 Rheostat Controls Runx1 Activity during Embryonic Hematopoiesis

(2011) K. Knezevic et al.   MOLECULAR AND CELLULAR BIOLOGY

A somitic Wnt16/Notch pathway specifies haematopoietic stem cells

(2011) Wilson K. Clements et al.   NATURE

Three-dimensional cartography of hematopoietic clusters in the vasculature of whole mouse embryos

(2010) T. Yokomizo et al.   DEVELOPMENT

Distinct Sonic Hedgehog signaling dynamics specify floor plate and ventral neuronal progenitors in the vertebrate neural tube

(2010) V. Ribes et al.   GENES & DEVELOPMENT

Hematopoietic stem cell activity in the aorta-gonad-mesonephros region enhances after mid-day 11 of mouse development

(2010) Erin Taylor et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY

In vivo imaging of haematopoietic cells emerging from the mouse aortic endothelium

(2010) Jean-Charles Boisset et al.   NATURE

Blood stem cells emerge from aortic endothelium by a novel type of cell transition

(2010) Karima Kissa et al.   NATURE

Haematopoietic stem cells derive directly from aortic endothelium during development

(2010) Julien Y. Bertrand et al.   NATURE

BMP4 regulates the hematopoietic stem cell niche

(2009) D. C. Goldman et al.   BLOOD

A rapid and sensitive bioassay for the simultaneous measurement of multiple bone morphogenetic proteins. Identification and quantification of BMP4, BMP6 and BMP9 in bovine and human serum

(2009) Blanca Herrera et al.   BMC CELL BIOLOGY

Ventral embryonic tissues and Hedgehog proteins induce early AGM hematopoietic stem cell development

(2009) M. Peeters et al.   DEVELOPMENT

Hedgehog and Bmp Polarize Hematopoietic Stem Cell Emergence in the Zebrafish Dorsal Aorta

(2009) Robert N. Wilkinson et al.   DEVELOPMENTAL CELL

Runx1 is required for the endothelial to haematopoietic cell transition but not thereafter

(2009) Michael J. Chen et al.   NATURE

Extensive Hematopoietic Stem Cell Generation in the AGM Region via Maturation of VE-Cadherin+CD45+ Pre-Definitive HSCs

(2008) Samir Taoudi et al.   Cell Stem Cell