Article
Environmental Sciences
Weitao Shen, Yu Chen, Ning Wang, Ping Wan, Zhenyan Peng, Huajin Zhao, Wei Wang, Lilin Xiong, Shenghu Zhang, Ran Liu
Summary: This study analyzed the removal capacity of antibiotics, antibiotic resistance determinants, and bacteria in sewage treatment plants and their impact on environmental waters. The results showed that the removal capacity of bacteria was poor in summer, and the concentration of fluoroquinolone was higher in the effluent. Furthermore, the study found that the relationship between these pollutants differed between summer and winter.
JOURNAL OF ENVIRONMENTAL MANAGEMENT
(2022)
Article
Infectious Diseases
Lenka Doubravska, Miroslava Htoutou Sedlakova, Katerina Fiserova, Vendula Pudova, Karel Urbanek, Jana Petrzelova, Magdalena Roderova, Katerina Langova, Kristyna Mezerova, Pavla Kucova, Karel Axmann, Milan Kolar
Summary: This observational retrospective study analyzed the changes in bacterial pathogens and their resistance to antibiotics among intensive care patients in a Czech hospital during the COVID-19 pandemic. The study found that there were shifts in the distribution and resistance of bacterial pathogens, possibly due to antibiotic selection pressure and clonal spread of bacteria.
Review
Pharmacology & Pharmacy
Jiaxin Yao, Pengfei Zou, Yanan Cui, Liangzhu Quan, Chunsheng Gao, Zhiping Li, Wei Gong, Meiyan Yang
Summary: Bacterial infection is a common clinical disease, and antibiotics are effective in fighting against bacteria. However, the widespread use of antibiotics has led to the emergence of drug resistance, posing a significant threat to human health. Recent studies have explored various strategies to combat drug-resistant bacteria, including nano-drug delivery systems. This review summarizes the mechanistic insights of using different strategies, highlights recent advancements in antimicrobial materials and drug delivery systems for different carriers, and discusses the challenges and future perspectives in combating antimicrobial resistance.
Review
Genetics & Heredity
Steven P. Djordjevic, Veronica M. Jarocki, Torsten Seemann, Max L. Cummins, Anne E. Watt, Barbara Drigo, Ethan R. Wyrsch, Cameron J. Reid, Erica Donner, Benjamin P. Howden
Summary: This article discusses the complexity of antimicrobial resistance (AMR) and its threat to health and security. Genomic technologies are used to monitor and model the spread and evolution of AMR. However, there are challenges in the broader adoption of genomic surveillance.
NATURE REVIEWS GENETICS
(2023)
Article
Engineering, Environmental
Manman Cao, Fei Wang, Beihai Zhou, Huilun Chen, Rongfang Yuan, Shuai Ma, Huanhuan Geng, Junhong Li, Wenxiao Lv, Yan Wang, Baoshan Xing
Summary: In this study, we investigated the comprehensive effect of nanoparticles and antibiotics stress on the dispersal and abundance of antibiotic-resistance genes (ARGs) in the phycosphere. We found that antibiotics had a greater impact on ARGs compared to nanoparticles at environmentally relevant concentrations, and the lifestyle of bacteria significantly determined the abundance of ARGs and bacterial communities. Additionally, the interaction between algae and bacteria may indirectly affect the distribution and abundance of ARGs.
JOURNAL OF HAZARDOUS MATERIALS
(2023)
Review
Medicine, Research & Experimental
Asuka Joy Tobuse, Chee Wei Ang, Keng Yoon Yeong
Summary: With the continuous evolution of bacteria, the global health threat of antimicrobial resistance, which causes millions of deaths annually, is becoming increasingly serious. While relying on antibiotics as the primary treatment method has its advantages, effective alternatives against some drug-resistant bacteria are still lacking in the pharmaceutical market. In recent years, vaccinology has gained significant attention in scientific research, and with the advancement of technology, vaccine research has become faster and more efficient. Although less discussed, bacterial vaccines are a feasible strategy to combat antimicrobial resistance. Some vaccines have shown promising results with good efficacy against numerous multidrug-resistant strains of bacteria. This review aims to discuss the findings from studies utilizing reverse vaccinology for the development of vaccines against multidrug-resistant bacteria, as well as provide a summary of multi-year bacterial vaccine studies in clinical trials. The advantages of reverse vaccinology in generating new bacterial vaccines are also highlighted. Meanwhile, the limitations and future prospects of bacterial vaccines are concluded in this review.
Article
Multidisciplinary Sciences
Jose Molina, Clara Maria Rosso-Fernandez, Enrique Montero-Mateos, Jose Ramon Pano-Pardo, Maria Solla, Ana Belen Guisado-Gil, Rocio Alvarez-Marin, Maria Eugenia Pachon-Ibanez, Adelina Gimeno, Guillermo Martin-Gutierrez, Jose Antonio Lepe, Jose Miguel Cisneros
Summary: Research priorities in AMS have evolved rapidly, with short-term trials being used to explore the effectiveness of short-course treatments for Pseudomonas aeruginosa infections, thus allowing for more efficient use of antibiotics. The SHORTEN-2 trial aligns with priorities in AMS research and overcomes common obstacles through methodological innovation.
Article
Microbiology
Elyse J. Roach, Tsuyoshi Uehara, Denis M. Daigle, David A. Six, Cezar M. Khursigara
Summary: Gram-negative bacteria producing carbapenemases are resistant to beta-lactam antibiotics, posing a significant health risk. Taniborbactam is an investigational broad-spectrum beta-lactamase inhibitor effective against serine- and metallo-beta-lactamases, including KPC. This study demonstrated the effectiveness of taniborbactam in restoring the antibacterial activity of cefepime against KPC-3-producing Escherichia coli, highlighting its potential in combating beta-lactamase-mediated antibiotic resistance.
MICROBIOLOGY SPECTRUM
(2021)
Review
Environmental Sciences
Rui Zhang, Shu Yang, Yuwei An, Yangqing Wang, Yu Lei, Liyan Song
Summary: Landfill serves as important reservoirs for antibiotics and antibiotic resistance genes, with risks of transferring to the local environment. Studies have shown complex linkages among antibiotics, ARGs, and bacterial communities, highlighting the need for further research.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Review
Microbiology
Tanzeel Zohra, Muhammad Numan, Aamer Ikram, Muhammad Salman, Tariq Khan, Misbahud Din, Ayesha Farooq, Afreenish Amir, Muhammad Ali
Summary: Antimicrobial resistance is a growing silent pandemic, with multidrug-resistant strains threatening public health improvement and posing challenges in clinical practice. Understanding resistance mechanisms and developing new antimicrobial agents and alternative tools are crucial in combating this issue.
Article
Biochemistry & Molecular Biology
Fei Ye, Hafeez S. Haniff, Blessy M. Suresh, Dong Yang, Peiyuan Zhang, Gogce Crynen, Christiana N. Teijaro, Wei Yan, Daniel Abegg, Alexander Adibekian, Ben Shen, Matthew D. Disney
Summary: This study identified compounds with RNA affinity through direct screening of partially purified NPs and correlated the interactions with the human transcriptome. One compound, nocathiacin I (NOC-I), demonstrated low affinity binding to oncogenic noncoding microRNA-18a, selectively inhibiting its nuclease processing and triggering apoptosis in vitro and in prostate cancer cells.
ACS CHEMICAL BIOLOGY
(2022)
Article
Materials Science, Composites
Michelle M. Makhoul-Mansour, Joshua J. Maraj, Stephen A. Sarles
Summary: In this concept article, recent works on the use of biologically-derived materials for neuromorphic computing applications are reviewed. The focus is on the memory resistance functionality achieved through bio-inspired systems that closely emulate living neurons. The potential of biocompatible and tissue-like materials for smart monitoring and treatment, therapeutic delivery, and neural activity interpretation is discussed.
JOURNAL OF COMPOSITE MATERIALS
(2022)
Review
Biochemistry & Molecular Biology
Aleksandra Baran, Aleksandra Kwiatkowska, Leszek Potocki
Summary: Despite the development of medicine, antibiotics are still the first choice for patients with infectious disorders. However, the widespread availability and overprescription of antibiotics has led to an increase in multidrug-resistant microbes. Understanding the interaction between antibiotic mechanisms and bacterial defense strategies is crucial for developing new drugs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Infectious Diseases
Patrick Muinde, John Maina, Kelvin Momanyi, Victor Yamo, John Mwaniki, John Kiiru
Summary: There is a growing problem of bacterial resistance to antibiotics globally, jeopardizing the effectiveness of essential antimicrobials in reducing disease mortality and morbidity. Bacteria in animals are believed to serve as reservoirs of resistance genes that can be transmitted to humans through the food chain. A study in Kenya examined the resistance patterns of bacteria in pork and poultry meat samples from leading retail outlets, and found high contamination rates and a significant proportion of multidrug-resistant isolates, including resistance to critically important antimicrobials for human and veterinary medicine. It is crucial to raise awareness on the proper use of antibiotics and implement preventive measures to reduce the burden of disease.
Review
Biotechnology & Applied Microbiology
Nayanika Chakraborty, Diksha Jha, Indrajit Roy, Pradeep Kumar, Shailendra Singh Gaurav, Kalisvar Marimuthu, Oon-Tek Ng, Rajamani Lakshminarayanan, Navin Kumar Verma, Hemant K. Gautam
Summary: With the increment in antimicrobial resistance, the world is on the brink of a post-antibiotic era. The current COVID-19 pandemic is expected to exacerbate the situation due to the lack of new antimicrobial drugs. Nanoscale materials have the potential to effectively treat deadly pathogens and avoid the development of antimicrobial resistance.
JOURNAL OF NANOBIOTECHNOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Rupy Kaur Matharu, Lena Ciric, Guogang Ren, Mohan Edirisinghe
Article
Chemistry, Multidisciplinary
Yuen-Ki Cheong, Mariana P. Arce, Alejandro Benito, Daijie Chen, Noemi Luengo Crisostomo, Laxmi Kerai, Guillermo Rodriguez, Jose L. Valverde, Mansukhlal Vadalia, Arisbel Cerpa-Naranjo, Guogang Ren
Article
Pharmacology & Pharmacy
Muhammet Emin Cam, Ayse Nur Hazar-Yavuz, Sumeyye Cesur, Ozan Ozkan, Hussain Alenezi, Hilal Turkoglu Sasmazel, Mehmet Sayip Eroglu, Francis Brako, Jubair Ahmed, Levent Kabasakal, Guogang Ren, Oguzhan Gunduz, Mohan Edirisinghe
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2020)
Review
Chemistry, Multidisciplinary
Xiuyi Yang, Etelka Chung, Ian Johnston, Guogang Ren, Yuen-Ki Cheong
Summary: Antibiotic resistance poses a significant threat to public health, and nanoparticles with antimicrobial efficacy have the potential to combat this issue. More research is needed to fully understand the mechanisms of action and advance biomedical applications further.
APPLIED SCIENCES-BASEL
(2021)
Article
Chemistry, Multidisciplinary
Simon P. Graham, Yuen-Ki Cheong, Summer Furniss, Emma Nixon, Joseph A. Smith, Xiuyi Yang, Rieke Fruengel, Sabha Hussain, Monika A. Tchorzewska, Roberto M. La Ragione, Guogang Ren
Summary: The study evaluated five AVNPs for their viricidal activity against PRRSV, with CuNP showing the most effective reduction in virus titers at lower concentrations and achieving significant reduction in just 1.5 minutes. Direct contact between viruses and AVNP was necessary for optimal virus reduction, which was attributed to the inert nature of the AVNPs.
Review
Physics, Applied
Esra Altun, Mehmet Onur Aydogdu, Etelka Chung, Guogang Ren, Shervanthi Homer-Vanniasinkam, Mohan Edirisinghe
Summary: The synergy of metal-based nanoparticles (MBNPs) and antibiotics plays a crucial role in overcoming bacterial resistance, enhancing antibacterial effect, and reducing the dosage of active pharmaceutical ingredients.
APPLIED PHYSICS REVIEWS
(2021)
Article
Materials Science, Multidisciplinary
Rupy Kaur Matharu, Yuen-Ki Cheong, Guogang Ren, Mohan Edirisinghe, Lena Ciric
Summary: This study demonstrates the strong antiviral properties of novel copper-silver and copper-zinc intermetallic nanoparticles against RNA and DNA viruses, making them significant alternatives to conventional antiviral therapies and decontamination agents.
EMERGENT MATERIALS
(2022)
Article
Nanoscience & Nanotechnology
Adil Loya, Antash Najib, Fahad Aziz, Asif Khan, Guogang Ren, Kun Luo, Adil Loya
Summary: Adding metal oxide nanoparticles to fluids can enhance their thermal conductive properties, which is useful for high-end fluid heat-transfer applications. These nanoparticles can improve the properties of both polar and nonpolar fluids. Molecular dynamic simulations were used to disperse nanoparticles in hydrocarbon and aqueous-based fluids, and the results were validated using autocorrelation function and experimental data.
BEILSTEIN JOURNAL OF NANOTECHNOLOGY
(2022)
Review
Chemistry, Multidisciplinary
Maarij Khan, Zia-ur-Rehman Mashwani, Muhammad Ikram, Naveed Raja, Azza H. Mohamed, Guogang Ren, Ahmad A. Omar
Summary: This review article provides a detailed overview of the therapeutic actions and mechanisms of green synthesized cerium oxide nanoparticles in the medical field, which can contribute to the advancement and precision of medicine and provide important information for disease diagnosis and treatment strategies.
Article
Multidisciplinary Sciences
Adil Loya, Jacqueline L. Stair, Farid Uddin, Guogang Ren
Summary: This research focuses on investigating the interactions between surface-treated nanoparticles and liquid media through lab-based experimentation and simulation. The study explores the compatibility and diffusivity of modified CuO nanoparticles with short-chain carboxylate-terminated molecules in biofluids. Additionally, the efficacy of Cu/CuONPs in killing SARS-CoV1/2 and other airborne viruses is highlighted.
SCIENTIFIC REPORTS
(2022)
Article
Engineering, Environmental
Hailiang Mu, Xiangqun Zhuge, Guogang Ren, Kun Luo, Zhengping Ding, Yurong Ren, Zhihong Luo, Maryam Bayati, Ben Bin Xu, Xiaoteng Liu
Summary: A significantly extended battery life, improved rate performance and full-discharge capacity were achieved by using dual functional mesoporous silica (mSiO2) colloidal electrolytes for lithium-oxygen batteries. The mSiO2 with a high specific surface area exhibited a stable colloid after mixing with 1.0 M LiClO4/DMSO, suppressing side reactions and accelerating the decomposition of the discharge product. This study provides new insights into the design and development of novel lithium metal batteries using non-aqueous electrolytes.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Infectious Diseases
Amalia Miranda, Tamara Akpobolokemi, Etelka Chung, Guogang Ren, Bahijja Tolulope Raimi-Abraham
Summary: Plant-mediated green synthesis is a cost-effective and eco-friendly method to synthesize metallic nanoparticles. This study investigated the influence of experimental pH on the antimicrobial properties of silver nanoparticles synthesized using Spinacia oleracea leaf extract. The results showed that experimental pH played a significant role in determining the antimicrobial activity of the synthesized silver nanoparticles.
Article
Oncology
Zohreh Salari, Ahmad Khosravi, Elham Pourkhandani, Elaheh Molaakbari, Ehsan Salarkia, Alireza Keyhani, Iraj Sharifi, Hadi Tavakkoli, Samira Sohbati, Shahriar Dabiri, Guogang Ren, Mohammad Shafie'ei
Summary: This study compared the effects of 6-gingerol, cisplatin, and their combination on apoptotic and angiogenetic activities in ovarian cancer cells. The results showed that the combination therapy of 6-gingerol and cisplatin had a significant promotion on cell apoptosis and suppression on angiogenesis.
FRONTIERS IN ONCOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Kun Luo, Ya Li, Tong Liu, Xiangqun Zhuge, Etelka Chung, Andrew R. Timms, Simon P. Graham, Guogang Ren
Summary: Copper nanoparticles and gold nanoclusters have high catalytic performance in generating hydrogen peroxide, which can be used to kill disease-causing microbes and carry carbon-free energy. By decorating the surface of copper nanoparticles with gold nanoclusters using galvanic displacement, a novel method was demonstrated to selectively produce hydrogen peroxide. The optimized copper-gold bimetallic nanoparticles exhibited excellent catalytic activity and durability.
Article
Multidisciplinary Sciences
Ehsan Salarkia, Mahdis Mehdipoor, Elahe Molaakbari, Ahmad Khosravi, Mohammad Reza Sazegar, Zohreh Salari, Iman Rad, Shahriar Dabiri, Siyavash Joukar, Iraj Sharifi, Guogang Ren
Summary: The study investigates the effectiveness of synthesized polymeric mesoporous silica nanoparticles (MSN) as carriers for oral insulin and their interactions with insulin and IR through in-silico docking. The MSN family demonstrated a significant reduction in blood glucose levels and exhibited safety, non-toxicity, fast operation, self-repairing pancreas, cost-effectiveness, and high efficiency in the oral insulin delivery system. Docking results revealed strong interactions between MSN compounds and insulin and IR, offering promising prospects for diabetes treatment.