Article
Oncology
Yuko Nagamura, Makoto Miyazaki, Yoshiko Nagano, Arata Tomiyama, Rieko Ohki, Kazuyoshi Yanagihara, Ryuichi Sakai, Hideki Yamaguchi
Summary: Diffuse-type gastric carcinoma (DGC) is characterized by aggressive progression associated with rapid infiltrative growth, massive fibrosis, and peritoneal dissemination. In this study, SHP2 was identified as a critical regulator downstream of the amplified Met and FGFR2 receptor tyrosine kinases (RTKs) in DGC cell lines. Targeting SHP2 selectively suppressed the growth and malignant phenotypes of RTK-addicted DGC, highlighting its potential as a therapeutic target for DGC treatment.
Review
Biochemistry & Molecular Biology
Manali Tilak, Jennifer Holborn, Laura A. New, Jasmin Lalonde, Nina Jones
Summary: Glioblastoma multiforme (GBM) is a deadly cancer with limited response to existing therapies. Subtypes of GBM with distinct genetic signatures show aberrant activation of signal transduction pathways. Current research focuses on understanding these molecular alterations to develop more efficient targeted therapies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Yinhua Jin, Teni Anbarchian, Peng Wu, Abby Sarkar, Matt Fish, Weng Chuan Peng, Roel Nusse
Summary: Cell proliferation is tightly regulated by various factors, including transcriptional repressors E2F7 and E2F8. In this study, it was discovered that Wnt/β-catenin signaling maintains active cell division in the liver through the transcription factor Tbx3. Tbx3 directly represses the transcription of E2f7 and E2f8, thereby promoting mitosis.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Multidisciplinary Sciences
Hanne-Line Rabben, Goran Troseth Andersen, Magnus Kringstad Olsen, Anders Overby, Aleksandr Ianevski, Denis Kainov, Timothy Cragin Wang, Steinar Lundgren, Jon Erik Gronbech, Duan Chen, Chun-Mei Zhao
Summary: The study identified a link between neural signaling and tumor metabolism, proposing a therapeutic strategy targeting nerve-cancer metabolism which demonstrated efficacy in mouse models and feasibility in patients.
Review
Pharmacology & Pharmacy
Sareshma Sudhesh Dev, Syafiq Asnawi Zainal Abidin, Reyhaneh Farghadani, Iekhsan Othman, Rakesh Naidu
Summary: Receptor tyrosine kinases (RTKs) are crucial cell-surface proteins that regulate essential cellular processes, with alterations in them playing a key role in cancer progression. Curcumin, as an attractive anti-cancer agent, exhibits potent effects by inhibiting RTKs and downstream signaling pathways.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Oncology
Hideki Yamaguchi, Yuko Nagamura, Makoto Miyazaki
Summary: Gastric cancer is a leading cause of cancer-related death globally, with diffuse-type gastric carcinoma exhibiting aggressive progression and high recurrence rate. Gene amplification and aberrant activation of receptor tyrosine kinase signaling play a crucial role in the development and peritoneal metastasis of diffuse-type gastric carcinoma.
Article
Biochemistry & Molecular Biology
May Meltzer, Noam Eliash, Ziv Azoulay, Uzi Hadad, Niv Papo
Summary: The study focuses on the importance of Tie1 and Tie2 receptor tyrosine kinases in various diseases, especially cancer. Using non-immune nanobodies, the researchers discovered a highly expressive and specific nanobody that binds to Tie1, with potential therapeutic effects on cancer.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Biology
Payam E. Farahani, Xiaoyu Yang, Emily Mesev, Kaylan A. Fomby, Ellen H. Brumbaugh-Reed, Caleb J. Bashor, Celeste M. Nelson, Jared E. Toettcher
Summary: pYtags is a modular approach for monitoring the activity of a specific RTK by live-cell microscopy. It enables monitoring of a specific RTK on different time and space scales with high specificity. Using pYtag biosensors, signaling dynamics can be quantitatively characterized with different activating ligands. The specificity and modularity of pYtags open the door to robust biosensors of multiple tyrosine kinases.
Editorial Material
Genetics & Heredity
Ivona Aksentijevich
Summary: Immune responses require a delicate balance - too weak or too strong a response can cause issues. Spleen tyrosine kinase plays a crucial role in multiple signaling pathways, and its gain-of-function alterations can lead to various problems, including hypogammaglobulinemia and predisposition to B cell lymphoma.
Article
Biochemistry & Molecular Biology
Hua-jian Shan, Kun Jiang, Ming-zhi Zhao, Wen-jing Deng, Wen-hao Cao, Jia-jun Li, Ke-ran Li, Chang She, Wei-feng Luo, Jin Yao, Xiao-zhong Zhou, Dan Zhang, Cong Cao
Summary: This study demonstrated that Gai1/3 proteins mediate SCF/c-Kit-activated signaling and angiogenesis in endothelial cells. Knockdown or knockout of Gai1/3, as well as dominant negative mutations, attenuated SCF-induced activation of Akt-mTOR and Erk, as well as endothelial cell proliferation, migration, and capillary tube formation.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Thomas Chabot, Yvonnick Cheraud, Fabrice Fleury
Summary: Receptor Tyrosine Kinases (RTKs) play a crucial role in cancer cell survival and are relevant targets in cancer research. Recent studies have shown a close relationship between RTK signaling and DNA repair regulation, providing new research directions for the development of therapeutic strategies targeting both pathways.
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
(2021)
Article
Anatomy & Morphology
Wenxue Liang, Ting Zhang, Juan Huo, Jin Yang
Summary: This study found that MARCH1 maintains the stemness characteristics of GC cells and promotes their proliferation by activating the Wnt/ll-catenin signaling pathway.
Review
Hematology
Thomas J. Kipps
Summary: ROR1 is a cell receptor with significant importance in embryonic development and cancer. It plays a crucial role in the pathophysiology of CLL and has distinctive expression in this malignancy. Researchers have conducted studies on the expression, biology, and therapeutic strategies targeting ROR1.
Review
Medicine, General & Internal
Soo Young Jeong, Kyung-jun Lee, Jieum Cha, So Yoon Park, Hyeong Su Kim, Jung Han Kim, Jae-Jun Lee, Namhyeok Kim, Sung Taek Park
Summary: This study aimed to evaluate the prognostic value of ROR1 expression in various cancers. The meta-analysis found that high expression of ROR1 was associated with worse overall survival and progression-free survival. The results highlight the potential of targeting ROR1 for cancer therapeutics.
MEDICINA-LITHUANIA
(2022)
Article
Cell Biology
Pardis Mohammadzadeh, Mina Roueinfar, Gregory C. Amberg
Summary: This study reveals a novel role for AXL as a modulator of GnRH receptor signaling. Gas6 enhances GnRH-dependent ERK phosphorylation and Egr-1 transcript abundance, and promotes LH beta production and pro-MMP9 protein generation, as well as cell migration.
CELL COMMUNICATION AND SIGNALING
(2023)
Article
Cell Biology
Ruiting Liu, Guorong Wang, Chang Liu, Jian Qiu, Likun Yan, Xiaojun Li, Xiaoqiang Wang
CELL BIOLOGY INTERNATIONAL
(2016)
Article
Medicine, Research & Experimental
Rui-Ting Liu, Guo-Rong Wang, Chang Liu, Jian Qiu, Li-Kun Yan, Xiao-Jun Li, Xiao-Qiang Wang
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2016)