Posttranslational Modifications of Tubulin and Cilia

Graded Control of Microtubule Severing by Tubulin Glutamylation

(2016) Max L. Valenstein et al.   CELL

Mechanism of ciliary disassembly

(2016) Yinwen Liang et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

The nexin link and B-tubule glutamylation maintain the alignment of outer doublets in the ciliary axoneme

(2016) Lea M. Alford et al.   Cytoskeleton

Ttll9−/−mice sperm flagella show shortening of doublet 7, reduction of doublet 5 polyglutamylation and a stall in beating

(2016) Alu Konno et al.   JOURNAL OF CELL SCIENCE

Glutamylation of the DNA sensor cGAS regulates its binding and synthase activity in antiviral immunity

(2016) Pengyan Xia et al.   NATURE IMMUNOLOGY

Loss of RPGR glutamylation underlies the pathogenic mechanism of retinal dystrophy caused byTTLL5mutations

(2016) Xun Sun et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Microtubule doublets are double-track railways for intraflagellar transport trains

(2016) L. Stepanek et al.   SCIENCE

Structural basis of cofactor-mediated stabilization and substrate recognition of the α-tubulin acetyltransferase αTAT1

(2015) Satoru Yuzawa et al.   BIOCHEMICAL JOURNAL

Multivalent Microtubule Recognition by Tubulin Tyrosine Ligase-like Family Glutamylases

(2015) Christopher P. Garnham et al.   CELL

Writing and Reading the Tubulin Code

(2015) Ian Yu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Reduced tubulin polyglutamylation suppresses flagellar shortness in Chlamydomonas

(2015) Tomohiro Kubo et al.   MOLECULAR BIOLOGY OF THE CELL

Lineage specificity of primary cilia in the mouse embryo

(2015) Fiona K. Bangs et al.   NATURE CELL BIOLOGY

Intrinsically disordered tubulin tails: complex tuners of microtubule functions?

(2015) Antonina Roll-Mecak   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Post-translational modifications of tubulin: pathways to functional diversity of microtubules

(2015) Yuyu Song et al.   TRENDS IN CELL BIOLOGY

Deacetylation of α-tubulin and cortactin is required for HDAC6 to trigger ciliary disassembly

(2015) Jie Ran et al.   Scientific Reports

New HDAC6-mediated deacetylation sites of tubulin in the mouse brain identified by quantitative mass spectrometry

(2015) Ningning Liu et al.   Scientific Reports

Polyglutamylated Tubulin Binding Protein C1orf96/CSAP Is Involved in Microtubule Stabilization in Mitotic Spindles

(2015) Shinya Ohta et al.   PLoS One

Biallelic Variants in TTLL5, Encoding a Tubulin Glutamylase, Cause Retinal Dystrophy

(2014) Panagiotis I. Sergouniotis et al.   AMERICAN JOURNAL OF HUMAN GENETICS

The Motility of Axonemal Dynein Is Regulated by the Tubulin Code

(2014) Joshua D. Alper et al.   BIOPHYSICAL JOURNAL

Effects of α-Tubulin K40 Acetylation and Detyrosination on Kinesin-1 Motility in a Purified System

(2014) Neha Kaul et al.   BIOPHYSICAL JOURNAL

Molecular Basis for Age-Dependent Microtubule Acetylation by Tubulin Acetyltransferase

(2014) Agnieszka Szyk et al.   CELL

CYLD mediates ciliogenesis in multiple organs by deubiquitinating Cep70 and inactivating HDAC6

(2014) Yunfan Yang et al.   CELL RESEARCH

Tubulin glycylases are required for primary cilia, control of cell proliferation and tumor development in colon

(2014) C. Rocha et al.   EMBO JOURNAL

Trypanosoma cruzi Bromodomain Factor 3 Binds Acetylated α-Tubulin and Concentrates in the Flagellum during Metacyclogenesis

(2014) Victoria Lucia Alonso et al.   EUKARYOTIC CELL

The tubulin code: Molecular components, readout mechanisms, and functions

(2014) Carsten Janke   JOURNAL OF CELL BIOLOGY

Cytosolic carboxypeptidase CCP6 is required for megakaryopoiesis by modulating Mad2 polyglutamylation

(2014) Buqing Ye et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Structural and Functional Characterization of the α-Tubulin Acetyltransferase MEC-17

(2014) Andrew M. Davenport et al.   JOURNAL OF MOLECULAR BIOLOGY

The cytosolic carboxypeptidases CCP2 and CCP3 catalyze posttranslational removal of acidic amino acids

(2014) Olivia Tort et al.   MOLECULAR BIOLOGY OF THE CELL

Cytoplasmic carboxypeptidase 5 regulates tubulin glutamylation and zebrafish cilia formation and function

(2014) Narendra Pathak et al.   MOLECULAR BIOLOGY OF THE CELL

FAP20 is an inner junction protein of doublet microtubules essential for both the planar asymmetrical waveform and stability of flagella in Chlamydomonas

(2014) Haru-aki Yanagisawa et al.   MOLECULAR BIOLOGY OF THE CELL

Regulation of microtubule motors by tubulin isotypes and post-translational modifications

(2014) Minhajuddin Sirajuddin et al.   NATURE CELL BIOLOGY

SIRT2 regulates ciliogenesis and contributes to abnormal centrosome amplification caused by loss of polycystin-1

(2013) Xia Zhou et al.   HUMAN MOLECULAR GENETICS

Disruption ofTtll5/StampGene (Tubulin Tyrosine Ligase-like Protein 5/SRC-1 and TIF2-associated Modulatory Protein Gene) in Male Mice Causes Sperm Malformation and Infertility

(2013) Geun-Shik Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mice Lacking α-Tubulin Acetyltransferase 1 Are Viable but Display α-Tubulin Acetylation Deficiency and Dentate Gyrus Distortion

(2013) Go-Woon Kim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural basis of tubulin tyrosination by tubulin tyrosine ligase

(2013) Andrea E. Prota et al.   JOURNAL OF CELL BIOLOGY

Tubulin glycylases and glutamylases have distinct functions in stabilization and motility of ependymal cilia

(2013) Montserrat Bosch Grau et al.   JOURNAL OF CELL BIOLOGY

Centrosomal protein CEP104 (Chlamydomonas FAP256) moves to the ciliary tip during ciliary assembly

(2013) T. V. Satish Tammana et al.   JOURNAL OF CELL SCIENCE

A conserved flagella-associated protein in Chlamydomonas, FAP234, is essential for axonemal localization of tubulin polyglutamylase TTLL9

(2013) Tomohiro Kubo et al.   MOLECULAR BIOLOGY OF THE CELL

Effects of tubulin acetylation and tubulin acetyltransferase binding on microtubule structure

(2013) Stuart C. Howes et al.   MOLECULAR BIOLOGY OF THE CELL

αTAT1 is the major α-tubulin acetyltransferase in mice

(2013) Nereo Kalebic et al.   Nature Communications

Molecular basis of the acetyltransferase activity of MEC-17 towards α-tubulin

(2012) Wenjing Li et al.   CELL RESEARCH

Posttranslational Acetylation of α-Tubulin Constrains Protofilament Number in Native Microtubules

(2012) Juan G. Cueva et al.   CURRENT BIOLOGY

Genetically Separable Functions of the MEC-17 Tubulin Acetyltransferase Affect Microtubule Organization

(2012) Irini Topalidou et al.   CURRENT BIOLOGY

Tubulin polyglutamylation regulates flagellar motility by controlling a specific inner-arm dynein that interacts with the dynein regulatory complex

(2012) Tomohiro Kubo et al.   Cytoskeleton

Crystal Structures of Tubulin Acetyltransferase Reveal a Conserved Catalytic Core and the Plasticity of the Essential N Terminus

(2012) Vasilisa Kormendi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PF19 encodes the p60 catalytic subunit of katanin and is required for assembly of the flagellar central apparatus in Chlamydomonas

(2012) E. E. Dymek et al.   JOURNAL OF CELL SCIENCE

Tubulin Acetyltransferase αTAT1 Destabilizes Microtubules Independently of Its Acetylation Activity

(2012) Nereo Kalebic et al.   MOLECULAR AND CELLULAR BIOLOGY

CSAP localizes to polyglutamylated microtubules and promotes proper cilia function and zebrafish development

(2012) Chelsea B. Backer et al.   MOLECULAR BIOLOGY OF THE CELL

CEP41 is mutated in Joubert syndrome and is required for tubulin glutamylation at the cilium

(2012) Ji Eun Lee et al.   NATURE GENETICS

Tubulin Acetylation Alone Does Not Affect Kinesin-1 Velocity and Run Length In Vitro

(2012) Wilhelm J. Walter et al.   PLoS One

Luminal Localization of α-tubulin K40 Acetylation by Cryo-EM Analysis of Fab-Labeled Microtubules

(2012) Virupakshi Soppina et al.   PLoS One

Structure of the  -tubulin acetyltransferase,  TAT1, and implications for tubulin-specific acetylation

(2012) D. R. Friedmann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Atomic resolution structure of human  -tubulin acetyltransferase bound to acetyl-CoA

(2012) M. Taschner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Tubulin Deglutamylase CCPP-1 Regulates the Function and Stability of Sensory Cilia in C. elegans

(2011) Robert O'Hagan et al.   CURRENT BIOLOGY

Tubulin Tyrosine Ligase-like Genesttll3andttll6Maintain Zebrafish Cilia Structure and Motility

(2011) Narendra Pathak et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Three-dimensional structure of the radial spokes reveals heterogeneity and interactions with dyneins in Chlamydomonas flagella

(2011) Cynthia F. Barber et al.   MOLECULAR BIOLOGY OF THE CELL

Tubulin tyrosine ligase structure reveals adaptation of an ancient fold to bind and modify tubulin

(2011) Agnieszka Szyk et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Cryo-electron tomography reveals conserved features of doublet microtubules in flagella

(2011) D. Nicastro et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Family of Protein-Deglutamylating Enzymes Associated with Neurodegeneration

(2010) Krzysztof Rogowski et al.   CELL

Tubulin Glutamylation Regulates Ciliary Motility by Altering Inner Dynein Arm Activity

(2010) Swati Suryavanshi et al.   CURRENT BIOLOGY

Tubulin Polyglutamylation Regulates Axonemal Motility by Modulating Activities of Inner-Arm Dyneins

(2010) Tomohiro Kubo et al.   CURRENT BIOLOGY

Identification of Tubulin Deglutamylase amongCaenorhabditis elegansand Mammalian Cytosolic Carboxypeptidases (CCPs)

(2010) Yoshishige Kimura et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Discrete PIH proteins function in the cytoplasmic preassembly of different subsets of axonemal dyneins

(2010) Ryosuke Yamamoto et al.   JOURNAL OF CELL BIOLOGY

Tubulin polyglutamylation stimulates spastin-mediated microtubule severing

(2010) Benjamin Lacroix et al.   JOURNAL OF CELL BIOLOGY

A novel acetylation of β-tubulin by San modulates microtubule polymerization via down-regulating tubulin incorporation

(2010) Chih-Wen Chu et al.   MOLECULAR BIOLOGY OF THE CELL

Functional genomic screen for modulators of ciliogenesis and cilium length

(2010) Joon Kim et al.   NATURE

MEC-17 is an α-tubulin acetyltransferase

(2010) Jyothi S. Akella et al.   NATURE

Tubulin polyglutamylation is essential for airway ciliary function through the regulation of beating asymmetry

(2010) K. Ikegami et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The major  -tubulin K40 acetyltransferase  TAT1 promotes rapid ciliogenesis and efficient mechanosensation

(2010) T. Shida et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tubulin Tyrosine Ligase–Like 1 Deficiency Results in Chronic Rhinosinusitis and Abnormal Development of Spermatid Flagella in Mice

(2010) P. Vogel et al.   VETERINARY PATHOLOGY

Recombinant Mammalian Tubulin Polyglutamylase TTLL7 Performs both Initiation and Elongation of Polyglutamylation on β-Tubulin through a Random Sequential Pathway†

(2009) Masahiro Mukai et al.   BIOCHEMISTRY

Evolutionary Divergence of Enzymatic Mechanisms for Posttranslational Polyglycylation

(2009) Krzysztof Rogowski et al.   CELL

TTLL3 Is a Tubulin Glycine Ligase that Regulates the Assembly of Cilia

(2009) Dorota Wloga et al.   DEVELOPMENTAL CELL

DYF-1 Is Required for Assembly of the Axoneme inTetrahymena thermophila

(2009) Drashti Dave et al.   EUKARYOTIC CELL

Hyperglutamylation of Tubulin Can either Stabilize or Destabilize Microtubules in the Same Cell

(2009) Dorota Wloga et al.   EUKARYOTIC CELL

TTLL10 can perform tubulin glycylation when co-expressed with TTLL8

(2009) Koji Ikegami et al.   FEBS LETTERS

Electron-tomographic analysis of intraflagellar transport particle trains in situ

(2009) Gaia Pigino et al.   JOURNAL OF CELL BIOLOGY

The ubiquitin conjugation system is involved in the disassembly of cilia and flagella

(2009) Kaiyao Huang et al.   JOURNAL OF CELL BIOLOGY

Asymmetry of inner dynein arms and inter-doublet links inChlamydomonasflagella

(2009) Khanh Huy Bui et al.   JOURNAL OF CELL BIOLOGY

Lysine Acetylation Targets Protein Complexes and Co-Regulates Major Cellular Functions

(2009) C. Choudhary et al.   SCIENCE

Axoneme β-Tubulin Sequence Determines Attachment of Outer Dynein Arms

(2008) Elizabeth C. Raff et al.   CURRENT BIOLOGY

Glutamylation on α-Tubulin Is Not Essential but Affects the Assembly and Functions of a Subset of Microtubules inTetrahymena thermophila

(2008) Dorota Wloga et al.   EUKARYOTIC CELL

TTLL10 is a protein polyglycylase that can modify nucleosome assembly protein 1

(2008) Koji Ikegami et al.   FEBS LETTERS

Mice Lacking Histone Deacetylase 6 Have Hyperacetylated Tubulin but Are Viable and Develop Normally

(2008) Y. Zhang et al.   MOLECULAR AND CELLULAR BIOLOGY

Structural basis of microtubule severing by the hereditary spastic paraplegia protein spastin

(2008) Antonina Roll-Mecak et al.   NATURE

Axoneme-dependent tubulin modifications in singlet microtubules of theDrosophila sperm tail

(2008) Henry D. Hoyle et al.   CELL MOTILITY AND THE CYTOSKELETON