Article
Immunology
A. Elisabeth Gressler, Daniela Volke, Carolina Firacative, Christiane L. Schnabel, Uwe Mueller, Andor Krizsan, Bianca Schulze-Richter, Matthias Brock, Frank Brombacher, Patricia Escandon, Ralf Hoffmann, Gottfried Alber
Summary: The study showed an increase in anti-cryptococcal IgG titers in CM patients, while IgM titers were not affected. Additionally, pre-existing IgG and IgM antibodies were detected even in healthy individuals' sera.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Herdson Renney de Sousa, Stefania de Frazao, Getulio Pereira de Oliveira Junior, Patricia Albuquerque, Andre Moraes Nicola
Summary: Cryptococcosis, caused by Cryptococcus spp, has a high mortality rate and lacks effective prevention and treatment methods. Understanding fungal virulence and host responses could lead to improved therapies. Studies using clinical isolates to correlate laboratory and patient data have provided valuable insights into the pathophysiology of cryptococcosis.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Multidisciplinary Sciences
Sally H. Mohamed, Man Shun Fu, Sofia Hain, Alanoud Alselami, Eliane Vanhoffelen, Yanjian Li, Ebrima Bojang, Robert Lukande, Elizabeth R. Ballou, Robin C. May, Chen Ding, Greetje Vande Velde, Rebecca A. Drummond
Summary: Microglia do not provide protection against Cryptococcus neoformans brain infection, but may act as a reservoir for early infection and a site for the fungus to access copper micronutrient.
NATURE COMMUNICATIONS
(2023)
Review
Immunology
Chen Yang, Yemei Huang, Yangyu Zhou, Xuelei Zang, Hengyu Deng, Yitong Liu, Dingxia Shen, Xinying Xue
Summary: Cryptococcus is an invasive fungus that poses a serious threat to human life and health, with a complex and well-established immune-escaping mechanism that interferes with the function of the host immune system.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Medicine, General & Internal
Nazia Khursheed, Amna Umer, Fareeha Adnan
Summary: This is a rare case of disseminated cryptococcosis. The patient is a six-year-old boy undergoing evaluation for lymphoma. In this case, Cryptococcus neoformans was diagnosed through blood culture rather than cerebrospinal fluid.
PAKISTAN JOURNAL OF MEDICAL SCIENCES
(2022)
Article
Microbiology
Yina Wang, Keyi Wang, Amariliz Rivera, Chaoyang Xue
Summary: Invasive fungal infections, such as cryptococcosis, are difficult to treat and lack effective vaccines. However, heat-killed fbp1 Delta cells (HK-fbp1) have shown potential as a vaccine candidate, providing immunity against lethal fungal pathogens. This study revealed that T cells, specifically CD4(+) or CD8(+) T cells, are critical for the vaccine-induced protection. Additionally, HK-fbp1 administration can inhibit disease dissemination when used as a therapeutic agent at the early stage of infection.
MICROBIOLOGY SPECTRUM
(2023)
Article
Immunology
Xu Zhao, Lei Shen, Jianming Zheng, Haiyan Zhu, Li Li, Hong Shi, Zhongqing Chen, Qian Li
Summary: C1qa deficiency in mice increases susceptibility to Cryptococcus neoformans lung infection, leading to higher mortality and enhanced inflammation. It also promotes the formation of more pathogenic Titan cells and reduces macrophage killing of the pathogen.
OPEN FORUM INFECTIOUS DISEASES
(2023)
Article
Medicine, General & Internal
Pakornswit Sathongdejwisit, Kritsada Pruksaphon, Akarin Intaramat, Pisinee Aiumurai, Nitat Sookrung, Kavi Ratanabanangkoon, Joshua D. Nosanchuk, Sirida Youngchim
Summary: The study developed a novel lateral flow immunochromatographic strip test for detecting cryptococcal polysaccharide capsular antigens using a single specific monoclonal antibody, mAb 18B7, which showed high sensitivity and accuracy in diagnosing cryptococcal meningitis with cerebrospinal fluid samples. The mAb 18B7 ICT was also effective in serum samples, providing a reliable and cost-effective point-of-care immunodiagnostic test for cryptococcosis, especially in countries where commercial kits are not available or affordable.
Article
Biochemistry & Molecular Biology
Itai Doron, Irina Leonardi, Xin Li, William D. Fiers, Alexa Semon, Meghan Bialt-DeCelie, Melanie Migaud, Iris H. Gao, Woan-Yu Lin, Takato Kusakabe, Anne Puel, Iliyan D. Iliev
Summary: This study reveals the important role of gut commensal fungi in shaping the human antibody repertoire through CARD9-dependent induction of host-protective antifungal IgG.
Candida albicans is the major inducer of antifungal immunoglobulin G (IgG) and provides protection against disseminated candidiasis.
Review
Microbiology
Abdulaziz H. Alanazi, Mir S. Adil, Xiaorong Lin, Daniel B. Chastain, Andres F. Henao-Martinez, Carlos Franco-Paredes, Payaningal R. Somanath
Summary: Intracranial hypertension is the main cause of increased mortality in cryptococcal meningoencephalitis. Pharmacologic therapy aimed at reducing cerebrospinal fluid production or increasing resorption may improve clinical outcomes for patients with this condition.
Review
Infectious Diseases
Qingyu Huang, Zhuquan Hong, Quanlong Hong
Summary: This case report describes a rare combined infection of Actinomyces odontolyticus sepsis and cryptococcal encephalitis. The patient was successfully treated with a combination therapy of penicillin, amphotericin, and fluconazole.
BMC INFECTIOUS DISEASES
(2023)
Article
Immunology
Tyler G. Normile, Maurizio Del Poeta
Summary: This study found that the Cryptococcus neoformans Delta sgl1 mutant has the potential to be a vaccine for preventing and treating cryptococcosis, providing effective protection even in immunocompromised conditions. It was also discovered that the HK Delta sgl1 vaccine can prevent the reactivation of lung granuloma after immunosuppression.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Infectious Diseases
Yanchun Zhong, Yuxi Huang, Di Zhang, Zhaoyuan Chen, Zhenxing Liu, Yongjun Ye
Summary: This article reports a rare case of isolated sacral cryptococcal osteomyelitis in an immunocompetent patient. Furthermore, it identified and reviewed 18 published cases of spine cryptococcal osteomyelitis. Clinical manifestation and imaging are insufficient to diagnose cryptococcal osteomyelitis of the spine, and invasive examinations, such as puncture biopsy and fungal examinations, are needed. Antifungal therapy yields satisfactory results for the treatment of cryptococcal osteomyelitis of the spine, however, if the infective lesion is large, especially when it compresses the spinal cord and nerves, a regimen combining aggressive surgery with antifungal therapy is indispensable.
BMC INFECTIOUS DISEASES
(2023)
Article
Medicine, Research & Experimental
Lu Xu, Yi-Jun Mo, Xing-Bei Weng
Summary: This report describes a case of a false-negative cerebral spinal fluid (CSF) cryptococcal antigen (CrAg) lateral flow assay (LFA) in a 25-year-old HIV-positive male. Initial CSF CrAg LFA test was negative, but a weakly positive result was obtained at a 1:4 dilution and a positive result at a 1:8 dilution of CSF. Serum cryptococcal antigen test was also weakly positive. Blood and CSF cultures were positive for Cryptococcus neoformans. The false-negative CSF CrAg LFA test was attributed to the high antigen concentration causing the postzone phenomenon.
JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
(2023)
Article
Immunology
Chao Li, Yang Meng, Hailong Li, Wei Du, Xindi Gao, Chenhao Suo, Yiru Gao, Yue Ni, Tianshu Sun, Sheng Yang, Tian Lan, Meiling Xin, Chen Ding
Summary: This study identifies Prm1 as a novel regulator of C. neoformans virulence and demonstrates that prm1? cells exhibit sensitivity to environmental stress conditions and deficiencies in the biosynthesis of chitosan and mannoprotein. Heat-killed prm1? cells facilitate host immunological defence against infection with wild-type C. neoformans and promote pulmonary production of interferon-γ, leading to activation of macrophage M1 differentiation and inhibition of M2 polarization. Therefore, C. neoformans Prm1 may be a potential target for anti-cryptococcosis medications and prm1? cells could be a candidate for a vaccine.
EMERGING MICROBES & INFECTIONS
(2023)
Article
Microbiology
Charles A. Specht, Chrono K. Lee, Haibin Huang, Donald J. Tipper, Zu T. Shen, Jennifer K. Lodge, John Leszyk, Gary R. Ostroff, Stuart M. Levitz
Article
Microbiology
Christina M. Homer, Diana K. Summers, Alexi I. Goranov, Starlynn C. Clarke, Darin L. Wiesner, Jolene K. Diedrich, James J. Moresco, Dena Toffaletti, Rajendra Upadhya, Ippolito Caradonna, Sarah Petnic, Veronica Pessino, Christina A. Cuomo, Jennifer K. Lodge, John Perfect, John R. Yates, Kirsten Nielsen, Charles S. Craik, Hiten D. Madhani
CELL HOST & MICROBE
(2016)
Article
Genetics & Heredity
Rajendra Upadhya, Woei C. Lam, Brian T. Maybruck, Maureen J. Donlin, Andrew L. Chang, Sarah Kayode, Kate L. Ormerod, James A. Fraser, Tamara L. Doering, Jennifer K. Lodge
FUNGAL GENETICS AND BIOLOGY
(2017)
Article
Microbiology
Charles A. Specht, Chrono K. Lee, Haibin Huang, Maureen M. Hester, Jianhua Liu, Bridget A. Luckie, Melanie A. Torres Santana, Zeynep Mirza, Payam Khoshkenar, Ambily Abraham, Zu T. Shen, Jennifer K. Lodge, Ali Akalin, Jane Homan, Gary R. Ostroff, Stuart M. Levitz
Article
Microbiology
Yeissa Chabrier-Rosello, Kimberly J. Gerik, Kristy Koselny, Louis DiDone, Jennifer K. Lodge, Damian J. Krysan
Article
Microbiology
Woei C. Lam, Kimberly J. Gerik, Jennifer K. Lodge
Article
Biochemistry & Molecular Biology
Rajendra Upadhya, Hyelim Kim, Kwang-Woo Jung, Goun Park, Woei Lam, Jennifer K. Lodge, Yong-Sun Bahn
MOLECULAR MICROBIOLOGY
(2013)
Article
Multidisciplinary Sciences
Rajendra Upadhya, Leona T. Campbell, Maureen J. Donlin, Rajeev Aurora, Jennifer K. Lodge
Article
Microbiology
Maureen J. Donlin, Rajendra Upadhya, Kimberly J. Gerik, Woei Lam, Laura G. VanArendonk, Charles A. Specht, Neil K. Sharma, Jennifer K. Lodge
Editorial Material
Microbiology
Rajendra Upadhya, Maureen J. Donlin, Jennifer K. Lodge
Article
Genetics & Heredity
Guilhem Janbon, Kate L. Ormerod, Damien Paulet, Edmond J. Byrnes, Vikas Yadav, Gautam Chatterjee, Nandita Mullapudi, Chung-Chau Hon, R. Blake Billmyre, Francois Brunel, Yong-Sun Bahn, Weidong Chen, Yuan Chen, Eve W. L. Chow, Jean-Yves Coppee, Anna Floyd-Averette, Claude Gaillardin, Kimberly J. Gerik, Jonathan Goldberg, Sara Gonzalez-Hilarion, Sharvari Gujja, Joyce L. Hamlin, Yen-Ping Hsueh, Giuseppe Ianiri, Steven Jones, Chinnappa D. Kodira, Lukasz Kozubowski, Woei Lam, Marco Marra, Larry D. Mesner, Piotr A. Mieczkowski, Frederique Moyrand, Kirsten Nielsen, Caroline Proux, Tristan Rossignol, Jacqueline E. Schein, Sheng Sun, Carolin Wollschlaeger, Ian A. Wood, Qiandong Zeng, Cecile Neuveglise, Carol S. Newlon, John R. Perfect, Jennifer K. Lodge, Alexander Idnurm, Jason E. Stajich, James W. Kronstad, Kaustuv Sanyal, Joseph Heitman, James A. Fraser, Christina A. Cuomo, Fred S. Dietrich
Article
Microbiology
Rodgoun Attarian, Guanggan Hu, Eddy Sanchez-Leon, Melissa Caza, Daniel Croll, Eunsoo Do, Horacio Bach, Tricia Missall, Jennifer Lodge, Won Hee Jung, James W. Kronstad
Article
Microbiology
Rajendra Upadhya, Lorina G. Baker, Woei C. Lam, Charles A. Specht, Maureen J. Donlin, Jennifer K. Lodge
Correction
Microbiology
Rodgoun Attarian, Guanggan Hu, Eddy Sanchez-Leon, Melissa Caza, Daniel Croll, Eunsoo Do, Horacio Bach, Tricia Missall, Jennifer Lodge, Won Hee Jung, James W. Kronstad