Review
Nutrition & Dietetics
Mariano Bizzarri, Noemi Monti, Aurora Piombarolo, Antonio Angeloni, Roberto Verna
Summary: Myo-inositol is the most abundant natural polyol among the nine structural isomers. It plays a crucial role in biochemical processes governing cellular transitions and insulin transduction. It also affects glucose metabolism and steroid hormone synthesis, and has been successfully used in the management of polycystic ovarian syndrome.
Article
Food Science & Technology
Feier Cheng, Xinhui Ge, Yao Zhang, Jia Li, Shaoqing Yan, Yunlong Li, Min Wang
Summary: The combination of quercetin and d-chiro-inositol improved antioxidant enzyme activity, reduced protein kinase Cc translocation, and increased signal transduction in the IRS-2/PI3K/Akt/FoxO1 pathway, thus ameliorating high fat diet-induced hepatic insulin resistance in mice.
Review
Biochemistry & Molecular Biology
Riccardo Gambioli, Mario Montanino Oliva, Maurizio Nordio, Alfonsina Chiefari, Giulia Puliani, Vittorio Unfer
Summary: D-chiro-inositol is a natural compound found in cell membranes, primarily involved in intracellular insulin transduction cascade in mammals. It also plays a role in regulating steroidogenesis, reducing adhesion molecule expression, and exerting anti-inflammatory activities. Research on this molecule is crucial due to its involvement in several fundamental physiological processes.
Article
Endocrinology & Metabolism
Feier Cheng, Shao-jun Yun, Jin-ling Cao, Ming-chang Chang, Jun-long Meng, Jing-yu Liu, Yan-fen Cheng, Cui-ping Feng
Summary: Dietary supplement DCI has shown significant effects in preventing obesity and metabolic diseases, particularly insulin resistance. Through studying its impact on primary hepatocytes, we identified its critical role in regulating glycolysis and gluconeogenesis. This research generated new insights into the functions and gene targets of DCI in metabolic health.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Medicine, General & Internal
Maurizio Nordio, Maria Salome Bezerra Espinola, Gabriele Bilotta, Elena Capoccia, Mario Montanino Oliva
Summary: Background: Previous studies raised concerns about the long-term use of high doses of D-chiro-inositol in women, but no clinical trials have investigated these concerns. This retrospective analysis and prospective pilot study aimed to address this issue. Methods: The retrospective analysis included insulin-resistant women who took 1200 mg/day D-chiro-inositol for 6 months. The prospective study enrolled 10 healthy women for supplementation. Statistical analyses were performed using the Wilcoxon Signed-Rank Test. Results: The treatment significantly decreased BMI, glycemia, insulinemia, HOMA-IR, serum levels of LH, total testosterone, and DHEAS. Serum estradiol rose and menstrual abnormalities occurred following the treatment. In the prospective study, increases in serum levels of total testosterone and asprosin were observed in healthy women. Conclusions: This study provides the first clinical evidence that long-term treatments with high dosages of D-chiro-inositol can lead to hormonal and menstrual abnormalities in women. The accumulation of D-chiro-inositol following such treatment regimen may also have detrimental effects in non-reproductive tissues, as demonstrated by the increase in asprosin levels.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Juan J. Sanchez-Gil, Sanne W. M. Poppeliers, Jordan Vacheron, Hao Zhang, Bart Odijk, Christoph Keel, Ronnie de Jonge
Summary: In this study, the iol locus in Pseudomonas was identified as a feature enriched among superior root colonizers in natural soil. Further characterization revealed that the iol locus increases competitiveness by inducing swimming motility and the production of fluorescent siderophore in response to inositol. Public data analyses indicate that the iol locus is broadly conserved in the Pseudomonas genus and linked to diverse host-microbe interactions. Therefore, the iol locus is a potential target for developing more effective bioinoculants for sustainable agriculture.
Article
Geriatrics & Gerontology
Xiaomei Du, Yichun Wang, Jilite Wang, Xiaozhi Liu, Jingnan Chen, Ji Kang, Xu Yang, Hao Wang
Summary: D-Chiro-Inositol (DCI) and D-Pinitol (DP) have positive effects on lifespan and antioxidant activity in Drosophila melanogaster. DCI shows slightly better effects than DP. The prolongation of lifespan by DCI and DP is achieved through regulating intestinal homeostasis and inhibiting abnormal proliferation of intestinal stem cells. Insulin signaling pathway and autophagy pathway are involved in the longevity-promoting effects of DCI and DP.
EXPERIMENTAL GERONTOLOGY
(2022)
Article
Endocrinology & Metabolism
Maria Magdalena Montt-Guevara, Michele Finiguerra, Ilaria Marzi, Tiziana Fidecicchi, Amerigo Ferrari, Alessandro D. Genazzani, Tommaso Simoncini
Summary: D-Chiro-Ins directly affects the differentiation and function of human adipocytes, synergizing with insulin and estrogen to promote lipid and glucose storage. This research provides insights into D-Chiro-Ins actions on fat metabolism and their implications in various diseases.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Plant Sciences
Jun Luo, Lingyi Kong, Yujin Sun, Zefan Wang, Wang Hua, Letian Cui
Summary: Eleven new D-chiro-inositol derivatives were isolated from the fruits of Chisocheton siamensis, along with a known analogue. Their structures and configurations were determined using spectroscopic methods, exciton chirality, and X-ray diffraction crystallography. This is the first report of crystallographic data for these derivatives. A structural elucidation strategy combining various methods was developed, leading to revisions of previously reported structures. Bioactivity evaluation showed that chisosiamols A, B, and J exhibited potential in reversing multidrug resistance in MCF-7/DOX cells.
JOURNAL OF NATURAL PRODUCTS
(2023)
Article
Chemistry, Analytical
Cristina Tortolini, Valeria Gigli, Flavio Rizzo, Andrea Lenzi, Mariano Bizzarri, Antonio Angeloni, Riccarda Antiochia
Summary: This paper describes the development of a simple voltammetric biosensor for the stereoselective discrimination of myo-inositol and D-chiro-inositol by means of bovine serum albumin adsorption onto a multi-walled carbon nanotube graphite screen-printed electrode.
Article
Nutrition & Dietetics
Sabrina Basciani, Maurizio Nordio, Simona Dinicola, Vittorio Unfer, Lucio Gnessi, Susanne Klaus
Summary: The primary control of dysmetabolic patients is challenging, and preventive measures usually fail. This pilot study suggests that supplementation with myo-inositol and d-chiro-inositol in the 40:1 ratio, alpha-lactalbumin, and Gymnema sylvestre can potentiate the beneficial effects induced via dietary programs in dysmetabolic patients.
Article
Medicine, General & Internal
Anupama Bahadur, Hitanshi Arora, Anoosha K. Ravi, Manisha Naithani, Yogesh Bahurupi, Jaya Chaturvedi, Megha Ajmani, Rajlaxmi Mundhra
Summary: The study indicates that combined therapy with metformin and MI plus DCI shows better treatment effects for women with PCOS compared to metformin alone, especially in improving global acne score and cycle regularity.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Giuseppina Porcaro, Gabriele Bilotta, Elena Capoccia, Maria Salome Bezerra Espinola, Cesare Aragona
Summary: We conducted a study to investigate the effect of insulin sensitizer D-chiro-inositol on patients with simple endometrial hyperplasia without atypia. The results showed that treatment with D-chiro-inositol significantly improved endometrial thickness, heavy menstrual bleeding, and menstrual cycle in these patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pharmacology & Pharmacy
A. K. Kiani, S. Paolacci, A. E. Calogero, R. Cannarella, G. C. Di Renzo, S. Gerli, C. Della Morte, G. M. Busetto, E. De Berardinis, F. Del Giudice, L. Stuppia, F. Facchinetti, S. Dinicola, M. Bertelli
Summary: Inositol and D-chiro-inositol play crucial roles in the body, and their synthesis and absorption mechanisms are vital for preventing diseases such as neural tube defects. Inositol deficiency may contribute to the pathogenesis of various diseases, hence supplementation of these conditions with inositol is necessary.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2021)
Article
Medicine, Research & Experimental
Antonio J. L. Lopez-Gambero, Beatriz Pacheco-Sanchez, Cristina Rosell-Valle, Dina Medina-Vera, Juan Antonio Navarro, Maria del Mar Fernandez-Arjona, Marialuisa de Ceglia, Carlos Sanjuan, Vincent Simon, Daniela Cota, Patricia Rivera, Fernando Rodriguez de Fonseca, Juan Suarez
Summary: The occurrence and progression of hypothalamic dysfunction, insulin resistance, and weight loss are associated with the cognitive decline in sporadic Alzheimer's Disease (AD) with sex differences. This study found that oral supplementation with insulin-sensitizing D-Chiro-inositol (DCI) partially restored energy balance and improved metabolic disorders in a mouse model of AD.
BIOMEDICINE & PHARMACOTHERAPY
(2022)