Structure and assembly mechanisms of toxic human islet amyloid polypeptide oligomers associated with copper

Solvent-induced structural transitions of lysozyme in an electrospray ionization source

(2015) Jong Wha Lee et al.   ANALYST

Rapid Assessment of Human Amylin Aggregation and Its Inhibition by Copper(II) Ions by Laser Ablation Electrospray Ionization Mass Spectrometry with Ion Mobility Separation

(2015) Hang Li et al.   ANALYTICAL CHEMISTRY

Structural Basis for the Inhibition of Truncated Islet Amyloid Polypeptide Aggregation by Cu(II): Insights into the Bioinorganic Chemistry of Type II Diabetes

(2015) Lina Rivillas-Acevedo et al.   INORGANIC CHEMISTRY

Probing Conformational Change of Intrinsically Disordered α-Synuclein to Helical Structures by Distinctive Regional Interactions with Lipid Membranes

(2014) Shin Jung C. Lee et al.   ANALYTICAL CHEMISTRY

Insulin secretion from beta cells in intact mouse islets is targeted towards the vasculature

(2014) Jiun T. Low et al.   DIABETOLOGIA

Human IAPP–induced pancreatic β cell toxicity and its regulation by autophagy

(2014) Nayumi Shigihara et al.   JOURNAL OF CLINICAL INVESTIGATION

Cu(II) inhibits hIAPP fibrillation and promotes hIAPP-induced beta cell apoptosis through induction of ROS-mediated mitochondrial dysfunction

(2014) Lijuan Ma et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

The Role of Stable α-Synuclein Oligomers in the Molecular Events Underlying Amyloid Formation

(2014) Nikolai Lorenzen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

X-ray Crystallographic Structures of Trimers and Higher-Order Oligomeric Assemblies of a Peptide Derived from Aβ17–36

(2014) Ryan K. Spencer et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Zinc stabilization of prefibrillar oligomers of human islet amyloid polypeptide

(2013) Jeffrey R. Brender et al.   CHEMICAL COMMUNICATIONS

Ion Mobility Spectrometry–Mass Spectrometry Defines the Oligomeric Intermediates in Amylin Amyloid Formation and the Mode of Action of Inhibitors

(2013) Lydia M. Young et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Cerium oxide caged metal chelator: anti-aggregation and anti-oxidation integrated H2O2-responsive controlled drug release for potential Alzheimer's disease treatment

(2013) Meng Li et al.   Chemical Science

Metal ions and amyloid fiber formation in neurodegenerative diseases. Copper, zinc and iron in Alzheimer's, Parkinson's and prion diseases

(2012) John H. Viles   COORDINATION CHEMISTRY REVIEWS

Association of serum copper levels and glycemic control in patients with type 2 diabetes

(2012) Toyoko Naka et al.   ENDOCRINE JOURNAL

Atomic View of a Toxic Amyloid Small Oligomer

(2012) Arthur Laganowsky et al.   SCIENCE

Membrane Disruption and Early Events in the Aggregation of the Diabetes Related Peptide IAPP from a Molecular Perspective

(2011) Jeffrey R. Brender et al.   ACCOUNTS OF CHEMICAL RESEARCH

Biphasic Effects of Insulin on Islet Amyloid Polypeptide Membrane Disruption

(2011) Jeffrey R. Brender et al.   BIOPHYSICAL JOURNAL

A Two-Site Mechanism for the Inhibition of IAPP Amyloidogenesis by Zinc

(2011) Samer Salamekh et al.   JOURNAL OF MOLECULAR BIOLOGY

2DIR Spectroscopy of Human Amylin Fibrils Reflects Stable β-Sheet Structure

(2011) Lu Wang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The Amyloid Formation Mechanism in Human IAPP: Dimers Have β-Strand Monomer−Monomer Interfaces

(2011) Nicholas F. Dupuis et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Islet amyloid polypeptide demonstrates a persistent capacity to disrupt membrane integrity

(2011) N. B. Last et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inhibition of metal-induced amyloid aggregation using light-responsive magnetic nanoparticle prochelator conjugates

(2011) Meng Li et al.   Chemical Science

Copper-induced cytotoxicity: reactive oxygen species or islet amyloid polypeptide oligomer formation

(2010) Ye-Ping Yu et al.   CHEMICAL COMMUNICATIONS

Role of Zinc in Human Islet Amyloid Polypeptide Aggregation

(2010) Jeffrey R. Brender et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Ion mobility–mass spectrometry reveals a conformational conversion from random assembly to β-sheet in amyloid fibril formation

(2010) Christian Bleiholder et al.   Nature Chemistry

Structural conversion of neurotoxic amyloid-β1–42 oligomers to fibrils

(2010) Mahiuddin Ahmed et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Copper and Zinc Binding to Amyloid-β: Coordination, Dynamics, Aggregation, Reactivity and Metal-Ion Transfer

(2009) Peter Faller   CHEMBIOCHEM

Role of Copper Ion in the Pathogenesis of Type 2 Diabetes

(2009) Ayako TANAKA et al.   ENDOCRINE JOURNAL

Human Islet Amyloid Polypeptide Monomers Form Ordered β-hairpins: A Possible Direct Amyloidogenic Precursor

(2009) Nicholas F. Dupuis et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Altered metabolism of copper, zinc, and magnesium is associated with increased levels of glycated hemoglobin in patients with diabetes mellitus

(2009) Alena Viktorínová et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Amyloid-β protein oligomerization and the importance of tetramers and dodecamers in the aetiology of Alzheimer's disease

(2009) Summer L. Bernstein et al.   Nature Chemistry

Two-dimensional IR spectroscopy and isotope labeling defines the pathway of amyloid formation with residue-specific resolution

(2009) S.-H. Shim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA