Review
Nutrition & Dietetics
Qi Zhang, Wenmin Xing, Qiao Wang, Zhan Tang, Yazhen Wang, Wenyan Gao
Summary: The increasing prevalence of non-alcoholic fatty liver disease (NAFLD) has become a significant healthcare burden worldwide. Recent investigations have shown that the gut microbiota plays a crucial role in the progression of NAFLD through the gut-liver axis or gut-brain-liver axis. The composition of the microbiota can be influenced by various factors, including dietary style, nutritional supplements, or exercise. Additionally, microbiota metabolites can impact mitochondrial function and inflammatory response, which are important factors in NAFLD.
FRONTIERS IN NUTRITION
(2022)
Review
Engineering, Multidisciplinary
Mingfei Yao, Lingling Qv, Yanmeng Lu, Baohong Wang, Bjorn Berglund, Lanjuan Li
Summary: NAFLD, with a global prevalence of 20%-33%, is the main cause of chronic liver disease and there is currently no definitive medical treatment. Probiotic research for the prevention and treatment of NAFLD is increasing, focusing on traditional probiotics and emerging NGPs. Further research is needed to understand the mechanisms among probiotics, gut microbiota, and NAFLD comprehensively.
Review
Biochemistry & Molecular Biology
Natalia Vallianou, Gerasimos Socrates Christodoulatos, Irene Karampela, Dimitrios Tsilingiris, Faidon Magkos, Theodora Stratigou, Dimitris Kounatidis, Maria Dalamaga
Summary: Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease worldwide, often starting as a benign liver fat accumulation that can progress to non-alcoholic steatohepatitis (NASH) and increase the risk of cirrhosis and hepatocellular carcinoma (HCC). Recent studies have highlighted the role of gut dysbiosis, which can lead to increased gut permeability and the release of toxic bacterial products and proinflammatory cytokines, causing and sustaining inflammation. The composition of the gut microbiota and various metabolites may vary during different stages of NAFLD and among population groups, and further research is needed to determine the causal relationship between gut microbiota profiles and NAFLD in patients. Additionally, multiple metabolites may contribute to the pathogenesis of NAFLD.
Article
Food Science & Technology
Moon Ho Do, Hyun Hee L. Lee, Yoonsook Kim, Hye-Bin Lee, Eunjung Lee, Jae Ho Park, Ho-Young Park
Summary: This study suggests that water-soluble extract from molokhia (WM) can alleviate alcohol-induced liver damage by improving gut microbial composition and gut barrier function.
JOURNAL OF FUNCTIONAL FOODS
(2021)
Article
Agriculture, Dairy & Animal Science
Qiuwen He, Chengcong Yang, Xiaohong Kang, Yongfu Chen, Tao Zhang, Heping Zhang, Lai-Yu Kwok
Summary: This study investigated the protective effect of probiotic-fermented milk in rats with alcoholic liver disease. The results showed that probiotic-fermented milk maintained gut microbiota stability, reduced liver inflammation and oxidative stress, and mitigated liver damages in alcoholic liver disease.
JOURNAL OF DAIRY SCIENCE
(2022)
Article
Endocrinology & Metabolism
Muthukumaran Jayachandran, Shen Qu
Summary: Non-alcoholic fatty liver disease (NAFLD) is the most common liver disease worldwide, with a strong link to obesity. Dysbiosis of the gut microbiota is associated with the development of NAFLD, and interventions such as probiotics can be beneficial for patients.
REVIEWS IN ENDOCRINE & METABOLIC DISORDERS
(2023)
Review
Pharmacology & Pharmacy
Catalina Fuenzalida, Maria Soledad Dufeu, Jaime Poniachik, Juan Pablo Roblero, Lucia Valenzuela-Perez, Caroll Jenny Beltran
Summary: ALD is a leading cause of morbidity among adults with alcohol use disorder globally. Its clinical course ranges from steatosis to severe forms of liver damage. The complex pathogenesis involves various factors such as environmental, genetic, immune response, and gut microbiota alterations.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Gastroenterology & Hepatology
Jung A. Eom, Jin-Ju Jeong, Sang Hak Han, Goo Hyun Kwon, Kyeong Jin Lee, Haripriya Gupta, Satya Priya Sharma, Sung-Min Won, Ki-Kwang Oh, Sang Jun Yoon, Hyun Chae Joung, Kyung Hwan Kim, Dong Joon Kim, Ki Tae Suk
Summary: The liver contains innate immune cells that are affected by alcohol consumption and the gut microbiome. This study aimed to evaluate the effects of probiotic strains on NK cells in alcoholic liver disease (ALD) patients. The study found that the gut microbiome may ameliorate ALD by regulating immune cells.
Article
Food Science & Technology
Hailong Li, Ziyang Xie, Yao Zhang, Yue Liu, Aijing Niu, Yingying Liu, Linbo Zhang, Lili Guan
Summary: The study found that polysaccharide from Rosa rugosa (RRP) has a significant protective effect on acute alcoholic liver disease (ALD), by regulating liver function and balancing gut microbiota, providing theoretical basis for the development of natural liver-protecting drugs.
Article
Microbiology
Haripriya Gupta, Sung Hun Kim, Seul Ki Kim, Sang Hak Han, Hak Cheol Kwon, Ki Tae Suk
Summary: This study investigated the effects of probiotic treatment on alcoholic hepatitis patients by restoring gut microbial balance. The results showed that probiotics improved liver function, decreased lipopolysaccharide levels, and modulated the composition of gut microbiota.
Review
Nutrition & Dietetics
Marta Maestri, Francesco Santopaolo, Maurizio Pompili, Antonio Gasbarrini, Francesca Romana Ponziani
Summary: Non-alcoholic fatty liver disease (NAFLD) is closely linked to metabolic disorders and is highly prevalent in obese and diabetic patients. The gut microbiota plays a key role in the pathogenesis of NAFLD, and modulating it through diet, medications, and other interventions can have a positive impact on liver health. Further research is needed to explore the potential of fecal microbial transplantation (FMT) and next-generation probiotics in the treatment of NAFLD.
FRONTIERS IN NUTRITION
(2023)
Article
Biochemistry & Molecular Biology
Huong Thi Nguyen, Mingkun Gu, Pia Werlinger, Joo-Hyung Cho, Jinhua Cheng, Joo-Won Suh
Summary: The study found that Lactobacillus sakei MJM60958 (MJM60958) has inhibitory effects on non-alcoholic fatty liver disease (NAFLD), and it can influence the gut microbiota and alter the production of short-chain fatty acids. This suggests that MJM60958 has the potential to be a probiotic for the prevention and treatment of NAFLD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Haripriya Gupta, Byeong-Hyun Min, Raja Ganesan, Yoseph Asmelash Gebru, Satya Priya Sharma, Eunju Park, Sung-Min Won, Jin-Ju Jeong, Su-Been Lee, Min-Gi Cha, Goo-Hyun Kwon, Min-Kyo Jeong, Ji-Ye Hyun, Jung-A Eom, Hee-Jin Park, Sang-Jun Yoon, Mi-Ran Choi, Dong-Joon Kim, Ki-Tae Suk
Summary: Non-alcoholic fatty liver disease (NAFLD) is a significant health threat globally and has attracted attention in the field of liver diseases. It comprises various fatty degenerative disorders in the liver, with complex and multifactor-driven pathophysiology. In addition to viruses, metabolic syndrome, and alcohol, evidence suggests that the microbiome is also associated with the development and progression of NAFLD.
Article
Gastroenterology & Hepatology
Qian Song, Xiang Zhang, Weixin Liu, Hong Wei, Wei Liang, Yunfei Zhou, Yanqiang Ding, Fenfen Ji, Alvin Ho-Kwan Cheung, Nathalie Wong, Jun Yu
Summary: The study identified Bifidobacterium pseudolongum as a beneficial bacterium that can prevent NAFLD-HCC by secreting acetate, which inhibits tumor formation and progression. Acetate reaches the liver via the portal vein and binds to GPR43 on hepatocytes, activating a signaling pathway that suppresses NAFLD-HCC development.
JOURNAL OF HEPATOLOGY
(2023)
Article
Nutrition & Dietetics
Jose Riezu-Boj, Miguel Barajas, Tania Perez-Sanchez, Maria J. Pajares, Miriam Arana, Fermin Milagro, Raquel Urtasun
Summary: Non-alcoholic fatty liver disease (NAFLD) is a common chronic liver disease, and modulating the gut microbiota may be a promising therapeutic approach. This study found that the Lactiplantibacillus plantarum strain DSM20174 (L.p. DSM20174) can prevent NAFLD progression, improve metabolic balance, and reduce inflammation.