Article
Chemistry, Multidisciplinary
Fotios Mpekris, Myrofora Panagi, Chrysovalantis Voutouri, John D. Martin, Rekha Samuel, Shinichiro Takahashi, Naoto Gotohda, Toshiyuki Suzuki, Panagiotis Papageorgis, Philippos Demetriou, Chryso Pierides, Laura Koumas, Paul Costeas, Motohiro Kojima, Genichiro Ishii, Anastasia Constantinidou, Kazunori Kataoka, Horacio Cabral, Triantafyllos Stylianopoulos
Summary: Nano-immunotherapy has shown potential in improving outcomes for triple negative breast cancer patients, but mechanisms of resistance need to be understood. By decompressing compressed blood vessels in lung metastases, perfusion can be restored and hypoxia alleviated, leading to more efficient delivery of nanomedicines and enhancement of anti-tumor immunity. Mechanotherapeutics in combination with nano-immunotherapy may offer synergistic effects on efficacy in breast cancer treatment.
Article
Immunology
Malvika Sharma, Ravi Chakra Turaga, Yi Yuan, Ganesh Satyanarayana, Falguni Mishra, Zhen Bian, Wei Liu, Li Sun, Jenny Yang, Zhi-Ren Liu
Summary: ProAgio, a protein targeting integrin α(v)β(3), induces apoptosis in CAFs and aECs, reduces intratumoral collagen and growth factor release, improves drug delivery, and decreases TNBC progression and metastasis.
JOURNAL OF EXPERIMENTAL MEDICINE
(2021)
Review
Oncology
Xianzhe Yu, Shan He, Jian Shen, Qiushi Huang, Peng Yang, Lin Huang, Dan Pu, Li Wang, Lu Li, Jinghua Liu, Zelong Liu, Lingling Zhu
Summary: Gastric cancer is a common malignant tumor with limited effective treatment methods and low survival rates. Angiogenesis and immune evasion are key processes in gastric cancer progression, and targeting both can improve treatment efficacy and prolong patient survival.
THERAPEUTIC ADVANCES IN MEDICAL ONCOLOGY
(2022)
Article
Oncology
Jing Zhou, Xuejing Shi, Shulan Hao, Fupeng Zhang, Zhi Guo, Yu Gao, Hao Guo, Likun Liu
Summary: The study demonstrated the potential anti-angiogenesis and vessel normalization effects of ORI, which may be mediated partly by suppressing the JAK2/STAT3 signaling pathway. The results also suggest an optimal time point for ORI therapy in conjunction with chemoradiotherapy or immunotherapy.
Article
Oncology
Wei Yan, Lin Qiu, Meiling Yang, Anran Xu, Manqi Ma, Qinzi Yuan, Xiaochen Ma, Wenjuan Liang, Xuenong Li, Yanxia Lu
Summary: Immunotherapy and anti-EGFR targeted treatment play a crucial role in colorectal cancer, but resistance remains a challenge. CXCL10 expression is associated with CD8+ T cell infiltration and tumor vascular normalization in colorectal cancer. CXCL10 overexpression inhibits tumor growth, increases CD8+ T cell infiltration, and induces tumor vascular normalization. CXCL10 interacts with VCAN to mediate tumor vascular normalization. Elevated CXCL10 expression enhances the sensitivity of colorectal cancer cells to cetuximab/anti-PD1 combination therapy. CXCL10 may be used to enhance the efficacy of anti-EGFR therapy and immunotherapy by targeting both tumor vessels and immune cells in colorectal cancer.
Article
Environmental Sciences
Selinay Ozdemir, Clara G. Sears, James M. Harrington, Aslak Harbo Poulsen, Jessie Buckley, Chanelle J. Howe, Katherine A. James, Anne Tjonneland, Gregory A. Wellenius, Ole Raaschou-Nielsen, Jaymie Meliker
Summary: Urine osmolality and creatinine are strongly correlated, with creatinine explaining 60% of the variability in osmolality. Additional 9% of the variability in osmolality is explained by urine thallium, cesium, and strontium, suggesting they can supplement creatinine for urine dilution adjustment.
Review
Endocrinology & Metabolism
Paolo Marzullo, Silvia Bettini, Davide Menafra, Sara Aprano, Giovanna Muscogiuri, Luigi Barrea, Silvia Savastano, Annamaria Colao, Silvia Magno, Andrea Di Nisio, Fiammetta Romano, Giovanna Muscogiuri, Eleonora Poggiogalle, Mary Venneri, Alessia Liccardi, Maria Grazia Tarsitano, Luigi Barrea, Laura Di Renzo, Dario Tuccinardi, Massimiliano Caprio, Maria Angela Guzzardi, Caterina Pelosini, Gabriella Pugliese, Filomena Bottiglieri, Paolo MarzulloSara Aprano, Silvia BettiniDavide Menafra, Gianluca Gortan Capellari, Daniela Laudisio, Francesca Pivari, Caterina Brasacchio, Andrea Lenzi, Fabrizio Muratori, Ferruccio Santini, Luca Busetto, Paolo Sbraccia, Laura Soldati, Domenico Salvatore, Carolina Di Somma, Dario Giugliano, Lucio Gnessi, Brunella Capaldo, Gabriele Riccardi, Rocco Barazzoni, Brunella Guida, Maurizio Bifulco, Katherine Esposito, Roberto Vettor, Paolo Emidio Macchia, Andrea Di NisioFelipe Casanueva, Carla Lubrano, Francesco Beguinot, Giovanni Spera, Annamaria Belfiore, Luigi Di Luigi, Laura SoldatiAlberto Ritieni, Raffaele Napoli, Olga Vaccaro, Samir Sukkar, Carlo Alviggi, Rosario Pivonello, Giuseppe Bellastella, Giovanni Scambia, Giuseppe Bifulco
Summary: Recent studies have shown a bidirectional association between gut microbiota and human health, as well as metabolic disorders, playing a crucial role in the onset and progression of obesity-related cancers. Healthy diet and lifestyle choices, along with the complex interplay between microbiota and neoplastic and metabolic diseases, could help improve cancer treatment strategies and outcomes.
INTERNATIONAL JOURNAL OF OBESITY
(2021)
Article
Instruments & Instrumentation
Xin-jun Cai, Zeng Wang, Ying-ying Xu, Gao-yi Yang, Ruo-ying Zhang, Yu Wang
Summary: The study focused on enhancing drug delivery and therapeutic efficacy in solid tumors by depleting ECM and normalizing tumor vessels using candesartan, an angiotensin system inhibitor. Results showed that candesartan inhibited breast cancer cell migration, reduced ECM content, and improved tumor vessel permeability, leading to better delivery of PEG-ZOL-LPs. Surprisingly, candesartan did not impact the efficacy of PEG-ZOL-LPs treatment, suggesting a potential for synergistic effect with different administration protocols.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2021)
Article
Astronomy & Astrophysics
M. Farhang, S. M. S. Movahed
Summary: The study investigates the anomalous Cold Spot in the cosmic microwave background sky, evaluating whether different sets of subvoids could have produced this anomaly. It was found that some models showed gravitational redshift amplitudes higher than expected, while the lensing imprint amplitudes were consistent with zero.
ASTROPHYSICAL JOURNAL
(2021)
Article
Chemistry, Physical
Hao Jiang, Yilang He, Jia Zhao, Ruimin Chang, Hailun He, Tan Li, Xingyu Zhang, Bo Shu, Wenxuan Zhang, Huaiyu Wang, Jing Liu, Shubing Zhang, Yuetao Zhao
Summary: Tumor vascular dysfunction and immune suppression can lead to poor outcomes in tumor therapy. This study developed an immunostimulatory nanomodulator for the treatment of triple-negative breast cancer (TNBC), which combines photothermal therapy, vessel normalization, and immunotherapy. The nanomodulator effectively inhibits tumor neovascularization, normalizes blood vessels, and boosts immune response. This synergistic therapeutic strategy shows potential in suppressing the growth of TNBC in mice.
Article
Medicine, Research & Experimental
Lizhou Lin, Yichao Du, Jialing Hao, Rong Wu, Lianfang Du
Summary: Pancreatic cancer is a hypovascular tumor that is not very responsive to conventional chemotherapy. Recent advancements in ultrasound targeted microbubble destruction have improved drug delivery by redirecting macrophage polarization and inducing anti-tumor immune responses. These findings provide new insights into UTMD-mediated drug delivery for anti-tumor and anti-angiogenic treatment.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Multidisciplinary Sciences
Bei-Bei Zhang, Xu Shen, Xiu-Jin Li, Yun-Bo Tian, Hong-Jia Ouyang, Yun-Mao Huang
Summary: Appropriate reference genes play a crucial role in determining accurate mRNA expression levels in quantitative PCR research. This study identified suitable reference genes for detecting gene expression in different tissues of Magang geese under light treatment, providing references for tissue expression studies. The results indicated tissue-specific differences in the most suitable reference genes at different breeding stages, contributing to the analysis of gene expression stability.
SCIENTIFIC REPORTS
(2021)
Article
Chemistry, Multidisciplinary
Cuihong Yang, Ganen Mu, Ying Zhang, Yang Gao, Wenxue Zhang, Jinjian Liu, Wenwen Zhang, Paiyun Li, Lijun Yang, Zhimou Yang, Jie Gao, Jianfeng Liu
Summary: Nitric oxide (NO) acts as a radiosensitizer by directly reacting with DNA and increasing oxygen supply through normalizing tumor vessels. A NO depot system is designed to control the release of NO and reverse tumor radioresistance.
ADVANCED MATERIALS
(2022)
Review
Biochemistry & Molecular Biology
Ombretta Melaiu, Gianluca Vanni, Ilaria Portarena, Chiara Adriana Pistolese, Lucia Anemona, Silvia Pomella, Roberto Bei, Oreste Claudio Buonomo, Mario Roselli, Alessandro Mauriello, Giovanni Barillari
Summary: Immune checkpoint inhibitors have limited clinical activity as monotherapy against breast cancer, and novel combinatorial strategies are being investigated to improve treatment response. The abnormal vasculature in breast cancer is associated with immune suppression and hampers drug delivery and immune cell trafficking. Combining immune checkpoint inhibitors with tumor vessel normalizing agents shows promise in enhancing antitumor immune responses.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Computer Science, Interdisciplinary Applications
Min-Ji Kim, Kyung-Ho Lee, Young-Soo Han, Jaejoon Lee, Byungwook Nam
Summary: Research and development of smart vessels have become significant, with a focus on efficient management, technical design, and maintenance aspects. The use of deep-learning-based CycleGAN technology has shown promise in improving texture performance in AR/VR models for shipbuilding.
JOURNAL OF COMPUTATIONAL DESIGN AND ENGINEERING
(2021)
Review
Physiology
Massimiliano Mazzone, Gabriele Bergers
ANNUAL REVIEW OF PHYSIOLOGY, VOL 81
(2019)
Article
Oncology
Cristina Travelli, Francesca Maria Consonni, Sabina Sangaletti, Mariangela Storto, Sara Morlacchi, Ambra A. Grolla, Ubaldina Galli, Gian Cesare Tron, Paola Portararo, Lorenza Rimassa, Tiziana Pressiani, Massimiliano Mazzone, Rosalinda Trovato, Stefano Ugel, Vincenzo Bronte, Claudio Tripodo, Mario P. Colombo, Armando A. Genazzani, Antonio Sica
Article
Biochemistry & Molecular Biology
Fernanda G. Kugeratski, Samuel J. Atkinson, Lisa J. Neilson, Sergio Lilla, John R. P. Knight, Jens Serneels, Amelie Juin, Shehab Ismail, David M. Bryant, Elke K. Markert, Laura M. Machesky, Massimiliano Mazzone, Owen J. Sansom, Sara Zanivan
Article
Oncology
Carlotta Tacconi, Federica Ungaro, Carmen Correale, Vincenzo Arena, Luca Massimino, Michael Detmar, Antonino Spinelli, Michele Carvello, Massimiliano Mazzone, Ana I. Oliveira, Federica Rubbino, Valentina Garlatti, Salvatore Spano, Enrico Lugli, Federico S. Colombo, Alberto Malesci, Laurent Peyrin-Biroulet, Stefania Vetrano, Silvio Danese, Silvia D'Alessio
Editorial Material
Cell Biology
Federico Virga, Manuel Ehling, Massimiliano Mazzone
Review
Physiology
Carla Riera-Domingo, Annette Audige, Sara Granja, Wan-Chen Cheng, Ping-Chih Ho, Fatima Baltazar, Christian Stockmann, Massimiliano Mazzone
PHYSIOLOGICAL REVIEWS
(2020)
Article
Medicine, Research & Experimental
Nathalie Tisch, Aida Freire-Valls, Rosario Yerbes, Isidora Paredes, Silvia La Porta, Xiaohong Wang, Rosa Martin-Perez, Laura Castro, Wendy Wei-Lynn Wong, Leigh Coultas, Boris Strilic, Hermann-Josef Grone, Thomas Hielscher, Carolin Mogler, Ralf H. Adams, Peter Heiduschka, Lena Claesson-Welsh, Massimiliano Mazzone, Abelardo Lopez-Rivas, Thomas Schmidt, Hellmut G. Augustin, Carmen Ruiz de Almodovar
JOURNAL OF CLINICAL INVESTIGATION
(2019)
Editorial Material
Cell Biology
Massimiliano Mazzone
Article
Oncology
Jermaine Goveia, Katerina Rohlenova, Federico Taverna, Lucas Treps, Lena-Christin Conradi, Andreas Pircher, Vincent Geldhof, Laura P. M. H. de Rooij, Joanna Kalucka, Liliana Sokol, Melissa Garcia-Caballero, Yingfeng Zheng, Junbin Qian, Laure-Anne Teuwen, Shawez Khan, Bram Boeckx, Els Wauters, Herbert Decaluwe, Paul De Leyn, Johan Vansteenkiste, Birgit Weynand, Xavier Sagaert, Erik Verbeken, Albert Wolthuis, Baki Topal, Wouter Everaert, Hanibal Bohnenberger, Alexander Emmert, Dena Panovska, Frederik De Smet, Frank J. T. Staal, Rene J. Mclaughlin, Francis Impens, Vincenzo Lagani, Stefan Vinckier, Massimiliano Mazzone, Luc Schoonjans, Mieke Dewerchin, Guy Eelen, Tobias K. Karakach, Huanming Yang, Jian Wang, Lars Bolund, Lin Lin, Bernard Thienpont, Xuri Li, Diether Lambrechts, Yonglun Luo, Peter Carmeliet
Review
Oncology
Marina Serra, Amedeo Columbano, Ummi Ammarah, Massimiliano Mazzone, Alessio Menga
FRONTIERS IN ONCOLOGY
(2020)
Article
Oncology
Yannick De Vlaeminck, Stefano Bonelli, Robin Maximilian Awad, Maarten Dewilde, Sabrina Rizzolio, Quentin Lecocq, Evangelia Bolli, Ana Rita Santos, Damya Laoui, Steve Schoonooghe, Luca Tamagnone, Cleo Goyvaerts, Massimiliano Mazzone, Karine Breckpot, Jo A. Van Ginderachter
News Item
Biochemistry & Molecular Biology
Massimiliano Mazzone, Alessandra Castegna
Summary: Studies on the microbiome-host interaction reveal metabolic mutual crosstalk between host tissues and gut microbiota.
NATURE CHEMICAL BIOLOGY
(2023)
Article
Oncology
Charlotte Bisilliat Donnet, Valerie Acolty, Abdulkader Azouz, Anaelle Taquin, Coralie Henin, Sarah Trusso Cafarello, Sebastien Denanglaire, Massimiliano Mazzone, Guillaume Oldenhove, Oberdan Leo, Stanislas Goriely, Muriel Moser
Summary: The PHD/HIF pathway is involved in immune and inflammatory processes, including in the hypoxic tumor microenvironment. Deleting PHD2 in T lymphocytes resulted in regression of EG7-OVA tumors, which depended on HIF-1a. The enhanced control of tumor growth was associated with increased polyfunctionality of CD8+ tumor-infiltrating lymphocytes, indicating the importance of glycolysis in sustaining CTL activity.
CANCER IMMUNOLOGY RESEARCH
(2023)
Article
Endocrinology & Metabolism
Melissa Garcia-Caballero, Annalisa Zecchin, Joris Souffreau, Anh-Co Khanh Truong, Laure-Anne Teuwen, Wesley Vermaelen, Rosa Martin-Perez, Pauline de Zeeuw, Ann Bouche, Stefan Vinckier, Ivo Cornelissen, Guy Eelen, Bart Ghesquiere, Massimiliano Mazzone, Mieke Dewerchin, Peter Carmeliet
Review
Biochemistry & Molecular Biology
Hans Prenen, Massimiliano Mazzone
CELLULAR AND MOLECULAR LIFE SCIENCES
(2019)
