Review
Immunology
Justin Jacobse, Jing Li, Edmond H. H. M. Rings, Janneke N. Samsom, Jeremy A. Goettel
Summary: Intestinal FOXP3(+) regulatory T cells play a crucial role in maintaining immune balance and preventing autoimmunity in the gut. Dysregulation of these cells can lead to chronic inflammatory disorders, including inflammatory bowel disease, highlighting the importance of understanding their biology for therapeutic interventions. Intestinal Treg cells are not fixed subsets, but rather plastic and responsive to microenvironmental cues, similar to T helper cells.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Cell Biology
Min Deng, Christian F. Guerrero-Juarez, Xiaole Sheng, Jiuzhi Xu, Xi Wu, Kai Yao, Mengzhen Li, Xu Yang, Guilin Li, Jintao Xiao, Xiaowei Liu, Kaichun Wu, Fazheng Ren, Qing Nie, Maksim Plikus, Zhengquan Yu, Cong Lv
Summary: This study reveals that mesenchymal cells (MCs) surrounding the intestine can sense diet changes and modulate the function of intestinal stem cells (ISCs) through the secretion of IGF1. MCs play a critical role in maintaining the proliferation of ISC and progenitor cells, and these findings may provide a novel therapeutic target for gut diseases.
Review
Biochemistry & Molecular Biology
Jun Chen, Haopeng Zhong, Zhouyin Huang, Xingping Chen, Jinming You, Tiande Zou
Summary: Kaempferol, a natural flavonoid, has shown significant potential in various biological activities. Recent studies have emphasized the role of kaempferol in regulating intestinal function and mitigating intestinal inflammation. This review focuses on its antioxidant properties, inflammation, maintenance of intestinal barrier function, and potential in the treatment of colorectal cancer and obesity.
Article
Multidisciplinary Sciences
Tsunaki Higa, Yasutaka Okita, Akinobu Matsumoto, Shogo Nakayama, Takeru Oka, Osamu Sugahara, Daisuke Koga, Shoichiro Takeishi, Hirokazu Nakatsumi, Naoki Hosen, Sylvie Robine, Makoto M. Taketo, Toshiro Sato, Keiichi Nakayama
Summary: The mammalian intestinal epithelium has robust regenerative capacity. p57(+) cells located around the +4 position of intestinal crypts serve as markers for a quiescent cell population. These cells dedifferentiate after injury and act as facultative stem cells to support regeneration.
NATURE COMMUNICATIONS
(2022)
Review
Biochemistry & Molecular Biology
Marta Surbek, William Tse, Richard Moriggl, Xiaonan Han
Summary: Cytokines, growth factors or hormones act through the JAK/STAT5 signaling pathway to regulate the intestinal response to infection and inflammation. However, the regulation of intestinal epithelial compartment by STAT5 is often ignored due to lack of genetic tools. This review article discusses the advances in growth factor/cytokine-JAK/STAT5 research in intestinal mucosal inflammation and immunity, highlighting the importance of studying intestinal STAT5 signaling.
Article
Cell Biology
Leen Catrysse, Bastiaan Maes, Parul Mehrotra, Arne Martens, Esther Hoste, Liesbet Martens, Christian Maueroder, Anneleen Remmerie, Anna Bujko, Karolina Slowicka, Mozes Sze, Hanna Vikkula, Bart Ghesquiere, Charlotte L. Scott, Yvan Saeys, Bart van de Sluis, Kodi Ravichandran, Sophie Janssens, Geert van Loo
Summary: The study found that myeloid-specific A20-deficient mice are protected from diet-induced obesity and insulin resistance despite the presence of an inflammatory environment in their metabolic tissues. Macrophages lacking A20 show impaired mitochondrial respiratory function and metabolize more palmitate, resulting in a lean phenotype and protection from metabolic disease. These findings suggest a role for A20 in regulating macrophage immunometabolism.
Article
Immunology
Jan-Hendrik Schroeder, Katrin Meissl, Dominika Hromadova, Jonathan W. Lo, Joana F. Neves, Jane K. Howard, Helena Helmby, Nick Powell, Birgit Strobl, Graham M. Lord
Summary: T-bet deficient mice show an increase in ILC3 cellularity but do not have a greater risk of developing spontaneous colitis. T-bet appears to control the number of ILC3 cells, but does not drive a pathogenic role of ILC3 in mice with a conventional specific pathogen-free microbiota.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Franze Progatzky, Michael Shapiro, Song Hui Chng, Bethania Garcia-Cassani, Cajsa Helena Classon, Selin Sevgi, Anna Laddach, Ana Carina Bon-Frauches, Reena Lasrado, Maryam Rahim, Eleni-Maria Amaniti, Stefan Boeing, Kathleen Shah, Lewis J. Entwistle, Alejandro Suarez-Bonnet, Mark S. Wilson, Brigitta Stockinger, Vassilis Pachnis
Summary: Enteric glial cells play important roles in immune regulation and tissue repair in the mouse intestine, with IFN gamma signaling being central to intestinal homeostasis and tissue repair. The gliosis and upregulation of specific genes in enteric glial cells contribute to immune homeostasis and tissue repair after parasite infection-induced intestinal damage.
Article
Agriculture, Dairy & Animal Science
Lingzi Yu, Xiaochen Xie, Keyang Jiang, Yi Hong, Zhou Zhou, Yuling Mi, Caiqiao Zhang, Jian Li
Summary: The study found that in the early stage of intestinal inflammation in chickens, Paneth cells were impaired but quickly recovered, leading to a decrease in intestinal stem cell activity initially, followed by rapid recovery.
Review
Immunology
Wenbin Gong, Kui Yang, Wei Zhao, Jianbao Zheng, Junhui Yu, Kun Guo, Xuejun Sun
Summary: Gasdermins (GSDMs) protein family plays an important role in gut homeostasis, mediating inflammatory reactions, clearing pathogenic organisms, and participating in a novel inflammatory cell death called PANoptosis. They also have potential intrinsic physiological functions independent of cell death.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Medicine, Research & Experimental
Yu Chen, Zhenghao Ye, Ursula Seidler, Dean Tian, Fang Xiao
Summary: During intestinal inflammation, niche cells around ISCs and their secreted niche factors can facilitate the regeneration of ISCs via niche signals. Additionally, the growth of ISCs can respond to inflammatory cells, inflammatory cytokines, and inflammatory signals. Understanding the adaptive mechanism of ISCs in supporting intestinal epithelial regeneration during inflammation is crucial for the treatment of patients with intestinal inflammation.
Article
Cell Biology
Hiroki Nagai, Luis Augusto Eijy Nagai, Sohei Tasaki, Ryuichiro Nakato, Daiki Umetsu, Erina Kuranaga, Masayuki Miura, Yuichiro Nakajima
Summary: Nutrient fluctuation induces dedifferentiation in Drosophila adult midgut and drives adaptive intestinal growth by converting enteroendocrine cells into functional intestinal stem cells.
DEVELOPMENTAL CELL
(2023)
Review
Cell Biology
Meryem B. Baghdadi, Tae-Hee Kim
Summary: The gastrointestinal tract is innervated by the enteric nervous system (ENS), also called the second brain. Enteric glial cells, a major cell type in the ENS, play critical roles in gut physiology, including the regulation of intestinal stem cells and immunity. Recent advances in single-cell genomics have revealed the heterogeneity and plasticity of enteric glial cells. This review discusses the established and emerging concepts regarding the roles of mammalian enteric glial cells in gut development, homeostasis, and regeneration.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2023)
Article
Pharmacology & Pharmacy
Shipei Yang, Xu Li, Minghui Xiu, Yuting Dai, Shengfang Wan, Yan Shi, Yongqi Liu, Jianzheng He
Summary: Flos Puerariae extract (FPE) has a protective effect against intestinal injury possibly via increasing the Nrf2/keap1 pathway and suppressing the JAK-STAT and Wnt signaling pathways. This study provides potential for the treatment of inflammatory bowel disease (IBD).
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Won Dong Yu, Yu Jin Kim, Min Jeong Cho, Gi Jin Kim, Soon Ha Kim, Myung Joo Kim, Jung Jae Ko, Jae Ho Lee
Summary: This study found that MIT-001 can protect the altered phenotypes and mitochondrial features of MSCs exposed to inflammatory cytokines, improving mitochondrial quiescence and cellular phenotypes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Surgery
Monika E. Hagen, Minoa K. Jung, Jassim Fakhro, Nicolas C. Buchs, Leo Buehler, Jona M. Mendoza, Philippe Morel
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2018)
Article
Surgery
Michel Adamina, Nicolas C. Buchs, Marta Penna, Roel Hompes
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2018)
Article
Surgery
Monika E. Hagen, Alexandre Balaphas, Michele Podetta, Peter Rohner, Minoa K. Jung, Nicolas C. Buchs, Leo Buehler, Jona M. Mendoza, Philippe Morel
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2018)
Article
Surgery
F. Ris, E. Liot, N. C. Buchs, R. Kraus, G. Ismael, V. Belfontali, J. Douissard, C. Cunningham, I. Lindsey, R. Guy, O. Jones, B. George, P. Morel, N. J. Mortensen, R. Hompes, R. A. Cahill
BRITISH JOURNAL OF SURGERY
(2018)
Article
Radiology, Nuclear Medicine & Medical Imaging
Pierre-Alexandre Poletti, Diomidis Botsikas, Minerva Becker, Marlise Picarra, Olivier T. Rutschmann, Nicolas C. Buchs, Habib Zaidi, Alexandra Platon
EUROPEAN RADIOLOGY
(2019)
Article
Surgery
Emilie Liot, Michela Assalino, Nicolas Christian Buchs, Boris Schiltz, Jonathan Douissard, Philippe Morel, Frederic Ris
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2018)
Letter
Surgery
J. Meyer, N. C. Buchs, F. Ris
BRITISH JOURNAL OF SURGERY
(2020)
Review
Gastroenterology & Hepatology
Gregoire Longchamp, Emilie Liot, Jeremy Meyer, Alban Longchamp, Christian Toso, Nicolas C. Buchs, Frederic Ris
INTERNATIONAL JOURNAL OF COLORECTAL DISEASE
(2020)
Review
Gastroenterology & Hepatology
Gregoire Longchamp, Jeremy Meyer, Niki Christou, Sotirios Popeskou, Elin Roos, Christian Toso, Nicolas C. Buchs, Frederic Ris
INTERNATIONAL JOURNAL OF COLORECTAL DISEASE
(2020)
Article
Surgery
A. Broennimann, M. K. Jung, N. Niclauss, M. E. Hagen, C. Toso, Nicolas C. Buchs
Review
Gastroenterology & Hepatology
Gregoire Longchamp, Ziad Abbassi, Jeremy Meyer, Christian Toso, Nicolas C. Buchs, Frederic Ris
Summary: This study reviewed the risk factors associated with diverticulitis recurrence after elective sigmoidectomy. Factors such as age, irritable bowel syndrome, surgical indication, anastomotic level, absence of active diverticulitis on pathology, and persistence of postoperative pain were found to be associated with recurrence. Preoperative variables can help predict the risk of recurrence, while peri- and postoperative factors are important for optimal patient follow-up.
INTERNATIONAL JOURNAL OF COLORECTAL DISEASE
(2021)
Review
Engineering, Biomedical
Gregoire Longchamp, Emilie Liot, Jeremy Meyer, Christian Toso, Nicolas C. Buchs, Frederic Ris
Summary: Non-excisional laser therapies are emerging as treatments for grades II and III hemorrhoidal disease, with efficacy based on low-level evidence. These therapies show good results in relieving symptoms and reducing recurrence rates.
LASERS IN MEDICAL SCIENCE
(2021)
Review
Surgery
Jeremy Meyer, Constantinos Simillis, Heman Joshi, Athanasios Xanthis, James Ashcroft, Nicolas Buchs, Frederic Ris, R. Justin Davies
Summary: This study aims to determine the impact of extraction site choice on the incidence of incisional hernia in minimally invasive colorectal surgery through a systematic review and network meta-analysis, providing guidance for surgeons to reduce complications and costs.
INTERNATIONAL JOURNAL OF SURGERY PROTOCOLS
(2021)
Review
Gastroenterology & Hepatology
Jeremy Meyer, Elin Roos, Christophe Combescure, Nicolas C. Buchs, Jean-Louis Frossard, Frederic Ris, Christian Toso, Jacques Schrenzel
SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY
(2020)
Article
Surgery
R. P. H. Meier, V. Piller, M. E. Hagen, C. Joliat, J. -B. Buchs, A. Nastasi, R. Ruttimann, N. C. Buchs, S. Moll, J. -P. Vallee, F. Lazeyras, P. Morel, L. Buehler
AMERICAN JOURNAL OF TRANSPLANTATION
(2018)