Article
Chemistry, Physical
Yupeng Guan, Chengyuan Xing, Tongyu Tong, Xinyi Zhang, Jun Li, Huikun Chen, Junfeng Zhu, Yang Kang, Jun Pang
Summary: Conventional chemotherapy is limited by poor water solubility, inferior tissue targeting, and systemic toxic effects. In this study, smart dual responsive nanocarriers that release chemotherapy drugs in response to high levels of reactive oxygen species (ROS) and esterase in the tumor microenvironment have been developed. These nanocarriers have the ability to amplify ROS and sustain the release of chemotherapeutics, leading to enhanced sensitivity to chemotherapy. They show promise for the treatment of prostate cancer and synergistic cancer therapy.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2022)
Article
Polymer Science
Yuxin Feng, Yan Long, Jiahe Guo, Xiaofan Yang, Heng Song
Summary: In this study, a low cytotoxic water-soluble flexible organic framework was synthesized and a facile strategy was developed for efficient photo-chemotherapy under fluorescence imaging, thereby improving tumor treatment efficacy.
MACROMOLECULAR RAPID COMMUNICATIONS
(2023)
Article
Chemistry, Physical
Chun-Mei Lai, Jia Xu, Bing-Chen Zhang, Dong-Miao Li, Jiang-Wen Shen, Shi-Jing Yu, Jing-Wei Shao
Summary: This study proposes a tumor microenvironment-responsive drug delivery system that combines chemotherapy and phototherapy for synergistic cancer therapy. By assembling photosensitizers, carbon dots, chemotherapeutic agents, and copper ions, the nanoplatforms exhibit stimuli-responsive drug release and enhanced therapeutic efficacy through phototherapy and chemodynamic therapy.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2023)
Article
Chemistry, Multidisciplinary
Jingjing Ding, Guihong Lu, Weidong Nie, Li-Li Huang, Yahui Zhang, Wenlin Fan, Guanghao Wu, Houli Liu, Hai-Yan Xie
Summary: An engineered self-activatable photo-EV for synergistic trimodal anticancer therapy has been reported, which utilizes M1 EVs to simultaneously load multiple drugs, achieving synergism of immunotherapy, photodynamic therapy, and chemotherapy with great promise in fighting cancers.
ADVANCED MATERIALS
(2021)
Article
Nanoscience & Nanotechnology
Dong-Yang Zhang, Fanglin Huang, Yan Ma, Guangzhong Liang, Zhuo Peng, Shixia Guan, Junqiu Zhai
Summary: The integration of ROS-involved MDT and PDT using a biodegradable nanoplatform has shown enhanced anticancer effects through the production of H2O2 and O-1(2) while depleting GSH. This theranostic nanoplatform increases uptake and penetration of photosensitizers, induces cellular apoptosis through excessive ROS production, and enhances the effectiveness of PDT. The platform provides a new avenue for tumor microenvironment-responsive and ROS-involved therapeutic strategies with synergistic enhancement of antitumor activity.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Medicine, Research & Experimental
Liying Wang, Jingya Xia, Hongjie Fan, Min Hou, Huiyang Wang, Xiaoyan Wang, Ke Zhang, Liping Cao, Xiangrui Liu, Jun Ling, Hong Yu, Xia Wu, Jihong Sun
Summary: This study presents a tumor microenvironment-responsive nanosystem for chemodynamic/chemical synergistic therapy and magnetic resonance imaging. The nanosystem improves the cycling time and solubility of chemotherapeutic drugs, releasing them gradually in tumor tissues through glutathione-triggered biodegradation. With improved generation of reactive oxygen species and controlled release of the chemotherapeutic drug, it shows excellent inhibition of tumor growth in colorectal cancer models.
Article
Engineering, Biomedical
Xinyue Wang, Jiahui Gao, Chunhua Li, Chen Xu, Xiang Li, Fanyan Meng, Qin Liu, Qin Wang, Lixia Yu, Baorui Liu, Rutian Li
Summary: This study aimed to establish a biocompatible and biodegradable nanocomplex for enhancing the efficacy and safety of intraperitoneal chemotherapy. The results showed that this nanocomplex could more effectively inhibit the growth of disseminated gastric cancer and reduce the proportion of cancer stem cells and the expression of PD-L1 on tumor cells.
MATERIALS TODAY BIO
(2022)
Article
Chemistry, Multidisciplinary
Jianxiong Li, Song Liao, Yanan Wu, Jingyou Bi, Yuchen Han, Yinglong Zhang, Meng Xu, Wenzhi Bi
Summary: Dual-responsive nanoparticles (NP2) that can respond to pH and glutathione [GSH] enhance the delivery efficiency of chemotherapy drugs, stimulate the immune response, and remodel the tumor micro-environment, thereby improving the prognosis of osteosarcoma (OS) patients.
Article
Nanoscience & Nanotechnology
Yi Lu, Die Jia, Xianbin Ma, Mengyun Liang, Shengxin Hou, Wei Qiu, Yuan Gao, Peng Xue, Yuejun Kang, Zhigang Xu
Summary: A stimuli-responsive prodrug nanogel was developed using a two-in-one cross-linking strategy to deliver a combination of chemotherapeutic drugs for improving the deficiencies of chemotherapy and enhancing cancer therapeutic efficiency. The high drug loading capacity and suitable nanoscale size of the obtained nanogel facilitate cell uptake and tumor penetration, leading to enhanced tumor growth inhibition by the synergistic DNA damage in response to the reductive tumor microenvironment. This unique prodrug nanogel shows promise as a candidate for effective tumor treatment-based chemotherapy.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Chemistry, Multidisciplinary
Chunxiao Gao, Xijun Wang, Bing Yang, Wei Yuan, Wei Huang, Guoju Wu, Jie Ma
Summary: Clinical and experimental evidence has shown that bacteria infiltrate various tumors, affecting tumor progression and therapeutic effects. In this study, an antibiotic was nanonized to address the challenge of systemic distribution of antibiotics and the consequent imbalance of microbiomes. The nanonized antibiotic exhibited a synergistic antitumor effect by targeting both intratumoral bacteria and tumor cells.
Article
Engineering, Biomedical
Yu-Han Wen, Po-I Hsieh, Hsin-Cheng Chiu, Chil-Wei Chiang, Chun-Liang Lo, Yi-Ting Chiang
Summary: This study developed dual pH-sensitive and tumor microenvironment-active targeting micelles for combining immunotherapy and chemotherapy, which effectively inhibited tumor cell growth, exhibited high tumor accumulation, and reduced adverse effects in a mouse model.
MATERIALS TODAY BIO
(2022)
Article
Chemistry, Applied
Jia-Xin Liao, Qun-Fa Huang, Yan-Hong Li, Da-Wei Zhang, Guan-Hai Wang
Summary: In this study, a dual ROS-responsive nanocarriers were developed for specific and controlled drug release in cancer cells by gradually responding to the endogenous ROS level, thereby enhancing the synergistic therapy effect.
CARBOHYDRATE POLYMERS
(2022)
Article
Chemistry, Analytical
Zhou Xu, Qing-Xia Li, Lin-Wei Zhang, Mao-Long Chen, Jia Tu, Wei Chen, Ying-Yue Zhu, Yun-Hui Cheng
Summary: A FRET-labeled microenvironment-responsive immunosensor modulated by AChE was designed to enhance sensitivity to AFB1. By reducing the microenvironment pH around UCNPs and destroying UCNP-FITC for signal amplification, this system achieved quantitative determination of AFB1 with LODs as low as 0.003 nM, demonstrating a promising approach for future research in up-conversion fluorescence sensing.
SENSORS AND ACTUATORS B-CHEMICAL
(2022)
Article
Chemistry, Multidisciplinary
Zhengzhong Wu, Panfeng Zhang, Peiwen Wang, Zizhen Wang, Xianglin Luo
Summary: The study utilized amino-PEG decorated copper sulfide nanoparticles as a cross-linker to enhance the stability of polymeric micelles and provide photothermal therapy. The cross-linked micelles exhibited high photothermal transformation efficiency and excellent stability against dilution, as well as pH and redox responsive drug release. Under near-infrared laser irradiation, the cytotoxicity of doxorubicin-loaded micelles increased significantly, leading to the disappearance of tumors and inhibition of tumor metastases in tumor-bearing mice. The nanoparticles acted as both a photothermal agent and a micelle cross-linker, offering new insights for combination therapy.
Article
Biotechnology & Applied Microbiology
Jinxiao Song, Mingyang Cheng, Yi Xie, Kangkang Li, Xinlong Zang
Summary: In this study, a self-augmented reactive oxygen species (ROS) responsive nanocarrier with immunogenic inducer paclitaxel (PTX) and indoleamine 2,3-dixoygenase 1 (IDO1) blocker 1-methyl-d, L-tryptophan (1-MT) co-entrapment was developed for tumor rejection. The carrier could self-assemble into prodrug-based nanoparticles with PTX, realizing a positive feedback loop of ROS-accelerated PTX release and PTX induced ROS generation. The nanoparticles presented efficient immunogenic cell death (ICD) and simultaneously modulated the immunosuppressive tumor microenvironment with reduced regulatory T cells (Tregs) and M2-tumor associated macrophages (M2-TAMs) infiltration mediated by IDO inhibition. The combination of PTX and 1-MT achieved significant tumor regression and reduction of lung metastasis in 4T1 tumor bearing mice.
JOURNAL OF NANOBIOTECHNOLOGY
(2023)
Article
Computer Science, Artificial Intelligence
Ruilong Zhang, Qun Zong, Xiuyun Zhang, Liqian Dou, Bailing Tian
Summary: In this article, the application of multiquadcopter and target pursuit-evasion game in obstacles environment is investigated. A pursuit-evasion scenario framework is proposed for high-quality simulation of urban environment, and a multiagent coronal bidirectionally coordinated network with target prediction is constructed to ensure the effectiveness of the damaged "swarm" system in pursuit-evasion mission.
IEEE TRANSACTIONS ON NEURAL NETWORKS AND LEARNING SYSTEMS
(2023)
Article
Nanoscience & Nanotechnology
Zhuo Yan, Zhiping Zhou, Ziwei Zhang, Ruilong Zhang, Jiuyun Cui, Jiangdong Dai
Summary: Membrane separation technology is gaining attention for its low energy consumption and excellent availability in treating oily wastewater. This study prepared a superhydrophilic/underwater superoleophobic nanoparticles modified PVDF membrane using mussel-inspired chemistry. The modified membrane showed outstanding water flux and effective separation of oil-water emulsions, with the potential for large-scale application in oily wastewater treatment.
Article
Environmental Sciences
Libo Liu, Yuyan Yang, Huijun Le, Yiding Chen, Ruilong Zhang, Hui Zhang, Wenjie Sun, Guozhu Li
Summary: This study reveals unexpected strong longitudinal structures in the low-latitude ionosphere over Asia, which exhibit diverse patterns even under geomagnetically quiet conditions. The findings highlight the need for higher zonal resolution in Global Ionospheric Maps (GIMs) to accurately capture these intense and regional-scale structures.
Article
Environmental Sciences
Yuyan Yang, Libo Liu, Xiukuan Zhao, Haiyong Xie, Yiding Chen, Huijun Le, Ruilong Zhang, M. Arslan Tariq, Wenbo Li
Summary: Using observations from GNSS receivers and ionosondes, this study investigates the spatial features of two ionospheric nighttime enhancement (INE) events at low latitudes. The study reveals dramatic latitudinal and longitudinal features in the INEs, and compares the performance of Global Ionospheric Maps (GIMs) in reproducing the ionospheric structure during these events.
Article
Environmental Sciences
Wendong Liu, Libo Liu, Yiding Chen, Huijun Le, Ruilong Zhang, Wenbo Li, Jiacheng Li, Tongtong Zhang, Yuyan Yang, Han Ma
Summary: This study presents a new method to invert electron density profiles of the Martian topside ionosphere from MARSIS ionograms, improving the utilization rate of the records. The method accurately captures the altitude structure and has been validated with MGS and MAVEN data. The average absolute difference in peak height is within the margin of MARSIS height resolution, and the average relative difference is only 3%.
Article
Astronomy & Astrophysics
Ruilong Zhang, Libo Liu, Han Ma, Yiding Chen, Huijun Le, Akimasa Yoshikawa
Summary: This study reports the changes in topside ionospheric electron temperature during the October 2016 storm using in-situ observations from DMSP and SWARM satellites. The results show a dramatic increase in electron temperature in the afternoon sector of low latitudes during the recovery phase of the storm. The temperature enhancements have a clear dependence on longitude, concentrated mainly around 100 degrees-150 degrees E.
JOURNAL OF GEOPHYSICAL RESEARCH-SPACE PHYSICS
(2022)
Article
Astronomy & Astrophysics
Qiaoling Li, Ruilong Zhang, Libo Liu, Jiawei Kuai, Na Yang, Jiahao Zhong, Xin Wan, Jing Liu
Summary: Recent case studies have shown that during the recovery phase of geomagnetic storms, there can be persistent long-duration eastward enhancements in the equatorial ionospheric electric field, contrary to what was previously anticipated. This study examines the occurrence and morphology of this persistent enhancement and its impact on the distribution of ionospheric plasma at low latitudes. The results indicate that the dayside eastward enhancement is an important disturbed pattern of the equatorial ionospheric electric field during the late recovery phases, and it generally intensifies the equatorial ionization anomaly.
JOURNAL OF GEOPHYSICAL RESEARCH-SPACE PHYSICS
(2022)
Article
Astronomy & Astrophysics
Ruilong Zhang, Libo Liu, Yiding Chen, Huijun Le, Hui Zhang
Summary: We use C/NOFS satellite observations to provide direct evidence for ultra-low-frequency fluctuations in the low-latitude ionospheric electric field, and discover different patterns of these fluctuations.
JOURNAL OF GEOPHYSICAL RESEARCH-SPACE PHYSICS
(2022)
Article
Astronomy & Astrophysics
Ruidi Sun, Sheng-Yang Gu, Xiankang Dou, Ruilong Zhang, Jiawei Kuai, Toshitaka Tsuda
Summary: This study reveals the responses of the mesosphere and ionosphere to the quasi-biennial oscillation in the stratosphere by analyzing observational data, and proposes a linkage between the QBO in the mesosphere and the QBO in the ionosphere.
JOURNAL OF GEOPHYSICAL RESEARCH-SPACE PHYSICS
(2022)
Article
Chemistry, Medicinal
Jerome P. L. Ng, Mohit K. Tiwari, Ali Adnan Nasim, Rui Long Zhang, Yuanqing Qu, Richa Sharma, Betty Yuen Kwan Law, Dharmendra K. Yadav, Sandeep Chaudhary, Paolo Coghi, Vincent Kam Wai Wong
Summary: The cytotoxic effects and anticancer mechanisms of 10 selected peroxides were investigated on different cancer cell lines. Peroxides 7 and 8 showed a better P-gp inhibitory effect and induced apoptosis through a ROS- and caspase-3-independent pathway.
Article
Chemistry, Physical
Xiaohua Tian, Sujun Tian, Lulu Wang, Yanping Yang, Ruilong Zhang, Jiangdong Dai, Jianming Pan
Summary: The authors successfully developed artificial nacre-inspired meshes with excellent mechanical properties and superwetting characteristics. The optimized mesh showed a high separation efficiency and ultrahigh flux. This study provides a promising approach for oily wastewater treatment.
APPLIED CLAY SCIENCE
(2023)
Article
Geosciences, Multidisciplinary
Ruilong Zhang, Libo Liu, Yiding Chen, Huijun Le, Wenbo Li
Summary: Previous studies have shown that sudden stratospheric warmings (SSW) can alter the global atmosphere from the troposphere to the thermosphere/ionosphere. Using DMSP satellite morning measurements, we examined the composition of O+ and H+ at 840-km altitude during the 2009 SSW. Our findings indicate that the stratospheric variation at around 30-km altitude can impact the ion exchange between the ionosphere and protonosphere due to enhanced lunar semidiurnal tides, resulting in the conversion of O+ to H+ and changes in their distribution at different altitudes.
GEOPHYSICAL RESEARCH LETTERS
(2023)
Article
Astronomy & Astrophysics
Yiding Chen, Libo Liu, Huijun Le, Hui Zhang, Ruilong Zhang
Summary: The Martian ionospheric peak is primarily influenced by photochemical processes, and its variations can be described by the Chapman theory with deviations. The upper atmosphere plays an important role in the variability of the ionospheric peak. Ionospheric radio occultation measurements can be used to investigate this effect. This study quantitatively evaluates the influence of the upper atmosphere on the variability of the peak electron density and suggests a modification method based on available data.
Article
Chemistry, Analytical
Dong Wang, Zheng Gong, Wei Huang, Jun Zhao, Junlong Geng, Zhengjie Liu, Ruilong Zhang, Guangmei Han, Zhongping Zhang
Summary: Viscosity is crucial in biological systems for physiological processes like signal transduction and substance and energy metabolisms. Abnormal viscosity is a key feature of many diseases, making real-time monitoring of viscosities in cells and in vivo significant for diagnosis and therapy.
Article
Biochemistry & Molecular Biology
Lin Lin Song, Yuan Qing Qu, Yong Pei Tang, Xi Chen, Hang Hong Lo, Li Qun Qu, Yun Xiao Yun, Vincent Kam Wai Wong, Rui Long Zhang, Hui Miao Wang, Meng Han Liu, Wei Zhang, Hui Xia Zhang, Joyce Tsz Wai Chan, Cai Ren Wang, Jian Hui Wu, Betty Yuen Kwan Law
Summary: Alzheimer's disease is a neurodegenerative disorder characterized by cognitive decline. The beta-amyloid pathway plays a vital role in neuronal apoptosis through altering Ca2+ signaling. In this study, a flavonol glycoside, hyperoside, was identified with anti-A beta aggregation, BACE inhibition, and neuroprotective effects. Pharmacokinetic analysis showed higher brain bioavailability of hyperoside via intranasal administration, and further in vivo studies demonstrated its ability to improve motor deficits, spatial memory, learning ability, and reduce A beta plaques in Alzheimer's disease mice model. Hyperoside was found to interact with A beta and ryanodine receptors, regulating cellular apoptosis via the endoplasmic reticulum-mitochondrial calcium signaling pathway. Moreover, it increased Bcl2, decreased Bax and cyto-c levels, and ameliorated neuronal cell death. These findings suggest that hyperoside could be a potential therapeutic agent or preventive remedy for Alzheimer's disease.
