Article
Multidisciplinary Sciences
Ashfaque A. Memon, Jan Sundquist, Anna Hedelius, Karolina Palmer, Xiao Wang, Kristina Sundquist
Summary: Research in a long-term study of middle-aged Swedish women found that mitochondrial DNA-copy number is associated with the risk of type 2 diabetes mellitus, with lower levels of mtDNA-CN indicating a higher risk of developing T2DM, especially in women who smoke. Further investigation into the clinical utility of mtDNA-CN in predicting the future risk of T2DM is warranted.
SCIENTIFIC REPORTS
(2021)
Article
Endocrinology & Metabolism
Fukashi Ishibashi, Aiko Kosaka, Mitra Tavakoli
Summary: In patients with type 2 diabetes, the use of SGLT2 inhibitors can reduce glycemic variability and provide neurologic and renal protection.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Medicine, General & Internal
Ehtasham Ahmad, Soo Lim, Roberta Lamptey, David R. Webb, Melanie J. Davies
Summary: Type 2 diabetes accounts for nearly 90% of global diabetes cases, with an increasing number of affected individuals, particularly among young people. Early detection and proactive management are crucial for preventing complications and reducing mortality. Technology and precision medicine offer potential improvements to treatment outcomes but face significant barriers.
Article
Surgery
Mohamed AbdAlla Salman, Ahmed Rabiee, Ahmed Salman, Ahmed Elewa, Mohamed Tourky, Ahmed Abdelrahman Mahmoud, Ahmed Moustafa, Hossam El-Din Shaaban, Ahmed Abdelaziz Ismail, Khaled Noureldin, Mohamed Issa, Mohamed Farah, Hesham Barbary, Mujahid Gasemelseed Fadlallah Elhaj, Haitham S. E. Omar
Summary: This study aimed to identify predictors of diabetes remission after two types of bariatric procedures. The results showed that nearly half of the patients achieved complete remission of T2DM two years after surgery. The duration of diabetes and preoperative BMI and C-peptide levels were independent factors predicting complete remissions.
ASIAN JOURNAL OF SURGERY
(2022)
Article
Endocrinology & Metabolism
Anniek J. Sluiman, Stela McLachlan, Rachel B. Forster, Mark W. J. Strachan, Ian J. Deary, Jackie F. Price
Summary: In older individuals with type 2 diabetes, higher baseline levels of inflammatory markers such as plasma IL-6, fibrinogen, and C-reactive protein were associated with subsequent cognitive decline. This association appeared to be specific to certain cognitive domains and independent of vascular and diabetes-related risk factors.
Article
Endocrinology & Metabolism
Lilian Fernandes Silva, Jenna Hokkanen, Jagadish Vangipurapu, Anniina Oravilahti, Markku Laakso
Summary: This study identified multiple metabolites associated with diabetic retinopathy, some of which increased the risk and some decreased the risk for the disease from different metabolic pathways.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Medicine, General & Internal
Jui-An Lin, Jin-De Hou, Szu-Yuan Wu
Summary: This study aims to investigate the impact of sarcopenia on the survival of patients with type 2 diabetes. According to the results, patients with diabetes and sarcopenia have a higher mortality rate compared to those without sarcopenia.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Gastroenterology & Hepatology
Oumarou Nabi, Jerome Boursier, Nathanael Lapidus, Philippe Mathurin, Victor de Ledinghen, Jean-Michel Petit, Marcel Goldberg, Marie Zins, Karine Lacombe, Lawrence Serfaty
Summary: This study evaluates the characteristics of non-alcoholic fatty liver disease (NAFLD) and its impact on morbidity and mortality in type 2 diabetic subjects in a community setting. The results show that diabetes significantly increases the risk of NAFLD and advanced fibrosis in diabetic patients. Furthermore, the presence of NAFLD in diabetic subjects is associated with an increased risk of severe liver-related events, cardiovascular disease, and overall mortality. The severity of fibrosis also correlates with an increased risk of hepatic and extrahepatic complications. These findings provide real-world evidence of the clinical and economic burden of NAFLD in diabetic subjects.
LIVER INTERNATIONAL
(2022)
Article
Endocrinology & Metabolism
Wenqi Geng, Yinan Jiang, Xia Hong, Weigang Zhao, Jie Ren, Cathy Lloyd, Norman Sartorius, Jing Wei
Summary: This study investigated the help-seeking behaviors of patients with comorbid type 2 diabetes mellitus and major depressive disorder. The results showed that voluntary psychiatric help-seeking is uncommon among these patients, highlighting the need for increased awareness of depression among patients and healthcare professionals.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Multidisciplinary Sciences
Xiaoying Wang, Bo Tian, Shengfa Zhang, Jinsui Zhang, Weiping Yang, Jina Li, Weiwei Wang, Yuchen Wang, Weijun Zhang
Summary: This study aimed to examine whether diabetes knowledge could predict glycemic levels in rural Chinese people with low education levels and type 2 diabetes mellitus (T2DM). The results demonstrated a significant negative correlation between diabetes knowledge and glycemic levels, even after controlling for other factors. This highlights the importance of interventions to enhance diabetes knowledge among patients in rural China in order to improve health outcomes and reduce disease burden.
SCIENTIFIC REPORTS
(2023)
Article
Endocrinology & Metabolism
Kristina E. Almby, Petros Katsogiannos, Maria J. Pereira, F. Anders Karlsson, Magnus Sundbom, Urban Wiklund, Prasad G. Kamble, Jan W. Eriksson
Summary: RYGB surgery leads to rapid glucose lowering, reduced cortisol axis activity and inflammation, increased parasympathetic tone, and improved adipose glucose uptake. These changes contribute to improved insulin sensitivity and normoglycemia over time.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Endocrinology & Metabolism
Roger E. Henriksen, Roy M. Nilsen, Ragnhild B. Strandberg
Summary: Loneliness may be a factor that increases the risk of type 2 diabetes, but there is no strong evidence that the effect of loneliness on type 2 diabetes is mediated by depression or insomnia.
Article
Gastroenterology & Hepatology
Hajime Yamazaki, Jui Wang, Shinichi Tauchi, Mitsuru Dohke, Nagisa Hanawa, Akio Katanuma, Yoshifumi Saisho, Tsukasa Kamitani, Shunichi Fukuhara, Yosuke Yamamoto
Summary: The study revealed that patients with fatty liver had a lower rate of type-2 diabetes remission over a 2-year follow-up period, while improvement of fatty liver was significantly associated with a higher rate of type-2 diabetes remission.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Multidisciplinary Sciences
Sophia Eilat-Tsanani, Avital Margalit, Liran Nevet Golan
Summary: The burden of type 2 diabetes is increasing due to both increased incidence and its comorbidities. This study found that the combination of concordant and discordant comorbidities in persons with diabetes is common and indicates a continuum of morbidity, highlighting the significant contribution of discordant comorbidities to disease outcomes. The high prevalence of these comorbidities before the onset of type 2 diabetes emphasizes the importance of proactive management of both types of comorbidities.
SCIENTIFIC REPORTS
(2021)
Article
Medicine, General & Internal
Geltrude Mingrone, Simona Panunzi, Andrea De Gaetano, Caterina Guidone, Amerigo Iaconelli, Esmeralda Capristo, Ghassan Chamseddine, Stefan R. Bornstein, Francesco Rubino
Summary: Metabolic surgery is more effective than conventional medical therapy in long-term control of type 2 diabetes. Even with hyperglycemia relapse, patients maintain adequate glycemic control at 10 years.
Article
Clinical Neurology
Serena Scarpelli, Alessandra De Santis, Valentina Alfonsi, Maurizio Gorgoni, Charles M. Morin, Colin Espie, Ilona Merikanto, Frances Chung, Thomas Penzel, Bjorn Bjorvatn, Yves Dauvilliers, Brigitte Holzinger, Yun K. Wing, Markku Partinen, Giuseppe Plazzi, Luigi De Gennaro
Summary: Recent investigations have found that COVID-19 patients may continue to experience symptoms for 2-3 months after the onset of the infection. This study examined sleep and dream alterations in patients with long-COVID and identified the factors that contribute to these alterations. The results showed that long-COVID patients had more severe sleep problems compared to short-COVID patients. Additionally, the number of post-acute symptoms and psychological factors were found to be important determinants of sleep and dream alterations in long-COVID individuals.
JOURNAL OF SLEEP RESEARCH
(2023)
Article
Multidisciplinary Sciences
Eeva Sliz, Jaakko S. Tyrmi, Nilufer Rahmioglu, Krina T. Zondervan, Christian M. Becker, Outi Uimari, Johannes Kettunen, Aarno Palotie, Mark Daly, Bridget Riley-Gills, Howard Jacob, Dirk Paul, Athena Matakidou, Adam Platt, Heiko Runz, Sally John, George Okafo, Nathan Lawless, Heli Salminen-Mankonen, Robert Plenge, Joseph Maranville, Mark McCarthy, Margaret G. Ehm, Kirsi Auro, Simonne Longerich, Caroline Fox, Anders Malarstig, Katherine Klinger, Clement Chatelain, Matthias Gossel, Karol Estrada, Robert Graham, Robert Yang, Chris O'Donnell, Tomi P. Makela, Jaakko Kaprio, Petri Virolainen, Antti Hakanen, Terhi Kilpi, Markus Perola, Jukka Partanen, Anne Pitkaranta, Taneli Raivio, Raisa Serpi, Tarja Laitinen, Veli-Matti Kosma, Jari Laukkanen, Marco Hautalahti, Outi Tuovila, Raimo Pakkanen, Jeffrey Waring, Bridget Riley-Gillis, Fedik Rahimov, Ioanna Tachmazidou, Chia-Yen Chen, Zhihao Ding, Marc Jung, Shameek Biswas, Rion Pendergrass, David Pulford, Neha Raghavan, Adriana Huertas-Vazquez, Jae-Hoon Sul, Xinli Hu, Asa Hedman, Manuel Rivas, Dawn Waterworth, Nicole Renaud, Ma'en Obeidat, Samuli Ripatti, Johanna Schleutker, Mikko Arvas, Olli Carpen, Reetta Hinttala, Arto Mannermaa, Katriina Aalto-Setala, Mika Kahonen, Johanna Makela, Reetta Kalviainen, Valtteri Julkunen, Hilkka Soininen, Anne Remes, Mikko Hiltunen, Jukka Peltola, Minna Raivio, Pentti Tienari, Juha Rinne, Roosa Kallionpaa, Juulia Partanen, Ali Abbasi, Adam Ziemann, Nizar Smaoui, Anne Lehtonen, Susan Eaton, Sanni Lahdenpera, Natalie Bowers, Edmond Teng, Fanli Xu, Laura Addis, John Eicher, Qingqin S. Li, Karen He, Ekaterina Khramtsova, Martti Farkkila, Jukka Koskela, Sampsa Pikkarainen, Airi Jussila, Katri Kaukinen, Timo Blomster, Mikko Kiviniemi, Markku Voutilainen, Tim Lu, Linda McCarthy, Amy Hart, Meijian Guan, Jason Miller, Kirsi Kalpala, Melissa Miller, Kari Eklund, Antti Palomaki, Pia Isomaki, Laura Pirila, Oili Kaipiainen-Seppanen, Johanna Huhtakangas, Nina Mars, Apinya Lertratanakul, Marla Hochfeld, Jorge Esparza Gordillo, Fabiana Farias, Nan Bing, Margit Pelkonen, Paula Kauppi, Hannu Kankaanranta, Terttu Harju, Riitta Lahesmaa, Glenda Lassi, Hubert Chen, Joanna Betts, Rajashree Mishra, Majd Mouded, Debby Ngo, Teemu Niiranen, Felix Vaura, Veikko Salomaa, Kaj Metsarinne, Jenni Aittokallio, Jussi Hernesniemi, Daniel Gordin, Juha Sinisalo, Marja-Riitta Taskinen, Tiinamaija Tuomi, Timo Hiltunen, Amanda Elliott, Mary Pat Reeve, Sanni Ruotsalainen, Benjamin Challis, Audrey Chu, Dermot Reilly, Mike Mendelson, Jaakko Parkkinen, Tuomo Meretoja, Heikki Joensuu, Johanna Mattson, Eveliina Salminen, Annika Auranen, Peeter Karihtala, Paivi Auvinen, Klaus Elenius, Esa Pitkanen, Relja Popovic, Jennifer Schutzman, Diptee Kulkarni, Alessandro Porello, Andrey Loboda, Heli Lehtonen, Stefan McDonough, Sauli Vuoti, Kai Kaarniranta, Joni A. Turunen, Terhi Ollila, Hannu Uusitalo, Juha Karjalainen, Mengzhen Liu, Stephanie Loomis, Erich Strauss, Hao Chen, Kaisa Tasanen, Laura Huilaja, Katariina Hannula-Jouppi, Teea Salmi, Sirkku Peltonen, Leena Koulu, David Choy, Ying Wu, Pirkko Pussinen, Aino Salminen, Tuula Salo, David Rice, Pekka Nieminen, Ulla Palotie, Maria Siponen, Liisa Suominen, Paivi Mantyla, Ulvi Gursoy, Vuokko Anttonen, Kirsi Sipila, Hannele Laivuori, Venla Kurra, Laura Kotaniemi-Talonen, Oskari Heikinheimo, Ilkka Kalliala, Lauri Aaltonen, Varpu Jokimaa, Marja Vaarasmaki, Laure Morin-Papunen, Maarit Niinimaki, Terhi Piltonen, Katja Kivinen, Elisabeth Widen, Taru Tukiainen, Niko Valimaki, Eija Laakkonen, Heidi Silven, Riikka Arffman, Susanna Savukoski, Triin Laisk, Natalia Pujol, Janet Kumar, Iiris Hovatta, Erkki Isometsa, Hanna Ollila, Jaana Suvisaari, Thomas Damm Als, Antti Makitie, Argyro Bizaki-Vallaskangas, Sanna Toppila-Salmi, Tytti Willberg, Elmo Saarentaus, Antti Aarnisalo, Elisa Rahikkala, Kristiina Aittomaki, Fredrik Aberg, Mitja Kurki, Aki Havulinna, Juha Mehtonen, Priit Palta, Shabbeer Hassan, Pietro Della Briotta Parolo, Wei Zhou, Mutaamba Maasha, Susanna Lemmela, Aoxing Liu, Arto Lehisto, Andrea Ganna, Vincent Llorens, Henrike Heyne, Joel Ramo, Rodos Rodosthenous, Satu Strausz, Tuula Palotie, Kimmo Palin, Javier Garcia-Tabuenca, Harri Siirtola, Tuomo Kiiskinen, Jiwoo Lee, Kristin Tsuo, Kati Kristiansson, Kati Hyvarinen, Jarmo Ritari, Katri Pylkas, Minna Karjalainen, Tuomo Mantere, Eeva Kangasniemi, Sami Heikkinen, Nina Pitkanen, Samuel Lessard, Clement Chatelain, Perttu Terho, Tiina Wahlfors, Eero Punkka, Sanna Siltanen, Teijo Kuopio, Anu Jalanko, Huei-Yi Shen, Risto Kajanne, Mervi Aavikko, Henna Palin, Malla-Maria Linna, Masahiro Kanai, Zhili Zheng, L. Elisa Lahtela, Mari Kaunisto, Elina Kilpelainen, Timo P. Sipila, Oluwaseun Alexander Dada, Awaisa Ghazal, Anastasia Kytola, Rigbe Weldatsadik, Kati Donner, Anu Loukola, Paivi Laiho, Tuuli Sistonen, Essi Kaiharju, Markku Laukkanen, Elina Jarvensivu, Sini Lahteenmaki, Lotta Mannikko, Regis Wong, Auli Toivola, Minna Brunfeldt, Hannele Mattsson, Sami Koskelainen, Tero Hiekkalinna, Teemu Paajanen, Kalle Parn, Mart Kals, Shuang Luo, Shanmukha Sampath Padmanabhuni, Marianna Niemi, Javier Gracia-Tabuenca, Mika Helminen, Tiina Luukkaala, Iida Vahatalo, Jyrki Tammerluoto, Sarah Smith, Tom Southerington, Petri Lehto
Summary: Uterine leiomyomata (UL) are the most common tumours in women and often result in surgical removal of the uterus. This study identified 22 new genetic loci associated with UL risk, in addition to the previously known 50 loci. The identified genes are involved in development, growth, and cellular senescence, particularly in the smooth muscle cell differentiation and proliferation pathways.
NATURE COMMUNICATIONS
(2023)
Article
Psychiatry
Pei Xue, Ilona Merikanto, Frances Chung, Charles M. Morin, Colin Espie, Bjorn Bjorvatn, Jonathan Cedernaes, Anne-Marie Landtblom, Thomas Penzel, Luigi De Gennaro, Brigitte Holzinger, Kentaro Matsui, Harald Hrubos-Strom, Maria Korman, Damien Leger, Sergio Mota-Rolim, Courtney J. Bolstad, Michael Nadorff, Giuseppe Plazzi, Catia Reis, Rachel Ngan Yin Chan, Yun Kwok Wing, Juliana Yordanova, Adrijana Koscec Bjelajac, Yuichi Inoue, Markku Partinen, Yves Dauvilliers, Christian Benedict
Summary: Short and long sleep duration after receiving mRNA vaccines is associated with a higher risk of post-COVID symptoms. The study suggests that short and long sleepers are more likely to experience prolonged COVID-19 symptoms compared to normal sleepers. Further research is needed to validate these findings in cohorts with confirmed SARS-CoV-2 infection.
TRANSLATIONAL PSYCHIATRY
(2023)
Article
Multidisciplinary Sciences
Helena A. K. Lapatto, Minna Kuusela, Aino Heikkinen, Maheswary Muniandy, Birgitta W. van der Kolk, Swetha Gopalakrishnan, Noora Pollanen, Martin Sandvik, Mark S. Schmidt, Sini Heinonen, Sina Saari, Juho Kuula, Antti Hakkarainen, Janne Tampio, Tuure Saarinen, Marja-Riitta Taskinen, Nina Lundbom, Per-Henrik Groop, Marja Tiirola, Pekka Katajisto, Marko Lehtonen, Charles Brenner, Jaakko Kaprio, Satu Pekkala, Miina Ollikainen, Kirsi H. Pietilainen, Eija Pirinen
Summary: Nicotinamide riboside (NR), a precursor of nicotinamide adenine dinucleotide (NAD(+)), has shown promise in improving obesity-associated mitochondrial dysfunction and metabolic syndrome. However, short-term clinical trials have not yielded positive results. This study aimed to investigate the long-term effects of NR supplementation on mitochondrial biogenesis and metabolic health in humans. The results showed that NR improved NAD(+) metabolism, muscle mitochondrial number, myoblast differentiation, gut microbiota composition, and epigenetic control of gene expression. However, it did not improve adiposity or metabolic health.
Article
Biology
Anthony M. Musolf, Annechien E. G. Haarman, Robert N. Luben, Jue-Sheng Ong, Karina Patasova, Rolando Hernandez Trapero, Joseph Marsh, Ishika Jain, Riya Jain, Paul Zhiping Wang, Deyana D. Lewis, Milly S. Tedja, Adriana I. Iglesias, Hengtong Li, Cameron S. Cowan, Ginevra Biino, Alison P. Klein, Priya Duggal, David A. Mackey, Caroline Hayward, Toomas Haller, Andres Metspalu, Juho Wedenoja, Olavi Parssinen, Ching-Yu Cheng, Seang-Mei Saw, Dwight Stambolian, Pirro G. Hysi, Anthony P. Khawaja, Veronique Vitart, Christopher J. Hammond, Cornelia M. van Duijn, Virginie J. M. Verhoeven, Caroline C. W. Klaver, Joan E. Bailey-Wilson
Summary: Refractive error is a complex eye condition caused by genetic and environmental factors. Genome-wide association studies have identified common genetic risk factors, but a significant portion of the heritability is still unexplained. By conducting gene-based association tests, we identified 129 unique genes associated with refractive error in a large dataset. Some of the novel candidates, such as PDCD6IP, PER3, and P4HTM, show promise for future functional studies and validation.
COMMUNICATIONS BIOLOGY
(2023)
Article
Biology
Christer Hublin, Jaakko Kaprio
Summary: According to the Finnish Twin Cohort study, there was a small increase in overall mortality for evening types, but this effect was mainly due to smoking and alcohol. Morning types did not have a significant increase in mortality.
CHRONOBIOLOGY INTERNATIONAL
(2023)
Article
Physiology
Ola Ekstrom, Kristoffer Strom, Bilal Ahmad Mir, Esa Laurila, Ylva Wessman, Mikko Lehtovirta, Karl-Fredrik Eriksson, Ola Hansson
Summary: The aim of this study was to investigate whether a short anaerobic effort leads to increased levels of Tenascin C (TNC) in serum. The results showed that serum TNC levels increased on average by 23% in healthy males after the Wingate test. This increase was positively correlated with peak power output and power drop, but not with VO2max.
CLINICAL PHYSIOLOGY AND FUNCTIONAL IMAGING
(2023)
Article
Public, Environmental & Occupational Health
Eva Schernhammer, Leonie Bogl, Christer Hublin, Susanne Strohmaier, Magda Zebrowska, Astrid Erber, Shahab Haghayegh, Kyriaki Papantoniou, Miina Ollikainen, Jaakko Kaprio
Summary: Using a discordant twin pair design, this study examined the association between night shift work and breast cancer risk, finding that women who worked night shifts had a 1.58-fold higher risk of breast cancer compared to those who worked only during the day. The highest risk was observed among younger women born between 1950 and 1957. Women with longer sleep and night shift work had the greatest risk of breast cancer.
EUROPEAN JOURNAL OF EPIDEMIOLOGY
(2023)
Article
Public, Environmental & Occupational Health
Laurence J. Howe, Humaira Rasheed, Paul R. Jones, Dorret Boomsma, David M. Evans, Alexandros Giannelis, Caroline Hayward, John L. Hopper, Amanda Hughes, Hannu Lahtinen, Shuai Li, Penelope A. Lind, Nicholas G. Martin, Pekka Martikainen, Sarah E. Medland, Tim T. Morris, Michel G. Nivard, Jean-Baptiste Pingault, Karri Silventoinen, Jennifer A. Smith, Emily A. Willoughby, James F. Wilson, Bjorn Olav Asvold, Oyvind E. Naess, George Davey Smith, Jaakko Kaprio, Ben Brumpton, Neil M. Davies
Summary: Previous Mendelian randomization (MR) studies suggest that educational attainment has beneficial effects on adult health outcomes. However, these estimates may be biased due to population stratification, assortative mating, and indirect genetic effects. Using both population and within-sibship MR approaches, this study provides evidence that genetic liability to educational attainment is associated with decreased BMI, cigarette smoking, and SBP, and potentially with mortality.
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
(2023)
Article
Dentistry, Oral Surgery & Medicine
Jari Ahlberg, Frank Lobbezoo, Daniele Manfredini, Maarit Piirtola, Christer Hublin, Jaakko Kaprio
Summary: This study investigated the association between sleep bruxism and mortality and found that self-reported sleep bruxism is associated with increased risk of mortality. However, this association is no longer significant after adjusting for other risk factors, suggesting that bruxism is actually a behavior rather than a disease.
JOURNAL OF ORAL REHABILITATION
(2023)
Article
Genetics & Heredity
Bodine M. A. Gonggrijp, Karri Silventoinen, Conor V. Dolan, Dorret I. Boomsma, Jaakko Kaprio, Gonneke Willemsen
Summary: Assortative mating refers to the non-random mating of individuals based on their similarity or dissimilarity in certain traits. This study analyzed the mechanisms underlying assortative mating for educational attainment in Finland and the Netherlands. The results showed that both phenotypic assortment and social homogamy play important roles in spouse selection, but phenotypic assortment has a greater impact.
FRONTIERS IN GENETICS
(2023)
Article
Nutrition & Dietetics
Suvi T. Itkonen, Piia Karhu, Tiina Pellinen, Mikko Lehtovirta, Niina E. Kaartinen, Satu Mannisto, Essi Paivarinta, Anne-Maria Pajari
Summary: This study investigated the effects of partially replacing red and processed meat with non-soya legumes on bone turnover and mineral metabolism. The results showed that increasing the proportion of non-soya legumes and reducing red meat intake did not affect bone turnover and provided adequate amino acids in healthy men. This environmentally friendly dietary change is safe and easy to implement.
BRITISH JOURNAL OF NUTRITION
(2023)
Article
Endocrinology & Metabolism
Kirsten Mehlig, Ronja Foraita, Rajini N. Nagrani, Marvin Wright, Stefaan De Henauw, Denes A. Molnar, Luis Moreno, Paola Russo, Michael Tornaritis, Toomas Veidebaum, Lauren Lissner, Jaakko Kaprio, Iris Pigeot, I Family Consortium
Summary: This study identified genetic variants associated with the tails of the insulin distribution, which have been previously associated with metabolic diseases and dementia phenotypes. These findings suggest a shared genetic architecture for metabolic traits and neurodegenerative diseases.
Article
Public, Environmental & Occupational Health
Niko Paavo Tynkkynen, Timo Tormakangas, Teemu Palviainen, Matti Hyvarinen, Marie Klevjer, Laura Joensuu, Urho Kujala, Jaakko Kaprio, Anja Bye, Elina Sillanpaa
Summary: There may be genetic factors underlying the associations between higher levels of physical activity (PA) and better aerobic fitness as well as a lower risk for cardiometabolic diseases (CMDs). The study found that genotypes predisposing to higher PA were associated with greater self-reported PA, healthier cardiometabolic profile, and lower incidence of hypertensive diseases, stroke, and type 2 diabetes.
EUROPEAN JOURNAL OF EPIDEMIOLOGY
(2023)
Review
Medicine, General & Internal
G. David Batty, Philipp Frank, Urho M. Kujala, Seppo J. Sarna, Carlos A. Valencia-Hernandez, Jaakko Kaprio
Summary: This study found that retired amateur athletes have a higher risk of dementia compared to the general population, with professional boxers having the highest risk. Retired wrestlers and soccer players also have an increased risk, although lower in magnitude. Furthermore, professional American football players may have a higher risk compared to amateurs.
Article
Clinical Neurology
Melanie Strauss, Lucie Griffon, Maxime Elbaz, Isabelle Arnulf, Mounir Chennaoui, Damien Leger
Summary: This study examines decision-making impairments in individuals with central disorders of hypersomnolence (CDH), specifically narcolepsy type 1 (NT1). The results suggest that both NT1 and other CDH patients have decreased learning abilities to avoid losses, which is associated with alterations in vigilance. The study provides new insights into the nature of decision-making impairments in CDH and suggests the potential for minimizing these alterations by restoring adequate vigilance.
Article
Clinical Neurology
Kyriakos Dimitriadis, Christina Stathakopoulou, Nikolaos Pyrpyris, Eirini Beneki, Elena Adamopoulou, Stergios Soulaidopoulos, Ioannis Leontsinis, Alexandros Kasiakogias, Aggelos Papanikolaou, Panagiotis Tsioufis, Konstantinos Aznaouridis, Dimitris Tsiachris, Konstantina Aggeli, Konstantinos Tsioufis
Summary: This review provides a comprehensive analysis of the common pathophysiology between sleep disordered breathing (SDB) and mitral regurgitation (MR), and discusses the effects of SDB treatment on MR and the effects of mitral valve surgery or transcatheter repair on obstructive and central sleep apnea (OSA and CSA).
Article
Clinical Neurology
Szu-Yu Hou, Ching-Ju Chiu, Jeanne Laraine Shea, Chih-Liang Wang, Hsiao-Han Tang, Po-Ching Kuo, Yi-Chieh Yang, Chih-Hsing Wu
Summary: The study aimed to examine the effects of age, menopausal status, and symptoms on sleep patterns and circadian rhythms in midlife women. Premenopausal women had the most unstable day-to-day rhythms, and women with more severe symptoms experienced greater sleep problems. Psychological symptoms were the strongest predictors for all sleep parameters.
Article
Clinical Neurology
Ya-Wen Hsiao, Wei-Lun Lin, Yu-Hui Chou, Shin-Huei Liu, Ting-Wei Ernie Liao, Shih-Ann Chen, Li-Wei Lo
Summary: This study aimed to investigate the effects of RDN on heart inflammation associated with COSA. The results suggest that RDN treatment may prevent COSA-associated heart inflammation through the JAK2-STAT3 signaling pathway.
Article
Clinical Neurology
Amy C. Reynolds, Kelly A. Loffler, Nicole Grivell, Brandon W. J. Brown, Robert J. Adams
Summary: This study aimed to understand the experience of sleep disorder diagnosis and treatment in shift workers and propose patient-informed solutions to improve access to health services. The findings showed that there were varied experiences with diagnosis and management, often taking a long time to seek help from healthcare providers after noticing symptoms. The study also identified the need for education and awareness initiatives, convenient screening and referral pathways, and tailored models of care.
Article
Clinical Neurology
Hsi -Chung Chen, Nai-Wei Hsu, Ching-Heng Lin
Summary: This study found a relationship between daytime sleepiness and mortality risk among older adults. The moderating effects of sex and physical function were examined. Specifically, the passive factor predicted mortality risk in women with good muscle power, while the active factor predicted mortality risk in men with good muscle power.
Article
Clinical Neurology
Sean P. A. Drummond, Bei Bei
Summary: This study proposes a parsimonious two-stage model for defining stages of Cognitive Behavioural Therapy for Insomnia (CBT-I) based on Sleep Restriction Therapy (SRT). Using data from a randomized clinical trial, the model helps identify patterns of treatment progression and their association with baseline insomnia severity. The model holds potential for further research on various CBT-I processes that are currently not fully understood.
Article
Clinical Neurology
Janet Jezkova, Karel Sonka, Jakub Kreisinger, Petra Prochazkova, Helena Tlaskalova-Hogenova, Sona Nevsimalova, Jitka Buskova, Radana Merkova, Tereza Dvorakova, Iva Prihodova, Simona Dostalova, Radka Roubalova
Summary: In recent years, there has been a growing interest in the influence of gut microbiota on sleep physiology. The gut microbiota affects the central nervous system and circadian rhythms, and can be associated with sleep disorders. This study observed the gut microbiota composition of patients with different types of narcolepsy and idiopathic hypersomnia, and found changes in beta diversity in these patient groups compared to healthy controls. However, after adjusting for confounding factors, the differences were no longer statistically significant. The study suggests that using metabolomics and proteomics approaches to study the role of microbiota in sleep disorders may be beneficial.
Article
Clinical Neurology
Mauro Manconi, Linda C. van der Gaag, Francesca Mangili, Corrado Garbazza, Silvia Riccardi, Christian Cajochen, Susanna Mondini, Francesca Furia, Elena Zambrelli, Simone Baiardi, Alessandra Giordano, Nicola Rizzo, Cristina Fonti, Elsa Viora, Armando D'Agostino, Alessandro Cicolin, Fabio Cirignotta, Daniele Aquilino, Alessandra Barassi, Renata del Giudice, Giulia Fior, Orsola Gambini, Barbara Giordano, Alma Martini, Chiara Serrati, Rossana Stefanelli, Silvio Scarone, Mariapaola Canevini, Valentina Fanti, Hans-Christian Stein, Anna Maria Marconi, Erica Raimondo, Emanuela Viglietta, Rossella Santoro, Giuliana Simonazzi, Alessandra Bianconcini, Francesco Meani, Nicoletta Piazza, Filippos Filippakos, Thomas Gyr
Summary: The Life-ON study provides the largest polysomnographic dataset coupled with longitudinal subjective assessments of sleep quality in pregnant women to date. Sleep disorders are highly frequent and distributed differently during pregnancy and postpartum. Routine assessment of sleep disturbances in the perinatal period is necessary to improve early detection and clinical management.
Article
Clinical Neurology
Zhihua Huang, Anqi Duan, Zhihui Zhao, Qing Zhao, Yi Zhang, Xin Li, Sicheng Zhang, Luyang Gao, Chenhong An, Qin Luo, Zhihong Liu
Summary: This study aims to investigate pulmonary arterial hypertension (PAH) phenotypes and their prognostic implications by clustering overnight cardiorespiratory signals in PAH patients. Three distinct clusters were identified, with patients in Cluster 3 exhibiting worse clinical outcomes. The presence of nocturnal hypoxemia and obstructive sleep apnea (OSA) in PAH patients was associated with increased risk of clinical worsening. Tailored management strategies addressing both PAH and nocturnal hypoxemia may improve clinical outcomes.
Article
Clinical Neurology
Yudan Lv, Yujun Wen, Ramalingam Vetrivelan, Jun Lu
Summary: This study demonstrated that the projections from the pontine parabrachial nucleus (PB) to the basal forebrain (BF) and medial septum (MS) can activate the cerebral cortex and hippocampus, providing important insights into the activities of these brain regions during the sleep-wake cycle.
Article
Clinical Neurology
Annika M. Myers, Megan E. Rech, Bengi Baran, Cara Palmer, Dimitrios Mylonas, Candice A. Alfano
Summary: This study found that N2 sleep spindles are associated with emotional functioning in school-aged children. Higher spindle density is related to decreased state-based emotional arousal towards negative affective images, and higher spindle peak frequency is associated with greater use of the positive emotion regulatory strategy of savoring.
Article
Clinical Neurology
Hung Youl Seok, Yong Won Cho
Summary: This study investigated the long-term impact of dopamine agonist treatment on altered central sensory processing in restless legs syndrome (RLS) patients. The results showed that dopamine agonist treatment effectively reduced RLS symptoms but did not reverse the altered central sensory processing observed on testing. These findings suggest that RLS pathophysiology is multifactorial and not solely driven by dopaminergic dysfunction.
