Review
Nutrition & Dietetics
Elena Marisol Cruz-Garcia, Maria E. Frigolet, Samuel Canizales-Quinteros, Ruth Gutierrez-Aguilar
Summary: The main roles of adipose tissue are to store triglycerides and secrete adipokines, which regulate energy balance and inflammation. In obesity, dysfunction of adipocytes leads to inflammation and insulin resistance. This systematic review aimed to identify differentially expressed genes in subcutaneous adipose tissue of lean, obese, and post-RYGB individuals. The results showed that both the lean state and post-RYGB are similar in terms of increased expression of insulin-sensitizing molecules, promoting lipogenesis over lipolysis, and downregulating factors that promote inflammation.
Article
Endocrinology & Metabolism
Tania Amorim, Anamil Khiyami, Tariq Latif, Pouneh K. Fazeli
Summary: This review discusses the effects of famine on the evolution of the human species, including neuroendocrine adaptations to starvation and the clinical effects of chronic undernutrition.
PSYCHONEUROENDOCRINOLOGY
(2023)
Article
Immunology
Ivan Arias de la Rosa, Alejandro Escudero-Contreras, Miriam Ruiz-Ponce, Cristobal Roman-Rodriguez, Carlos Perez-Sanchez, Maria del Carmen Abalos-Aguilera, Rafaela Ortega-Castro, Juan Alcaide, Mora Murri, Pilar Font, Jerusalem Calvo-Gutierrez, Maria Luque-Tevar, Alejandra Maria Patino-Trives, Rocio Guzman-Ruiz, Maria del Mar Malagon, Francisco Jose Tinahones, Eduardo Collantes-Estevez, Chary Lopez-Pedrera, Nuria Barbarroja
Summary: Obesity may not directly impact disease activity in rheumatoid arthritis patients, but the induction of arthritis can lead to transcriptomic changes in adipose tissue under obesity conditions. Treatment with hydroxychloroquine can reduce weight and insulin resistance, with beneficial metabolic effects in adipose tissue.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Dentistry, Oral Surgery & Medicine
Yuan Su, Leilei Ye, Chen Hu, Yanli Zhang, Jia Liu, Longquan Shao
Summary: Periodontitis is closely related to the occurrence and development of type 2 diabetes, and the virulence factors produced by periodontitis can directly or indirectly regulate the function of islet beta cells and induce insulin resistance, thus influencing the occurrence and development of type 2 diabetes. Periodontal therapy has positive effects on type 2 diabetes.
INTERNATIONAL JOURNAL OF ORAL SCIENCE
(2023)
Article
Endocrinology & Metabolism
Petros Katsogiannos, Prasad G. Kamble, Maria J. Pereira, Magnus Sundbom, Per-Ola Carlsson, Jan W. Eriksson, Daniel Espes
Summary: The study compared cytokine and adipokine levels in obese patients before and after RYGB surgery, finding that despite improvements in metabolic status and weight loss, the altered cytokine profile persisted, indicating an inherent inflammatory state in obese patients.
Article
Endocrinology & Metabolism
Milica Vranic, Fozia Ahmed, Robin Kristofi, Susanne Hetty, Dariush Mokhtari, Maria K. Svensson, Jan W. Eriksson, Maria J. Pereira
Summary: This study evaluates the dopaminergic signaling in human adipose tissue in the context of obesity and type 2 diabetes (T2D) and its potential implications in adipose tissue metabolism. The results suggest that protein expression of DRD2 in subcutaneous adipose tissue is up-regulated with hyperglycemia and T2D, possibly as a compensatory mechanism. Additionally, dopamine receptor agonists inhibit adipocyte lipolysis and may have beneficial effects on lipid metabolism.
Article
Biochemistry & Molecular Biology
Da Hea Seo, Eugene Shin, Yong-ho Lee, Se-Eun Park, Ki Taek Nam, Jae-woo Kim, Bong-Soo Cha
Summary: Cilostazol treatment promotes browning of visceral adipose tissue by activating the cAMP/PKA signaling pathway and improves overall metabolism in HFD-fed mice.
Review
Biochemistry & Molecular Biology
Tabatha Petrillo, Christian Battipaglia, Mohamed Ashraf Virmani, Andrea R. Genazzani, Alessandro D. Genazzani
Summary: Carnitines, as quaternary amines, play a role in various cellular processes and have been studied for their beneficial effects in different physio-pathological conditions. They are capable of improving neuroendocrine impairments and metabolic parameters, making them a potential treatment option for reproductive disorders like functional hypothalamic amenorrhea and polycystic ovary syndrome.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Vicente Barrios, Ana Campillo-Calatayud, Santiago Guerra-Cantera, Sandra Canelles, Alvaro Martin-Rivada, Laura M. Frago, Julie A. Chowen, Jesus Argente
Summary: Leptin modulates insulin signaling through Akt pathway in a tissue-specific manner, with changes in inflammatory environment affecting cytokine synthesis. Chronic central leptin infusion in rats led to increased phosphorylation of JNK and NFkB in inguinal fat, with a pro-inflammatory profile, while liver showed reduced activation of JNK and NFkB with an anti-inflammatory pattern.
Article
Gastroenterology & Hepatology
Wei Shen, Michael S. Middleton, Guilherme M. Cunha, Timoteo I. Delgado, Tanya Wolfson, Anthony Gamst, Kathryn J. Fowler, Adina Alazraki, Andrew T. Trout, Michael A. Ohliger, Shetal N. Shah, Mustafa R. Bashir, David E. Kleiner, Rohit Loomba, Brent A. Neuschwander-Tetri, Arun J. Sanyal, Jane Zhou, Claude B. Sirlin, Joel E. Lavine
Summary: This study investigated the relationship between reduction in adipose tissue compartment volumes and hepatic histologic improvement in adults with obesity and non-alcoholic steatohepatitis (NASH). The findings showed that reductions in deep subcutaneous adipose tissue and visceral adipose tissue volumes were associated with histologic improvement in NASH.
JOURNAL OF HEPATOLOGY
(2023)
Article
Surgery
Matthew Stevenson, Ankita Srivastava, Jenny Lee, Christopher Hall, Thomas Palaia, Raymond Lau, Collin Brathwaite, Louis Ragolia
Summary: Roux-en-Y gastric bypass (RYGB) and vertical sleeve gastrectomy (VSG) have different effects on obesity-related metabolic disorders. RYGB can sustain weight loss and improve comorbidities, while VSG shows poorer long-term outcomes post-operatively.
Article
Multidisciplinary Sciences
Shubham Khetan, Susan Kales, Romy Kursawe, Alexandria Jillette, Jacob C. Ulirsch, Steven K. Reilly, Duygu Ucar, Ryan Tewhey, Michael L. Stitzel
Summary: Identifying causal variants at GWAS loci is crucial for understanding disease mechanisms, and this study used massively parallel reporter assays to pinpoint type 2 diabetes-associated variants and genetic mechanisms. The researchers revealed that multiple T2D-associated SNPs alter the activity of SINE-containing elements induced by ER stress, highlighting potential roles for repetitive elements in beta cell transcriptional stress response and T2D genetics.
NATURE COMMUNICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Beatriz Barakat, Martha E. F. Almeida
Summary: Obesity, categorized by excess adipose tissue, leads to oxidative stress and chronic inflammation in the body, causing hormonal imbalance and making individuals prone to various comorbidities. Proper treatment and prevention strategies, such as healthy eating and regular exercise, are essential in managing this syndrome.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2021)
Article
Endocrinology & Metabolism
Juliane Weiner, Lisa Roth, Mathias Kranz, Peter Brust, Anita Boelen, Nora Kloeting, John T. Heiker, Matthias Blueher, Anke Toenjes, Paul T. Pfluger, Michael Stumvoll, Jens Mittag, Kerstin Krause
Summary: This study identified a previously unknown endocrine loop where leptin acts in concert with the HPT axis to stabilize body temperature in hypothyroid mice. Leptin regulates body temperature not only by directly affecting heat production, but also by stimulating the HPT axis to maintain TH serum levels.
MOLECULAR METABOLISM
(2021)
Article
Endocrinology & Metabolism
Vibha Singhal, Nazanin Hazhir Karzar, Amita Bose, Colleen Buckless, Kathryn E. Ackerman, Miriam A. Bredella, Anne Klibanski, Madhusmita Misra
Summary: In a study of 15 adolescent and young adult females with FHA, 12 months of transdermal estradiol therapy led to a decrease in bone marrow adipose tissue at the lumbar vertebrae and an increase in radial and tibial cortical volumetric bone mineral density, suggesting a positive association between the two.
Article
Biophysics
Alejandra N. Torres, Ludgero Tavares, Maria J. Pereira, Jan W. Eriksson, John G. Jones
Summary: This study characterized the fatty acid composition and positional distribution of triglycerides in human subcutaneous adipose tissue using C-13 NMR spectroscopy. The study found that the sn2 position of triglycerides is enriched with monounsaturated fatty acids, while the sn1,3 position is enriched with saturated fatty acids. Furthermore, the study revealed a significant positive correlation between palmitoleic acid levels and both BMI and insulin sensitivity.
NMR IN BIOMEDICINE
(2023)
Article
Surgery
Erik Stenberg, Henrik Larsson, Richard Marsk, Yang Cao, Magnus Sundbom, Erik Naslund
Summary: This study aimed to assess the short-term and long-term outcomes of metabolic and bariatric surgery in patients with attention deficit hyperactivity disorder (ADHD). The results showed that patients with ADHD treated pharmacologically for ADHD experienced similar weight loss and remission of obesity-related diseases compared to patients without ADHD. However, they reported a lower health-related quality of life and had an increased risk of substance abuse and self-harm.
SURGERY FOR OBESITY AND RELATED DISEASES
(2023)
Article
Surgery
Anna Laurenius, Magnus Sundbom, Johan Ottosson, Erik Näslund, Erik Stenberg
Summary: Obesity is associated with an increased risk of kidney stones, especially after metabolic and bariatric surgery. However, there is a lack of reports on baseline risk factors and larger population-based cohorts. This study aimed to evaluate the incidence and risk factors for postoperative kidney stones after bariatric surgery by comparing them to a matched control group from the normal population.
Article
Surgery
Magnus Sundbom, Eladio Cabrera, Rickard Nyman, Charlotte Ebeling Barbier, Ulf Johnson, Mikael Ljungdahl
Summary: This study compared percutaneous endoscopic gastrostomy (PEG) with radiologically inserted gastrostomy (RIG) in adults and found that PEG had shorter operative time, lower rate of adverse events, and lower 30-day mortality, making it the recommended primary procedure. However, RIG is also a valid alternative method.
SCANDINAVIAN JOURNAL OF SURGERY
(2023)
Article
Microbiology
Jana Gruttner, Jorik M. van Rijn, Petra Geiser, Alexandra Florbrant, Dominic-Luc Webb, Per M. Hellstrom, Magnus Sundbom, Mikael E. Sellin, Staffan G. Svard
Summary: Giardia intestinalis is a parasite that infects the upper small intestine of mammals. It can cause diarrhoeal disease in humans, but many infections do not cause symptoms. The molecular mechanisms behind these different outcomes are still unclear.
Article
Endocrinology & Metabolism
Jan W. Eriksson, Reem A. Emad, Martin H. Lundqvist, Niclas Abrahamsson, Maria C. Kjellsson
Summary: This study aimed to investigate the association between insulin sensitivity and the secretion of counter-regulatory hormones, and how the dysregulation of these hormones can lead to insulin resistance and potentially diabetes. The results showed that insulin resistance explained the elevated glucagon levels and potentiated cortisol-axis response to hypoglycemia, which may contribute to dysglycemia and possibly type 2 diabetes over time.
ENDOCRINE CONNECTIONS
(2023)
Article
Surgery
Filip Moller, Jakob Hedberg, Martin Skogar, Magnus Sundbom
Summary: In super obesity, biliopancreatic diversion with duodenal switch (BPD/DS) is advocated by some surgeons as a more effective procedure compared to Roux-en-Y gastric bypass (RYGB). However, there is limited evidence on long-term outcomes beyond 10 years. This study compared the long-term outcome of BPD/DS and RYGB in patients with super obesity and found that BPD/DS resulted in superior weight loss, metabolic control, and BAROS score, but with more adverse events.
Editorial Material
Respiratory System
Magnus Sundbom
JOURNAL OF THORACIC DISEASE
(2023)
Article
Endocrinology & Metabolism
Eva Randell, Petros Katsogiannos, Janeth Leksell, Jan W. W. Eriksson, Magnus Sundbom, Maria Svedbo Engstrom
Summary: This qualitative study examined how adults with previous type 2 diabetes perceived different sources of support two years after bariatric surgery. The findings revealed that support needs changed over time and that long-term professional and day-to-day support from family and other networks were essential and complementary.
Article
Endocrinology & Metabolism
Giovanni Fanni, Christakis Kagios, Erika Roman, Magnus Sundbom, Johan Wikstrom, Sven Haller, Jan W. Eriksson
Summary: This study aimed to investigate the effect of Roux-en-Y gastric bypass (RYGB) on brain connectivity, and found that RYGB can alter the connectivity of neural pathways related to reward, inhibitory control, and energy homeostasis. These changes are associated with alterations in hypoglycemic responses and may contribute to the glucose metabolic outcomes of RYGB.
Article
Endocrinology & Metabolism
Martin H. Lundqvist, Maria J. Pereira, Jan W. Eriksson
Summary: This study investigates whether inflammatory responses to glycemic and insulinemic variations are altered in obese individuals. The results show that hyperinsulinemia, hypoglycemia, and hyperglycemia lead to a decrease in multiple inflammatory markers, and the inflammatory response is more pronounced in obese individuals during hypoglycemia and hyperglycemia.
Article
Endocrinology & Metabolism
Fozia Ahmed, Milica Vranic, Susanne Hetty, Argyri Mathioudaki, Vagia Patsoukaki, Giovanni Fanni, Maria J. Pereira, Jan W. Eriksson
Summary: This study investigated the association of organic cation transporter 3 (OCT3) mRNA levels in subcutaneous adipose tissue with aging and markers of insulin resistance. The results showed that mRNA and protein levels of OCT3 increased with aging and were negatively associated with markers of insulin resistance. In addition, estradiol treatment resulted in a reduction in OCT3 mRNA levels.
Review
Endocrinology & Metabolism
Magnus Sundbom, Ingmar Naslund, Johan Ottosson, Erik Stenberg, Erik Naslund
Summary: The Scandinavian Obesity Surgery Registry (SOReg) is a high-quality database used to monitor the results of bariatric surgery and conduct research. Swedish bariatric surgery has low mortality rates compared to other countries, and gastric bypass surgery significantly improves obesity-related diseases and quality of life while reducing the risk of cardiac failure and major adverse cardiovascular events. Additionally, the database reveals a correlation between low socioeconomic status and reduced opportunities for surgery and inferior outcomes.
Meeting Abstract
Gastroenterology & Hepatology
Lars Johansson, Magnus Sundbom, Edvin Johansson, Joel Kullberg
JOURNAL OF HEPATOLOGY
(2023)
Article
Endocrinology & Metabolism
Milica Vranic, Fozia Ahmed, Robin Kristofi, Susanne Hetty, Dariush Mokhtari, Maria K. Svensson, Jan W. Eriksson, Maria J. Pereira
Summary: This study evaluates the dopaminergic signaling in human adipose tissue in the context of obesity and type 2 diabetes (T2D) and its potential implications in adipose tissue metabolism. The results suggest that protein expression of DRD2 in subcutaneous adipose tissue is up-regulated with hyperglycemia and T2D, possibly as a compensatory mechanism. Additionally, dopamine receptor agonists inhibit adipocyte lipolysis and may have beneficial effects on lipid metabolism.