Article
Agricultural Engineering
Kogilavanee Devasvaran, Batoul Alallam, Vuanghao Lim
Summary: This study aimed to evaluate the optimal method for extracting crude polysaccharides from Clinacanthus nutans leaves (CNP) as natural antioxidants. Five different extraction methods were compared, and the alkaline and ultrasound-assisted methods were found to be the most effective, with the highest extraction yield and antioxidant properties. The total phenolic content (TPC) was directly related to antioxidant activity, with the freeze-thaw method showing the highest TPC. The extraction method played a significant role in determining the antioxidant properties of CNP extracts. These findings have implications for the food industry, which has a high demand for natural antioxidants for food preservation and enhancement.
INDUSTRIAL CROPS AND PRODUCTS
(2023)
Article
Agriculture, Multidisciplinary
Huwei Wu, Linping Shu, Tian Liang, Yanping Li, Yuanxiang Liu, Xiuli Zhong, Lingyu Xing, Wei Zeng, Rui Zhao, Xiaoyin Wang
Summary: This study optimized the extraction of polysaccharides from lotus seedpods and investigated their physicochemical properties, antioxidant activity, and inhibition of α-glucosidase. The results suggest that lotus seedpod polysaccharides have the potential to be natural antioxidants and hypoglycemic substitutes.
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
(2022)
Article
Biochemistry & Molecular Biology
Kai Song Ng, Sheri-Ann Tan, Chui Yin Bok, Khye Er Loh, Intan Safinar Ismail, Chen Son Yue, Chui Fung Loke
Summary: Antioxidants, particularly from Clinacanthus nutans leaves, show potential in preventing liver cancer in NAFLD patients. The study identified strong radical scavenging and reducing power properties in CNL compared to CNS, with the presence of specific metabolites contributing to antioxidant and hepatoprotective abilities. HepG2 cell model further supported the effectiveness of CNL in reducing ROS levels and protecting liver cells from oxidative stress.
Article
Crystallography
Dharshini Perumal, Emmellie Laura Albert, Norazalina Saad, Taufiq Yap Yun Hin, Ruzniza Mohd Zawawi, Huey Fang Teh, Che Azurahanim Che Abdullah
Summary: In this study, clinacanthus nutans leaf extract was used to synthesize reduced graphene oxide (rGO) using a simple reflux method. The synthesized rGO was characterized using various spectroscopic and microscopic techniques. The results showed that the oxygen groups in rGO were reduced, resulting in a changed structure and lower toxicity compared to conventional carbon-based materials. These findings support the potential of clinacanthus nutans as an eco-friendly substitute for carbon-based fabrication.
Article
Plant Sciences
Audrey Siew Foong Kow, Leng Wei Khoo, Ji Wei Tan, Faridah Abas, Ming-Tatt Lee, Daud Ahmad Israf, Khozirah Shaari, Chau Ling Tham
Summary: C. nutans, a herbal plant used traditionally to treat skin rash, was found to exert anti-allergic effects by suppressing the IgG pathway and the release of mediators.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Infectious Diseases
Saruda Thongyim, Salinee Chiangchin, Hataichanok Pandith, Yingmanee Tragoolpua, Siriphorn Jangsutthivorawat, Aussara Panya
Summary: Clinacanthus nutans is widely used as a traditional medicine in Southeast Asia, mainly as an anti-viral agent. This study demonstrates the therapeutic activity of C. nutans extracts in reducing inflammation in bovine mastitis caused by bacterial infection, indicating its potential as an alternative treatment option for this disease.
Article
Biochemistry & Molecular Biology
Weng Kit Ban, Isabel Lim Fong, Heng Yen Khong, Joyce Hui Yie Phung
Summary: Clinacanthus nutans and Strobilanthes crispus have multiple beneficial properties, including antimicrobial and wound healing activities. Strobilanthes crispus exhibits superior antimicrobial and wound healing activities.
Article
Engineering, Chemical
Siti N. S. Othman, Ana N. Mustapa, Ku Halim Ku Hamid
Summary: In this study, solvent-free microwave extraction (SFME) was used to extract polyphenols from Clinacanthus nutans Lindau, showing that extraction under vacuum pressure resulted in higher polyphenol content compared to ambient pressure extraction. This study demonstrates that vacuum conditions are beneficial for polyphenol extraction from C. nutans.
CHEMICAL ENGINEERING COMMUNICATIONS
(2021)
Article
Food Science & Technology
Yuwei Wang, Ying Ye, Le Wang, Wei Yin, Jian Liang
Summary: Subcritical water extraction (SWE) is an efficient and environmentally friendly method for extracting anthocyanins from raspberry, with high extraction efficiency and superior antioxidant activity compared to conventional extraction methods.
Review
Integrative & Complementary Medicine
Chung-Ming Lin, Hsin-Han Chen, Chi-Wen Lung, Hui-Jye Chen
Summary: Clinacanthus nutans is a traditional medicinal herb used for treating various diseases, including cancer. The underlying mechanisms of its anticancer activity are still unclear. Researchers hope that by collecting recent relevant studies, updating people's understanding of this herb, and speeding up its clinical application in the future.
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Pattamaporn Aksornchu, Netima Chamnansilpa, Sirichai Adisakwattana, Thavaree Thilavech, Charoonsri Choosak, Marisa Marnpae, Kittana Makynen, Winai Dahlan, Sathaporn Ngamukote
Summary: Antidesma bunius fruit extract, enriched with anthocyanins, showed inhibitory activity against digestive enzymes, reduced monosaccharide-induced protein glycation, and exhibited antioxidant properties. The findings suggest ABE may be a promising agent for these activities.
Article
Food Science & Technology
Jia Wang, Xiaoyu Zhang, Junyu Liu, Ruilin Li, Jingna Zhou, Mingyue Li, Jingyang Lu, Guangyu Zhao, Xiang Li, Wenjie Sui, Min Zhang, Haixia Chen
Summary: In this study, steam explosion technology was used to extract phytochemicals from Java tea. The results showed that steam explosion destroyed the cell wall structure and increased pore space, facilitating the dissolution of ingredients. After steam explosion treatment, the contents of phenolics, triterpenes, and sterols in Java tea extracts significantly increased, and the antioxidant and alpha-glucosidase inhibition capacity were also enhanced. Phenolics and triterpenes were identified as the main active substances in the extracts, and the leaves treated at 1.0 MPa and stems treated at 2.4 MPa showed higher comprehensive score. This method provides a promising approach for improving the extractability and bioactivity of Java tea.
INNOVATIVE FOOD SCIENCE & EMERGING TECHNOLOGIES
(2023)
Article
Chemistry, Multidisciplinary
Minh T. H. Nguyen, Quang Ngo, Huyen T. T. Nguyen, Quan M. Pham, Trang H. Dinh, Huong T. T. Nguyen, Nguyen Tinh, Phuong T. M. Nguyen
Summary: This study found that lupeol derived from Clinacanthus nutans Lindau exhibits osteogenic activity by enhancing alkaline phosphatase and mineralization activity of osteoblast cells, as well as upregulating the expression of marker genes related to osteoblast differentiation. Additionally, lupeol affects the MAPK signaling pathway involved in osteoblast differentiation.
JOURNAL OF CHEMISTRY
(2021)
Article
Food Science & Technology
Pattarin Supanivatin, Aluck Thipayarat, Suwit Siriwattanayotin, Paweena Ekkaphan, Anat Deepatana, Jakrapop Wongwiwat
Summary: This study investigated the extraction of antioxidants and antibacterial substances from Robusta-roasted coffee using different extraction techniques. The results showed that HCFC-22 extraction had the highest yield, while HFC-134a extraction exhibited the highest antioxidant potential. Room-temperature batch extraction yielded slightly higher amounts of extracts with higher antioxidant potential compared to other methods. The extracts obtained using SCCO2 extraction had similar yield and antioxidant potential to those obtained using HFC-134a and HCFC-22 extractions.
Article
Biochemistry & Molecular Biology
Jong Hoon Ahn, Se Hwan Ryu, Solip Lee, Sang Won Yeon, Ayman Turk, Yoo Kyong Han, Ki Yong Lee, Bang Yeon Hwang, Mi Kyeong Lee
Summary: The study on the leaves of Actinidia arguta identified multiple antioxidant compounds, including some that show inhibitory effects on α-glucosidase. These active components exhibit diverse structures and interactions with α-glucosidase.
Review
Biochemistry & Molecular Biology
Nur Farisya Shamsudin, Qamar Uddin Ahmed, Syed Mahmood, Syed Adnan Ali Shah, Alfi Khatib, Sayeed Mukhtar, Meshari A. Alsharif, Humaira Parveen, Zainul Amiruddin Zakaria
Summary: The latest report from the World Health Organization highlights the growing concern of bacterial resistance to commonly used antibacterial drugs worldwide. Various strategies have been developed to effectively address severe complications associated with multidrug-resistant bacteria, with natural products showing promise in this area.
Article
Zoology
Elfadil Elfadul Babiker, Khalid Ahmed Abdoun, Fahad AL Juhaimi, Kashif Ghafoor, Riyadh Salih Aljumaah, Ahmed Abrahim Al-Haidary
Summary: The present study examined the effects of dietary supplementation with Moringa on the oxidative state and blood parameters of ewes and goats. The results showed that Moringa supplementation increased vitamin C concentration, total antioxidant capacity, and catalase activity, while decreasing malondialdehyde, glucose, and cholesterol concentrations in the serum.
PAKISTAN JOURNAL OF ZOOLOGY
(2022)
Article
Food Science & Technology
Mehmet Musa Ozcan, Fahad Y. Al-Juhaimi, Nurhan Uslu, Kashif Ghafoor, Elfadil E. Babiker, Isam A. Mohamed Ahmed
Summary: The study showed that the properties of packaging materials have a significant impact on the oxidative stability of stored virgin olive oil, with an increase in viscosity, color, free fatty acid, and other values as storage time progresses.
JOURNAL OF FOOD MEASUREMENT AND CHARACTERIZATION
(2022)
Article
Food Science & Technology
Nurhan Uslu, Mehmet Musa Ozcan, Fahad Al-Juhaimi, Kashif Ghafoor, Elfadil E. Babiker, Magdi A. Osman, Hesham A. A. Salih
Summary: The total phenolic, flavonoid, gallic acid, and 3,4-dihydroxybenzoic acid contents of immature and ripe linden increased with the increase of sonication time. Ultrasound waves can be used as a new processing technology for extracting phenolic compounds from food.
JOURNAL OF FOOD PROCESSING AND PRESERVATION
(2022)
Article
Food Science & Technology
Kashif Ghafoor, Fahad Y. Al-Juhaimi, Elfadil E. Babiker, Isam A. Mohamed Ahmed, Syed Ali Shahzad, Omer N. Alsawmahi
Summary: Edible chitosan coatings with natural functional ingredients are effective in preserving the quality attributes of Barhi dates and inhibiting mold growth.
Article
Food Science & Technology
Kashif Ghafoor, Fahad Al Juhaimi, Mehmet Musa Ozcan, Nurhan Uslu, Isam A. Mohamed Ahmed, Elfadil E. Babiker
Summary: The protein, total phenolic and antioxidant activity, catechin, rutin trihydrate, linolenic acid, linoleic acid, phosphorus, and potassium contents of chia seeds changed after different treatments, with boiled chia seeds showing lower mineral content compared to control and other treated seeds.
INTERNATIONAL JOURNAL OF GASTRONOMY AND FOOD SCIENCE
(2022)
Article
Food Science & Technology
Kashif Ghafoor, Md. Zaidul Islam Sarker, Fahad Y. Al-Juhaimi, Elfadil E. Babiker, Mohammed S. Alkaltham, Abdullah K. Almubarak
Summary: Date (Phoenix dactylifera) seed can be a potential source of natural antioxidants. Innovative green and low temperature antioxidant recovery techniques, such as supercritical fluid (SFE) and subcritical (SubCO(2)) extractions using CO2 as a solvent, can improve the yields and quality of antioxidant extracts. This study compared SFE, SubCO(2), and Soxhlet techniques for enriching antioxidants in extracts from different date seed varieties. The results showed that SFE and SubCO(2) methods extracted significantly higher levels of phenolics, flavonoids, anthocyanins, and carotenoids compared to Soxhlet. In vitro evaluation also demonstrated that SFE and SubCO(2) extracts had promising antioxidant properties, making them potential candidates for functional and nutraceutical applications.
Article
Plant Sciences
Kashif Ghafoor, Fahad Y. Al-Juhaimi, Isam A. Mohamed Ahmed, Elfadil E. Babiker, Syed Ali Shahzad, Omer N. Alsawmahi
Summary: This study investigated the effect of functional coating using 2% chitosan and different concentrations of olive cake extract (OCE) and orange peel extract (OPE) on the physicochemical quality attributes of cucumber during cold storage. The results showed that the functional coated samples had higher moisture content, total soluble solids, pH value, total phenolic contents, DPPH radical scavenging activity, yellowness, and hardness, while lower lightness, greenness, total viable count, yeast and mold counts, and acidity compared to the uncoated samples. During storage, all cucumber samples experienced a reduction in most quality attributes, but the changes were minimal in the functionally coated samples, indicating the potential of OCE and OPE in preserving the quality attributes of cucumber during cold storage.
Article
Chemistry, Organic
Tariqul Islam, Md Zaidul Islam Sarker, A. B. M. Helal Uddin, Shah Samiur Rashid, Liew Kai Bin
Summary: In this study, N-phenylbenzamide (N-PBA) was synthesized using solvent-pair mixtures containing hydrogen bond donor and hydrogen bond acceptor to explore the replacement/limitation of hazardous dipolar aprotic solvents in amide drug synthesis. Different pure solvents and mixed solvents were selected based on their Kamlet-Taft parameters and GSK 2016 health-safety scores. The yields of N-PBA were evaluated using high-performance liquid chromatography (HPLC) under an amide coupling system at 25 degrees C. The results showed that safe solvent mixtures could be used to avoid/limit hazardous dipolar aprotic solvents and significantly improve the yield of N-PBA.
Article
Food Science & Technology
Kashif Ghafoor, Md. Zaidul Islam Sarker, Fahad Y. Al-Juhaimi, Isam A. Mohamed Ahmed, Elfadil E. Babiker, Mohammed S. Alkaltham, Abdullah K. Almubarak
Summary: The bioactive compounds of four Saudi date flesh extracts were evaluated using different extraction methods. Both the date variety and extraction method affected the phenolic profile of the extracts. The incorporation of date flesh extracts into yogurt increased the total phenolic content, antiradical activity, viscosity, and redness of the product.
Review
Plant Sciences
Raden Bayu Indradi, Muhaimin Muhaimin, Melisa Intan Barliana, Alfi Khatib
Summary: Resistance to antimalarial medicine poses a threat to malaria eradication efforts worldwide. Recent reports from the World Health Organization have identified partial resistance to artemisinin in Southeast Asia and Africa, highlighting the need for new antimalarial drugs. Traditional medicine in Indonesia has identified several plant species with potential antimalarial properties, including Andrographis paniculata, Alstonia scholaris, Carica papaya, and Physalis minima. Among these, A. paniculata shows the highest potential as an antimalarial, with its extract and andrographolide exhibiting strong activity in vitro and in vivo. A. scholaris and C. papaya also show promise and warrant further investigation, while P. minima remains relatively understudied but presents an opportunity for exploration.
Article
Green & Sustainable Science & Technology
Nurul Hidayah Hishamuddin, Md Firoz Khan, Hamidah Suradi, B. M. Zuhair Siraj, Md. Towhidul Islam, Nor Asrina Sairi, Hairul Anuar Tajuddin, Arniza Khairani Mohd Jamil, Md. Jahurul Haque Akanda, Sumiani Yusoff
Summary: This research aimed to assess the levels of PAHs in road dust near bus stops, identify their sources, and evaluate potential health risks. The results showed that the concentrations of PAHs in road dust ranged from 137.8 to 5813 ng g(-1), with Indeno[1,2,3-c,d]pyrene having the highest concentration. The study identified three main sources of PAHs such as oil spills, fuel combustion, and coal burning, and found that long-term exposure to PAHs may negatively impact lung function and increase the risk of cancer and skin diseases.
Review
Biochemistry & Molecular Biology
Nur Farisya Shamsudin, Qamar Uddin Ahmed, Syed Mahmood, Syed Adnan Ali Shah, Murni Nazira Sarian, Muhammad Muzaffar Ali Khan Khattak, Alfi Khatib, Awis Sukarni Mohmad Sabere, Yusnaini Md Yusoff, Jalifah Latip
Summary: Flavonoids are naturally occurring polyphenolic secondary metabolites with antidiabetic and anti-inflammatory properties. The presence of a C2-C3 double bond and hydroxyl groups at certain positions are essential for exerting these effects. Structural features play an important role in synthesizing drugs with dual effects.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Veterinary Sciences
Hesham R. El-Seedi, Hanan R. Ahmed, Aida A. Abd El-Wahed, Aamer Saeed, Ahmed F. Algethami, Nour F. Attia, Zhiming Guo, Syed G. Musharraf, Alfi Khatib, Sultan M. Alsharif, Yahya Al Naggar, Shaden A. M. Khalifa, Kai Wang
Summary: This review focuses on the composition of the honeybee immune system and the effects of exposure to stressors on immune competence. Nutrition and phytochemicals play a crucial role in honeybee immunity.
VETERINARY SCIENCES
(2022)
