Review
Dermatology
J. Karim Ead, David G. Armstrong
Summary: GM-CSF is a glycoprotein with immunomodulatory properties derived from both hemopoietic and nonhemopoietic sources. In patients with diabetic foot ulcers, GM-CSF activation is impaired, leading to impaired inflammatory response. Correcting macrophage immune dysfunction with exogenous GM-CSF may help restore immune balance and promote wound healing.
INTERNATIONAL WOUND JOURNAL
(2023)
Article
Biotechnology & Applied Microbiology
Rui Chen, Yujie Li, Yangyang Zhuang, Yiming Zhang, Hailong Wu, Tao Lin, Shixuan Chen
Summary: This study combines GM-CSF and 3D nanofiber scaffolds to promote tissue regeneration. Through subcutaneous implantation in humanized mice, it was found that GM-CSF could accelerate cell migration and cytokine release, and ultimately enhance tissue regeneration. Therefore, GM-CSF loaded 3D nanofiber scaffolds have potential applications in tissue regeneration.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Oncology
Lan Huang, Guisi Chen, Ying Chen, Wanwen Wu, Changli Tao, Hongwei Shao, Shulin Huang, Han Shen
Summary: Tumor immunotherapy targeting tumor-associated antigens and the impact of GM-CSF and CCL17 on tumor immunity have been widely studied. Combining survivin-specific CTL with CCL17 and GM-CSF genes can inhibit tumor growth more effectively through stable cell lines expressing these genes.
Article
Physiology
Satoshi Okamori, Makoto Ishii, Takanori Asakura, Shoji Suzuki, Ho Namkoong, Shizuko Kagawa, Ahmed E. Hegab, Kazuma Yagi, Hirofumi Kamata, Tatsuya Kusumoto, Takunori Ogawa, Hayato Takahashi, Masaki Yoda, Keisuke Horiuchi, Naoki Hasegawa, Koichi Fukunaga
Summary: The study showed that ADAM10 plays a protective role in regulating influenza virus infection and may be a potential therapeutic target.
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
(2021)
Article
Immunology
Ainhoa Arbues, Sarah Schmidiger, Michael Kammuller, Damien Portevin
Summary: In this study, 2D and 3D granuloma models were compared, revealing enhanced granuloma formation in the 2D model and reduced Mtb burden with increased GM-CSF production in the 3D model. Lipid inclusions within Mtb were observed only in 3D models, suggesting a hypoxic environment within the ECM. Exposure to a TNF-alpha antagonist reversed Mtb dormancy in the 3D model, mimicking TB reactivation seen in patients receiving this therapy.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Xinmei Huang, Mengshu Cao, Yonglong Xiao
Summary: Pulmonary alveolar proteinosis (PAP) is a rare pulmonary disorder characterized by surfactant accumulation in the alveoli. Alveolar macrophages (AMs) play a crucial role in PAP pathogenesis, particularly in cholesterol clearance and surfactant homeostasis. Novel therapies targeting GM-CSF signaling, cholesterol metabolism, and immune modulation of AMs are being developed to address this disease.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Pharmacology & Pharmacy
Malidi Ahamadi, Johannes Kast, Po-Wei Chen, Xiaojun Huang, Sandeep Dutta, Vijay V. V. Upreti
Summary: T-VEC is a first-in-class oncolytic virotherapy approved for unresectable melanoma recurrent. Our analysis found that viral infection rate greatly influences T-VEC treatment efficacy, increasing T-VEC dose resulted in a 12% increase in response, and the ratio of resting innate immune cells to the death rate of innate immune impacts T-VEC treatment efficacy at the systemic level.
CPT-PHARMACOMETRICS & SYSTEMS PHARMACOLOGY
(2023)
Article
Multidisciplinary Sciences
Darshan S. Chandrashekar, Mohammad Athar, Upender Manne, Sooryanarayana Varambally
Summary: Research compared gene expression in human lung epithelial cells infected with different viruses, identifying specific genes associated with SARS-CoV-2, including CSF2 and calcium-binding proteins. These genes are related to respiratory diseases and inflammation. Protein-protein interaction analyses indicated functional roles of CSF2 and S100A9 in COVID-19 disease.
SCIENTIFIC REPORTS
(2021)
Article
Immunology
Nicolas Jacquelot, Cyril Seillet, Minyu Wang, Angela Pizzolla, Yang Liao, Soroor Hediyeh-zadeh, Sharon Grisaru-Tal, Cynthia Louis, Qiutong Huang, Jaring Schreuder, Fernando Souza-Fonseca-Guimaraes, Carolyn A. de Graaf, Kevin Thia, Sean Macdonald, Mary Camilleri, Kylie Luong, Shengbo Zhang, Michael Chopin, Tristan Molden-Hauer, Stephen L. Nutt, Viktor Umansky, Bogoljub Ciric, Joanna R. Groom, Paul S. Foster, Philip M. Hansbro, Andrew N. J. McKenzie, Daniel H. D. Gray, Andreas Behren, Jonathan Cebon, Eric Vivier, Ian P. Wicks, Joseph A. Trapani, Ariel Munitz, Melissa J. Davis, Wei Shi, Paul J. Neeson, Gabrielle T. Belz
Summary: ILC2s play a critical role in melanoma immunity by producing cytokines that enhance antitumor responses. High infiltration of ILC2s in melanoma is associated with good clinical prognosis, but their antitumor functions may be restricted by programmed cell death protein-1.
Review
Immunology
Ali Ataya, Vijaya Knight, Brenna C. Carey, Elinor Lee, Elizabeth J. Tarling, Tisha Wang
Summary: The article reviews the role of GM-CSF in aPAP pathogenesis and pulmonary homeostasis, as well as the increased incidence of infections.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Pharmacology & Pharmacy
Thomas S. McCormick, Rana B. Hejal, Luis O. Leal, Mahmoud A. Ghannoum
Summary: This review summarizes the role of alveolar macrophages and epithelial cells in responding to infection and maintaining pulmonary immune system homeostasis. GM-CSF plays a critical role in this process and is being considered as a potential treatment for COVID-19 and other pulmonary infectious diseases. The review provides an overview of clinical and preclinical data for GM-CSF and highlights its potential therapeutic benefits.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Virology
Sarah Stonedahl, J. Smith Leser, Penny Clarke, Huntington Potter, Timothy D. D. Boyd, Kenneth L. L. Tyler
Summary: West Nile virus (WNV) is the main cause of epidemic arboviral encephalitis in the United States. Depleting microglia in WNV-infected mice enhances viral replication and tissue injury, while augmenting microglial activation through GM-CSF administration reduces viral titers and apoptotic activity and increases survival. Stimulation of microglial activation may be a viable therapeutic approach for WNV neuroinvasive disease.
JOURNAL OF VIROLOGY
(2023)
Article
Health Care Sciences & Services
Bi-Cheng Wang, Peng-Cheng Li, Bo-Hua Kuang, Zhan-Jie Zhang, Bo-Ya Xiao, Guo-He Lin, Quentin Liu
Summary: In this study of thoracic cancer patients treated with concurrent radiotherapy and GM-CSF, it was found that the combination therapy with a total dose of at least 3000 μg GM-CSF (subcutaneously injected q.o.d) was tolerable and safe, with only one patient experiencing a grade >= 3 hematological adverse event. Further research is needed to confirm the effects and optimal total GM-CSF injection doses in this treatment combination.
ANNALS OF PALLIATIVE MEDICINE
(2021)
Review
Immunology
Anil Kumar, Adeleh Taghi Khani, Ashly Sanchez Ortiz, Srividya Swaminathan
Summary: GM-CSF is a cytokine that drives the generation of myeloid cell subsets in response to stress, infections, and cancers. The levels of GM-CSF can either promote or inhibit cancer aggressiveness, depending on the specific conditions. The impact of GM-CSF signaling on cancer progression varies depending on the levels of GM-CSF, the cancer type, and the tumor microenvironment.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Dentistry, Oral Surgery & Medicine
Gabriela Lopes Santos, Kellen Cristine Tjioe, Marco Antonio de Oliveira Magalhaes, Denise Tostes Oliveira
Summary: This study reviewed the molecular mechanisms and biological roles of granulocyte-macrophage colony-stimulating factor (GM-CSF) in head and neck squamous cell carcinoma, highlighting its potential clinical applications. The specific roles of GM-CSF in head and neck cancer are limited, with conflicting findings observed when studied alone. GM-CSF has been shown to induce angiogenesis and local tumor invasion, but it is also implicated in immune evasion. The potential of GM-CSF as adjuvant therapy in head and neck cancer needs further investigation.
ARCHIVES OF ORAL BIOLOGY
(2023)