Restoring oxidant signaling suppresses proarthritogenic T cell effector functions in rheumatoid arthritis

Mechanisms of ATM Activation

(2015) Tanya T. Paull   Annual Review of Biochemistry

The Energy Sensor AMPK Regulates T Cell Metabolic Adaptation and Effector Responses In Vivo

(2015) Julianna Blagih et al.   IMMUNITY

Mitochondria in the Regulation of Innate and Adaptive Immunity

(2015) Samuel E. Weinberg et al.   IMMUNITY

Metabolic programming and PDHK1 control CD4+ T cell subsets and inflammation

(2014) Valerie A. Gerriets et al.   JOURNAL OF CLINICAL INVESTIGATION

Cellular mechanisms and physiological consequences of redox-dependent signalling

(2014) Kira M. Holmström et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Metabolic Regulation of T Lymphocytes

(2013) Nancie J. MacIver et al.   Annual Review of Immunology

T-cell aging in rheumatoid arthritis

(2013) Cornelia M. Weyand et al.   CURRENT OPINION IN RHEUMATOLOGY

Metabolic Pathways in Immune Cell Activation and Quiescence

(2013) Erika L. Pearce et al.   IMMUNITY

Phosphofructokinase deficiency impairs ATP generation, autophagy, and redox balance in rheumatoid arthritis T cells

(2013) Zhen Yang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Back to the future: oral targeted therapy for RA and other autoimmune diseases

(2013) John J. O'Shea et al.   Nature Reviews Rheumatology

Fueling Immunity: Insights into Metabolism and Lymphocyte Function

(2013) E. L. Pearce et al.   SCIENCE

Hydrogen Peroxide As an Immunological Transmitter Regulating Autoreactive T Cells

(2012) Rikard Holmdahl et al.   ANTIOXIDANTS & REDOX SIGNALING

N-acetylcysteine reduces disease activity by blocking mammalian target of rapamycin in T cells from systemic lupus erythematosus patients: A randomized, double-blind, placebo-controlled trial

(2012) Zhi-Wei Lai et al.   ARTHRITIS AND RHEUMATISM

Process for immune defect and chromosomal translocation during early thymocyte development lacking ATM

(2012) T. Isoda et al.   BLOOD

Reducing Mitochondrial ROS Improves Disease-related Pathology in a Mouse Model of Ataxia-telangiectasia

(2012) Anthony D D'Souza et al.   MOLECULAR THERAPY

The CD46-Jagged1 interaction is critical for human TH1 immunity

(2012) Gaëlle Le Friec et al.   NATURE IMMUNOLOGY

Decline in miR-181a expression with age impairs T cell receptor sensitivity by increasing DUSP6 activity

(2012) Guangjin Li et al.   NATURE MEDICINE

Aberrant CD8+ T-Cell Responses and Memory Differentiation upon Viral Infection of an Ataxia-Telangiectasia Mouse Model Driven by Hyper-Activated Akt and mTORC1 Signaling

(2011) Anthony D. D'Souza et al.   AMERICAN JOURNAL OF PATHOLOGY

Premature ageing of the immune system underlies immunodeficiency in ataxia telangiectasia

(2011) Andrew Robert Exley et al.   CLINICAL IMMUNOLOGY

Chronic granulomatous disease: Overview and hematopoietic stem cell transplantation

(2011) Elizabeth M. Kang et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

The kinase mTOR regulates the differentiation of helper T cells through the selective activation of signaling by mTORC1 and mTORC2

(2011) Greg M Delgoffe et al.   NATURE IMMUNOLOGY

Spontaneous and aging-dependent development of arthritis in NADPH oxidase 2 deficiency through altered differentiation of CD11b+ and Th/Treg cells

(2011) K. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Atm-Deficient Mice Exhibit Increased Sensitivity to Dextran Sulfate Sodium-Induced Colitis Characterized by Elevated DNA Damage and Persistent Immune Activation

(2010) A. M. Westbrook et al.   CANCER RESEARCH

DNA-dependent protein kinase catalytic subunit mediates T-cell loss in rheumatoid arthritis

(2010) Lan Shao et al.   EMBO Molecular Medicine

Effects of tempol and redox-cycling nitroxides in models of oxidative stress

(2010) Christopher S. Wilcox   PHARMACOLOGY & THERAPEUTICS

ATM Activation by Oxidative Stress

(2010) Z. Guo et al.   SCIENCE

Deficiency of the DNA repair enzyme ATM in rheumatoid arthritis

(2009) Lan Shao et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Telomerase insufficiency in rheumatoid arthritis

(2009) H. Fujii et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Developments in the scientific understanding of rheumatoid arthritis

(2009) Jörg J Goronzy et al.   ARTHRITIS RESEARCH & THERAPY