Selective targeting of mutant adenomatous polyposis coli (APC) in colorectal cancer

A Century of Cholesterol and Coronaries: From Plaques to Genes to Statins

(2015) Joseph L. Goldstein et al.   CELL

Understanding Phenotypic Variation in Rodent Models with Germline Apc Mutations

(2013) M. Zeineldin et al.   CANCER RESEARCH

Point Mutation in Luminal Loop 7 of Scap Protein Blocks Interaction with Loop 1 and Abolishes Movement to Golgi

(2013) Yinxin Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Effects on 11-year mortality and morbidity of lowering LDL cholesterol with simvastatin for about 5 years in 20 536 high-risk individuals: a randomised controlled trial

(2013) Heart Protection Study Collaborative Group   LANCET

Lack of Effect of Lowering LDL Cholesterol on Cancer: Meta-Analysis of Individual Data from 175,000 People in 27 Randomised Trials of Statin Therapy

(2012)   PLoS One

A Common Role for Various Human Truncated Adenomatous Polyposis Coli Isoforms in the Control of Beta-Catenin Activity and Cell Proliferation

(2012) Shree Harsha Vijaya Chandra et al.   PLoS One

Functional Parsing of Driver Mutations in the Colorectal Cancer Genome Reveals Numerous Suppressors of Anchorage-Independent Growth

(2011) U. Eskiocak et al.   CANCER RESEARCH

Small molecule Wnt inhibitors enhance the efficiency of BMP-4-directed cardiac differentiation of human pluripotent stem cells

(2011) Yongming Ren et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Deconstructing the ßcatenin destruction complex: mechanistic roles for the tumor suppressor APC in regulating Wnt signaling

(2011) David M. Roberts et al.   MOLECULAR BIOLOGY OF THE CELL

Exploiting the mevalonate pathway to distinguish statin-sensitive multiple myeloma

(2010) J. W. Clendening et al.   BLOOD

Effect of statin therapy on colorectal cancer

(2010) M. Bardou et al.   GUT

Severe polyposis in Apc1322Tmice is associated with submaximal Wnt signalling and increased expression of the stem cell markerLgr5

(2010) Annabelle Lewis et al.   GUT

Chemoprevention of colorectal cancer by targeting APC-deficient cells for apoptosis

(2010) Ling Zhang et al.   NATURE

Immortalized Epithelial Cells Derived From Human Colon Biopsies Express Stem Cell Markers and Differentiate In Vitro

(2009) Andres I. Roig et al.   GASTROENTEROLOGY

Small molecule–mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer

(2009) Baozhi Chen et al.   Nature Chemical Biology

Complete deletion of Apc results in severe polyposis in mice

(2009) A F Cheung et al.   ONCOGENE

A Targeted Constitutive Mutation in the Apc Tumor Suppressor Gene Underlies Mammary But Not Intestinal Tumorigenesis

(2009) Claudia Gaspar et al.   PLoS Genetics

Simvastatin induces apoptosis in human colon cancer cells and in tumor xenografts, and attenuates colitis-associated colon cancer in mice

(2008) Soo-Jeong Cho et al.   INTERNATIONAL JOURNAL OF CANCER