A “Trojan horse” bispecific-antibody strategy for broad protection against ebolaviruses
出版年份 2016 全文链接
标题
A “Trojan horse” bispecific-antibody strategy for broad protection against ebolaviruses
作者
关键词
-
出版物
SCIENCE
Volume 354, Issue 6310, Pages 350-354
出版商
American Association for the Advancement of Science (AAAS)
发表日期
2016-09-09
DOI
10.1126/science.aag3267
参考文献
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- Cross-Reactive and Potent Neutralizing Antibody Responses in Human Survivors of Natural Ebolavirus Infection
- (2016) Andrew I. Flyak et al. CELL
- Ebola Viral Glycoprotein Bound to Its Endosomal Receptor Niemann-Pick C1
- (2016) Han Wang et al. CELL
- Isolation of potent neutralizing antibodies from a survivor of the 2014 Ebola virus outbreak
- (2016) Z. A. Bornholdt et al. SCIENCE
- Host-Primed Ebola Virus GP Exposes a Hydrophobic NPC1 Receptor-Binding Pocket, Revealing a Target for Broadly Neutralizing Antibodies
- (2016) Zachary A. Bornholdt et al. mBio
- Direct Visualization of Ebola Virus Fusion Triggering in the Endocytic Pathway
- (2016) Jennifer S. Spence et al. mBio
- Chasing Ebola through the Endosomal Labyrinth
- (2016) M. Javad Aman mBio
- Bispecific Antibody Affords Complete Post-Exposure Protection of Mice from Both Ebola (Zaire) and Sudan Viruses
- (2016) Julia C. Frei et al. Scientific Reports
- Antibody Treatment of Ebola and Sudan Virus Infection via a Uniquely Exposed Epitope within the Glycoprotein Receptor-Binding Site
- (2016) Katie A. Howell et al. Cell Reports
- A Single Residue in Ebola Virus Receptor NPC1 Influences Cellular Host Range in Reptiles
- (2016) Esther Ndungo et al. mSphere
- Discovery of an antibody for pan-ebolavirus therapy
- (2016) Wakako Furuyama et al. Scientific Reports
- Structural Basis for Marburg Virus Neutralization by a Cross-Reactive Human Antibody
- (2015) Takao Hashiguchi et al. CELL
- Mechanism of Human Antibody-Mediated Neutralization of Marburg Virus
- (2015) Andrew I. Flyak et al. CELL
- Interferon α/β Receptor–Deficient Mice as a Model for Ebola Virus Disease
- (2015) Jennifer M. Brannan et al. JOURNAL OF INFECTIOUS DISEASES
- Ebolavirus Glycoprotein Directs Fusion through NPC1 + Endolysosomes
- (2015) James A. Simmons et al. JOURNAL OF VIROLOGY
- Macaque Monoclonal Antibodies Targeting Novel Conserved Epitopes within Filovirus Glycoprotein
- (2015) Zhen-Yong Keck et al. JOURNAL OF VIROLOGY
- Pan-ebolavirus and Pan-filovirus Mouse Monoclonal Antibodies: Protection against Ebola and Sudan Viruses
- (2015) Frederick W. Holtsberg et al. JOURNAL OF VIROLOGY
- Alternative molecular formats and therapeutic applications for bispecific antibodies
- (2015) Christoph Spiess et al. MOLECULAR IMMUNOLOGY
- Niemann-Pick C1 Is Essential for Ebolavirus Replication and Pathogenesis In Vivo
- (2015) Andrew S. Herbert et al. mBio
- Haploid Genetic Screen Reveals a Profound and Direct Dependence on Cholesterol for Hantavirus Membrane Fusion
- (2015) Lara M. Kleinfelter et al. mBio
- Filovirus receptor NPC1 contributes to species-specific patterns of ebolavirus susceptibility in bats
- (2015) Melinda Ng et al. eLife
- Reversion of advanced Ebola virus disease in nonhuman primates with ZMapp
- (2014) Xiangguo Qiu et al. NATURE
- Controlled Fab-arm exchange for the generation of stable bispecific IgG1
- (2014) Aran F Labrijn et al. Nature Protocols
- Structures of protective antibodies reveal sites of vulnerability on Ebola virus
- (2014) Charles D. Murin et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Lassa virus entry requires a trigger-induced receptor switch
- (2014) L. T. Jae et al. SCIENCE
- Cell entry by a novel European filovirus requires host endosomal cysteine proteases and Niemann–Pick C1
- (2014) Melinda Ng et al. VIROLOGY
- IgBLAST: an immunoglobulin variable domain sequence analysis tool
- (2013) Jian Ye et al. NUCLEIC ACIDS RESEARCH
- Efficient generation of stable bispecific IgG1 by controlled Fab-arm exchange
- (2013) A. F. Labrijn et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Ebola virus entry requires the host-programmed recognition of an intracellular receptor
- (2012) Emily Happy Miller et al. EMBO JOURNAL
- Filoviruses Require Endosomal Cysteine Proteases for Entry but Exhibit Distinct Protease Preferences
- (2012) J. Misasi et al. JOURNAL OF VIROLOGY
- The use of Bcl-2 over-expression to stabilize hybridomas specific to the HERG potassium channel
- (2011) Jakub Sroubek et al. JOURNAL OF IMMUNOLOGICAL METHODS
- Small molecule inhibitors reveal Niemann–Pick C1 is essential for Ebola virus infection
- (2011) Marceline Côté et al. NATURE
- Ebola virus entry requires the cholesterol transporter Niemann–Pick C1
- (2011) Jan E. Carette et al. NATURE
- A Forward Genetic Strategy Reveals Destabilizing Mutations in the Ebolavirus Glycoprotein That Alter Its Protease Dependence during Cell Entry
- (2009) A. C. Wong et al. JOURNAL OF VIROLOGY
- Newly Discovered Ebola Virus Associated with Hemorrhagic Fever Outbreak in Uganda
- (2008) Jonathan S. Towner et al. PLoS Pathogens
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