CRISPR/gRNA-directed synergistic activation mediator (SAM) induces specific, persistent and robust reactivation of the HIV-1 latent reservoirs
出版年份 2015 全文链接
标题
CRISPR/gRNA-directed synergistic activation mediator (SAM) induces specific, persistent and robust reactivation of the HIV-1 latent reservoirs
作者
关键词
-
出版物
Scientific Reports
Volume 5, Issue 1, Pages -
出版商
Springer Nature
发表日期
2015-11-05
DOI
10.1038/srep16277
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Short Communication: SAHA (Vorinostat) Induces CDK9 Thr-186 (T-Loop) Phosphorylation in Resting CD4+ T Cells: Implications for Reactivation of Latent HIV
- (2015) Rajesh Ramakrishnan et al. AIDS RESEARCH AND HUMAN RETROVIRUSES
- Designed Transcription Activator-Like Effector Proteins Efficiently Induced the Expression of Latent HIV-1 in Latently Infected Cells
- (2015) Xiaohui Wang et al. AIDS RESEARCH AND HUMAN RETROVIRUSES
- Mixed effects of suberoylanilide hydroxamic acid (SAHA) on the host transcriptome and proteome and their implications for HIV reactivation from latency
- (2015) Cory H. White et al. ANTIVIRAL RESEARCH
- Engineering Complex Synthetic Transcriptional Programs with CRISPR RNA Scaffolds
- (2015) Jesse G. Zalatan et al. CELL
- The therapeutic application of CRISPR/Cas9 technologies for HIV
- (2015) Sheena Saayman et al. EXPERT OPINION ON BIOLOGICAL THERAPY
- Ex vivo analysis identifies effective HIV-1 latency–reversing drug combinations
- (2015) Gregory M. Laird et al. JOURNAL OF CLINICAL INVESTIGATION
- Innate Immune Activity Correlates with CD4 T Cell-Associated HIV-1 DNA Decline during Latency-Reversing Treatment with Panobinostat
- (2015) Rikke Olesen et al. JOURNAL OF VIROLOGY
- Toward Whole-Transcriptome Editing with CRISPR-Cas9
- (2015) Dirk Heckl et al. MOLECULAR CELL
- Genome-scale transcriptional activation by an engineered CRISPR-Cas9 complex
- (2015) Silvana Konermann et al. NATURE
- In vivo genome editing using Staphylococcus aureus Cas9
- (2015) F. Ann Ran et al. NATURE
- Epigenome editing by a CRISPR-Cas9-based acetyltransferase activates genes from promoters and enhancers
- (2015) Isaac B Hilton et al. NATURE BIOTECHNOLOGY
- Highly efficient Cas9-mediated transcriptional programming
- (2015) Alejandro Chavez et al. NATURE METHODS
- Genome-editing tools for stem cell biology
- (2015) E A Vasileva et al. Cell Death & Disease
- Somatic CRISPR/Cas9-mediated tumour suppressor disruption enables versatile brain tumour modelling
- (2015) Marc Zuckermann et al. Nature Communications
- Application of CRISPR/Cas9 for biomedical discoveries
- (2015) Sean M. Riordan et al. Cell and Bioscience
- Broadly Neutralizing Antibodies and Viral Inducers Decrease Rebound from HIV-1 Latent Reservoirs in Humanized Mice
- (2014) Ariel Halper-Stromberg et al. CELL
- A Protein-Tagging System for Signal Amplification in Gene Expression and Fluorescence Imaging
- (2014) Marvin E. Tanenbaum et al. CELL
- Low Incidence of Off-Target Mutations in Individual CRISPR-Cas9 and TALEN Targeted Human Stem Cell Clones Detected by Whole-Genome Sequencing
- (2014) Adrian Veres et al. Cell Stem Cell
- Whole-Genome Sequencing Analysis Reveals High Specificity of CRISPR/Cas9 and TALEN-Based Genome Editing in Human iPSCs
- (2014) Cory Smith et al. Cell Stem Cell
- Specific reactivation of latent HIV-1 with designer zinc-finger transcription factors targeting the HIV-1 5′-LTR promoter
- (2014) P Wang et al. GENE THERAPY
- The Histone Deacetylase Inhibitor Vorinostat (SAHA) Increases the Susceptibility of Uninfected CD4+ T Cells to HIV by Increasing the Kinetics and Efficiency of Postentry Viral Events
- (2014) M. B. Lucera et al. JOURNAL OF VIROLOGY
- Negative Elongation Factor Is Required for the Maintenance of Proviral Latency but Does Not Induce Promoter-Proximal Pausing of RNA Polymerase II on the HIV Long Terminal Repeat
- (2014) J. K. Jadlowsky et al. MOLECULAR AND CELLULAR BIOLOGY
- CRISPR-Cas systems for editing, regulating and targeting genomes
- (2014) Jeffry D Sander et al. NATURE BIOTECHNOLOGY
- GUIDE-seq enables genome-wide profiling of off-target cleavage by CRISPR-Cas nucleases
- (2014) Shengdar Q Tsai et al. NATURE BIOTECHNOLOGY
- Genome-wide detection of DNA double-stranded breaks induced by engineered nucleases
- (2014) Richard L Frock et al. NATURE BIOTECHNOLOGY
- RNA-directed gene editing specifically eradicates latent and prevents new HIV-1 infection
- (2014) W. Hu et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Transcriptional control of HIV latency: Cellular signaling pathways, epigenetics, happenstance and the hope for a cure
- (2014) Uri Mbonye et al. VIROLOGY
- Targeted and genome-wide sequencing reveal single nucleotide variations impacting specificity of Cas9 in human stem cells
- (2014) Luhan Yang et al. Nature Communications
- Modularized CRISPR/dCas9 Effector Toolkit for Target-Specific Gene Regulation
- (2014) Michael Agne et al. ACS Synthetic Biology
- Activation of HIV-1 from Latent Infection via Synergy of RUNX1 Inhibitor Ro5-3335 and SAHA
- (2014) Zachary Klase et al. PLoS Pathogens
- Histone Deacetylase Inhibitor Romidepsin Induces HIV Expression in CD4 T Cells from Patients on Suppressive Antiretroviral Therapy at Concentrations Achieved by Clinical Dosing
- (2014) Datsen George Wei et al. PLoS Pathogens
- CRISPR-Mediated Modular RNA-Guided Regulation of Transcription in Eukaryotes
- (2013) Luke A. Gilbert et al. CELL
- Multiplexed activation of endogenous genes by CRISPR-on, an RNA-guided transcriptional activator system
- (2013) Albert W Cheng et al. CELL RESEARCH
- A Pilot Study Assessing the Safety and Latency-Reversing Activity of Disulfiram in HIV-1-Infected Adults on Antiretroviral Therapy
- (2013) A. M. Spivak et al. CLINICAL INFECTIOUS DISEASES
- Cas9 effector-mediated regulation of transcription and differentiation in human pluripotent stem cells
- (2013) N. A. Kearns et al. DEVELOPMENT
- Genome-wide recessive genetic screening in mammalian cells with a lentiviral CRISPR-guide RNA library
- (2013) Hiroko Koike-Yusa et al. NATURE BIOTECHNOLOGY
- CRISPR RNA–guided activation of endogenous human genes
- (2013) Morgan L Maeder et al. NATURE METHODS
- RNA-Guided Human Genome Engineering via Cas9
- (2013) P. Mali et al. SCIENCE
- Multiplex Genome Engineering Using CRISPR/Cas Systems
- (2013) L. Cong et al. SCIENCE
- Therapeutics for HIV-1 reactivation from latency
- (2013) Marco Sgarbanti et al. Current Opinion in Virology
- Targeting HIV latency: pharmacologic strategies toward eradication
- (2012) Sifei Xing et al. DRUG DISCOVERY TODAY
- Methamphetamine activates nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) and induces human immunodeficiency virus (HIV) transcription in human microglial cells
- (2012) Emily S. Wires et al. JOURNAL OF NEUROVIROLOGY
- High Cleavage Efficiency of a 2A Peptide Derived from Porcine Teschovirus-1 in Human Cell Lines, Zebrafish and Mice
- (2011) Jin Hee Kim et al. PLoS One
Add your recorded webinar
Do you already have a recorded webinar? Grow your audience and get more views by easily listing your recording on Peeref.
Upload NowAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started