A Role for the Inflammasome in Spontaneous Labor at Term with Acute Histologic Chorioamnionitis

Cytokines in noninvasively obtained amniotic fluid as predictors of fetal inflammatory response syndrome

(2016) Mirjam Kunze et al.   AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY

Mathematical Modeling of the Biomarker Milieu to Characterize Preterm Birth and Predict Adverse Neonatal Outcomes

(2016) Christina N. Cordeiro et al.   AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY

An M1-like Macrophage Polarization in Decidual Tissue during Spontaneous Preterm Labor That Is Attenuated by Rosiglitazone Treatment

(2016) Yi Xu et al.   JOURNAL OF IMMUNOLOGY

Inflammatory predictors of neurologic disability after preterm premature rupture of membranes

(2015) Jennifer Armstrong-Wells et al.   AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY

282: Chorioamnionitis induced by intramniotic injection of IL1, LPS or Ureaplasma parvum is associated with an altered microbiome in a primate model of inflammatory preterm birth (PTB)

(2015) Amanda Prince et al.   AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY

Acute chorioamnionitis and funisitis: definition, pathologic features, and clinical significance

(2015) Chong Jai Kim et al.   AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY

Neutrophil Recruitment and Activation in Decidua with Intra-Amniotic IL-1beta in the Preterm Rhesus Macaque1

(2015) Pietro Presicce et al.   BIOLOGY OF REPRODUCTION

An imbalance between innate and adaptive immune cells at the maternal–fetal interface occurs prior to endotoxin-induced preterm birth

(2015) Marcia Arenas-Hernandez et al.   Cellular & Molecular Immunology

Evasion of inflammasome activation by microbial pathogens

(2015) Tyler K. Ulland et al.   JOURNAL OF CLINICAL INVESTIGATION

Clinical chorioamnionitis at term I: microbiology of the amniotic cavity using cultivation and molecular techniques

(2015) Roberto Romero et al.   JOURNAL OF PERINATAL MEDICINE

Inflammasomes: mechanism of action, role in disease and therapeutics

(2015) Haitao Guo et al.   NATURE MEDICINE

Chorioamnionitis Occurring in Women With Preterm Rupture of the Fetal Membranes Is Associated With a Dynamic Increase in mRNAs Coding Cytokines in the Maternal Circulation

(2015) Owen Stock et al.   Reproductive Sciences

Resveratrol Protects Against Pathological Preterm Birth by Suppression of Macrophage-Mediated Inflammation

(2015) Hitomi Furuya et al.   Reproductive Sciences

Mechanisms of inflammasome activation: recent advances and novel insights

(2015) Sivapriya K. Vanaja et al.   TRENDS IN CELL BIOLOGY

Caspase-1-mediated cytokine release from gestational tissues, placental, and cord blood

(2015) Ebtehaj Maneta et al.   Frontiers in Physiology

A Novel Molecular Microbiologic Technique for the Rapid Diagnosis of Microbial Invasion of the Amniotic Cavity and Intra-Amniotic Infection in Preterm Labor with Intact Membranes

(2014) Roberto Romero et al.   AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY

Prevalence and Clinical Significance of Sterile Intra-amniotic Inflammation in Patients with Preterm Labor and Intact Membranes

(2014) Roberto Romero et al.   AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY

NLRP1L155H Polymorphism is a Risk Factor for Preeclampsia Development

(2014) Alessandra Pontillo et al.   AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY

Mechanism of NLRP3 inflammasome activation

(2014) Fayyaz S. Sutterwala et al.   Annals of the New York Academy of Sciences

Human Fetal Membranes Generate Distinct Cytokine Profiles in Response to Bacterial Toll-Like Receptor and Nod-Like Receptor Agonists1

(2014) Mai Hoang et al.   BIOLOGY OF REPRODUCTION

Evidence of an immunosuppressive effect of progesterone uponin vitrosecretion of proinflammatory and prodegradative factors in a model of choriodecidual infection

(2014) M Pineda-Torres et al.   BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY

Mechanisms and Functions of Inflammasomes

(2014) Mohamed Lamkanfi et al.   CELL

A clear and present danger: inflammasomes DAMPing down disorders of pregnancy

(2014) R. N. Khan et al.   HUMAN REPRODUCTION UPDATE

NLR proteins and parasitic disease

(2014) Gwendolyn M. Clay et al.   IMMUNOLOGIC RESEARCH

Cutting Edge: Alum Adjuvant Stimulates Inflammatory Dendritic Cells through Activation of the NALP3 Inflammasome

(2014) M. Kool et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: Inflammasome Activation by Alum and Alum's Adjuvant Effect Are Mediated by NLRP3

(2014) H. Li et al.   JOURNAL OF IMMUNOLOGY

17β-Estradiol and Lipopolysaccharide Additively Promote Pelvic Inflammation and Growth of Endometriosis

(2014) Khaleque Newaz Khan et al.   Reproductive Sciences

Group B Streptococcal Infection of the Choriodecidua Induces Dysfunction of the Cytokeratin Network in Amniotic Epithelium: A Pathway to Membrane Weakening

(2014) Jeroen P. Vanderhoeven et al.   PLoS Pathogens

Amniotic fluid infection, inflammation, and colonization in preterm labor with intact membranes

(2013) C. Andrew Combs et al.   AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY

250: The role of NALP3 inflammasome in preeclampsia–a translational approach

(2013) Laxmisilpa Hansen et al.   AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY

Cardiolipin and the Nlrp3 Inflammasome

(2013) Luke A.J. O’Neill   Cell Metabolism

Inflammasomes and host defenses against bacterial infections

(2013) Gregory I Vladimer et al.   CURRENT OPINION IN MICROBIOLOGY

Cytokines in umbilical cord blood and the impact of labor events in low-risk term pregnancies

(2013) Cynthia J Chan et al.   EARLY HUMAN DEVELOPMENT

Of inflammasomes and pathogens - sensing of microbes by the inflammasome

(2013) Franz Bauernfeind et al.   EMBO Molecular Medicine

Mitochondrial Cardiolipin Is Required for Nlrp3 Inflammasome Activation

(2013) Shankar S. Iyer et al.   IMMUNITY

A Role for Uric Acid and the Nalp3 Inflammasome in Antiphospholipid Antibody-Induced IL-1β Production by Human First Trimester Trophoblast

(2013) Melissa J. Mulla et al.   PLoS One

Acute Histologic Chorioamnionitis Is a Risk Factor for Adverse Neonatal Outcome in Late Preterm Birth after Preterm Premature Rupture of Membranes

(2013) Seung Mi Lee et al.   PLoS One

Polymyxin B Agonist Capture Therapy for Intrauterine Inflammation

(2013) Masatoshi Saito et al.   Reproductive Sciences

The Interplay of the Interleukin 1 System in Pregnancy and Labor

(2013) Yujing Jan Heng et al.   Reproductive Sciences

506: Intraamniotic interleukin-1 (IL1β) induces histologic chorioamnionitis and alters the microbiome in a primate model of inflammatory preterm birth

(2012) Kjersti Aagaard et al.   AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY

TRIF Licenses Caspase-11-Dependent NLRP3 Inflammasome Activation by Gram-Negative Bacteria

(2012) Vijay A.K. Rathinam et al.   CELL

Caspase-4 Is Required for Activation of Inflammasomes

(2012) G. Sollberger et al.   JOURNAL OF IMMUNOLOGY

Control of innate and adaptive immunity by the inflammasome

(2012) Ceren Ciraci et al.   MICROBES AND INFECTION

Caspase-11 increases susceptibility to Salmonella infection in the absence of caspase-1

(2012) Petr Broz et al.   NATURE

Regulation of inflammasome signaling

(2012) Vijay A K Rathinam et al.   NATURE IMMUNOLOGY

Inflammasomes: far beyond inflammation

(2012) Jorge Henao-Mejia et al.   NATURE IMMUNOLOGY

Sensing and reacting to microbes through the inflammasomes

(2012) Luigi Franchi et al.   NATURE IMMUNOLOGY

Acute Histologic Chorioamnionitis at Term: Nearly Always Noninfectious

(2012) Drucilla J. Roberts et al.   PLoS One

Bacterial LPS Differently Modulates Inflammasome Gene Expression and IL-1β Secretion in Trophoblast Cells, Decidual Stromal Cells, and Decidual Endothelial Cells

(2012) A. Pontillo et al.   Reproductive Sciences

Orchestrating Inflammasomes

(2012) L. Franchi et al.   SCIENCE

Uric Acid Induces Trophoblast IL-1β Production Via the Inflammasome: Implications for the Pathogenesis of Preeclampsia

(2011) Melissa J. Mulla et al.   AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY

The inflammasome: in memory of Dr. Jurg Tschopp

(2011) M Dagenais et al.   CELL DEATH AND DIFFERENTIATION

Inflammasome activation via intracellular NLRs triggered by bacterial infection

(2011) Yukiko Koizumi et al.   CELLULAR MICROBIOLOGY

The NLRP3 inflammasome in health and disease: the good, the bad and the ugly

(2011) P. Menu et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Gain-of-Function Pyrin Mutations Induce NLRP3 Protein-Independent Interleukin-1β Activation and Severe Autoinflammation in Mice

(2011) Jae Jin Chae et al.   IMMUNITY

Sensing damage by the NLRP3 inflammasome

(2011) Jaklien C. Leemans et al.   IMMUNOLOGICAL REVIEWS

Intracellular sensing of microbes and danger signals by the inflammasomes

(2011) Gabor L. Horvath et al.   IMMUNOLOGICAL REVIEWS

The inflammasome: an integrated view

(2011) Olaf Gross et al.   IMMUNOLOGICAL REVIEWS

Molecular mechanisms of inflammasome activation during microbial infections

(2011) Petr Broz et al.   IMMUNOLOGICAL REVIEWS

Modulation of Inflammasome Pathways by Bacterial and Viral Pathogens

(2011) M. Lamkanfi et al.   JOURNAL OF IMMUNOLOGY

The role of the Nod-like receptor family in trophoblast innate immune responses

(2011) Vikki M. Abrahams   JOURNAL OF REPRODUCTIVE IMMUNOLOGY

Non-canonical inflammasome activation targets caspase-11

(2011) Nobuhiko Kayagaki et al.   NATURE

Inflammasome activation and IL-1β and IL-18 processing during infection

(2011) Frank L. van de Veerdonk et al.   TRENDS IN IMMUNOLOGY

The Inflammasomes: Molecular Effectors of Host Resistance Against Bacterial, Viral, Parasitic, and Fungal Infections

(2011) Alexander Skeldon et al.   Frontiers in Microbiology

Regulation of Interleukin-6 Expression in Human Decidual Cells and Its Potential Role in Chorioamnionitis

(2010) Charles J. Lockwood et al.   AMERICAN JOURNAL OF PATHOLOGY

The Inflammasomes

(2010) Kate Schroder et al.   CELL

Inflammasomes: current understanding and open questions

(2010) Franz Bauernfeind et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

The inflammasomes: mechanisms of activation and function

(2010) Eicke Latz   CURRENT OPINION IN IMMUNOLOGY

IL-6 and TNFα across the umbilical circulation in term pregnancies: Relationship with labour events

(2010) Greg Duncombe et al.   EARLY HUMAN DEVELOPMENT

Sterile inflammatory responses mediated by the NLRP3 inflammasome

(2010) Suzanne L. Cassel et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Inflammasomes as microbial sensors

(2010) Luigi Franchi et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome

(2010) Kiichi Nakahira et al.   NATURE IMMUNOLOGY

Histologic Chorioamnionitis is More Common after Spontaneous Labor than after Induced Labor at Term

(2010) H.S. Park et al.   PLACENTA

The NLRP3 Inflammasome: A Sensor for Metabolic Danger?

(2010) K. Schroder et al.   SCIENCE

Sensing pathogens and danger signals by the inflammasome

(2009) Joao HF Pedra et al.   CURRENT OPINION IN IMMUNOLOGY

The NLRP3 Inflammasome Mediates In Vivo Innate Immunity to Influenza A Virus through Recognition of Viral RNA

(2009) Irving C. Allen et al.   IMMUNITY

The Intracellular Sensor NLRP3 Mediates Key Innate and Healing Responses to Influenza A Virus via the Regulation of Caspase-1

(2009) Paul G. Thomas et al.   IMMUNITY

NLRP3/Cryopyrin Is Necessary for Interleukin-1β (IL-1β) Release in Response to Hyaluronan, an Endogenous Trigger of Inflammation in Response to Injury

(2009) Kenshi Yamasaki et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inflammasomes: too big to miss

(2009) Andrea Stutz et al.   JOURNAL OF CLINICAL INVESTIGATION

Inflammasome recognition of influenza virus is essential for adaptive immune responses

(2009) Takeshi Ichinohe et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Cutting Edge: TNF-  Mediates Sensitization to ATP and Silica via the NLRP3 Inflammasome in the Absence of Microbial Stimulation

(2009) L. Franchi et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: NF- B Activating Pattern Recognition and Cytokine Receptors License NLRP3 Inflammasome Activation by Regulating NLRP3 Expression

(2009) F. G. Bauernfeind et al.   JOURNAL OF IMMUNOLOGY

A Critical Role for Hemolysins and Bacterial Lipoproteins in Staphylococcus aureus-Induced Activation of the Nlrp3 Inflammasome

(2009) R. Munoz-Planillo et al.   JOURNAL OF IMMUNOLOGY

Inflammasome-Associated Nucleotide-Binding Domain, Leucine-Rich Repeat Proteins and Inflammatory Diseases

(2009) S. Jha et al.   JOURNAL OF IMMUNOLOGY

Neisseria gonorrhoeae Activates the Proteinase Cathepsin B to Mediate the Signaling Activities of the NLRP3 and ASC-Containing Inflammasome

(2009) Joseph A. Duncan et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: Candida albicans Hyphae Formation Triggers Activation of the Nlrp3 Inflammasome

(2009) S. Joly et al.   JOURNAL OF IMMUNOLOGY

Placental blood leukocytes are functional and phenotypically different than peripheral leukocytes during human labor

(2009) Rodrigo Vega-Sanchez et al.   JOURNAL OF REPRODUCTIVE IMMUNOLOGY

Increased Umbilical Cord Plasma Interleukin-1  Levels was Correlated with Adverse Outcomes of Neonatal Hypoxic-ischemic Encephalopathy

(2009) J. Liu et al.   JOURNAL OF TROPICAL PEDIATRICS

The inflammasome: a caspase-1-activation platform that regulates immune responses and disease pathogenesis

(2009) Luigi Franchi et al.   NATURE IMMUNOLOGY

Mechanisms of Leukocyte Accumulation and Activation in Chorioamnionitis: Interleukin 1β and Tumor Necrosis Factor α Enhance Colony Stimulating Factor 2 Expression in Term Decidua

(2009) Felice Arcuri et al.   Reproductive Sciences

The NLRP3 inflammasome: A sensor of immune danger signals

(2009) Suzanne L. Cassel et al.   SEMINARS IN IMMUNOLOGY

Inflammasome-activating nanoparticles as modular systems for optimizing vaccine efficacy

(2009) Stacey L. Demento et al.   VACCINE

The frequency of microbial invasion of the amniotic cavity and histologic chorioamnionitis in women at term with intact membranes in the presence or absence of labor

(2008) Hyo Suk Seong et al.   AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY

ORIGINAL ARTICLE: CXCL6 (Granulocyte Chemotactic Protein-2): A Novel Chemokine Involved in the Innate Immune Response of the Amniotic Cavity

(2008) Pooja Mittal et al.   AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY

Differential requirement for the activation of the inflammasome for processing and release of IL-1  in monocytes and macrophages

(2008) M. G. Netea et al.   BLOOD

ESX-1-dependent cytolysis in lysosome secretion and inflammasome activation during mycobacterial infection

(2008) Ingrid C. Koo et al.   CELLULAR MICROBIOLOGY

NLRC4/IPAF: a CARD carrying member of the NLR family

(2008) Fayyaz S. Sutterwala et al.   CLINICAL IMMUNOLOGY

The Nlrp3 inflammasome is critical for aluminium hydroxide-mediated IL-1β secretion but dispensable for adjuvant activity

(2008) Luigi Franchi et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Inflammasomes: guardians of cytosolic sanctity

(2008) Mohamed Lamkanfi et al.   IMMUNOLOGICAL REVIEWS

Evidence of the involvement of caspase-1 under physiologic and pathologic cellular stress during human pregnancy: A link between the inflammasome and parturition

(2008) Francesca Gotsch et al.   Journal of Maternal-Fetal & Neonatal Medicine

The inflammasome recognizes cytosolic microbial and host DNA and triggers an innate immune response

(2008) Daniel A. Muruve et al.   NATURE

Crucial role for the Nalp3 inflammasome in the immunostimulatory properties of aluminium adjuvants

(2008) Stephanie C. Eisenbarth et al.   NATURE

Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization

(2008) Veit Hornung et al.   NATURE IMMUNOLOGY

The Nalp3 inflammasome is essential for the development of silicosis

(2008) Suzanne L. Cassel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Innate Immune Activation Through Nalp3 Inflammasome Sensing of Asbestos and Silica

(2008) C. Dostert et al.   SCIENCE

Placental Pathology: A Systematic Approach with Clinical Correlations

(2007) R.W. Redline   PLACENTA