Article
Urology & Nephrology
Lirui Wang, Jiangtao Li, Chen Yu
Summary: The study indicated that SENP3 played a significant regulatory role in LPS-induced AKI, inducing cell apoptosis through protein deSUMOylation and exacerbating damage to renal tubular epithelial cells.
Review
Urology & Nephrology
Longhui Qiu, Xin Zheng, Dinesh Jaishankar, Richard Green, Deyu Fang, Satish Nadig, Zheng Jenny Zhang
Summary: Kidney damage due to ischemia or rejection leads to ER stress and accumulation of unfolded and misfolded proteins. The IRE1a signaling pathway plays a crucial role in the unfolded protein response and is involved in regulating autophagy, cell differentiation, and cell death. The roles of IRE1a vary depending on cell type and disease setting.
KIDNEY INTERNATIONAL
(2023)
Article
Cell Biology
Min Pu, Jing Zhang, Yongcheng Zeng, Fuyan Hong, Weiwei Qi, Xia Yang, Guoquan Gao, Ti Zhou
Summary: This study provides evidence that succinate acts as a risk factor for renal injury and induces cell apoptosis through SUCNR1 activation. In addition, succinate upregulates ERK by binding to SUCNR1, and inhibition of ERK can attenuate the proapoptotic effects of succinate.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2023)
Article
Environmental Sciences
Xiaoyu Wang, Huabin Cao, Yukun Fang, He Bai, Jing Chen, Chenghong Xing, Yu Zhuang, Xiaoquan Guo, Guoliang Hu, Fan Yang
Summary: This study revealed the interaction between Mfn2-dependent MAM dynamics and autophagy in duck renal tubular epithelial cells under Cu exposure. Excessive Cu disrupted MAM integrity and activated autophagy.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Biochemistry & Molecular Biology
Kiran Kumar Soni, Jinsu Hwang, Mahesh Ramalingam, Choonghyo Kim, Byeong C. Kim, Han-Seong Jeong, Sujeong Jang
Summary: A spinal cord injury (SCI) is a devastating trauma that leads to functional deterioration through apoptosis. Unlike most laboratory SCI models involving direct impact on the spinal cord, our model induces ischemia in the descending aortas of mice using clamp compression. This ischemic SCI (ISCI) model is hypothesized to trigger apoptosis via the endoplasmic reticulum (ER) stress pathway, which is enhanced by inducible nitric oxide synthase (iNOS).
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Shaoxiong Ming, Jia Tian, Ke Ma, Chengbin Pei, Ling Li, Zeyu Wang, Ziyu Fang, Min Liu, Hao Dong, Weijian Li, Jianwen Zeng, Yonghan Peng, Xiaofeng Gao
Summary: This study reveals that oxalate induces HK-2 cell injury through the interaction between the NF-kappa B signaling and ERS/ROS pathways. When the NF-kappa B signaling pathway is inhibited, the ERS/ROS pathway is also inhibited.
MOLECULAR MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Ajinath Kale, Vishwadeep Shelke, Tahib Habshi, Neha Dagar, Anil Bhanudas Gaikwad
Summary: This study aims to explore the relationship between endoplasmic reticulum (ER) stress and Klotho regulation in acute kidney injury (AKI) under diabetic condition. Results showed that ER stress and apoptosis were worsened by downregulation of Klotho in diabetic AKI. Treatment with Tauroursodeoxycholic acid (TUDCA) inhibited ER stress and apoptosis, restored endogenous Klotho levels, and ameliorated AKI under both diabetic and non-diabetic conditions.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Article
Urology & Nephrology
Yifan Xie, E. Jing, Hong Cai, Fang Zhong, Wenzhen Xiao, Ronald E. Gordon, Lois Wang, Ya-Li Zheng, Aihua Zhang, Kyung Lee, John Cijiang He
Summary: Recent studies have shown that kidney tubular epithelial cell (TEC) injury plays an important role in the progression of diabetic kidney disease (DKD). In this study, researchers found that overexpression of the protein RTN1A worsened DKD in mice by enhancing tubular injury, tubulointerstitial fibrosis, and kidney function decline. However, RTN1A overexpression did not exacerbate diabetes-induced glomerular injury or albuminuria. The study also identified the involvement of RTN1A in regulating ER-mitochondrial contacts, which contributed to TEC injury and DKD progression.
KIDNEY INTERNATIONAL
(2022)
Article
Environmental Sciences
Xiaoyu Wang, Yu Zhuang, Yukun Fang, Huabin Cao, Caiying Zhang, Chenghong Xing, Xiaoquan Guo, Guyue Li, Ping Liu, Guoliang Hu, Fan Yang
Summary: Excessive copper can trigger ER stress and apoptosis in duck renal tubular epithelial cells via the PERK/ATF4/CHOP signaling pathway. Treatment with PERK inhibitor can ameliorate the adverse effects caused by copper exposure.
ENVIRONMENTAL POLLUTION
(2021)
Article
Pharmacology & Pharmacy
Jialu Li, Chao Yu, Fengchen Shen, Binbin Cui, Na Liu, Shougang Zhuang
Summary: This study found that the inhibition of class IIa HDACs can improve renal function and reduce tubular cell injury and apoptosis in acute kidney injury (AKI), while promoting cellular autophagy and renal tubular cell proliferation. It also targets multiple signaling pathways associated with AKI pathogenesis.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Multidisciplinary Sciences
Xinyi Cao, Jiuchen Wang, Tianye Zhang, Zhiheng Liu, Lijun Liu, Ying Chen, Zehua Li, Youlu Zhao, Qi Yu, Tong Liu, Jing Nie, Yuanjie Niu, Yupeng Chen, Li Yang, Lirong Zhang
Summary: Renal tubular epithelial cells can respond to varying kidney injuries either adaptively or maladaptively. This study elucidates the chromatin-mediated mechanism underlying the responses of renal tubular epithelial cells to different kidney injuries, and identifies RXR alpha as a therapeutic target for acute kidney injury.
NATURE COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Theodoros Eleftheriadis, Georgios Pissas, Spyridon Golfinopoulos, Maria Efthymiadi, Christina Poulianiti, Maria Anna Polyzou Konsta, Vassilios Liakopoulos, Ioannis Stefanidis
Summary: This study evaluated the response of renal proximal tubular epithelial cells (RPTECs) to high albumin concentration, focusing on the unfolded protein response (UPR) and DNA damage response (DDR). The results showed that albumin led to reactive oxygen species (ROS) overproduction and protein modification, which activated both UPR and DDR. This resulted in cellular apoptosis, senescence, and epithelial-to-mesenchymal transition (EMT). While agents against endoplasmic reticulum stress (ERS) only partially alleviated the harmful effects, inhibiting ROS upregulation prevented both UPR and DDR. Therefore, suppressing ROS overproduction may be more effective in mitigating the deleterious effects of albumin overload.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Marta Correia de Sousa, Etienne Delangre, Miranda Turkal, Michelangelo Foti, Monika Gjorgjieva
Summary: The endoplasmic reticulum plays crucial roles in protein production, metabolism homeostasis, and cell signaling. Endoplasmic reticulum stress occurs when cells are damaged and its normal functions are compromised. In renal cancer cells, the activation of endoplasmic reticulum stress pathway is exploited to promote cell survival through rewiring of metabolism, activation of stress responses, autophagy, and inhibition of cell death. However, a certain threshold of endoplasmic reticulum stress activation is required to shift the response from pro-survival to pro-apoptotic outcome. The therapeutic potential of targeting endoplasmic reticulum stress in renal cancer is still poorly understood and further research is needed.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, Research & Experimental
Fei Deng, Heping Zhang, Wei Zhou, Shijie Ma, Yuwei Kang, Wei Yang, Liangbin Zhao, Wei Qin
Summary: TRPA1 enhances cisplatin-induced acute kidney injury by modulating endoplasmic reticulum stress and mitochondrial damage.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Environmental Sciences
Yung-Li Wang, Yu-Hsuan Lee, Yung-Ho Hsu, I-Jen Chiu, Cathy Chia-Yu Huang, Chih-Chia Huang, Zi-Chun Chia, Chung-Pei Lee, Yuh-Feng Lin, Hui-Wen Chiu
Summary: The study aimed to investigate the effects of PS-MPs on kidney cells in vitro and in vivo. The results showed that PS-MPs caused mitochondrial dysfunction, ER stress, inflammation, and autophagy in kidney cells, and accumulated in both cells and mouse kidneys.
ENVIRONMENTAL HEALTH PERSPECTIVES
(2021)