P2Y2R is a direct target of HIF-1α and mediates secretion-dependent cyst growth of renal cyst-forming epithelial cells

Glucose promotes secretion-dependent renal cyst growth

(2015) Andre Kraus et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Modulating Ca2+ signals: a common theme for TMEM16, Ist2, and TMC

(2015) Karl Kunzelmann et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Determinants of renal tissue hypoxia in a rat model of polycystic kidney disease

(2014) Connie P. C. Ow et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Extensive regulation of the non-coding transcriptome by hypoxia: role of HIF in releasing paused RNApol2

(2013) Hani Choudhry et al.   EMBO REPORTS

Hypoxia-Inducible Factor-1  Causes Renal Cyst Expansion through Calcium-Activated Chloride Secretion

(2013) B. Buchholz et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Anoctamin 1 induces calcium-activated chloride secretion and proliferation of renal cyst–forming epithelial cells

(2013) Bjoern Buchholz et al.   KIDNEY INTERNATIONAL

P2Y2 receptor agonist with enhanced stability protects the heart from ischemic damage in vitro and in vivo

(2013) Edith Hochhauser et al.   Purinergic Signalling

Role of extracellular ATP and P2 receptor signaling in regulating renal cyst growth and interstitial inflammation in polycystic kidney disease

(2013) Gopi Rangan   Frontiers in Physiology

P2 purinoceptors: Renal pathophysiology and therapeutic potential

(2012) John W. R. Booth et al.   CLINICAL NEPHROLOGY

Common genetic variants at the 11q13.3 renal cancer susceptibility locus influence binding of HIF to an enhancer of cyclin D1 expression

(2012) Johannes Schödel et al.   NATURE GENETICS

Tolvaptan in Patients with Autosomal Dominant Polycystic Kidney Disease

(2012) Vicente E. Torres et al.   NEW ENGLAND JOURNAL OF MEDICINE

Distinct Mesenchymal Alterations in N-Cadherin and E-Cadherin Positive Primary Renal Epithelial Cells

(2012) Christof Keller et al.   PLoS One

Fluid transport and cystogenesis in autosomal dominant polycystic kidney disease

(2011) Sara Terryn et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

High-resolution genome-wide mapping of HIF-binding sites by ChIP-seq

(2011) J. Schodel et al.   BLOOD

CFTR and TMEM16A are Separate but Functionally Related Cl- Channels

(2011) Jiraporn Ousingsawat et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Formation of cysts by principal-like MDCK cells depends on the synergy of cAMP- and ATP-mediated fluid secretion

(2011) Bjoern Buchholz et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Inhibition of the P2X7 Receptor Reduces Cystogenesis in PKD

(2011) M.-Y. Chang et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Why kidneys fail in autosomal dominant polycystic kidney disease

(2011) Jared J. Grantham et al.   Nature Reviews Nephrology

The protective effect of prolyl-hydroxylase inhibition against renal ischaemia requires application prior to ischaemia but is superior to EPO treatment

(2011) Z. Wang et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

The Raf kinase inhibitor PLX5568 slows cyst proliferation in rat polycystic kidney disease but promotes renal and hepatic fibrosis

(2011) B. Buchholz et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Anoctamins

(2011) Karl Kunzelmann et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Development of a comprehensive set of P2 receptor pharmacological research compounds

(2011) R. A. Felix et al.   Purinergic Signalling

CFTR-Adenylyl Cyclase I Association Responsible for UTP Activation of CFTR in Well-Differentiated Primary Human Bronchial Cell Cultures

(2010) Wan Namkung et al.   MOLECULAR BIOLOGY OF THE CELL

Sirolimus and Kidney Growth in Autosomal Dominant Polycystic Kidney Disease

(2010) Andreas L. Serra et al.   NEW ENGLAND JOURNAL OF MEDICINE

Everolimus in Patients with Autosomal Dominant Polycystic Kidney Disease

(2010) Gerd Walz et al.   NEW ENGLAND JOURNAL OF MEDICINE

Inactivation of Pkd1 in principal cells causes a more severe cystic kidney disease than in intercalated cells

(2009) Kalani L. Raphael et al.   KIDNEY INTERNATIONAL

KCa3.1 potassium channels are critical for cAMP-dependent chloride secretion and cyst growth in autosomal-dominant polycystic kidney disease

(2008) Mamdouh Albaqumi et al.   KIDNEY INTERNATIONAL

CFTR is activated through stimulation of purinergic P2Y2 receptors

(2008) Diana Faria et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY