Ultrahigh-throughput–directed enzyme evolution by absorbance-activated droplet sorting (AADS)

A guiding light: spectroscopy on digital microfluidic devices using in-plane optical fibre waveguides

(2015) Kihwan Choi et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Expanding the Enzyme Universe: Accessing Non-Natural Reactions by Mechanism-Guided Directed Evolution

(2015) Hans Renata et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Enzyme engineering in biomimetic compartments

(2015) Pierre-Yves Colin et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Accurate microfluidic sorting of droplets at 30 kHz

(2015) Adam Sciambi et al.   LAB ON A CHIP

On-chip cavity-enhanced absorption spectroscopy using a white light-emitting diode and polymer mirrors

(2015) Cathy M. Rushworth et al.   LAB ON A CHIP

Beating the odds

(2015) Uwe T Bornscheuer   Nature Chemical Biology

High-throughput analysis and protein engineering using microcapillary arrays

(2015) Bob Chen et al.   Nature Chemical Biology

Ultrahigh-throughput discovery of promiscuous enzymes by picodroplet functional metagenomics

(2015) Pierre-Yves Colin et al.   Nature Communications

One in a Million: Flow Cytometric Sorting of Single Cell-Lysate Assays in Monodisperse Picolitre Double Emulsion Droplets for Directed Evolution

(2014) Anastasia Zinchenko et al.   ANALYTICAL CHEMISTRY

Droplet-Based Microfluidics Platform for Ultra-High-Throughput Bioprospecting of Cellulolytic Microorganisms

(2014) Majdi Najah et al.   CHEMISTRY & BIOLOGY

Recent achievements in developing the biocatalytic toolbox for chiral amine synthesis

(2014) Hannes Kohls et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Generating electric fields in PDMS microfluidic devices with salt water electrodes

(2014) Adam Sciambi et al.   LAB ON A CHIP

Evolution of enzyme catalysts caged in biomimetic gel-shell beads

(2014) Martin Fischlechner et al.   Nature Chemistry

A Fully Unsupervised Compartment-on-Demand Platform for Precise Nanoliter Assays of Time-Dependent Steady-State Enzyme Kinetics and Inhibition

(2013) Fabrice Gielen et al.   ANALYTICAL CHEMISTRY

Modulating protein stability - directed evolution strategies for improved protein function

(2013) Raymond D. Socha et al.   FEBS Journal

High-throughput screening for industrial enzyme production hosts by droplet microfluidics

(2013) Staffan L. Sjostrom et al.   LAB ON A CHIP

Asymmetric Preparation of prim-, sec-, and tert-Amines Employing Selected Biocatalysts

(2013) Wolfgang Kroutil et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Toward a Molecular Understanding of Protein Solubility: Increased Negative Surface Charge Correlates with Increased Solubility

(2012) Ryan M. Kramer et al.   BIOPHYSICAL JOURNAL

Picoliter Cell Lysate Assays in Microfluidic Droplet Compartments for Directed Enzyme Evolution

(2012) Balint Kintses et al.   CHEMISTRY & BIOLOGY

Engineering the third wave of biocatalysis

(2012) U. T. Bornscheuer et al.   NATURE

Self-Regulated, Droplet-Based Sample Chopper for Microfluidic Absorbance Detection

(2011) Kennon S. Deal et al.   ANALYTICAL CHEMISTRY

Enantioenriched Compounds via Enzyme-Catalyzed Redox Reactions

(2011) Mélanie Hall et al.   CHEMICAL REVIEWS

Microdroplets in Microfluidics: An Evolving Platform for Discoveries in Chemistry and Biology

(2010) Ashleigh B. Theberge et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A modular approach for the generation, storage, mixing, and detection of droplet libraries for high throughput screening

(2010) Varun Trivedi et al.   LAB ON A CHIP

Ultrahigh-throughput screening in drop-based microfluidics for directed evolution

(2010) J. J. Agresti et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Controlling the Retention of Small Molecules in Emulsion Microdroplets for Use in Cell-Based Assays

(2009) Fabienne Courtois et al.   ANALYTICAL CHEMISTRY

Directed enzyme evolution: climbing fitness peaks one amino acid at a time

(2009) Cara A Tracewell et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Fluorescence-activated droplet sorting (FADS): efficient microfluidic cell sorting based on enzymatic activity

(2009) Jean-Christophe Baret et al.   LAB ON A CHIP

The potential of microfluidic water-in-oil droplets in experimental biology

(2009) Yolanda Schaerli et al.   Molecular BioSystems

Directed evolution drives the next generation of biocatalysts

(2009) Nicholas J Turner   Nature Chemical Biology

Exploring protein fitness landscapes by directed evolution

(2009) Philip A. Romero et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

In the light of directed evolution: Pathways of adaptive protein evolution

(2009) J. D. Bloom et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Design of therapeutic proteins with enhanced stability

(2009) N. Chennamsetty et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An Integrated Device for Monitoring Time-Dependent in vitro Expression From Single Genes in Picolitre Droplets

(2008) Fabienne Courtois et al.   CHEMBIOCHEM

Advances in laboratory evolution of enzymes

(2008) Shimon Bershtein et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

How Protein Stability and New Functions Trade Off

(2008) Nobuhiko Tokuriki et al.   PLoS Computational Biology