Neurotensin stimulates sortilin and mTOR in human microglia inhibitable by methoxyluteolin, a potential therapeutic target for autism
出版年份 2016 全文链接
标题
Neurotensin stimulates sortilin and mTOR in human microglia inhibitable by methoxyluteolin, a potential therapeutic target for autism
作者
关键词
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出版物
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 113, Issue 45, Pages E7049-E7058
出版商
Proceedings of the National Academy of Sciences
发表日期
2016-09-24
DOI
10.1073/pnas.1604992113
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- A Case Series of a Luteolin Formulation (Neuroprotek®) in Children with Autism Spectrum Disorders
- (2017) T.C. Theoharides et al. INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY
- Mast cells, brain inflammation and autism
- (2016) Theoharis C. Theoharides et al. EUROPEAN JOURNAL OF PHARMACOLOGY
- The maternal interleukin-17a pathway in mice promotes autism-like phenotypes in offspring
- (2016) G. B. Choi et al. SCIENCE
- From molecules to neural morphology: understanding neuroinflammation in autism spectrum condition
- (2016) Adam M. H. Young et al. Molecular Autism
- Atopic diseases and inflammation of the brain in the pathogenesis of autism spectrum disorders
- (2016) T C Theoharides et al. Translational Psychiatry
- Dynamic light scattering analysis of SNARE-driven membrane fusion and the effects of SNARE-binding flavonoids
- (2015) Yoosoo Yang et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- The blood–brain barrier endothelium: a target for pro-inflammatory cytokines: Figure 1
- (2015) Keith D. Rochfort et al. BIOCHEMICAL SOCIETY TRANSACTIONS
- Autism spectrum disorders: from genes to neurobiology
- (2015) A Jeremy Willsey et al. CURRENT OPINION IN NEUROBIOLOGY
- The crucial role of mast cells in blood–brain barrier alterations
- (2015) Domenico Ribatti EXPERIMENTAL CELL RESEARCH
- The novel flavone tetramethoxyluteolin is a potent inhibitor of human mast cells
- (2015) Zuyi Weng et al. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
- Dysregulation of Mammalian Target of Rapamycin Signaling in Mouse Models of Autism
- (2015) K. M. Huber et al. JOURNAL OF NEUROSCIENCE
- Immune mediators in the brain and peripheral tissues in autism spectrum disorder
- (2015) Myka L. Estes et al. NATURE REVIEWS NEUROSCIENCE
- Mast Cells, Mastocytosis, and Related Disorders
- (2015) Theoharis C. Theoharides et al. NEW ENGLAND JOURNAL OF MEDICINE
- Intersection of mTOR and STAT signaling in immunity
- (2015) Diana Saleiro et al. TRENDS IN IMMUNOLOGY
- Microglia Plasticity During Health and Disease: An Immunological Perspective
- (2015) Anat Shemer et al. TRENDS IN IMMUNOLOGY
- Children with autism spectrum disorders, who improved with a luteolin-containing dietary formulation, show reduced serum levels of TNF and IL-6
- (2015) I Tsilioni et al. Translational Psychiatry
- Roles of mTOR Signaling in Brain Development
- (2015) Da Yong Lee Experimental Neurobiology
- Rapamycin: One Drug, Many Effects
- (2014) Jing Li et al. Cell Metabolism
- The subpopulation of microglia sensitive to neurotransmitters/neurohormones is modulated by stimulation with LPS, interferon-γ, and IL-4
- (2014) Maria Pannell et al. GLIA
- Activation and Function of the mTORC1 Pathway in Mast Cells
- (2014) M.-S. Kim et al. JOURNAL OF IMMUNOLOGY
- Histamine Induces Upregulated Expression of Histamine Receptors and Increases Release of Inflammatory Mediators from Microglia
- (2014) Hongquan Dong et al. MOLECULAR NEUROBIOLOGY
- Cytokine aberrations in autism spectrum disorder: a systematic review and meta-analysis
- (2014) A Masi et al. MOLECULAR PSYCHIATRY
- Stereological Study of Amygdala Glial Populations in Adolescents and Adults with Autism Spectrum Disorder
- (2014) John T. Morgan et al. PLoS One
- The human side of microglia
- (2014) Amy M. Smith et al. TRENDS IN NEUROSCIENCES
- Transcriptome analysis reveals dysregulation of innate immune response genes and neuronal activity-dependent genes in autism
- (2014) Simone Gupta et al. Nature Communications
- Selective Activation of mTORC1 Signaling Recapitulates Microcephaly, Tuberous Sclerosis, and Neurodegenerative Diseases
- (2014) Hidetoshi Kassai et al. Cell Reports
- Elevated serum neurotensin and CRH levels in children with autistic spectrum disorders and tail-chasing Bull Terriers with a phenotype similar to autism
- (2014) I Tsilioni et al. Translational Psychiatry
- From Kanner to DSM-5: Autism as an Evolving Diagnostic Concept
- (2013) Fred R. Volkmar et al. Annual Review of Clinical Psychology
- Mast Cell Tryptase Induces Microglia Activation via Protease-activated Receptor 2 Signaling
- (2013) Shu Zhang et al. CELLULAR PHYSIOLOGY AND BIOCHEMISTRY
- An Open-Label Pilot Study of a Formulation Containing the Anti-Inflammatory Flavonoid Luteolin and Its Effects on Behavior in Children With Autism Spectrum Disorders
- (2013) Anilia Taliou et al. CLINICAL THERAPEUTICS
- Mast cells, glia and neuroinflammation: partners in crime?
- (2013) Stephen D. Skaper et al. IMMUNOLOGY
- Focal brain inflammation and autism
- (2013) Theoharis C Theoharides et al. Journal of Neuroinflammation
- Autism
- (2013) Meng-Chuan Lai et al. LANCET
- mTOR complexes in neurodevelopmental and neuropsychiatric disorders
- (2013) Mauro Costa-Mattioli et al. NATURE NEUROSCIENCE
- Drug discovery for autism spectrum disorder: challenges and opportunities
- (2013) Anirvan Ghosh et al. NATURE REVIEWS DRUG DISCOVERY
- Genomic responses in mouse models poorly mimic human inflammatory diseases
- (2013) Junhee Seok et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Reversing autism by targeting downstream mTOR signaling
- (2013) Hansen Wang et al. Frontiers in Cellular Neuroscience
- Polyphenols differentially inhibit degranulation of distinct subsets of vesicles in mast cells by specific interaction with granule-type-dependent SNARE complexes
- (2012) Yoosoo Yang et al. BIOCHEMICAL JOURNAL
- Maternal immune activation causes age- and region-specific changes in brain cytokines in offspring throughout development
- (2012) Paula A. Garay et al. BRAIN BEHAVIOR AND IMMUNITY
- Microglia and mast cells: two tracks on the road to neuroinflammation
- (2012) Stephen D. Skaper et al. FASEB JOURNAL
- Inflammatory cell trafficking across the blood-brain barrier: chemokine regulation and in vitro models
- (2012) Yukio Takeshita et al. IMMUNOLOGICAL REVIEWS
- Evidence of microglial activation in autism and its possible role in brain underconnectivity
- (2012) Juan I. Rodriguez et al. Neuron Glia Biology
- Modeling an autism risk factor in mice leads to permanent immune dysregulation
- (2012) E. Y. Hsiao et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Microglial Activation in Young Adults With Autism Spectrum Disorder
- (2012) Katsuaki Suzuki et al. JAMA Psychiatry
- Inflammation during fetal and neonatal life: Implications for neurologic and neuropsychiatric disease in children and adults
- (2011) Henrik Hagberg et al. ANNALS OF NEUROLOGY
- Next-generation mTOR inhibitors in clinical oncology: how pathway complexity informs therapeutic strategy
- (2011) Seth A. Wander et al. JOURNAL OF CLINICAL INVESTIGATION
- Synaptic Pruning by Microglia Is Necessary for Normal Brain Development
- (2011) R. C. Paolicelli et al. SCIENCE
- Microglial Activation and Increased Microglial Density Observed in the Dorsolateral Prefrontal Cortex in Autism
- (2010) John T. Morgan et al. BIOLOGICAL PSYCHIATRY
- Elevated plasma cytokines in autism spectrum disorders provide evidence of immune dysfunction and are associated with impaired behavioral outcome
- (2010) Paul Ashwood et al. BRAIN BEHAVIOR AND IMMUNITY
- Luteolin triggers global changes in the microglial transcriptome leading to a unique anti-inflammatory and neuroprotective phenotype
- (2010) Konstantin Dirscherl et al. Journal of Neuroinflammation
- Neurotensin is increased in serum of young children with autistic disorder
- (2010) Asimenia Angelidou et al. Journal of Neuroinflammation
- Luteolin inhibits cytokine expression in endotoxin/cytokine-stimulated microglia
- (2010) Tsung-Kuei Kao et al. JOURNAL OF NUTRITIONAL BIOCHEMISTRY
- Involvement of mTOR kinase in cytokine-dependent microglial activation and cell proliferation
- (2009) Cinzia Dello Russo et al. BIOCHEMICAL PHARMACOLOGY
- The prevalence of PTEN mutations in a clinical pediatric cohort with autism spectrum disorders, developmental delay, and macrocephaly
- (2009) Elizabeth A Varga et al. GENETICS IN MEDICINE
- Flavonoids, a prenatal prophylaxis via targeting JAK2/STAT3 signaling to oppose IL-6/MIA associated autism
- (2009) Ellisa Parker-Athill et al. JOURNAL OF NEUROIMMUNOLOGY
- Elevated immune response in the brain of autistic patients
- (2009) Xiaohong Li et al. JOURNAL OF NEUROIMMUNOLOGY
- Akt-dependent regulation of NF- B is controlled by mTOR and Raptor in association with IKK
- (2008) H. C. Dan et al. GENES & DEVELOPMENT
- The TSC-mTOR Signaling Pathway Regulates the Innate Inflammatory Response
- (2008) Thomas Weichhart et al. IMMUNITY
- Autism, Gut-Blood-Brain Barrier, and Mast Cells
- (2008) Theoharis C. Theoharides et al. JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY
- Luteolin reduces IL-6 production in microglia by inhibiting JNK phosphorylation and activation of AP-1
- (2008) S. Jang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
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