Quantitative MS-based enzymology of caspases reveals distinct protein substrate specificities, hierarchies, and cellular roles

Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling

(2015) Nobuhiko Kayagaki et al.   NATURE

Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death

(2015) Jianjin Shi et al.   NATURE

Destructin-1 is a collagen-degrading endopeptidase secreted byPseudogymnoascus destructans, the causative agent of white-nose syndrome

(2015) Anthony J. O’Donoghue et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inhibiting Caspase-6 Activation and Catalytic Activity for Neurodegenerative Diseases

(2014) John Flygare et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Tsc1 (hamartin) confers neuroprotection against ischemia by inducing autophagy

(2013) Michalis Papadakis et al.   NATURE MEDICINE

The caspase 6 derived N-terminal fragment of DJ-1 promotes apoptosis via increased ROS production

(2012) G Robert et al.   CELL DEATH AND DIFFERENTIATION

Fibrils Colocalize Caspase-3 with Procaspase-3 to Foster Maturation

(2012) Julie A. Zorn et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Degradomics Reveals That Cleavage Specificity Profiles of Caspase-2 and Effector Caspases Are Alike

(2012) Magdalena Wejda et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The DegraBase: A Database of Proteolysis in Healthy and Apoptotic Human Cells

(2012) Emily D. Crawford et al.   MOLECULAR & CELLULAR PROTEOMICS

Global identification of peptidase specificity by multiplex substrate profiling

(2012) Anthony J O'Donoghue et al.   NATURE METHODS

Global kinetic analysis of proteolysis via quantitative targeted proteomics

(2012) N. J. Agard et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Caspase-7 uses an exosite to promote poly(ADP ribose) polymerase 1 proteolysis

(2012) D. Boucher et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Caspase Substrates and Cellular Remodeling

(2011) Emily D. Crawford et al.   Annual Review of Biochemistry

SnapShot: Caspases

(2011) Guy S. Salvesen et al.   CELL

Selecting protein N-terminal peptides by combined fractional diagonal chromatography

(2011) An Staes et al.   Nature Protocols

Caspase-6 and neurodegeneration

(2011) Rona K. Graham et al.   TRENDS IN NEUROSCIENCES

Prediction of protease substrates using sequence and structure features

(2010) David T. Barkan et al.   BIOINFORMATICS

Skyline: an open source document editor for creating and analyzing targeted proteomics experiments

(2010) Brendan MacLean et al.   BIOINFORMATICS

Alternative cell death mechanisms in development and beyond

(2010) J. Yuan et al.   GENES & DEVELOPMENT

Inflammatory Stimuli Regulate Caspase Substrate Profiles

(2010) Nicholas J. Agard et al.   MOLECULAR & CELLULAR PROTEOMICS

Improved visualization of protein consensus sequences by iceLogo

(2009) Niklaas Colaert et al.   NATURE METHODS

Structural and kinetic determinants of protease substrates

(2009) John C Timmer et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Proteomics analyses reveal the evolutionary conservation and divergence of N-terminal acetyltransferases from yeast and humans

(2009) T. Arnesen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Global Sequencing of Proteolytic Cleavage Sites in Apoptosis by Specific Labeling of Protein N Termini

(2008) Sami Mahrus et al.   CELL

Global Mapping of the Topography and Magnitude of Proteolytic Events in Apoptosis

(2008) Melissa M. Dix et al.   CELL

Targets of Caspase-6 Activity in Human Neurons and Alzheimer Disease

(2008) Guy Klaiman et al.   MOLECULAR & CELLULAR PROTEOMICS

PMAP: databases for analyzing proteolytic events and pathways

(2008) Yoshinobu Igarashi et al.   NUCLEIC ACIDS RESEARCH

Executioner caspase-3 and caspase-7 are functionally distinct proteases

(2008) J. G. Walsh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA