A conserved amino acid residue critical for product and substrate specificity in plant triterpene synthases

Product Rearrangement from Altering a Single Residue in the Rice syn-Copalyl Diphosphate Synthase

(2016) Kevin C. Potter et al.   ORGANIC LETTERS

Blocking Deprotonation with Retention of Aromaticity in a Plant ent -Copalyl Diphosphate Synthase Leads to Product Rearrangement

(2015) Kevin C. Potter et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

One amino acid makes the difference: the formation of ent-kaurene and 16α-hydroxy-ent-kaurane by diterpene synthases in poplar

(2015) Sandra Irmisch et al.   BMC PLANT BIOLOGY

Efficient heterocyclisation by (di)terpene synthases

(2015) S. Mafu et al.   CHEMICAL COMMUNICATIONS

Novel Product Chemistry from Mechanistic Analysis ofent-Copalyl Diphosphate Synthases from Plant Hormone Biosynthesis

(2014) Kevin Potter et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Triterpene Biosynthesis in Plants

(2014) Ramesha Thimmappa et al.   Annual Review of Plant Biology

Metabolic and functional diversity of saponins, biosynthetic intermediates and semi-synthetic derivatives

(2014) Tessa Moses et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

Pseudoginsenoside-F11 (PF11) exerts anti-neuroinflammatory effects on LPS-activated microglial cells by inhibiting TLR4-mediated TAK1/IKK/NF-κB, MAPKs and Akt signaling pathways

(2014) Xiaoxiao Wang et al.   NEUROPHARMACOLOGY

Synthesis and biological evaluation of novel ocotillol-type triterpenoid derivatives as antibacterial agents

(2013) Zhiwen Zhou et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Purification, kinetics, inhibitors and CD for recombinant β-amyrin synthase fromEuphorbia tirucalli L and functional analysis of the DCTA motif, which is highly conserved among oxidosqualene cyclases

(2013) Ryousuke Ito et al.   FEBS Journal

Protein engineering of oxidosqualene-lanosterol cyclase into triterpene monocyclase

(2013) Cheng-Hsiang Chang et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Modularity of Plant Metabolic Gene Clusters: A Trio of Linked Genes That Are Collectively Required for Acylation of Triterpenes in Oat

(2013) S. T. Mugford et al.   PLANT CELL

Biochemical analysis of a multifunctional cytochrome P450 (CYP51) enzyme required for synthesis of antimicrobial triterpenes in plants

(2013) K. Geisler et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pseudoginsenoside F11, a Novel Partial PPARγAgonist, Promotes Adiponectin Oligomerization and Secretion in 3T3-L1 Adipocytes

(2013) Guoyu Wu et al.   PPAR Research

Glycosyltransferases from Oat (Avena) Implicated in the Acylation of Avenacins

(2012) Amorn Owatworakit et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Single Residue Change Leads to a Hydroxylated Product from the Class II Diterpene Cyclization Catalyzed by Abietadiene Synthase

(2012) Jared Criswell et al.   ORGANIC LETTERS

Transfer-PCR (TPCR): A highway for DNA cloning and protein engineering

(2011) Ariel Erijman et al.   JOURNAL OF STRUCTURAL BIOLOGY

The saponins – polar isoprenoids with important and diverse biological activities

(2011) Anne Osbourn et al.   NATURAL PRODUCT REPORTS

OPM database and PPM web server: resources for positioning of proteins in membranes

(2011) Mikhail A. Lomize et al.   NUCLEIC ACIDS RESEARCH

Molecular activities, biosynthesis and evolution of triterpenoid saponins

(2011) Jörg M. Augustin et al.   PHYTOCHEMISTRY

Mutational analysis of white spruce (Picea glauca) ent-kaurene synthase (PgKS) reveals common and distinct mechanisms of conifer diterpene synthases of general and specialized metabolism

(2011) Philipp Zerbe et al.   PHYTOCHEMISTRY

High throughput screening of mutants of oat that are defective in triterpene synthesis

(2010) Bo Qin et al.   PHYTOCHEMISTRY

mRNA Degradation Machinery in Plants

(2009) Yukako Chiba et al.   JOURNAL OF PLANT BIOLOGY

A Serine Carboxypeptidase-Like Acyltransferase Is Required for Synthesis of Antimicrobial Compounds and Disease Resistance in Oats

(2009) S. T. Mugford et al.   PLANT CELL

Functional plasticity of paralogous diterpene synthases involved in conifer defense

(2008) C. I. Keeling et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA