Article
Immunology
Suelen Queiroz Diniz, Maria Marta Figueiredo, Pedro Augusto Carvalho Costa, Olindo Assis Martins-Filho, Andrea Teixeira-Carvalho, Dhelio Batista Pereira, Mauro Shugiro Tada, Luis Carlos Crocco Afonso, Markus Kohlhoff, Carlos Leomar Zani, Ricardo Tostes Gazzinelli, Fabiano Oliveira, Lis Ribeiro Antonelli
Summary: This study reveals that monocytes in patients with malaria produce high levels of inflammatory cytokines and also have a regulatory role through specific receptors, suggesting a dual role of monocytes in malaria.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biology
Tobias Mourier, Denise Anete Madureira de Alvarenga, Abhinav Kaushik, Anielle de Pina-Costa, Olga Douvropoulou, Qingtian Guan, Francisco J. Guzman-Vega, Sarah Forrester, Filipe Vieira Santos de Abreu, Cesare Bianco Junior, Julio Cesar de Souza Junior, Silvia Bahadian Moreira, Zelinda Maria Braga Hirano, Alcides Pissinatti, Maria de Fatima Ferreira-da-Cruz, Ricardo Lourenco de Oliveira, Stefan T. Arold, Daniel C. Jeffares, Patricia Brasil, Cristiana Ferreira Alves de Brito, Richard Culleton, Claudio Tadeu Daniel-Ribeiro, Arnab Pain
Summary: Plasmodium simium, a malaria parasite of non-human primates, likely originated in South America from Plasmodium vivax and has recently acquired the ability to infect humans. Genetic analysis suggests that specific gene deletions in P. simium, especially in the Duffy-binding protein 1 (DBP1), may play a role in its ability to invade human red blood cells, leading to recent zoonotic infections.
Article
Biotechnology & Applied Microbiology
Jack Adderley, Christian Doerig
Summary: This study fills gaps in the kinomes of Plasmodium falciparum and Plasmodium vivax, highlighting their similarities and differences for target selection. It also identifies kinases that are not suitable targets for drug discovery due to their high similarity with human counterparts.
Editorial Material
Infectious Diseases
Fang Huang, Li Zhang, Zhi-Gui Xia
Summary: This article highlights China's practices and experience in targeting vivax malaria control and elimination, including radical cure strategies, comprehensive but adaptive strategies, mass drug administration, and case-/focus-centered surveillance and response systems. After nearly 70 years of effort, China was certified as a malaria-free country in June 2021.
INFECTIOUS DISEASES OF POVERTY
(2023)
Review
Immunology
Cindy S. Chu, Marie Stolbrink, Daniel Stolady, Makoto Saito, Candy Beau, Kan Choun, Tha Gay Wah, Ne Mu, Klay Htoo, Be Nu, Arunrot Keereevijit, Jacher Wiladpaingern, Verena Carrara, Aung Pyae Phyo, Khin Maung Lwin, Christine Luxemburger, Stephane Proux, Prakaykaew Charunwatthana, Rose McGready, Nicholas J. White, Francois Nosten
Summary: This study reviewed all malaria cases managed by the Shoklo Malaria Research Unit along the Thailand-Myanmar border between 2000 and 2016. The results showed that Plasmodium falciparum and Plasmodium vivax malaria had higher incidence and mortality rates in this area compared to areas of low seasonal malaria transmission.
CLINICAL INFECTIOUS DISEASES
(2023)
Review
Immunology
Gisele Tatiane Soares da Veiga, Matheus Ribeiro Moriggi, Jean Franciesco Vettorazzi, Marcelo Mueller-Santos, Letusa Albrecht
Summary: Malaria is a devastating infectious disease caused by Plasmodium parasites, and finding an effective vaccine is a major challenge. Plasmodium vivax, the second most prevalent species, has been neglected for decades, leading to a lack of knowledge and vaccine development. The main difficulties in developing a P. vivax vaccine are its high genetic diversity and complex life cycle. This review presents the main findings of vivax malaria vaccines to date to support future investigations.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Luis Carlos Salazar Alvarez, Omaira Vera Lizcano, Dayanne Kamylla Alves da Silva Barros, Djane Clarys Baia-da-Silva, Wuelton Marcelo Monteiro, Paulo Filemon Paolluci Pimenta, Marcus Vinicius Guimaraes de Lacerda, Fabio Trindade Maranhao Costa, Stefanie Costa Pinto Lopes
Summary: In a Plasmodium vivax infection, gametocytes show increased distribution in bone marrow aspirant, indicating the organ's role as a parasite reservoir. Ex vivo assays demonstrate gametocyte adherence to bone marrow endothelial cells, with ICAM1 as a significant receptor and CD36 showing high adhesion rate without significance.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Review
Immunology
Sonalika Kar, Abhinav Sinha
Summary: The neglected but highly prevalent Plasmodium vivax in South-east Asia and South America poses a great challenge for long-term in-vitro culturing and functional assays, hindering the development of new drugs and vaccines. The leading vaccine candidate antigen PvDBP, despite completing clinical trial Phase 1 successfully, faces challenges such as its highly polymorphic nature and strain-specific immunity.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Immunology
Kayla Sylvester, Steven P. Maher, Dora Posfai, Michael K. Tran, McKenna C. Crawford, Amelie Vantaux, Benoit Witkowski, Dennis E. Kyle, Emily R. Derbyshire
Summary: This study utilizes high-resolution microscopy to characterize temporal changes of the TVN in Plasmodium vivax liver stage, revealing its presence in dormant hypnozoites and association with host nuclei. The unexpected association of the host water channel protein AQP3 with TVN-derived vesicles is demonstrated, suggesting a potential function of AQP3 during this stage. These findings enhance understanding of host-parasite interactions in both dormant and replicating P. vivax liver stage forms.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Pharmacology & Pharmacy
Rajeev K. Mehlotra, Andrea Gaedigk, Rosalind E. Howes, Tovonahary A. Rakotomanga, Arsene C. Ratsimbasoa, Peter A. Zimmerman
Summary: The study found genetic variation in CYP2D6 in the population of Madagascar, where some individuals are predicted to be intermediate metabolizers, which is associated with therapeutic failure of PQ. The results also provide insights into the unique Asian-African admixed origin of Malagasy populations.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Microbiology
Isabell Berneburg, Satyamaheshwar Peddibhotla, Kim C. Heimsch, Kristina Haeussler, Patrick Maloney, Palak Gosalia, Janina Preuss, Mahsa Rahbari, Oleksii Skorokhod, Elena Valente, Daniela Ulliers, Luigi Felice Simula, Kathrin Buchholz, Michael P. Hedrick, Paul Hershberger, Thomas D. Y. Chung, Michael R. Jackson, Evelin Schwarzer, Stefan Rahlfs, Lars Bode, Katja Becker, Anthony B. Pinkerton
Summary: This study reports on a highly selective PfGluPho inhibitor, SBI-0797750, which shows potent activity against Plasmodium parasites. The compound disturbs the redox potential and H2O2 homeostasis of the parasites, without harming red blood cell integrity and phagocytosis.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2022)
Article
Medicine, General & Internal
Shalini Aggarwal, Selvamano Selvaraj, Jayaprakash Nattamai Subramanian, Mookambeswaran Arunachalam Vijayalakshmi, Swati Patankar, Sanjeeva Srivastava
Summary: The World Health Organization (WHO) is calling for the eradication of malaria, caused mainly by Plasmodium falciparum and Plasmodium vivax parasites. Lack of diagnostic biomarkers for P. vivax, particularly those that distinguish it from P. falciparum, hinders P. vivax elimination. This study demonstrates that the P. vivax tryptophan-rich antigen (PvTRAg) can be used as a diagnostic biomarker for P. vivax in malaria patients. The development of a diagnostic assay based on PvTRAg could improve identification and differentiation of P. vivax and make testing more accessible.
Review
Immunology
Richard Thomson-Luque, Jose M. Bautista
Summary: Although the understanding of reticulocytes is still incomplete, recent focus on a subset of highly immature reticulocytes has brought some hope. These very immature reticulocytes may serve as ideal host cells for in vitro cultivation of P. vivax.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Infectious Diseases
Yanwen Cui, Li Zhang, Zhigui Xia, Hejun Zhou, Fang Huang
Summary: In China, the number of imported recurrent cases of Plasmodium vivax and P. ovale is increasing, predominantly affecting males and migrant workers. Recurrent P. vivax cases show seasonality with peaks in February and June. The majority of recurrent cases did not receive radical treatment for previous infection.
INFECTIOUS DISEASES OF POVERTY
(2021)
Article
Immunology
Maelle Le Goff, Eric Kendjo, Marc Thellier, Renaud Piarroux, Pierre Yves Boelle, Stephane Jaureguiberry
Summary: This study analyzed the impact of chemoprophylaxis on the outcomes of Plasmodium vivax and Plasmodium ovale infections in civilian travelers. It found that travelers using blood-stage drugs were at a higher risk of delayed-onset illness. This calls for new chemoprophylaxis acting on liver stages.
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Microbiology
Hajime Kanamori, Christian M. Parobek, Jonathan J. Juliano, David van Duin, Bruce A. Cairns, David J. Weber, William A. Rutala
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2017)
Article
Biochemistry & Molecular Biology
Christian M. Parobek, Frederick I. Archer, Michelle E. Deprenger-Levin, Sean M. Hoban, Libby Liggins, Allan E. Strand
MOLECULAR ECOLOGY RESOURCES
(2017)
Article
Evolutionary Biology
Christian M. Parobek, Jonathan B. Parr, Nicholas F. Brazeau, Chanthap Lon, Suwanna Chaorattanakawee, Panita Gosi, Eric J. Barnett, Lauren D. Norris, Steven R. Meshnick, Michele D. Spring, Charlotte A. Lanteri, Jeffrey A. Bailey, David L. Saunders, Jessica T. Lin, Jonathan J. Juliano
GENOME BIOLOGY AND EVOLUTION
(2017)
Article
Immunology
Sonia Agrawal, Kara A. Moser, Lindsay Morton, Michael P. Cummings, Ankita Parihar, Ankit Dwivedi, Amol C. Shetty, Elliott F. Drabek, Christopher G. Jacob, Philipp P. Henrich, Christian M. Parobek, Krisada Jongsakul, Rekol Huy, Michele D. Spring, Charlotte A. Lanteri, Suwanna Chaorattanakawee, Chanthap Lon, Mark M. Fukuda, David L. Saunders, David A. Fidock, Jessica T. Lin, Jonathan J. Juliano, Christopher V. Plowe, Joana C. Silva, Shannon Takala-Harrison
JOURNAL OF INFECTIOUS DISEASES
(2017)
Article
Biochemistry & Molecular Biology
Nicholas J. Hathaway, Christian M. Parobek, Jonathan J. Juliano, Jeffrey A. Bailey
NUCLEIC ACIDS RESEARCH
(2018)
Article
Public, Environmental & Occupational Health
Andreea Waltmann, Jaymin C. Patel, Kyaw L. Thwai, Nicholas J. Hathaway, Christian M. Parobek, Achille Massougbodji, Nadine Fievet, Jeffery A. Bailey, Philippe Deloron, Jonathan J. Juliano, Nicaise Tuikue Ndam, Steven R. Meshnick
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
(2018)
Article
Immunology
Sujata Balasubramanian, Rifat S. Rahman, Chanthap Lon, Christian Parobek, Ratawan Ubalee, Nicholas Hathaway, Worachet Kuntawunginn, Mok My, Dav Vy, Jeremy Saxe, Charlotte Lanteri, Feng-Chang Lin, Michele Spring, Steven R. Meshnick, Jonathan J. Juliano, David L. Saunders, Jessica T. Lin
JOURNAL OF INFECTIOUS DISEASES
(2020)
Article
Multidisciplinary Sciences
Juliana M. Sa, Sarah R. Kaslow, Roberto R. Moraes Barros, Nicholas F. Brazeau, Christian M. Parobek, Dingyin Tao, Rebecca E. Salzman, Tyler J. Gibson, Soundarapandian Velmurugan, Michael A. Krause, Viviana Melendez-Muniz, Whitney A. Kite, Paul K. Han, Richard T. Eastman, Adam Kim, Evan G. Kessler, Yonas Abebe, Eric R. James, Sumana Chakravarty, Sachy Orr-Gonzalez, Lynn E. Lambert, Theresa Engels, Marvin L. Thomas, Pius S. Fasinu, David Serre, Robert W. Gwadz, Larry Walker, Derrick K. DeConti, Jianbing Mu, Jeffrey A. Bailey, B. Kim Lee Sim, Stephen L. Hoffman, Michael P. Fay, Rhoel R. Dinglasan, Jonathan J. Juliano, Thomas E. Wellems
NATURE COMMUNICATIONS
(2019)
Article
Genetics & Heredity
Christian M. Parobek, Melissa L. Russo, Adam K. Lewkowitz
Summary: The study found that most laboratories use prenatal genetic information for research and share genetic information with others. However, laboratories inadequately disclosed privacy risks, and the readability of most genetic privacy policies was high.
GENETICS IN MEDICINE
(2021)
Article
Obstetrics & Gynecology
Christian M. Parobek, Melissa L. Russo, Adam K. Lewkowitz
Summary: Modern prenatal genetic screening techniques, such as cell-free fetal DNA and expanded carrier screening, analyze substantial amounts of maternal and fetoplacental DNA. While anonymized DNA can be reidentified using genetic databases, raising long-term genetic privacy concerns, steps should be taken to improve patient awareness and control over their genetic privacy. It is important for prenatal care practitioners to be well-informed about the privacy implications of genetic tests and advocate for patients' genetic privacy.
OBSTETRICS AND GYNECOLOGY
(2021)
Editorial Material
Obstetrics & Gynecology
Christian M. Parobek, Phinnara Has, Paula Lorenzi, Melissa L. Russo, Melissa A. Clark, Adam K. Lewkowitz
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2021)
Article
Immunology
Natalie M. Bowman, Sujata Balasubramanian, Robert H. Gilman, Christian Parobek, Maritza Calderon, Andreea Waltmann, Louisa A. Messenger, Leny Sanchez, Caryn Bern, Jonathan J. Juliano
Summary: Researchers used amplicon deep sequencing to rapidly extract genetic diversity information of T. cruzi infection from clinical samples of HIV patients, identifying both different typing infections and the presence of multistrain infections.
JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Obstetrics & Gynecology
Christian M. Parobek, Margaret M. Thorsen, Phinnara Has, Paula Lorenzi, Melissa A. Clark, Melissa L. Russo, Adam K. Lewkowitz
Summary: Through a randomized controlled trial, the study found that most pregnant patients are unaware that their prenatal genetic data may be used for nonclinical purposes. Pregnant patients who were educated about the Genetic Information Nondiscrimination Act were not more willing to share genetic data than those who did not receive this education.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2022)
Letter
Obstetrics & Gynecology
Christian M. Parobek, Phinnara Has, Paula Lorenzi, Melissa A. Clark, Adam K. Lewkowitz, Melissa L. Russo
AMERICAN JOURNAL OF OBSTETRICS & GYNECOLOGY MFM
(2023)
Article
Microbiology
Hajime Kanamori, Christian M. Parobek, Jonathan J. Juliano, James R. Johnson, Brian D. Johnston, Timothy J. Johnson, David J. Weber, William A. Rutala, Deverick J. Anderson
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2017)