Directed Chemical Evolution with an Outsized Genetic Code

Encoded Library Technology Screening of Hepatitis C Virus NS4B Yields a Small-Molecule Compound Series withIn VitroReplicon Activity

(2015) Christopher Arico-Muendel et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Inhibition of PAD4 activity is sufficient to disrupt mouse and human NET formation

(2015) Huw D Lewis et al.   Nature Chemical Biology

Methods for the directed evolution of proteins

(2015) Michael S. Packer et al.   NATURE REVIEWS GENETICS

Application of encoded library technology (ELT) to a protein–protein interaction target: Discovery of a potent class of integrin lymphocyte function-associated antigen 1 (LFA-1) antagonists

(2014) Christopher S. Kollmann et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Prospective identification of parasitic sequences in phage display screens

(2013) Wadim L. Matochko et al.   NUCLEIC ACIDS RESEARCH

Directed Evolution of a Model Primordial Enzyme Provides Insights into the Development of the Genetic Code

(2013) Manuel M. Müller et al.   PLoS Genetics

Directed evolution: tailoring biocatalysts for industrial applications

(2012) Ashwani Kumar et al.   CRITICAL REVIEWS IN BIOTECHNOLOGY

Discovery of Highly Potent and Selective Small Molecule ADAMTS-5 Inhibitors That Inhibit Human Cartilage Degradation via Encoded Library Technology (ELT)

(2012) Hongfeng Deng et al.   JOURNAL OF MEDICINAL CHEMISTRY

Highly Parallel Translation of DNA Sequences into Small Molecules

(2012) Rebecca M. Weisinger et al.   PLoS One

Mesofluidic Devices for DNA-Programmed Combinatorial Chemistry

(2012) Rebecca M. Weisinger et al.   PLoS One

Selection of a synthetic glycan oligomer from a library of DNA-templated fragments against DC-SIGN and inhibition of HIV gp120 binding to dendritic cells

(2011) Mihai Ciobanu et al.   CHEMICAL COMMUNICATIONS

Engineering Antibodies for Cancer Therapy

(2011) Eric T. Boder et al.   Annual Review of Chemical and Biomolecular Engineering

High-Throughput Metabolic Engineering: Advances in Small-Molecule Screening and Selection

(2010) Jeffrey A. Dietrich et al.   Annual Review of Biochemistry

Aptamers and the RNA World, Past and Present

(2010) L. Gold et al.   Cold Spring Harbor Perspectives in Biology

A Yoctoliter-Scale DNA Reactor for Small-Molecule Evolution

(2009) Margit Haahr Hansen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Design, synthesis and selection of DNA-encoded small-molecule libraries

(2009) Matthew A Clark et al.   Nature Chemical Biology

Exploring Kinase Cosubstrate Promiscuity: Monitoring Kinase Activity through Dansylation

(2008) Keith D. Green et al.   CHEMBIOCHEM

The Intrinsic Contributions of Tyrosine, Serine, Glycine and Arginine to the Affinity and Specificity of Antibodies

(2008) Sara Birtalan et al.   JOURNAL OF MOLECULAR BIOLOGY

High-throughput sequencing allows the identification of binding molecules isolated from DNA-encoded chemical libraries

(2008) L. Mannocci et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Amino acid alphabet size in protein evolution experiments: better to search a small library thoroughly or a large library sparsely?

(2008) E. Munoz et al.   PROTEIN ENGINEERING DESIGN & SELECTION