Identification of a Small Molecule Inhibitor of RAD52 by Structure-Based Selection

Design, synthesis and preliminary bioactivity studies of imidazolidine-2,4-dione derivatives as Bcl-2 inhibitors

(2015) Gang Wang et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Small-Molecule Disruption of RAD52 Rings as a Mechanism for Precision Medicine in BRCA-Deficient Cancers

(2015) Gurushankar Chandramouly et al.   CHEMISTRY & BIOLOGY

Downregulation of BRCA1 protein in BCR-ABL1 leukemia cells depends on stress-triggered TIAR-mediated suppression of translation

(2014) Paulina Podszywalow-Bartnicka et al.   CELL CYCLE

Halogen-enriched fragment libraries as chemical probes for harnessing halogen bonding in fragment-based lead discovery

(2014) Markus O Zimmermann et al.   Future Medicinal Chemistry

Personalized synthetic lethality induced by targeting RAD52 in leukemias identified by gene mutation and expression profile

(2013) K. Cramer-Morales et al.   BLOOD

Crystallographic Fragment-Based Drug Discovery: Use of a Brominated Fragment Library Targeting HIV Protease

(2013) Theresa Tiefenbrunn et al.   Chemical Biology & Drug Design

Poly(ADP-ribosyl)ation in regulation of chromatin structure and the DNA damage response

(2013) Michael Tallis et al.   CHROMOSOMA

Halogen-Enriched Fragment Libraries as Leads for Drug Rescue of Mutant p53

(2012) Rainer Wilcken et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Quantitative Live Cell Imaging Reveals a Gradual Shift between DNA Repair Mechanisms and a Maximal Use of HR in Mid S Phase

(2012) Ketki Karanam et al.   MOLECULAR CELL

Family-wide chemical profiling and structural analysis of PARP and tankyrase inhibitors

(2012) Elisabet Wahlberg et al.   NATURE BIOTECHNOLOGY

Antileukemic effects of AMPK activators on BCR-ABL-expressing cells

(2011) E. Vakana et al.   BLOOD

Poly(ADP-Ribose) polymerase (PARP) inhibitors: Exploiting a synthetic lethal strategy in the clinic

(2011) Timothy A. Yap et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Lipophilicity in drug discovery

(2010) Michael J Waring   Expert Opinion on Drug Discovery

Rad52 inactivation is synthetically lethal with BRCA2 deficiency

(2010) Z. Feng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Automated Docking Screens: A Feasibility Study

(2009) John J. Irwin et al.   JOURNAL OF MEDICINAL CHEMISTRY

Identification of a Second DNA Binding Site in the Human Rad52 Protein

(2008) Wataru Kagawa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY