Review
Medicine, General & Internal
Malgorzata Kowalska, Wojciech Debek, Ewa Matuszczak
Summary: Most infantile hemangiomas can be managed with observation, but about 10% may require immediate treatment due to complications. Treatment options include systemic and topical therapy, with other forms of treatment considered in cases of inadequate response or rebound growth.
JOURNAL OF CLINICAL MEDICINE
(2021)
Letter
Dermatology
Tushar S. Dabade, Ryan Thomas Shaw, Imene Benlagha, Bichchau Michelle Nguyen
Summary: The treatment outcomes were classified into excellent, good, stable, or deterioration categories based on evaluation. The primary outcome measure was achieving excellent response at 24 weeks. Photographs of IHs were taken at weeks 0 and 24 and reviewed by an independent expert panel.
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2022)
Review
Pharmacology & Pharmacy
Laura Macca, Domenica Altavilla, Luca Di Bartolomeo, Natasha Irrera, Francesco Borgia, Federica Li Pomi, Federico Vaccaro, Violetta Squadrito, Francesco Squadrito, Mario Vaccaro
Summary: Hemangiomas are the most common benign vascular tumors in infants, affecting about 5-10% of one-year-old children. Most hemangiomas regress spontaneously, but some require treatment to prevent complications. Steroids have been the first-line treatment for over 30 years, but beta-blockers are increasingly being used. In this review, we discussed different treatment options and also explored laser treatment and cases involving the central nervous system.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Dermatology
Xin Tan, Shu Guo, Chenchao Wang
Summary: Propranolol, the first generation beta-blocker, was initially used for tachycardia and hypertension, but its discovery in the treatment of infantile hemangiomas has opened up new possibilities. Despite being the first-line medication for IHs, its mechanism and adverse effects require further research and development for more effective treatment.
CLINICAL COSMETIC AND INVESTIGATIONAL DERMATOLOGY
(2021)
Article
Otorhinolaryngology
Luying Wang, Shaohua Li, Qianqian Gao, Renrong Lv, Guangqi Xu, Xueqing Li, Jianhai Bi, Ran Huo
Summary: The study suggests that propranolol treatment for parotid hemangiomas may require longer duration compared to other infantile hemangiomas at different sites, but can achieve similar efficacy and relapse rates. Early treatment initiation and sufficient treatment duration can improve outcomes.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2021)
Article
Pediatrics
Rita Gomes, Luis Salazar, Carolina Fraga, Mario Rui Correia, Joana Barbosa-Sequeira, Alexandre Fernandes, Silvia Alvares, Jose Banquart Leitao, Margarida Paiva Coelho
Summary: The purpose of this study is to describe the experience of managing Infantile Hemangiomas (IH) in a multidisciplinary team in a tertiary hospital. The study analyzed IH patients diagnosed between January 2010 and May 2022, and found that focal and superficial lesions were more common, with facial location being the most frequent. Propranolol was the main treatment option, with majority of IH showing partial regression. The study emphasizes the importance of early detection and multidisciplinary assessment for effective management of high-risk IH.
EUROPEAN JOURNAL OF PEDIATRICS
(2023)
Article
Dermatology
Hongjie Zheng, Yizuo Cai, Yuda Xu, Qian Yu, Bijun Kang, Chingyu Chen, Xia Gong, Wei Li
Summary: Topical timolol is not effective in treating some superficial infantile hemangiomas (IHs). This study aimed to identify the predictors of treatment response to topical timolol for superficial IHs. The study found that lesion thickness and patient age at initial treatment were major factors affecting treatment response, while sex, lesion size, and location had no significant impact. Therefore, treatment for superficial IHs should be individualized according to lesion thickness and patient age.
DERMATOLOGIC THERAPY
(2022)
Article
Oncology
Juan Antonio Lenero-Bardallo, Begona Acha, Carmen Serrano, Jose Antonio Perez-Carrasco, Juan Ortiz-Alvarez, Jose Bernabeu-Wittel
Summary: Infantile hemangiomas are common vascular tumors in infants, and their diagnosis can be challenging. This study shows that thermographic imaging can be an accurate tool for monitoring hemangioma extensions and assessing treatment outcomes.
Article
Acoustics
Hong Meng, Licheng Jiang, Zhe Chen, Gaiying Zhang, Jianlin Liu
Summary: The clinical application of high-frequency ultrasound in the treatment of infantile hemangiomas was studied, with changes in tumor thickness being the most important observational indicator. After treatment, significant improvements were observed in the treatment-effective group, while no significant differences were found in the treatment-ineffective group.
JOURNAL OF ULTRASOUND IN MEDICINE
(2021)
Article
Multidisciplinary Sciences
Mingfeng Xie, Jianping Liu, Pingsheng Zhou, Xianyun Xu, Haijin Liu, Linshan Zeng, Feng Chen, Yong Zeng, Haijin Huang, Wei Peng, Hui Xiao, Qian Liu
Summary: To improve the treatment of superficial infantile hemangiomas (IH), a digital imaging system has been developed to objectively assess treatment response based on color changes in the lesion. The system quantifies RGB difference and ratio between tumor and normal tissue, showing strong correlation with visual grading systems. However, the correlation with biochemical methods is weak. This system provides a clinical tool for objective evaluation of disease progression and treatment response in superficial IH patients.
Article
Oncology
Changfeng Wang, Jiali Sun, Lei Guo, Dan Song, Xin Zhang, Zhuang Liu, Liang Wang
Summary: Through a retrospective analysis of 368 infants with infantile hemangioma who received lauromacrogol injections, the study showed that this novel injection therapy was effective in accelerating the regression of lesions with a low incidence of complications.
FRONTIERS IN ONCOLOGY
(2022)
Article
Dermatology
Justin D. Arnold, Sunjung Yoon, Nidhi Shah, Morgan Byrne, Lukas Kieswetter, Cathryn Sibbald, Irene Lara-Corrales, Neha Kinariwalla, Maria C. Garzon, Mitchell Braun, Sonal D. Shah, Ilona J. Frieden, Nicole Travis, Carmen Liy Wong, Alan N. Snyder, Lara Wine Lee, Erin K. Collier, Marcia Hogeling, Esteban Fernandez Faith, Nicole DeVaul, Anna Yasmine Kirkorian
Summary: This study provides a better understanding of the high-risk features of anogenital hemangiomas and demonstrates that segmental or partial segmental hemangiomas develop within specific anatomical territories.
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2023)
Article
Pharmacology & Pharmacy
Shih-Jen Chang, Huiyuan Wang, Jialin Chen, Qianyi Chen, Lei Chang, Yongzhuo Huang, Yajing Qiu, Xiaoxi Lin
Summary: This study developed a superior skin permeating drug, butyryl timolol maleate (BT) prodrug, which exhibited better skin permeation ability compared to timolol maleate (TM). BT did not cause skin irritation and was converted to timolol in the skin with higher accumulation than TM. This has potential implications for the treatment of infantile hemangiomas.
Article
Pediatrics
Marco Pensabene, Maria Rita Di Pace, Fabio Baldanza, Francesco Grasso, Maria Patti, Maria Sergio, Simona La Placa, Mario Giuffre, Gregorio Serra, Alessandra Casuccio, Marcello Cimador
Summary: Infantile hemangiomas often negatively impact the quality of life of patients and their families. Oral propranolol therapy can significantly improve the quality of life, especially when administered early.
ITALIAN JOURNAL OF PEDIATRICS
(2022)
Article
Biochemistry & Molecular Biology
Sushree Ambika Sahu, Saurav Panda, Abhaya Chandra Das, Lora Mishra, Satchidananda Rath, Krzysztof Sokolowski, Manoj Kumar, Rinkee Mohanty, Rashmita Nayak, Anurag Satpathy, Barbara Lapinska
Summary: The efficacy of sub-gingivally delivered propolis nanoparticles in the non-surgical management of periodontal pockets was evaluated in this study. The results showed that the combination of propolis nanoparticles and scaling and root planing (SRP) significantly improved the clinical parameters of periodontal pockets, including plaque index, gingival index, probing pocket depth, and bleeding on probing.
Article
Engineering, Biomedical
Yang Lv, Xinyu Lv, Weiping Liu, Martin S. Judenhofer, Allison Zwingenberger, Erik Wisner, Eric Berg, Sarah McKenney, Edwin Leung, Benjamin A. Spencer, Simon R. Cherry, Ramsey D. Badawi
PHYSICS IN MEDICINE AND BIOLOGY
(2019)
Article
Radiology, Nuclear Medicine & Medical Imaging
Ramsey D. Badawi, Hongcheng Shi, Pengcheng Hu, Shuguang Chen, Tianyi Xu, Patricia M. Price, Yu Ding, Benjamin A. Spencer, Lorenzo Nardo, Weiping Liu, Jun Bao, Terry Jones, Hongdi Li, Simon R. Cherry
JOURNAL OF NUCLEAR MEDICINE
(2019)
Article
Engineering, Biomedical
Junwei Du, Xiaowei Bai, Simon R. Cherry
PHYSICS IN MEDICINE AND BIOLOGY
(2019)
Article
Psychiatry
Melissa D. Bauman, Tyler A. Lesh, Douglas J. Rowland, Cynthia M. Schumann, Jason Smucny, David L. Kukis, Simon R. Cherry, A. Kimberley McAllister, Cameron S. Carter
TRANSLATIONAL PSYCHIATRY
(2019)
Article
Engineering, Biomedical
Gerard Arino-Estrada, Gregory S. Mitchell, Hadong Kim, Junwei Du, Sun Il Kwon, Leonard J. Cirignano, Kanai S. Shah, Simon R. Cherry
PHYSICS IN MEDICINE AND BIOLOGY
(2019)
Article
Computer Science, Information Systems
Ekaterina Mikhaylova, Jamison Brooks, Darren M. Zuro, Farouk Nouizi, Maciej Kujawski, Srideshikan Sargur Madabushi, Jinyi Qi, Mengxi Zhang, Junie Chea, Erasmus K. Poku, Nicole Bowles, Jeffrey Y. C. Wong, John E. Shively, Paul J. Yazaki, Gultekin Gulsen, Simon R. Cherry, Susanta K. Hui
Meeting Abstract
Radiology, Nuclear Medicine & Medical Imaging
Xuezhu Zhang, Zhaoheng Xie, Eric Berg, Martin Judenhofer, Weiping Liu, Yang Lv, Yu Ding, Xinyu Lv, Tianyi Xu, Yun Dong, Hongcheng Shi, Shuguang Chen, Pengcheng Hu, Jun Bao, Hongdi Li, Simon Cherry, Ramsey Badawi, Jinyi Qi
JOURNAL OF NUCLEAR MEDICINE
(2019)
Meeting Abstract
Radiology, Nuclear Medicine & Medical Imaging
Amirtaha Taebi, Bahman Roudsari, Catherine Vu, Simon Cherry, Emilie Roncali
JOURNAL OF NUCLEAR MEDICINE
(2019)
Meeting Abstract
Radiology, Nuclear Medicine & Medical Imaging
Guobao Wang, Benjamin Spencer, Souvik Sarkar, Hongcheng Shi, Shuguang Chen, Pengcheng Hu, Yu Ding, Debin Hu, Ping Zhou, Tianyi Xu, Chao Wang, Terry Jones, Simon Cherry, Ramsey Badawi
JOURNAL OF NUCLEAR MEDICINE
(2019)
Meeting Abstract
Radiology, Nuclear Medicine & Medical Imaging
Edwin Leung, Xuezhu Zhang, Eric Berg, Hongcheng Shi, Shuguang Chen, Pengcheng Hu, Yun Dong, Yong Zhao, Songsong Tang, Xinyu Lv, Shaoping Chu, Weiping Liu, Hongdi Li, Terry Jones, Simon Cherry, Ramsey Badawi
JOURNAL OF NUCLEAR MEDICINE
(2019)
Meeting Abstract
Radiology, Nuclear Medicine & Medical Imaging
Elizabeth Li, Simon Cherry, Alice Tarantal, Hongcheng Shi, Shuguang Chen, Pengcheng Hu, Yu Ding, Debin Hu, Ping Zhou, Tianyi Xu, Chao Wang, Terry Jones, Ramsey Badawi, Guobao Wang
JOURNAL OF NUCLEAR MEDICINE
(2019)
Meeting Abstract
Radiology, Nuclear Medicine & Medical Imaging
Tao Feng, Yizhang Zhao, Hongcheng Shi, Hongdi Li, Ramsey Badawi, Patricia Price, Terry Jones, Simon Cherry
JOURNAL OF NUCLEAR MEDICINE
(2019)
Meeting Abstract
Biochemical Research Methods
Simon Cherry
JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS
(2019)
Article
Radiology, Nuclear Medicine & Medical Imaging
Emilie Roncalii, Sun Il Kwon, Sebastien Jan, Eric Berg, Simon R. Cherry
BIOMEDICAL PHYSICS & ENGINEERING EXPRESS
(2019)
Article
Radiology, Nuclear Medicine & Medical Imaging
Peng Peng, Martin S. Judenhofer, Adam Q. Jones, Simon R. Cherry
BIOMEDICAL PHYSICS & ENGINEERING EXPRESS
(2019)