☆ 4.6 Article

Mini EXPLORER II: a prototype high-sensitivity PET/CT scanner for companion animal whole body and human brain scanning

PHYSICS IN MEDICINE AND BIOLOGY (2019)

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期刊

PHYSICS IN MEDICINE AND BIOLOGY
卷 64, 期 7, 页码 -

出版社

IOP PUBLISHING LTD
DOI: 10.1088/1361-6560/aafc6c

关键词

total-body PET; PET/CT; companion animal imaging; EXPLORER; brain PET

类别

Engineering, Biomedical Radiology, Nuclear Medicine & Medical Imaging

资金

  1. NIH [R01CA206187]

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As part of the EXPLORER total-body positron emission tomography (PET) project, we have designed and built a high-resolution, high-sensitivity PET/CT scanner, which is expected to have excellent performance for companion animal whole body and human brain imaging. The PET component has a ring diameter of 52 cm and an axial field of view of 48.3 cm. The detector modules are composed of arrays of lutetium (yttrium) oxyorthosilicate (LYSO) crystals of dimensions 2.76 x 2.76 x 18.1 mm(3) coupled to silicon photomultipliers (SiPMs) for read-out. The CT component is a 24 detector row CT scanner with a 50 kW x-ray tube. PET system time-of-flight resolution was measured to be 409 +/- 39 ps and average system energy resolution was 11.7% +/- 1.5% at 511 keV. The NEMA NU2-2012 system sensitivity was found to be 52-54 kcps MBq(-1). Spatial resolution was 2.6 mm at 10 mm from the center of the FOV and 2.0 mm rods were clearly resolved on a mini-Derenzo phantom. Peak noise-equivalent count (NEC) rate, using the NEMA NU 2-2012 phantom, was measured to be 314 kcps at 9.2 kBq cc(-1). The CT scanner passed the technical components of the American College of Radiology (ACR) accreditation tests. We have also performed scans of a Hoffman brain phantom and we show images from the first canine patient imaged on this device.

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