Article
Plant Sciences
Ruth E. Marquez-Lopez, Patricia Araceli Santiago-Garcia, Mercedes G. Lopez
Summary: In this study, the morphological diversity, carbohydrate composition, and fructan fluctuation during plant development were examined in two important Agave species, Agave angustifolia and Agave potatorum, in Mexico. The results showed morphological divergence and differences in carbohydrate composition between the two species.
Article
Multidisciplinary Sciences
May Ling Lu, Charles E. Wyman
Summary: Biofuels have the potential to help California quickly reduce greenhouse gas emissions in the transportation sector, with agave being a particularly promising energy crop due to its drought tolerance and high productivity. Compositional analysis of wild A. deserti and cultivated A. americana suggests they can be rich in fructans and have low recalcitrance, making them potential biofuel feedstocks in the State.
Article
Multidisciplinary Sciences
Luis Francisco Salome-Abarca, Ruth Esperanza Marquez-Lopez, Mercedes G. Lopez
Summary: This study focused on the characterization of carbohydrates in the bulbs of Agave amica, testing its feasibility as a model for the study of agavins. The analysis showed potential content of fructans and a mixture of branched fructans in the bulbs. The study also demonstrated the correlation between the presence of agavins and the phenology of A. amica, highlighting its potential as a new biological model for the study of agavins' metabolism.
SCIENTIFIC REPORTS
(2023)
Article
Biotechnology & Applied Microbiology
Nayeli Martha-Lucero, Gustavo Viniegra-Gonzalez, Luis Gonzalez-Olivares, Alma Cruz-Guerrero
Summary: The aim of this study was to investigate the formation of biofilms by lactic acid bacteria (LAB) using agave fructans as substrates. The results showed that LAB strains Lacticaseibacillus and Enterococcus isolated from agave plants were able to produce exopolysaccharides directly from agave fructans. This finding has significant implications for industrial lactic acid production using agave fructans.
WORLD JOURNAL OF MICROBIOLOGY & BIOTECHNOLOGY
(2023)
Review
Food Science & Technology
Ndegwa H. Maina, Anne Rieder, Yamina De Bondt, Noora Maekelae-Salmi, Stefan Sahlstrom, Outi Mattila, Lisa M. Lamothe, Laura Nystroem, Christophe M. Courtin, Kati Katina, Kaisa Poutanen
Summary: Daily consumption of wholegrain foods rich in dietary fiber can reduce the risk of chronic diseases, as the diverse components of cereal fiber play a key role in influencing food digestion and nutrient absorption throughout the gastrointestinal tract. Understanding the effects of food processing on fiber components is crucial for maximizing the health benefits associated with whole grains.
Review
Nutrition & Dietetics
Ludovico Abenavoli, Tiziana Larussa, Alessandro Corea, Anna Caterina Procopio, Luigi Boccuto, Marcello Dallio, Alessandro Federico, Francesco Luzza
Summary: NAFLD, characterized by a wide spectrum of liver disorders, is considered a major public health issue globally. Polyphenols, known for their anti-inflammatory and antioxidant properties, are believed to have potential benefits in preventing and treating NAFLD, though limited human clinical trials are available.
Review
Food Science & Technology
Hugo Espinosa-Andrews, Judith Esmeralda Urias-Silvas, Norma Morales-Hernandez
Summary: Agave fructans are natural reserve carbohydrates in agave plants and have been used as functional ingredients in food products due to their technological properties and health benefits. They promote the growth of beneficial bacteria, regulate serum glucose, lessen health problems associated with obesity, favor calcium absorption, and have chemoprotective, immunomodulatory, and antioxidant effects. Agave fructans also improve flavor, color, texture, sweetness, and sensory attributes in various food applications.
TRENDS IN FOOD SCIENCE & TECHNOLOGY
(2021)
Article
Nutrition & Dietetics
Brenda Hildeliza Camacho-Diaz, Martha Lucia Arenas-Ocampo, Perla Osorio-Diaz, Antonio Ruperto Jimenez-Aparicio, Guadalupe Monserrat Alvarado-Jasso, Eden Valfre Saavedra-Briones, Miguel angel Valdovinos-Diaz, Elisa Gomez-Reyes
Summary: Irritable bowel syndrome has three subtypes: constipation, diarrhea, and mixed. Dietary fiber treatment is used for different subtypes considering the fiber's composition. The low-FODMAPs diet is recommended for IBS-D subtype, while prebiotics and probiotics are suggested for IBS-C subtype. This study assessed the effects of using agave fructans as soluble fiber in a jelly for the IBS-C group, resulting in improved bowel movements, quality of life, and reduced anxiety and depression.
Article
Food Science & Technology
Maria Guadalupe Sosa-Herrera, Laura Patricia Martinez-Padilla, Virginia Agustina Delgado-Reyes, Maria de los Angeles de Avila Ortega, Irene Paulina Cruz Martinez
Summary: This study evaluated the influence of agave fructans and xanthan on the rheological and physicochemical properties of aqueous phases and emulsions. The interactions between agave fructans and sodium caseinate, as well as agave fructans and xanthan, modified the flow behavior and stability of the systems. These findings are important for designing stable functional emulsions, particularly when using agave fructans as dietary fiber.
JOURNAL OF FOOD SCIENCE
(2022)
Article
Food Science & Technology
Cesar Ozuna, Elena Franco-Robles
Summary: This critical review provides an overview of recent scientific research regarding the applications of agave syrup in the food industry and its effects on consumer health. While agave syrup contains some natural compounds with potential health benefits, its high fructose concentration can have serious adverse effects on human health. Therefore, there is a need to find ways to reduce the health risks and adverse effects of fructose intake while maintaining its technological properties for food product development.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2022)
Article
Food Science & Technology
Martha Lucia Arenas Ocampo, Idanelly Celeste Figueroa-Arriaga, Herminia Lopez-Salazar, Sandra Victoria Avila Reyes, Perla Osorio Diaz, Maria Araceli Ortiz Rodriguez, Maribel Lucila Herrera-Ruiz, Brenda Hildeliza Camacho-Diaz
Summary: This study investigated the potential health effects of consuming bread enriched with agave fructans, beta-cyclodextrins, and probiotics on the health of growing mice. The results showed that the bread enriched with agave fructans, beta-cyclodextrins, and probiotics can improve blood glucose levels and intestinal structure in mice.
JOURNAL OF FUNCTIONAL FOODS
(2023)
Review
Biochemistry & Molecular Biology
Guilherme da Silva Ferreira, Sergio Catanozi, Marisa Passarelli
Summary: Restriction in sodium intake is important for reducing cardiovascular diseases, but the influence on the development of nonalcoholic fatty liver disease (NAFLD) has been less studied. This systematic review compiled evidence from human and animal studies to examine the influence of dietary sodium intake patterns on NAFLD markers;
Article
Plant Sciences
Amneris IraidaCastillo Andrade, Erika Garcia Chavez, Cecilia Rivera Bautista, Cuauhtemoc Oros Ovalle, Miguel Angel Ruiz Cabrera, Alicia Grajales Lagunes
Summary: The consumption of Agave salmiana fructans showed positive effects on the epithelial health of the colon, increasing mucus-secreting cells and reducing TNF-alpha concentrations. A dose of 12.5% fructans helped maintain cell structure and decrease inflammation, demonstrating health benefits in the colon over a 35-day period.
FRONTIERS IN PLANT SCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Rogelio Rodriguez-Rodriguez, Paloma Barajas-Alvarez, Norma Morales-Hernandez, Rosa Maria Camacho-Ruiz, Hugo Espinosa-Andrews
Summary: This research developed gelatine-based gels using carbohydrates from Azul variety of Agave tequilana as substitutes for sucrose and glucose. The gel formulations with agave syrups and agave fructans showed improved techno-functional properties and prebiotic effects, making them suitable for producing gel soft candies.
Article
Biochemistry & Molecular Biology
Kamila Koj, Ewa Pejcz
Summary: This study aimed to investigate the changes in complex carbohydrate contents in sourdoughs inoculated with potential probiotic microorganisms and the polysaccharide composition of the resulting bread. The results showed that the inoculation of potential probiotic strains increased the total content of arabinoxylans in the bread and improved their solubility in water. The use of the S.boulardii strain appeared to have the greatest potential in reducing fructans in rye bread. Rye sourdough bread is a promising source of dietary fiber that can be tailored to different nutritional needs.
Article
Medicine, Research & Experimental
Paulina Maria Reyes-Mata, Argelia Esperanza Rojas-Mayorquin, Lucrecia Carrera-Quintanar, Celia Gonzalez-Castillo, Mario Alberto Mireles-Ramirez, Jose de Jesus Guerrero-Garcia, Daniel Ortuno-Sahagun
Summary: This study aimed to investigate the serum levels of Pleiotrophin (PTN) in patients with Multiple Sclerosis (MS). The results showed that PTN serum levels were significantly higher in RRMS patients compared to the healthy control group, and were associated with sex, body mass index (BMI), and IFN-beta treatment.
ARCHIVES OF MEDICAL RESEARCH
(2022)
Article
Engineering, Environmental
Mayra Alejandra Lopez-Ortega, Adriana Ines Rodriguez-Hernandez, Norberto Chavarria-Hernandez, Ma Del Rocio Lopez-Cuellar, Yolanda Gonzalez-Garcia, Jesus Cordova, Alejandra Barbachano-Torres, Rosa M. Camacho-Ruiz
Summary: This study characterized the EPS synthesized by a halophilic bacterium Salibacterium halochares STm isolated from saline soil in Mexico. The EPS showed high emulsification indexes against various non-polar substances and retained stability under harsh conditions, with potential industrial applications as an emulsion stabilizer, viscosity modifier, and thickener.
JOURNAL OF POLYMERS AND THE ENVIRONMENT
(2022)
Review
Cell Biology
Mercedes A. Hernandez-Sapiens, Edwin E. Reza-Zaldivar, Ana L. Marquez-Aguirre, Ulises Gomez-Pinedo, Jorge Matias-Guiu, Ricardo R. Cevallos, Juan C. Mateos-Diaz, Victor J. Sanchez-Gonzalez, Alejandro A. Canales-Aguirre
Summary: This article discusses the neuronal differentiation dysregulation mediated by PSEN1 mutations in Alzheimer's disease, emphasizing the importance of Alzheimer's disease-induced pluripotent stem cell models in analyzing the implication of PSEN1 mutations in the early stages of Alzheimer's disease pathogenesis.
NEURAL REGENERATION RESEARCH
(2022)
Article
Pharmacology & Pharmacy
Arturo Orozco-Barocio, Blanca Susana Robles-Rodriguez, Maria del Rayo Camacho-Corona, Luis Fernando Mendez-Lopez, Marisol Godinez-Rubi, Jorge Peregrina-Sandoval, Gildardo Rivera, Argelia E. Rojas Mayorquin, Daniel Ortuno-Sahagun
Summary: This study found that extracts of L. schottii have cytotoxic effects on cancer cells and splenocytes, with the polar fraction being the most effective. The main secondary metabolites present are flavonoids and alkaloids.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Cell Biology
Foteini Vasilopoulou, Aina Bellver-Sanchis, Julia Companys-Alemany, Julia Jarne-Ferrer, Alba Irisarri, Veronica Palomera-Avalos, Celia Gonzalez-Castillo, Daniel Ortuno-Sahagun, Coral Sanfeliu, Merce Pallas, Christian Grinan-Ferre
Summary: This study investigates the molecular mechanisms underlying the behavioural and psychological symptoms of dementia (BPSD) in Alzheimer's Disease (AD) patients. It suggests that epigenetic modulation, particularly through G9a methyltransferase and its histone mark (H3K9me2), plays a key role in shaping learning and memory. The study also reveals the association between increased levels of G9a, autophagic deficits, and alterations in synaptic plasticity, providing further understanding of the cognitive decline and BPSD exhibited by the AD model.
Review
Cell Biology
Daniel Ortuno-Sahagun, Julia Enterria-Rosales, Vanesa Izquierdo, Christian Grinan-Ferre, Merce Pallas, Celia Gonzalez-Castillo
Summary: This article discusses the important role of the miR-17-92 cluster in regulating cellular metabolism and autophagy, as well as its potential involvement in the pathogenesis of lysosomal storage diseases.
Article
Biochemistry & Molecular Biology
Maria Paulina Reyes-Mata, Mario Alberto Mireles-Ramirez, Christian Grinan-Ferre, Merce Pallas, Lenin Pavon, Jose de Jesus Guerrero-Garcia, Daniel Ortuno-Sahagun
Summary: Multiple sclerosis is a chronic disease characterized by an autoimmune attack on axonal myelin sheaths in the central nervous system. Epigenetics has been studied as a research topic in the search for biomarkers and treatment targets for this disease. This study examined epigenetic marks in Peripheral Blood Mononuclear Cells (PBMCs) from MS patients treated with IFN-beta and GA or untreated, as well as healthy controls, and found that DNA methylation decreased in treated patients and correlated with clinical variables. However, no biomarker has been identified to predict treatment response before initiation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Physical
Jose Martin Marquez-Villa, Juan Carlos Mateos-Diaz, Jorge A. Rodriguez, Rosa Maria Camacho-Ruiz
Summary: The synthesis of butyl oleate by the lipase B from Candida antarctica (CalB) was studied in a reverse micellar system under extreme halophilic conditions. The impact of aqueous content and NaCl variation on the enzymatic activity of CalB in the butyl oleate reaction in reverse micelles was investigated. The results showed that increasing NaCl concentration led to higher enzymatic activity, reaching a maximum of 444.85 μmol/min at 5 M NaCl and Wo = 10, with pH 7.2 and 30 degrees C being the optimal conditions. However, the synthesis of butyl oleate by lipase CalB increased due to the reduction in the average reverse micelle size, as determined by dynamic light scattering (DLS). This study demonstrated the potential of reverse micelles as a system to enhance mass transport in heterogeneous biocatalysis and highlighted their promise for extreme halophilic lipases research.
Editorial Material
Neurosciences
Daniel Ortuno-Sahagun, Juan Rafael Riesgo-Escovar
FRONTIERS IN NEUROSCIENCE
(2023)
Review
Immunology
Pilar Flores-Espinosa, Isabel Mendez, Claudine Irles, Andrea Olmos-Ortiz, Cecilia Helguera-Repetto, Ismael Mancilla-Herrera, Daniel Ortuno-Sahagun, Vincent Goffin, Veronica Zaga-Clavellina
Summary: The close interaction between fetal and maternal cells during pregnancy requires various immune-endocrine mechanisms to provide a tolerant environment for the fetus and protect it against infections. Prolactin (PRL), a hormone synthesized by the maternal decidua, is transported through the amnion-chorion and accumulates in the amniotic cavity, creating a hyperprolactinemic environment for the fetus. PRL has multiple immunomodulatory functions, but its precise role at the maternal-fetal interface is still not fully understood. This review summarizes the current knowledge on the immunological effects of PRL and its biological significance for the immune privilege of the maternal-fetal interface.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Medicine, General & Internal
Oscar Pizano-Martinez, Edgar Mendieta-Condado, Monica Vazquez-Del Mercado, Erika Aurora Martinez-Garcia, Efrain Chavarria-Avila, Daniel Ortuno-Sahagun, Ana Laura Marquez-Aguirre
Summary: Autoimmune rheumatic diseases are a group of heterogeneous disorders characterized by clinical symptoms such as pain, tissue damage, immune deregulation, and inflammation. Biologic disease-modifying antirheumatic drugs are effective treatments, but their complexity can induce the development of anti-drug antibodies. TNF inhibitors, widely used in rheumatoid arthritis, appear to be the main contributors to immunogenicity. This review provides an overview of the immunogenicity of biological agents in autoimmune rheumatic diseases, focusing on the prevalence of anti-drug antibodies.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Cell Biology
Margarita Belem Santana-Bejarano, Paula Romina Grosso-Martinez, Ana Graciela Puebla-Mora, Maria Guadalupe Martinez-Silva, Mario Nava-Villalba, Ana Laura Marquez-Aguirre, Daniel Ortuno-Sahagun, Marisol Godinez-Rubi
Summary: The study investigated the expression of PTN and its receptors in the human cerebellar cortex during fetal and early neonatal development. The results showed that PTN, PTPRZ1, and NRP-1 were expressed from week 17 to the postnatal stage, while ALK was only expressed during week 31. These findings suggest that PTN is involved in cell communication during cerebellar development.
Article
Microbiology
Mariana Delgado-Garcia, Osvaldo Gomez-Secundino, Jorge A. Rodriguez, Juan Carlos Mateos-Diaz, Marcelo Muller-Santos, Cristobal N. Aguilar, Rosa Maria Camacho-Ruiz
Summary: This study aims to characterize bacterioruberin and its isomers, explore their antioxidant activity, and evaluate their MMP-9 inhibition activity in extracts from Natronoccoccus sp. TC6 and Halorubrum tebenquichense SU10.
Review
Rheumatology
B. -t. Martin-Marquez, F. Sandoval-Garcia, F. -i. Corona-Meraz, M. -h. Petri, Y. -k. Gutierrez-Mercado, M. Vazquez-Del Mercado
Summary: This review highlights the role of osteopontin in systemic lupus erythematosus and neuropsychiatric SLE and discusses the associated immunopathology mechanisms.
CLINICAL AND EXPERIMENTAL RHEUMATOLOGY
(2022)
