A chemical chaperone induces inhomogeneous conformational changes in flexible proteins

Microscopic significance of hydrophobic residues in the protein-stabilizing effect of trimethylamine N-oxide (TMAO)

(2016) Yanmei Yang et al.   PHYSICAL CHEMISTRY CHEMICAL PHYSICS

Trimethylamine-N-oxide switches from stabilizing nature: A mechanistic outlook through experimental techniques and molecular dynamics simulation

(2016) Anjeeta Rani et al.   Scientific Reports

Flavin–Protein Complexes: Aromatic Stacking Assisted by a Hydrogen Bond

(2015) Djemel Hamdane et al.   BIOCHEMISTRY

Density and Volumetric Properties of Aqueous Solutions of Trimethylamine N-Oxide in the Temperature Range from (278.15 to 323.15) K and at Pressures up to 100 MPa

(2015) Dmitriy M. Makarov et al.   JOURNAL OF CHEMICAL AND ENGINEERING DATA

Discovery of multiple hidden allosteric sites by combining Markov state models and experiments

(2015) Gregory R. Bowman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

How osmolytes influence hydrophobic polymer conformations: A unified view from experiment and theory

(2015) Jagannath Mondal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Classification of Chemical Chaperones Based on Their Effect on Protein Folding Landscapes

(2014) Rohan Dandage et al.   ACS Chemical Biology

Physicochemical Properties of Cells and Their Effects on Intrinsically Disordered Proteins (IDPs)

(2014) Francois-Xavier Theillet et al.   CHEMICAL REVIEWS

Protein Stabilization by Macromolecular Crowding through Enthalpy Rather Than Entropy

(2014) Michael Senske et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Energy landscapes of functional proteins are inherently risky

(2014) Anne Gershenson et al.   Nature Chemical Biology

Irreversible Denaturation of Maltodextrin Glucosidase Studied by Differential Scanning Calorimetry, Circular Dichroism, and Turbidity Measurements

(2014) Megha Goyal et al.   PLoS One

Microscopic insights into the protein-stabilizing effect of trimethylamine N-oxide (TMAO)

(2014) J. Ma et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Engineering of Flexible Loops in Enzymes

(2014) Bettina M. Nestl et al.   ACS Catalysis

Cosolvent Effects on Protein Stability

(2013) Deepak R. Canchi et al.   Annual Review of Physical Chemistry

Activation of a Unique Flavin-Dependent tRNA-Methylating Agent

(2013) Djemel Hamdane et al.   BIOCHEMISTRY

Overview of the Stability of α-Chymotrypsin in Different Solvent Media

(2012) Awanish Kumar et al.   CHEMICAL REVIEWS

Molten globules, entropy-driven conformational change and protein folding

(2012) Robert L Baldwin et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Packing in molten globules and native states

(2012) Sanchari Bhattacharyya et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Molecular Mechanism for the Preferential Exclusion of TMAO from Protein Surfaces

(2012) Deepak R. Canchi et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Volume Exclusion and H-Bonding Dominate the Thermodynamics and Solvation of Trimethylamine-N-oxide in Aqueous Urea

(2012) Jörg Rösgen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

FAD/Folate-Dependent tRNA Methyltransferase: Flavin as a New Methyl-Transfer Agent

(2012) Djemel Hamdane et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Modulation of a Pre-existing Conformational Equilibrium Tunes Adenylate Kinase Activity

(2012) Jörgen Ådén et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Chemical chaperones assist intracellular folding to buffer mutational variations

(2012) Anannya Bandyopadhyay et al.   Nature Chemical Biology

Counteracting chemical chaperone effects on the single-molecule  -synuclein structural landscape

(2012) A. C. M. Ferreon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Effect of Osmolytes on Protein Dynamics in the Lactate Dehydrogenase-Catalyzed Reaction

(2011) Nickolay Zhadin et al.   BIOCHEMISTRY

A Catalytic Intermediate and Several Flavin Redox States Stabilized by Folate-Dependent tRNA Methyltransferase fromBacillus subtilis

(2011) Djemel Hamdane et al.   BIOCHEMISTRY

Modulation of Functionally Significant Conformational Equilibria in Adenylate Kinase by High Concentrations of Trimethylamine Oxide Attributed to Volume Exclusion

(2011) Sureshbabu Nagarajan et al.   BIOPHYSICAL JOURNAL

Insights into Folate/FAD-dependent tRNA Methyltransferase Mechanism

(2011) Djemel Hamdane et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Osmolyte-Induced Folding of an Intrinsically Disordered Protein: Folding Mechanism in the Absence of Ligand

(2010) Yu-Chu Chang et al.   BIOCHEMISTRY

Key Residues that Play a Critical Role in Urea-Induced Lysozyme Unfolding

(2010) Meng Gao et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Conformational selection in the molten globule state of the nuclear coactivator binding domain of CBP

(2010) Magnus Kjaergaard et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Expression and purification of untagged and histidine-tagged folate-dependent tRNA:m5U54 methyltransferase from Bacillus subtilis

(2010) Djemel Hamdane et al.   PROTEIN EXPRESSION AND PURIFICATION

Counteraction of Urea by Trimethylamine N-Oxide Is Due to Direct Interaction

(2009) Filip Meersman et al.   BIOPHYSICAL JOURNAL

Interrupted Hydrogen/Deuterium Exchange Reveals the Stable Core of the Remarkably Helical Molten Globule of α-β Parallel Protein Flavodoxin

(2009) Sanne M. Nabuurs et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Topological Switching between an α−β Parallel Protein and a Remarkably Helical Molten Globule

(2009) Sanne M. Nabuurs et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Atomic structure of a folate/FAD-dependent tRNA T54 methyltransferase

(2009) H. Nishimasu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure and Energetics of the Hydrogen-Bonded Backbone in Protein Folding

(2008) D. Wayne Bolen et al.   Annual Review of Biochemistry

Macromolecular Crowding and Confinement: Biochemical, Biophysical, and Potential Physiological Consequences

(2008) Huan-Xiang Zhou et al.   Annual Review of Biophysics

Molten Globule and Native State Ensemble of Helicobacter pylori Flavodoxin: Can Crowding, Osmolytes or Cofactors Stabilize the Native Conformation Relative to the Molten Globule?

(2008) N. Cremades et al.   BIOPHYSICAL JOURNAL

Between-Species Variation in the Kinetic Stability of TIM Proteins Linked to Solvation-Barrier Free Energies

(2008) Miguel Costas et al.   JOURNAL OF MOLECULAR BIOLOGY

Urea denaturation by stronger dispersion interactions with proteins than water implies a 2-stage unfolding

(2008) L. Hua et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA