Review
Veterinary Sciences
Maimaiti Tuniyazi, Wenqing Wang, Naisheng Zhang
Summary: Fecal microbiota transplantation (FMT) is a technique that involves transferring fecal matter from a healthy donor to a recipient in order to restore a healthy gut microbiome. It has been used in horses to treat gastrointestinal disorders such as colitis and diarrhea. The authors conducted a systematic review of the existing literature to evaluate the efficacy, safety, and potential applications of FMT in horses.
VETERINARY SCIENCES
(2023)
Article
Medicine, General & Internal
Wenqiang Zhi, Wenzhu Song, Yasin Abdi Saed, Yi Wang, Yafeng Li
Summary: This report presents a case of IgA nephropathy (IgAN) in which FMT treatment was administered to a patient who showed an acute exacerbation with massive proteinuria and diarrhea. The treatment resulted in significant improvement in the patient's condition.
FRONTIERS IN MEDICINE
(2022)
Review
Microbiology
Caroline Jensen, Marie Fagervik Antonsen, Gulen Arslan Lied
Summary: The prevalence of food allergies has increased, and the modulation of gut microbiota is proposed as a potential strategy for prevention and treatment. This systematic review found differences in gut microbiota profiles between individuals with food allergies and healthy individuals. Fecal microbiota transplantation may be a promising strategy but requires further exploration.
Review
Psychiatry
Jing Zhang, Gang Zhu, Lin Wan, Yan Liang, Xinting Liu, Huimin Yan, Bo Zhang, Guang Yang
Summary: Through a systematic review of multiple studies, it was found that fecal microbiota transplantation (FMT) may be helpful in the treatment of autism spectrum disorder (ASD) by rebalancing the gut microbiome, potentially improving behavioral symptoms in children with ASD. Although five studies showed significantly improved neuropsychological assessment of ASD with FMT treatment, rigorously designed randomized controlled clinical trials are still needed to establish the safety and efficacy of FMT as a treatment for ASD.
FRONTIERS IN PSYCHIATRY
(2023)
Review
Health Care Sciences & Services
Andrea Pession, Daniele Zama, Edoardo Muratore, Davide Leardini, Davide Gori, Federica Guaraldi, Arcangelo Prete, Silvia Turroni, Patrizia Brigidi, Riccardo Masetti
Summary: FMT has been used in allo-HSCT patients for therapeutic and preventive purposes, but further research on the biological mechanisms is needed. Concerns exist regarding the safety and efficacy of administering microbial consortia in immune-compromised patients.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Review
Infectious Diseases
Jordan Macareno-Castro, Adan Solano-Salazar, Le Thanh Dong, Md Mohiuddin, J. Luis Espinoza
Summary: The prevalence of Carbapenem-resistant Enterobacteriaceae (CRE) has increased, and antibiotic combination regimens and fecal microbiota transplantation (FMT) have been used for treatment. This systematic review examines the use of FMT to eliminate CRE colonization and finds it to be a relatively safe and effective procedure. However, more research is needed to validate its safety and clinical utility.
JOURNAL OF INFECTION
(2022)
Review
Biochemistry & Molecular Biology
Adrian Boicean, Victoria Birlutiu, Cristian Ichim, Paula Anderco, Sabrina Birsan
Summary: Inflammatory bowel diseases (IBD) are complex diseases characterized by chronic inflammation in the gastrointestinal tract. Fecal microbiota transplantation (FMT) has shown increasing effectiveness and safety in treating recurrent Clostridium difficile infection (CDI) and co-infection of SARS-CoV-2 and CDI. By modifying the gut microbiota, FMT offers an alternative approach to indirectly influence the host's immune system in a safe way, improving clinical symptoms and endoscopic findings in IBD patients. Further validation is needed to establish a clinical protocol for FMT in IBD.
Review
Biochemistry & Molecular Biology
Adrian Boicean, Victoria Birlutiu, Cristian Ichim, Olga Brusnic, Danusia Maria Onisor, Amedeo Amedei, Ryota Niikura
Summary: Imbalances in the gut microbiota play a crucial role in the development of liver diseases, and fecal microbiota transplantation has shown promise as an effective treatment for chronic liver diseases and cirrhosis.
Review
Immunology
Yunxia Li, Siting Xia, Xiaohan Jiang, Can Feng, Saiming Gong, Jie Ma, Zhengfeng Fang, Jie Yin, Yulong Yin
Summary: Diarrhea is closely linked to gut microbiota, and reshaping gut microbiota through dietary probiotics or fecal bacteria transplantation can help prevent or treat diarrhea.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Gastroenterology & Hepatology
Maribeth R. Nicholson, Suchitra K. Hourigan, Maire Conrad, Alka Goyal, Kyle Jensen, Judith Kelsen, Melissa Kennedy, Madison Weatherly, Stacy A. Kahn
Summary: The impact of the 2019 US FDA safety alert and the COVID-19 pandemic on the use of FMT in children has led to changes in practices for many pediatric gastroenterologists, with a majority of programs being halted as a result.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2021)
Review
Biochemistry & Molecular Biology
Ivana Cibulkova, Veronika Rehorova, Jan Hajer, Frantisek Duska
Summary: The human gut microbiota is a dynamic ecosystem consisting of bacteria, archaea, fungi, and viruses that play a crucial role in maintaining human health. Dysbiosis, or disruption of the gut microbiota, can increase susceptibility to various diseases, leading to rapid overgrowth of pathogenic bacteria in critically ill patients. Restoring a healthy microbiota through fecal microbiota transplantation is a promising concept, especially in intensive care settings, but further research is needed to fully understand its potential benefits and safety in various clinical conditions.
Review
Endocrinology & Metabolism
Zecheng Li, Donghai Liu, Runchuan Gu, Qiao Yuan, Jin Qi, Yijia Zhang, Shuaman Ran, Xiaoqi Liu, Wang Yi, Mao Ni, Yijin Qin, Peng Liang, Wang Jun
Summary: This systematic review and meta-analysis investigated the effect of fecal microbiota transplantation (FMT) on microbiota engraftment in patients with metabolic syndrome. The study found a significant negative association between FMT and various clinically relevant parameters related to obesity and metabolic syndrome. FMT was shown to be more beneficial for obese patients with elevated blood pressure, disordered glucose and insulin metabolism, and elevated blood lipids.
DIABETES RESEARCH AND CLINICAL PRACTICE
(2023)
Review
Medicine, General & Internal
Yun Wang, Sheng Zhang, Thomas J. Borody, Faming Zhang
Summary: This review provides a comprehensive overview of the clinical applications of fecal microbiota transplantation (FMT) from 2011 to 2021. The study examines the clinical benefits, processing methodology, usage strategies, and global regulations of FMT. The findings suggest that while further controlled trials are needed, FMT shows promising potential for treating dysbiosis-related diseases in the gut or beyond.
CHINESE MEDICAL JOURNAL
(2022)
Review
Gastroenterology & Hepatology
Sasha R. Fehily, Chamara Basnayake, Emily K. Wright, Michael A. Kamm
Summary: Fecal microbiota transplantation (FMT) shows potential as an effective therapy for Crohn's disease in preliminary studies, but larger controlled trials are needed to confirm its efficacy. No serious safety concerns have been identified so far.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Review
Immunology
Hanghang Yuan, Ruirui Gui, Zhicheng Wang, Fang Fang, Hongguang Zhao
Summary: Colorectal cancer (CRC) is a common and deadly cancer that poses a major burden on human health. Gut microbiota regulate human immunity and metabolism through producing numerous metabolites, but the specific mechanisms by which gut microbiota interact with immunotherapy and radiotherapy remain incongruent. This review discusses recent advances and the potential of targeting gut microbiota to enhance the efficacy of radioimmunotherapy in CRC, providing references and fresh ideas for the clinical application of this novel strategy.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Gastroenterology & Hepatology
S. K. Hourigan, L. A. Chen, Z. Grigoryan, G. Laroche, M. Weidner, C. L. Sears, M. Oliva-Hemker
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2015)
Article
Gastroenterology & Hepatology
Victoria Grossi, Trudy Lerer, Anne Griffiths, Neal LeLeiko, Jose Cabrera, Anthony Otley, James Rick, David Mack, Athos Bousvaros, Joel Rosh, Andrew Grossman, Shehzaad Saeed, Marsha Kay, Brendan Boyle, Maria Oliva-Hemker, David Keljo, Marian Pfefferkorn, William Faubion, Michael D. Kappelman, Boris Sudel, James Markowitz, Jeffrey S. Hyams
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2015)
Article
Pediatrics
Maria Oliva-Hemker, Susan Hutfless, Elie S. Al Kazzi, Trudy Lerer, David Mack, Neal LeLeiko, Anne Griffiths, Jose Cabrera, Anthony Otley, James Rick, Athos Bousvaros, Joel Rosh, Andrew Grossman, Shehzad Saeed, Marsha Kay, Ryan Carvalho, David Keljo, Marian Pfefferkorn, William Faubion, Michael Kappelman, Boris Sudel, Marc E. Schaefer, James Markowitz, Jeffrey S. Hyams
JOURNAL OF PEDIATRICS
(2015)
Article
Multidisciplinary Sciences
David J. Cutler, Michael E. Zwick, David T. Okou, Sampath Prahalad, Thomas Walters, Stephen L. Guthery, Marla Dubinsky, Robert Baldassano, Wallace V. Crandall, Joel Rosh, James Markowitz, Michael Stephens, Richard Kellermayer, Marian Pfefferkorn, Melvin B. Heyman, Neal LeLeiko, David Mack, Dedrick Moulton, Michael D. Kappelman, Archana Kumar, Jarod Prince, Promita Bose, Kajari Mondal, Dhanya Ramachandran, John F. Bohnsack, Anne M. Griffiths, Yael Haberman, Jonah Essers, Susan D. Thompson, Bruce Aronow, David J. Keljo, Jeffrey S. Hyams, Lee A. Denson, Subra Kugathasan
Review
Gastroenterology & Hepatology
Suchitra K. Hourigan, Cynthia L. Sears, Maria Oliva-Hemker
INFLAMMATORY BOWEL DISEASES
(2016)
Article
Medicine, General & Internal
Subra Kugathasan, Lee A. Denson, Thomas D. Walters, Mi-Ok Kim, Urko M. Marigorta, Melanie Schirmer, Kajari Mondal, Chunyan Liu, Anne Griffiths, Joshua D. Noe, Wallace V. Crandall, Scott Snapper, Shervin Rabizadeh, Joel R. Rosh, Jason M. Shapiro, Stephen Guthery, David R. Mack, Richard Kellermayer, Michael D. Kappelman, Steven Steiner, Dedrick E. Moulton, David Keljo, Stanley Cohen, Maria Oliva-Hemker, Melvin B. Heyman, Anthony R. Otley, Susan S. Baker, Jonathan S. Evans, Barbara S. Kirschner, Ashish S. Patel, David Ziring, Bruce C. Trapnell, Francisco A. Sylvester, Michael C. Stephens, Robert N. Baldassano, James F. Markowitz, Judy Cho, Ramnik J. Xavier, Curtis Huttenhower, Bruce J. Aronow, Greg Gibson, Jeffrey S. Hyams, Marla C. Dubinsky
Article
Pediatrics
Marlene W. Borschel, Dean L. Antonson, Nancy D. Murray, Maria Oliva-Hemker, Lynn E. Mattis, Benny Kerzner, Vasundhara Tolia, Geraldine Baggs
Article
Gastroenterology & Hepatology
S. K. Hourigan, M. Oliva-Hemker, S. Hutfless
DIGESTIVE DISEASES AND SCIENCES
(2014)
Article
Gastroenterology & Hepatology
Thomas D. Walters, Mi-Ok Kim, Lee A. Denson, Anne M. Griffiths, Marla Dubinsky, James Markowitz, Robert Baldassano, Wallace Crandall, Joel Rosh, Marian Pfefferkorn, Anthony Otley, Melvin B. Heyman, Neal LeLeiko, Susan Baker, Stephen L. Guthery, Jonathan Evans, David Ziring, Richard Kellermayer, Michael Stephens, David Mack, Maria Oliva-Hemker, Ashish S. Patel, Barbara Kirschner, Dedrick Moulton, Stanley Cohen, Sandra Kim, Chunyan Liu, Jonah Essers, Subra Kugathasan, Jeffrey S. Hyams
Article
Gastroenterology & Hepatology
Suchitra K. Hourigan, Sankar R. Chirumamilla, Tracy Ross, Jonathan E. Golub, Shervin Rabizadeh, Shehzad A. Saeed, Charles O. Elson, Ciaran P. Kelly, Karen C. Carroll, Maria Oliva-Hemker, Cynthia Sears
INFLAMMATORY BOWEL DISEASES
(2013)
Article
Gastroenterology & Hepatology
Whitney Sunseri, Jeffrey S. Hyams, Trudy Lerer, David R. Mack, Anne M. Griffiths, Anthony R. Otley, Joel R. Rosh, Ryan Carvalho, Andrew B. Grossman, Jose Cabrera, Marian D. Pfefferkorn, James Rick, Neal S. Leleiko, Meredith C. Hitch, Maria Oliva-Hemker, Shehzad A. Saeed, Michael Kappelman, James Markowitz, David J. Keljo
INFLAMMATORY BOWEL DISEASES
(2014)
Article
Radiology, Nuclear Medicine & Medical Imaging
T. Bosemani, A. Ozturk, A. Tekes, M. O. Hemker, T. A. G. M. Huisman
Article
Gastroenterology & Hepatology
Bella Zeisler, Trudy Lerer, James Markowitz, David Mack, Anne Griffiths, Athos Bousvaros, David Keljo, Joel Rosh, Jonathan Evans, Michael Kappelman, Anthony Otley, Marsha Kay, Andrew Grossman, Shehzad Saeed, Ryan Carvalho, Maria Oliva-Hemker, William Faubion, Boris Sudel, Marian Pfefferkorn, Farhat Ashai-Khan, Neal LeLeiko, Jeffrey Hyams
JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION
(2013)
Article
Gastroenterology & Hepatology
Alka Goyal, Jeffery S. Hyams, Trudy Lerer, Neal S. Leleiko, Anthony R. Otley, Anne M. Griffiths, Joel R. Rosh, Jose M. Cabrera, Maria M. Oliva-Hemker, David R. Mack, James N. Rick, Marian D. Pfefferkorn, Ryan Carvalho, Andrew B. Grossman, Meredith C. Hitch, Boris Sudel, Michael D. Kappelman, Shehzad A. Saeed, William A. Faubion, Marc E. Schaefer, James F. Markowitz, David J. Keljo
JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION
(2014)