Article
Chemistry, Multidisciplinary
Carmen C. Piras, Anna K. Patterson, David K. Smith
Summary: This study describes the fabrication of new pH-responsive hybrid gel beads and explores the impact of different gelator combinations on drug release performance. By controlling the formulation of gel beads, drug release under different pH conditions can be achieved. These gel beads show promising potential for controlled drug delivery applications.
CHEMISTRY-A EUROPEAN JOURNAL
(2021)
Article
Chemistry, Multidisciplinary
Protap Biswas, Hemanta Kumar Datta, Parthasarathi Dastidar
Summary: Metallogelators/metallogels derived from a series of multi-NSAID-based Zn(ii)-coordination complexes exhibit anti-cancer and anti-bacterial properties, designed as potential multi-drug self-delivery systems based on structural rationale.
CHEMICAL COMMUNICATIONS
(2022)
Article
Microbiology
Jeremy Ardanuy, Robert Johnson, Carly Dillen, Louis Taylor, Holly Hammond, Stuart Weston, Matthew Frieman
Summary: Pyronaridine triphosphate has demonstrated efficacy in inhibiting SARS-CoV-2 infection and reducing lung inflammation in both cellular and animal models. It can be combined with current COVID-19 treatments to further inhibit viral infections. Pyronaridine represents a promising therapeutic option for COVID-19 and future coronavirus outbreaks.
Article
Pharmacology & Pharmacy
Yewon Park, Joo Young Na, Joo-Youn Cho, Jaeseong Oh, Su-jin Rhee
Summary: Current understanding suggests that a cytokine storm plays a major role in COVID-19 mortality, leading to the proposal of anti-inflammatory therapeutics for severe patients. This study proposed a clinical trial design for the development of anti-inflammatory agents for COVID-19 treatment, considering the physiological and immunological processes of the disease.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Chemistry, Multidisciplinary
Jasmin Omar, Daniel Ponsford, Cecile A. Dreiss, Tung-Chun Lee, Xian Jun Loh
Summary: This article provides a detailed overview of the dynamic chemistry and design strategies behind supramolecular hydrogel formation, as well as the potential applications in the field of medicine and the considerations for further development.
CHEMISTRY-AN ASIAN JOURNAL
(2022)
Article
Chemistry, Organic
Giacomo Picci, M. Carla Aragoni, Massimiliano Arca, Claudia Caltagirone, Mauro Formica, Vieri Fusi, Luca Giorgi, Filippo Ingargiola, Vito Lippolis, Eleonora Macedi, Luca Mancini, Liviana Mummolo, Luca Prodi
Summary: Bis-squaramide receptors L1-L4 with a dansyl moiety were synthesized and their potential as fluorescent probes for the nonsteroidal anti-inflammatory drugs naproxen and ketoprofen was investigated. Photophysical characterization showed that macrocyclic receptors L1 and L2 exhibited good sensitivity towards ketoprofen with an ON-OFF fluorescent response, while open chain receptors L3 and L4 showed similar behavior with the three guests studied. Theoretical calculations and NMR spectroscopy confirmed the interaction between the receptors and the guests through H-bonds.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Santanu Panja, Bart Dietrich, Adriana Trabold, Agata Zydel, Aleena Qadir, Dave J. Adams
Summary: By increasing the hydrophobic chain length, the properties of the resulting multicomponent systems can be altered to exhibit ambidextrous phase behavior on pH perturbation.
CHEMICAL COMMUNICATIONS
(2021)
Article
Chemistry, Multidisciplinary
Yutaka Ohsedo
Summary: Low-molecular-weight hydrogelators containing stearoyl, glycine, and D-glucamine moieties with or without methyl groups were synthesized to prepare chemically tuned molecular hydrogels. The role of hydrogen bonding in hydrogel formation was evaluated by synthesizing hydrogelators with or without methyl groups at their N-H in amide groups, resulting in the formation of fiber in molecular hydrogels. The obtained hydrogels exhibited improved thixotropic performance with tunable softness, and the thixotropic cycles depended on the methyl substitution positions in the hydrogelators. Chemical modification to change the positions of hydrogen bonds allowed for tuning of the mechanical properties of molecular gels.
CHEMISTRY-AN ASIAN JOURNAL
(2022)
Article
Nanoscience & Nanotechnology
Ning Li, He-Kuan Luo, Adrielle Xianwen Chen, Jeremy Pang Kern Tan, Chuan Yang, Melgious Jin Yan Ang, Huaqiang Zeng, Yi Yan Yang
Summary: This study introduces a novel class of supramolecules with highly potent antimicrobial activities. These supramolecules exhibit high antimicrobial potency against various bacteria and fungus, with negligible toxicity to mammalian cells.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Chemistry, Multidisciplinary
Carmen C. Piras, David K. Smith
Summary: Hybrid gel beads combining low-molecular-weight gelator with polymer gelator demonstrate enhanced self-propulsion in water. These beads show potential for effectively accumulating dye pollutants and have promising environmental and biological applications.
CHEMISTRY-A EUROPEAN JOURNAL
(2021)
Article
Chemistry, Multidisciplinary
Martin Molkenthin, Werner M. Nau, Boris J. Nachtsheim
Summary: Two minimalistic diketopiperazine-based gelators with efficient gelation abilities through multiple stimuli for hydrogelation and organogelation, respectively, were reported. Insights into the aggregation and gelation properties were gained through examination of the photophysical and material properties of selected gels, representative of different modes of gelation. The modular synthesis of gelators based on readily available amino acid building blocks allows efficient diversification and fine-tuning of gel properties.
CHEMISTRY-A EUROPEAN JOURNAL
(2021)
Article
Chemistry, Multidisciplinary
Jie Yang, Dihua Dai, Lianjun Ma, Ying-Wei Yang
Summary: By utilizing water-soluble macrocyclic hosts like CLT6 and CBpP6, this study successfully loaded the chemotherapy drug oxaliplatin, and achieved drug release through competitive binding, leading to enhanced cytotoxicity in cancer cells while reducing toxicity in normal cells, offering a new approach to reduce side effects of anticancer drugs.
CHINESE CHEMICAL LETTERS
(2021)
Article
Chemistry, Multidisciplinary
Julien Es Sayed, Mohammad Khoonkari, Marta Oggioni, Patrick Perrin, Nicolas Sanson, Marleen Kamperman, Malgorzata Katarzyna Wlodarczyk-Biegun
Summary: A new hydrogel ink is proposed, which is made of micro-gels and metal ligands, enabling the printed scaffold to remain stable under specific conditions while also having the ability to disintegrate. This ink exhibits good rheological characteristics and maintains scaffold integrity after curing.
ADVANCED FUNCTIONAL MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Canglei Yang, Lixing Luo, Jinqiu Chen, Bo Yang, Wei Wang, Hebin Wang, Guankui Long, Guangfeng Liu, Jing Zhang, Wei Huang
Summary: The translation discusses the synthesis of helical structures from achiral molecules and the importance of stimulus-responsive shape transformations in biomimetics and mechanical actuators. By studying the helix motion kinetics of Form 1 crystal and the growth process of self-assembled helical microstructures, a new approach in achieving helical morphologies is illustrated.
CHEMICAL COMMUNICATIONS
(2021)
Article
Chemistry, Multidisciplinary
Alice Johnson, Chibuzor Olelewe, Jong Hyun Kim, Joshua Northcote-Smith, R. Tyler Mertens, Ginevra Passeri, Kuldip Singh, Samuel G. Awuah, Kogularamanan Suntharalingam
Summary: The study reports on the anti-breast cancer stem cell (CSC) properties of gold(I) complexes containing various non-steroidal anti-inflammatory drugs (NSAIDs) and triphenylphosphine 1-8. A significant finding is that the gold(I)-NSAID complex 1 is more effective against breast CSCs than bulk breast cancer cells, with a potency up to 80-fold higher. Mechanistically, complex 1 induces breast CSC death through a series of cellular processes including entry, localization, oxidative stress, and apoptosis. Furthermore, complex 1 demonstrates promising inhibitory effects on tumor growth in animals.