期刊
CHEMISTRY-AN ASIAN JOURNAL
卷 10, 期 7, 页码 1457-1462出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/asia.201500232
关键词
drug delivery; magnetic-guided chemotherapy; nanoparticles; iron oxide; Prussian blue
资金
- Culture Affairs & Missions Sector of the Ministry of Higher Education in Egypt
- Ministry of Science and Technology (MOST), Taiwan [101-2628-E-002-015-MY3]
- National Taiwan University [102R7842, 102R7740, 102R104100]
- Center of Strategic Materials Alliance for Research and Technology (SMART Center)
- National Health Research Institutes of Taiwan [03A1-BNMP14-014]
New nanoporous iron oxide nanoparticles with superparamagnetic behavior were successfully synthesized from Prussian blue (PB) nanocubes through a thermal conversion method and applied to the intracellular drug-delivery systems (DDS) of bladder cancer cells (i.e., T24) with controlled release and magnetic guiding properties. The results of the MTT assay and confocal laser scanning microscopy indicate that the synthesized iron oxide nanoparticles were successfully uptaken by T24 cells with excellent biocompatibility. An anticancer drug, that is, cisplatin, was used as a model drug, and its loading/release behavior was investigated. The intracellular drug delivery efficiency was greatly enhanced for the cisplatin-loaded, PB-derived, magnetic-guided drug-delivery system compared with the non-drug case. The synthesized nanomaterials show great potential as drug vehicles with high biocompatibility, controlled release, and magnetic targeting features for future intracellular DDS.
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