Rapid Generation and Safe Use of Carbenes Enabled by a Novel Flow Protocol with In-line IR spectroscopy

Flow chemistry as a discovery tool to access sp2–sp3 cross-coupling reactions via diazo compounds

(2015) Duc N. Tran et al.   Chemical Science

Taming Hazardous Chemistry in Flow: The Continuous Processing of Diazo and Diazonium Compounds

(2014) Benjamin J. Deadman et al.   CHEMISTRY-A EUROPEAN JOURNAL

Diazo Compounds in Continuous-Flow Technology

(2014) Simon T. R. Müller et al.   ChemSusChem

Continuous Flow Synthesis of α-Halo Ketones: Essential Building Blocks of Antiretroviral Agents

(2014) Vagner D. Pinho et al.   JOURNAL OF ORGANIC CHEMISTRY

Safe Generation and Direct Use of Diazoesters in Flow Chemistry

(2014) Thomas Wirth et al.   SYNLETT

Novel Multicomponent Reactions via Trapping of Protic Onium Ylides with Electrophiles

(2013) Xin Guo et al.   ACCOUNTS OF CHEMICAL RESEARCH

“Batch” Kinetics in Flow: Online IR Analysis and Continuous Control

(2013) Jason S. Moore et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Continuous-Flow Oxidative Cyanation of Primary and Secondary Amines Using Singlet Oxygen

(2013) Dmitry B. Ushakov et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Catalytic X–H insertion reactions based on carbenoids

(2013) Dennis Gillingham et al.   CHEMICAL SOCIETY REVIEWS

Continuous flow synthesis of toxic ethyl diazoacetate for utilization in an integrated microfluidic system

(2013) Ram Awatar Maurya et al.   GREEN CHEMISTRY

Cross-Coupling Reactions Involving Metal Carbene: From C═C/C–C Bond Formation to C–H Bond Functionalization

(2013) Zhenxing Liu et al.   JOURNAL OF ORGANIC CHEMISTRY

Copper-Catalyzed B–H Bond Insertion Reaction: A Highly Efficient and Enantioselective C–B Bond-Forming Reaction with Amine–Borane and Phosphine–Borane Adducts

(2013) Qing-Qing Cheng et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Hydrogen-Free Alkene Reduction in Continuous Flow

(2013) Andrew S. Kleinke et al.   ORGANIC LETTERS

Continuous Flow Generation and Reactions of Anhydrous Diazomethane Using a Teflon AF-2400 Tube-in-Tube Reactor

(2013) Federica Mastronardi et al.   ORGANIC LETTERS

Efficient synthesis of α-aryl serine derivatives via three-component reactions of aryldiazoacetates, anilines and formaldehyde

(2013) Chengjin Wang et al.   TETRAHEDRON

Continuous-flow generation of diazoesters and their direct use in S–H and P–H insertion reactions: synthesis of α-sulfanyl, α-sulfonyl, and α-phosphono carboxylates

(2013) Hannah E. Bartrum et al.   TETRAHEDRON

Intramolecular generation and rearrangement of oxonium ylides: methodology studies and their application in synthesis

(2013) Graham K. Murphy et al.   TETRAHEDRON

Highly enantioselective S–H bond insertion cooperatively catalyzed by dirhodium complexes and chiral spiro phosphoric acids

(2013) Bin Xu et al.   Chemical Science

Highly Diastereoselective Multicomponent Cascade Reactions: Efficient Synthesis of Functionalized 1-Indanols

(2012) Jun Jiang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Continuous-Flow Synthesis of Monoarylated Acetaldehydes Using Aryldiazonium Salts

(2012) Natalia Chernyak et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Continuous Multiple Liquid–Liquid Separation: Diazotization of Amino Acids in Flow

(2012) Dennis X. Hu et al.   ORGANIC LETTERS

Automated Multitrajectory Method for Reaction Optimization in a Microfluidic System using Online IR Analysis

(2012) Jason S. Moore et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Continuous Hydrolysis and Liquid–Liquid Phase Separation of an Active Pharmaceutical Ingredient Intermediate Using a Miniscale Hydrophobic Membrane Separator

(2012) Albert E. Cervera-Padrell et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

An Automated Continuous-Flow Platform for the Estimation of Multistep Reaction Kinetics

(2012) Brandon J. Reizman et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Continuous In Situ Generation, Separation, and Reaction of Diazomethane in a Dual-Channel Microreactor

(2011) Ram Awatar Maurya et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Deciding Whether To Go with the Flow: Evaluating the Merits of Flow Reactors for Synthesis

(2011) Ryan L. Hartman et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Guiding principles for site selective and stereoselective intermolecular C–H functionalization by donor/acceptor rhodium carbenes

(2011) Huw M. L. Davies et al.   CHEMICAL SOCIETY REVIEWS

Rapid Access to α-Alkoxy and α-Amino Acid Derivatives through Safe Continuous-Flow Generation of Diazoesters

(2011) Hannah E. Bartrum et al.   CHEMISTRY-A EUROPEAN JOURNAL

A fully automated, multistep flow synthesis of 5-amino-4-cyano-1,2,3-triazoles

(2011) Catherine J. Smith et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Scalable in Situ Diazomethane Generation in Continuous-Flow Reactors

(2011) Emiliano Rossi et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Asymmetric synthesis of highly functionalized cyclopentanes by a rhodium- and scandium-catalyzed five-step domino sequence

(2011) Brendan T. Parr et al.   Chemical Science

The Flow’s the Thing…︁Or Is It? Assessing the Merits of Homogeneous Reactions in Flask and Flow

(2010) Fernando E. Valera et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Continuous flow azide formation: Optimization and scale-up

(2010) Mariëlle M.E. Delville et al.   CHEMICAL ENGINEERING JOURNAL

Synthesis of β-Keto Esters In-Flow and Rapid Access to Substituted Pyrimidines

(2010) Hannah E. Bartrum et al.   JOURNAL OF ORGANIC CHEMISTRY

Enantiomerically Puretrans-β-Lactams from α-Amino Acids via Compact Fluorescent Light (CFL) Continuous-Flow Photolysis

(2010) Yvette S. Mimieux Vaske et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Enantioenriched Synthesis of Cyclopropenes with a Quaternary Stereocenter, Versatile Building Blocks

(2010) Misaki Uehara et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Enantioselective iron-catalysed O–H bond insertions

(2010) Shou-Fei Zhu et al.   Nature Chemistry

Ruthenium Catalyzed Directing Group-Free C2-Selective Carbenoid Functionalization of Indoles by α-Aryldiazoesters

(2010) Wai-Wing Chan et al.   ORGANIC LETTERS

Safe and Reliable Synthesis of Diazoketones and Quinoxalines in a Continuous Flow Reactor

(2010) Laetitia J. Martin et al.   ORGANIC LETTERS

Controlling hazardous chemicals in microreactors: Synthesis with iodine azide

(2009) Johan C Brandt et al.   Beilstein Journal of Organic Chemistry

Catalytic Carbene Insertion into C−H Bonds

(2009) Michael P. Doyle et al.   CHEMICAL REVIEWS

Application of donor/acceptor-carbenoids to the synthesis of natural products

(2009) Huw M. L. Davies et al.   CHEMICAL SOCIETY REVIEWS

Why Is Copper(I) Complex More Competent Than Dirhodium(II) Complex in Catalytic Asymmetric O−H Insertion Reactions? A Computational Study of the Metal Carbenoid O−H Insertion into Water

(2009) Yong Liang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Rhodium-Mediated Enantioselective Cyclopropanation of Allenes

(2009) Timothy M. Gregg et al.   ORGANIC LETTERS

Continuous Production of the Diazomethane PrecursorN-Methyl-N-nitroso-p-toluenesulfonamide: Batch Optimization and Transfer into a Microreactor Setup

(2009) Michael Struempel et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Heck reactions using segmented flow conditions

(2009) Batoul Ahmed-Omer et al.   TETRAHEDRON LETTERS

Copper-Catalyzed Highly Enantioselective Carbenoid Insertion into SiH Bonds

(2008) Yong-Zhen Zhang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Flash Chemistry: Fast Chemical Synthesis by Using Microreactors

(2008) Jun-ichi Yoshida et al.   CHEMISTRY-A EUROPEAN JOURNAL

Palladium-Catalyzed Cross Coupling Reaction of Benzyl Bromides with Diazoesters for Stereoselective Synthesis of (E)-α,β-Diarylacrylates

(2008) Wing-Yiu Yu et al.   ORGANIC LETTERS

Recent studies on the reactions of α-diazocarbonyl compounds

(2008) Zhenhua Zhang et al.   TETRAHEDRON

Copper(І) hexafluorophosphate: a dual functional catalyst for three-component reactions of methyl phenyldiazoacetate with alcohols and aldehydes or α-ketoesters

(2008) Yongli Yue et al.   TETRAHEDRON LETTERS

Catalytic Asymmetric Reaction with Water: Enantioselective Synthesis of α-Hydroxyesters by a Copper–Carbenoid OH Insertion Reaction

(2007) Shou-Fei Zhu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Effect of segmented fluid flow, sonication and phase transfer catalysis on biphasic reactions in capillary microreactors

(2007) B AHMEDOMER et al.   CHEMICAL ENGINEERING JOURNAL