AP39, a Mitochondria-Targeted Hydrogen Sulfide Donor, Supports Cellular Bioenergetics and Protects against Alzheimer’s Disease by Preserving Mitochondrial Function in APP/PS1 Mice and Neurons

Mitochondrial DNA Copy Numbers in Pyramidal Neurons are Decreased and Mitochondrial Biogenesis Transcriptome Signaling is Disrupted in Alzheimer's Disease Hippocampi

(2018) Ann C. Rice et al.   JOURNAL OF ALZHEIMERS DISEASE

2015 Alzheimer's disease facts and figures

(2015)   Alzheimers & Dementia

Fyn inhibition rescues established memory and synapse loss in Alzheimer mice

(2015) Adam C. Kaufman et al.   ANNALS OF NEUROLOGY

Effects of AP39, a novel triphenylphosphonium derivatised anethole dithiolethione hydrogen sulfide donor, on rat haemodynamic parameters and chloride and calcium Cav3 and RyR2 channels

(2015) Lenka Tomasova et al.   NITRIC OXIDE-BIOLOGY AND CHEMISTRY

Early alterations in energy metabolism in the hippocampus of APPswe/PS1dE9 mouse model of Alzheimer's disease

(2014) Ignacio Pedrós et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Association of Amyloid Burden, Brain Atrophy and Memory Deficits in Aged Apolipoprotein ε4 Mice

(2014) Junxiang Yin et al.   Current Alzheimer Research

Therapeutic benefits of H2S in Alzheimer’s disease

(2014) Hai-Jun Wei et al.   JOURNAL OF CLINICAL NEUROSCIENCE

Contribution of cysteine aminotransferase and mercaptopyruvate sulfurtransferase to hydrogen sulfide production in peripheral neurons

(2014) Ryo Miyamoto et al.   JOURNAL OF NEUROCHEMISTRY

Nuclear 82-kDa choline acetyltransferase decreases amyloidogenic APP metabolism in neurons from APP/PS1 transgenic mice

(2014) Shawn Albers et al.   NEUROBIOLOGY OF DISEASE

Hydrogen sulfide improves spatial memory impairment and decreases production of Aβ in APP/PS1 transgenic mice

(2014) Xuan-li He et al.   NEUROCHEMISTRY INTERNATIONAL

AP39, a novel mitochondria-targeted hydrogen sulfide donor, stimulates cellular bioenergetics, exerts cytoprotective effects and protects against the loss of mitochondrial DNA integrity in oxidatively stressed endothelial cells in vitro

(2014) Bartosz Szczesny et al.   NITRIC OXIDE-BIOLOGY AND CHEMISTRY

Effect of S-adenosyl-l-methionine (SAM), an allosteric activator of cystathionine-β-synthase (CBS) on colorectal cancer cell proliferation and bioenergetics in vitro

(2014) Katalin Módis et al.   NITRIC OXIDE-BIOLOGY AND CHEMISTRY

The synthesis and functional evaluation of a mitochondria-targeted hydrogen sulfide donor, (10-oxo-10-(4-(3-thioxo-3H-1,2-dithiol-5-yl)phenoxy)decyl)triphenylphosphonium bromide (AP39)

(2014) Sophie Le Trionnaire et al.   MedChemComm

Beyond amyloid: Getting real about nonamyloid targets in Alzheimer's disease

(2013) Karl Herrup et al.   Alzheimers & Dementia

Oxidative stress and mitochondrial dysfunction in Alzheimer's disease

(2013) Xinglong Wang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

3-Hydroxybutyrate methyl ester as a potential drug against Alzheimer's disease via mitochondria protection mechanism

(2013) Junyu Zhang et al.   BIOMATERIALS

Triphenylphosphonium salts of 1,2,4-benzothiadiazine 1,1-dioxides related to diazoxide targeting mitochondrial ATP-sensitive potassium channels

(2013) Céline Constant-Urban et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Regulation of mitochondrial bioenergetic function by hydrogen sulfide. Part II. Pathophysiological and therapeutic aspects

(2013) Katalin Módis et al.   BRITISH JOURNAL OF PHARMACOLOGY

Fluorescent and radiolabeled triphenylphosphonium probes for imaging mitochondria

(2013) Hushan Yuan et al.   CHEMICAL COMMUNICATIONS

Principles of the mitochondrial fusion and fission cycle in neurons

(2013) M. Cagalinec et al.   JOURNAL OF CELL SCIENCE

A Selective Mitochondrial-Targeted Chlorambucil with Remarkable Cytotoxicity in Breast and Pancreatic Cancers

(2013) Melissa Millard et al.   JOURNAL OF MEDICINAL CHEMISTRY

Mitochondrial Alterations near Amyloid Plaques in an Alzheimer's Disease Mouse Model

(2013) Hong Xie et al.   JOURNAL OF NEUROSCIENCE

Mitochondrial DNA sequence associations with dementia and amyloid-β in elderly African Americans

(2013) Gregory J. Tranah et al.   NEUROBIOLOGY OF AGING

Hydrogen sulfide slows down progression of experimental Alzheimer’s disease by targeting multiple pathophysiological mechanisms

(2013) Daniela Giuliani et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

A Novel Mechanism of Formaldehyde Neurotoxicity: Inhibition of Hydrogen Sulfide Generation by Promoting Overproduction of Nitric Oxide

(2013) Xiao-Qing Tang et al.   PLoS One

Deficiency in Repair of the Mitochondrial Genome Sensitizes Proliferating Myoblasts to Oxidative Damage

(2013) Bartosz Szczesny et al.   PLoS One

Tumor-derived hydrogen sulfide, produced by cystathionine- -synthase, stimulates bioenergetics, cell proliferation, and angiogenesis in colon cancer

(2013) C. Szabo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Oxygen-sensitive mitochondrial accumulation of cystathionine  -synthase mediated by Lon protease

(2013) H. Teng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Detoxification of H2S by Differentiated Colonic Epithelial Cells: Implication of the Sulfide Oxidizing Unit and of the Cell Respiratory Capacity

(2012) Sabria Mimoun et al.   ANTIOXIDANTS & REDOX SIGNALING

Intramitochondrial hydrogen sulfide production by 3-mercaptopyruvate sulfurtransferase maintains mitochondrial electron flow and supports cellular bioenergetics

(2012) Katalin Módis et al.   FASEB JOURNAL

Hydrogen sulfide attenuates spatial memory impairment and hippocampal neuroinflammation in beta-amyloid rat model of Alzheimer’s disease

(2012) Aiguo Xuan et al.   Journal of Neuroinflammation

Loss of Intranetwork and Internetwork Resting State Functional Connections with Alzheimer's Disease Progression

(2012) M. R. Brier et al.   JOURNAL OF NEUROSCIENCE

Accumulation of Exogenous Amyloid-BetaPeptide in Hippocampal Mitochondria Causes Their Dysfunction: A Protective Role for Melatonin

(2012) Sergio Rosales-Corral et al.   Oxidative Medicine and Cellular Longevity

Physiological Implications of Hydrogen Sulfide: A Whiff Exploration That Blossomed

(2012) Rui Wang   PHYSIOLOGICAL REVIEWS

TEMPERATURE AND CELL-TYPE DEPENDENCY OF SULFIDE EFFECTS ON MITOCHONDRIAL RESPIRATION

(2012) Michael Groeger et al.   SHOCK

Hydrogen Sulfide and Cell Signaling

(2011) Ling Li et al.   Annual Review of Pharmacology and Toxicology

Emerging role of hydrogen sulfide in health and disease: critical appraisal of biomarkers and pharmacological tools

(2011) Matthew Whiteman et al.   CLINICAL SCIENCE

Impaired mitochondrial biogenesis, defective axonal transport of mitochondria, abnormal mitochondrial dynamics and synaptic degeneration in a mouse model of Alzheimer's disease

(2011) M. J. Calkins et al.   HUMAN MOLECULAR GENETICS

Impaired mitochondrial biogenesis contributes to mitochondrial dysfunction in Alzheimer’s disease

(2011) Baiyang Sheng et al.   JOURNAL OF NEUROCHEMISTRY

Obovatol improves cognitive functions in animal models for Alzheimer’s disease

(2011) Dong-Young Choi et al.   JOURNAL OF NEUROCHEMISTRY

Adult hippocampal neurogenesis and its role in Alzheimer's disease

(2011) Yangling Mu et al.   Molecular Neurodegeneration

S-propargyl-cysteine (ZYZ-802), a sulphur-containing amino acid, attenuates beta-amyloid-induced cognitive deficits and pro-inflammatory response: involvement of ERK1/2 and NF-κB pathway in rats

(2010) Qi-Hai Gong et al.   AMINO ACIDS

Oxidation of hydrogen sulfide remains a priority in mammalian cells and causes reverse electron transfer in colonocytes

(2010) Emilie Lagoutte et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Application of high throughput perfusion micro 3-D cell culture platform for the precise study of cellular responses to extracellular conditions -effect of serum concentrations on the physiology of articular chondrocytes

(2010) Min-Hsien Wu et al.   BIOMEDICAL MICRODEVICES

Effect of VEGF and its receptor antagonist SU-5416, an inhibitor of angiogenesis, on processing of the β-amyloid precursor protein in primary neuronal cells derived from brain tissue of Tg2576 mice

(2010) Susanne Bürger et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE

Potential Applications of Hydrogen Sulfide-Induced Suspended Animation

(2009) Hamid Aslami et al.   CURRENT MEDICINAL CHEMISTRY

Amyloid beta, mitochondrial structural and functional dynamics in Alzheimer's disease

(2009) P. Hemachandra Reddy   EXPERIMENTAL NEUROLOGY

Impaired Balance of Mitochondrial Fission and Fusion in Alzheimer's Disease

(2009) X. Wang et al.   JOURNAL OF NEUROSCIENCE

Advances in measuring cellular bioenergetics using extracellular flux

(2008) David A. Ferrick et al.   DRUG DISCOVERY TODAY

MR Microimaging of amyloid plaques in Alzheimer’s disease transgenic mice

(2008) Thomas M. Wengenack et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Alzheimer's disease is associated with reduced expression of energy metabolism genes in posterior cingulate neurons

(2008) W. S. Liang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA