Article
Plant Sciences
Zhi-Xin Xiang, Wen Li, Ying-Tang Lu, Ting-Ting Yuan
Summary: Hydrogen sulfide (H2S) produced by d-cysteine desulfhydrase (DCD) enhances plant tolerance to abiotic stress by promoting auxin homeostasis, thereby alleviating osmotic stress-mediated inhibition of root growth. Under osmotic stress, DCD gene and protein expression, as well as H2S production, are up-regulated in roots. The overexpression of DCD leads to increased auxin accumulation and longer roots, while a dcd mutant exhibits increased sensitivity to osmotic stress and inhibited root growth. H2S treatment alleviates osmotic stress-mediated inhibition of auxin signaling by promoting auxin biosynthesis and the protein level of the auxin efflux carrier PIN-FORMED 1 (PIN1).
Article
Cell Biology
Xiang Cheng, Jia-Mei Jiang, Chun-Yan Wang, Wei Zou, Ping Zhang, Xiao-Qing Tang
Summary: Exogenous H2S protects against arecoline-induced neurotoxicity by enhancing the leptin/leptin receptor signaling pathway and attenuating endoplasmic reticulum stress.
CELL BIOLOGY INTERNATIONAL
(2022)
Article
Chemistry, Physical
Danqing Liu, Yuyao Liao, Erik Jan Cornel, Mingchen Lv, Tong Wu, Xinyue Zhang, Liujie Fan, Min Sun, Yunqing Zhu, Zhen Fan, Jianzhong Du
Summary: Diabetic wounds are difficult to heal due to bacterial infection and decreased cell proliferation and migration. A polymersome-based wound dressing spray was shown to inhibit bacteria, generate H2S, and promote cell growth and angiogenesis in diabetic wounds, offering a new insight into effective treatment.
CHEMISTRY OF MATERIALS
(2021)
Article
Cell Biology
Sheng-Lan Gao, Yi-Yun Tang, Jia-Mei Jiang, Wei Zou, Ping Zhang, Xiao-Qing Tang
Summary: Arecoline, the main alkaloid in areca nut, is toxic to neurons, while hydrogen sulfide (H2S) has neuroprotective effects. The study found that arecoline decreased endogenous H2S levels and disrupted autophagic flux in PC12 cells, and exogenous H2S administration alleviated arecoline-induced toxicity. The research also showed that H2S improves arecoline-induced disruption of autophagic flux to protect against neurotoxicity.
Article
Chemistry, Multidisciplinary
Jinlong Zhang, Shuai Mu, Weilin Wang, Huipeng Sun, Shuangqin Li, Xuezhao Shi, Yunbo Liu, Xiaoyan Liu, Haixia Zhang
Summary: In this study, a novel fluorescent probe was developed for the detection of H2S. The probe showed comparable imaging performance to the traditional probe but exhibited lower toxicity to cells and animals.
CHEMICAL COMMUNICATIONS
(2022)
Article
Biology
Milen Hristov, Lyudmil Lazarov
Summary: This study investigates whether the gasotransmitters nitric oxide (NO) and hydrogen sulfide (H2S) have a role in leptin-induced fever response. The researchers found that inhibiting certain enzymes involved in NO and H2S synthesis can suppress the fever response caused by leptin, without affecting appetite.
JOURNAL OF THERMAL BIOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Yuming Zhang, Yuncong Chen, Xiangchao Shi, Yang Bai, Weijiang He, Zijian Guo
Summary: In this study, a probe that can accurately and in real-time image H2S in the cytosol was developed. It showed fast and ratiometric response to H2S without interference from other species, and successfully monitored changes in H2S generation in cells.
NEW JOURNAL OF CHEMISTRY
(2022)
Article
Engineering, Environmental
Nishesh Kumar Gupta, Jiyeol Bae, Kwang Soo Kim
Summary: The fabrication of NaMnxOy from air calcination of (Na, Mn)-organic frameworks has been reported. The hexagonal microsheets of NaMnxOy were formed regardless of the type of organic linker or MOF morphology. The adsorption capacity of NaMnxOy was significantly higher compared to the precursor MOF, with the best adsorbent showing maximum capacity in wet and dry conditions.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Chemistry, Organic
Qi Cui, Tony W. Pan, Meg Shieh, Shane S. Kelly, Shi Xu, Wei-Jun Qian, Ming Xian
Summary: In this study, we predicted the reactivity of strained alkynes with sulfur-containing analogues through computational studies. Experimental results confirmed the predictions, showing that 2H-pyan-2-thiones were the most reactive substrates. This reaction was effective in aqueous buffers and cellular environments, producing COS as a byproduct which could be converted into H2S.
Article
Biochemistry & Molecular Biology
Bei-Bei Tao, Qi Zhu, Yi-Chun Zhu
Summary: This article reviews the regulatory role of hydrogen sulfide (H2S) on signaling pathways and its direct target molecules. It also discusses the underlying mechanisms of H2S functions, including epigenetic modification, protein expression levels, protein activity, protein localization, redox microenvironment, and interaction with other gas signaling molecules such as nitric oxide (NO) and carbon dioxide (CO). Further exploration of the mechanisms underlying H2S will contribute to a better understanding of its regulatory roles and the development of new clinical therapeutic drugs in the future.
ANTIOXIDANTS & REDOX SIGNALING
(2023)
Article
Chemistry, Analytical
Ajay Kumar, Sheetal Negi, Tejaswini Choudhury, Vishal Mutreja, Sunaina Sunaina, Subash C. Sahoo, Arjun Singh, Surinder K. Mehta, Ramesh Kataria, Vikram Saini
Summary: A novel carboxylate-type organic linker-based luminescent MOF (PUC2) was synthesized and characterized. PUC2 selectively reacts with nitric oxide (NO) and can detect NO production in living cells with high sensitivity. It is not affected by cellular proteins, biologically relevant metals, RNS/ROS, or H2S.
Review
Biochemistry & Molecular Biology
Dongliang Hu, Lijuan Wei, Weibiao Liao
Summary: This review discusses the interaction between brassinosteroids (BRs) and small-molecule compounds (SMCs) in plant growth, development, and stress responses, highlighting how they promote plant development and alleviate stress damage by modulating the antioxidant system, photosynthetic capacity, and carbohydrate metabolism.
Article
Biochemistry & Molecular Biology
Harsha Gautam, Mehar Fatma, Zebus Sehar, Iqbal R. Mir, Nafees A. Khan
Summary: This study investigates the effects of gaseous signaling molecules, ethylene, nitric oxide, and hydrogen sulfide, on high temperature stress tolerance in rice. The findings suggest that these molecules can enhance thermo-tolerance and protect photosynthesis in rice, with ethylene showing the most significant effect.
Article
Environmental Sciences
Yu-Juan Lin, Xing-Hui Feng, Yu-Xi Feng
Summary: This study evaluated the importance of hydrogen sulfide (NaHS) and nitric oxide (SNP) in the antioxidant systems of rice seedlings under Cr(III) stress. The results showed that NaHS and SNP effectively alleviated the toxic effects of Cr(III) by activating different antioxidants. NaHS had a stronger regulatory effect on non-enzymatic and enzymatic antioxidants compared to SNP.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Pharmacology & Pharmacy
Yu-Hui Tang, Lei Wu, Hong-Lin Huang, Pan-Pan Zhang, Wei Zou, Xiao-Qing Tang, Yi-Yun Tang
Summary: Previous research has shown that hydrogen sulfide (H2S) has a neuroprotective effect against formaldehyde-induced neurotoxicity. This study found that H2S reverses ferroptosis induced by formaldehyde by inhibiting ferritinophagy, thus providing neuroprotection.