Article
Cell Biology
Xiaochen Li, Xiaopei Cao, Hanqiu Zhao, Mingzhou Guo, Xiaoyu Fang, Ke Li, Lu Qin, Yuanzhou He, Xiansheng Liu
Summary: Hypoxia activates the Notch4-ERK/JNK/P38 MAPK signaling pathway to promote the proliferation, migration, and anti-apoptotic effects of LUAD cells. Notch4 plays a key role in the growth and metastasis of LUAD. Inhibitors of ERK, JNK, and P38 can partially reverse the effects of Notch4.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Nutrition & Dietetics
Marco Mouanness, Zaher Merhi
Summary: Advanced glycation end products (AGEs), formed by the reaction between protein and reducing sugars, can impact reproductive health and fertility through inducing inflammation and oxidative stress. This review summarizes the recent data on the pathogenesis of dietary AGEs and their potential impact on female reproductive health and offspring reproduction.
Article
Pharmacology & Pharmacy
Baocheng Xie, Zhanwei Zeng, Shiyi Liao, Chenhui Zhou, Longhuo Wu, Daohua Xu
Summary: Kaempferol exhibits beneficial effects on osteogenic differentiation and counteracts the inhibitory activity of dexamethasone by activating JNK and p38-MAPK signaling pathways, improving bone mineralization. This potential makes it a promising candidate for developing new drugs for treating glucocorticoid-induced osteoporosis.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Zhangshuo Yang, Hao Zhang, Maohui Yin, Zhixiang Cheng, Ping Jiang, Maohui Feng, Bo Liao, Zhisu Liu
Summary: This study found that NTF3 is significantly downregulated in human hepatocellular carcinoma (HCC) and its low expression is associated with shorter survival and poor clinical outcomes. NTF3 inhibits the progression of HCC cells by activating the p75NTR and JNK/P38 MAPK pathways to induce apoptosis. Therefore, NTF3 may serve as a potential treatment molecule for HCC.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Article
Plant Sciences
Ah-Won Kwak, Jin Woo Park, Seung-On Lee, Jin-Young Lee, Ji-hye Seo, Goo Yoon, Mee-Hyun Lee, Joon-Seok Choi, Jung-Hyun Shim
Summary: This study found that Isolinderalactone (ILL) can exert its anticancer effect in colorectal cancer (CRC) cells sensitive and resistant to oxaliplatin (Ox) by inducing ROS-mediated apoptosis through JNK/p38 MAPK signaling pathways. This provides a new insight into therapeutic strategies targeting drug-resistant CRC.
Article
Medicine, General & Internal
Mitra Nadali, Lovisa Lyngfelt, Malin C. Erlandsson, Sofia Toyra Silfversward, Karin M. E. Andersson, Maria Bokarewa, Rille Pullerits
Summary: The study suggests that low sRAGE is a marker of metabolic failure developed during chronic inflammation in rheumatoid arthritis (RA) patients. It emphasizes the importance of monitoring metabolic health in female RA patients for timely prevention of cardiovascular disease (CVD). Low sRAGE is associated with higher estimation of CVD risk and metabolic events, especially in patients younger than 50 years old.
FRONTIERS IN MEDICINE
(2021)
Article
Oncology
Sitong Zhou, Wen Ouyang, Xi Zhang, Lexi Liao, Xiaobing Pi, Ronghua Yang, Baiqiang Mei, Huaiyuan Xu, Shijian Xiang, Jiehua Li
Summary: Utrophin, a tumor suppressor gene, showed decreased expression in melanoma and was associated with poorer prognosis. Experimental evidence supported that up-regulated utrophin expression could inhibit melanoma cell proliferation. The inhibition of melanoma growth by utrophin was mediated through p38 and JNK1/c-Jun pathways.
CANCER CELL INTERNATIONAL
(2021)
Article
Cell Biology
Xi Chen, Weijie Ma, Ye Yao, Qi Zhang, Jinghua Li, Xiaoling Wu, Chengjie Mei, Xiang Jiang, Yiran Chen, Ganggang Wang, Kunlei Wang, Yingyi Liu, Yonghua Guo, Zhisu Liu, Yufeng Yuan
Summary: The study identified SDPR as a tumor suppressor in HCC by promoting apoptosis through the activation of the ASK1-JNK/p38 MAPK signaling pathways. This inhibits tumor growth and migration by enhancing cell apoptosis.
CELL DEATH & DISEASE
(2021)
Article
Biochemistry & Molecular Biology
Yusha Xiao, Lihua Ni, Hongjie Shi, Kang Yang, Jianguo Yang, Jinping Zhao, Jinping Liu, Pengcheng Luo
Summary: Heart failure (HF) is the end stage of many cardiovascular diseases, and cardiac remodeling is the main pathophysiological process leading to cardiac function deterioration in HF patients. Inflammation plays a crucial role in stimulating myocardial remodeling, which is significantly related to patient prognosis. SAA1, a lipid-binding protein involved in inflammation, has rarely been studied in the heart. This research aimed to investigate the role of SAA1 in cardiac remodeling using SAA1-deficient and wild-type mice. The results showed that SAA1 deficiency hindered cardiac fibrosis after 8 weeks of transverse aortic banding, but did not significantly affect cardiomyocyte hypertrophy. Additionally, SAA1 deficiency had no significant effect on cardiac fibrosis and hypertrophy in the sham group.
Article
Reproductive Biology
Neda Emami, AliReza Alizadeh, Arezoo Maleki-Hajiagha, Alireza Dizavi, Samira Vesali, Ashraf Moini
Summary: This study found no significant differences in the levels of serum sRAGE and FF sRAGE between Iranian women with and without PCOS. However, BMI and dietary intake of AGEs had more significant effects on sRAGE concentration in Iranian women.
JOURNAL OF OVARIAN RESEARCH
(2023)
Article
Cell Biology
Qingshi Chen, Guofu Lin, Yongfa Chen, Chaowei Li, Lizhen Wu, Xin Hu, Qichang Lin
Summary: In this study, we investigated the protective effect of miR-3574 on cardiomyocyte injury induced by intermittent hypoxia (IH) by targeting Axin1. The results suggest that miR-3574 could alleviate IH-induced cardiomyocyte injury by downregulating Axin1, providing a potential novel therapeutic target for obstructive sleep apnea (OSA) associated cardiovascular diseases.
Article
Plant Sciences
Jiansheng Li, Yang Xie, Peng Zhao, Yanqin Qin, Brian G. Oliver, Yange Tian, Suyun Li, Minghang Wang, Xuefang Liu
Summary: BYF shows therapeutic benefits for patients with COPD by reducing acute exacerbations, improving dyspnea and walking distance. Key active molecules (KAM) also demonstrate beneficial effects in COPD rat and in vitro models, improving lung function and pathological changes.
Article
Food Science & Technology
Hee-Weon Lee, Min Ji Gu, Jee-Young Lee, Seungju Lee, Yoonsook Kim, Sang Keun Ha
Summary: The study found that MOLD significantly increases RAGE expression in mouse mesangial cells, leading to ROS production and mitochondrial dysfunction. MOLD activates PI3KB and NF-kappa B signaling pathways, triggering inflammatory responses.
MOLECULAR NUTRITION & FOOD RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Xiaoyan Yuan, Junting Yang, Yuling Huang, Jia Li, Yuanyuan Li
Summary: In this study, it was found that 3-Indolepropionic acid (IPA) can directly activate hepatic stellate cells and promote the progression of liver fibrosis. IPA activates hepatic stellate cells by increasing reactive oxygen species (ROS) in mitochondria and the expression of inflammation-related genes. These findings reveal the mechanism by which IPA directly activates hepatic stellate cells through ROS-induced JNK and p38 signaling pathways.
Article
Pharmacology & Pharmacy
Run-Jing Li, Jia-Jia Xu, Zheng-Hao Zhang, Min-Wei Chen, Shi-Xiao Liu, Cui Yang, Yan-Ling Li, Ping Luo, Yi-Jiang Liu, Rong Tang, Zhong-Gui Shan
Summary: The anthraquinone rhein has been found to reduce transverse aortic constriction (TAC)-induced cardiac hypertrophy by inhibiting the molecular function of ERK and downregulating STAT3 and p38 MAPK signaling. Therapeutic doses of rhein have no significant adverse effects on liver and kidney function.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Respiratory System
Chuan Shao, Huan Qi, Ruyi Lang, Biyun Yu, Yaodong Tang, Lina Zhang, Xun Wang, Ling Wang
CANADIAN RESPIRATORY JOURNAL
(2019)
Article
Oncology
Nuo Xu, Fanglei Liu, Shengdi Wu, Maosong Ye, Haiyan Ge, Meiling Zhang, Yuanlin Song, Lin Tong, Jian Zhou, Chunxue Bai
Article
Substance Abuse
Chuan Shao, Huan Qi, Qing Fang, Jinjing Tu, Qianjun Li, Ling Wang
TOBACCO INDUCED DISEASES
(2020)
Article
Clinical Neurology
Qianjun Li, Ting Xu, Hai Zhong, Wenhui Gao, Chuan Shao, Lijie Feng, Taoping Li
Summary: The study found that plasma levels of D-LA and I-FABP are significantly higher in patients with obstructive sleep apnea (OSA), indicating that hypoxia resulting from OSA may impair the intestinal barrier before inducing multisystem dysfunction.
SLEEP AND BREATHING
(2021)
Article
Biotechnology & Applied Microbiology
Hui Xu, Chuan Shao
ONCOTARGETS AND THERAPY
(2020)
Article
Cell & Tissue Engineering
Wenjun Peng, Meijia Chang, Yuanyuan Wu, Wensi Zhu, Lin Tong, Ge Zhang, Qin Wang, Jie Liu, Xiaoping Zhu, Tingting Cheng, Yijia Li, Xi Chen, Dong Weng, Sanhong Liu, Hongwei Zhang, Yao Su, Jian Zhou, Huayin Li, Yuanlin Song
Summary: The study found that MSC SLP significantly promoted cell survival, inhibited epithelial cell apoptosis, attenuated inflammatory cell recruitment, and reversed immunological imbalances induced by bleomycin in ALI. MSC SLP ameliorated ALI by activating p63 and promoting p63(+) cell proliferation and the repair of damaged epithelial cells. The findings suggest that MSC SLP shows considerable therapeutic promise for treating ALI and ARDS.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Respiratory System
Weipeng Jiang, Yencheng Chao, Xiaoyue Wang, Cuicui Chen, Jian Zhou, Yuanlin Song
Summary: By analyzing home NPPV-related parameters in patients with AECOPD and stable COPD, it was found that abnormal values of respiratory rate, daily usage, leaks, and tidal volume may serve as biomarkers for detecting AECOPD. These findings provide insights into early detection of AECOPD.
INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE
(2021)
Article
Oncology
Liqin Wu, Juan Yin, Qi Zhang, Meiyan Wang, Wei Dai, Jian Zhou, Yuanrong Dai
Summary: Azithromycin can increase the apoptosis of airway smooth muscle cells through a mitochondrial pathway, which may play a key role in asthmatic remodeling.
ANNALS OF TRANSLATIONAL MEDICINE
(2021)
Article
Oncology
Jian Zhou, Tong Cheng, Xing Li, Jie Hu, Encheng Li, Ming Ding, Rulong Shen, John P. Pineda, Chun Li, Shaohua Lu, Hongyu Yu, Jiayuan Sun, Wenbin Huang, Xiaonan Wang, Han Si, Panying Shi, Jing Liu, Meijia Chang, Maosen Dou, Meng Shi, Xiaofeng Chen, Rex C. Yung, Qi Wang, Ning Zhou, Chunxue Bai
Summary: The study demonstrated the diagnostic value of epigenetic imprinting alterations as highly accurate translational biomarkers for a more definitive diagnosis of suspicious lung lesions. The QCIGISH method showed high sensitivity and specificity in diagnosing lung cancer, especially in early stage cancers, as well as in detecting pulmonary nodules with small diameters.
CLINICAL EPIGENETICS
(2021)
Article
Respiratory System
Wenjun Peng, Yuanyuan Wu, Ge Zhang, Wensi Zhu, Meijia Chang, Ainiwaer Rouzi, Weipeng Jiang, Lin Tong, Qin Wang, Jie Liu, Yuanlin Song, Huayin Li, Ka Li, Jian Zhou
Summary: GLIPR1 plays a pivotal role in the pathogenesis of COPD and protects against the inflammatory response and airway damage induced by cigarette smoke exposure.
INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE
(2021)
Article
Medical Laboratory Technology
Zhihui Lin, Biyun Yu, Li Yuan, Jinjing Tu, Chuan Shao, Yaodong Tang
Summary: Down-regulation of RAGE expression is associated with poor prognosis, defective immune infiltration, and cellular senescence in lung adenocarcinoma.
JOURNAL OF CLINICAL LABORATORY ANALYSIS
(2022)
Article
Medicine, General & Internal
Chuan Shao, Hailong Wang, Yibing He, Biyun Yu, Haiying Zhao
Summary: This study examined the clinical phenotypic characteristics of older patients with newly diagnosed obstructive sleep apnea (OSA) and found that older patients displayed more symptoms and comorbidities associated with OSA, such as nocturia and decreased sleep quality. Additionally, being aged 65 years or older increased the risk of developing hypertension, coronary artery disease (CAD), and ischemic stroke.
IRISH JOURNAL OF MEDICAL SCIENCE
(2023)
Article
Immunology
Chao Cao, Obulkasim Memet, Fuli Liu, Hanbing Hu, Lin Zhang, Heng Jin, Yiqun Cao, Jian Zhou, Jie Shen
Summary: This study performed single-cell RNA sequencing on bronchoalveolar lavage fluid samples from phosgene-induced acute lung injury rat models and healthy controls. The results showed that dendritic cells and specific macrophage subclusters exhibited increased function during the early stage of pulmonary tissue damage. Nine subpopulations were identified that play multiple functional roles, including immune responses, pulmonary tissue repair, cellular metabolic cycle, and cholesterol metabolism. Pseudo-time trajectory analysis also suggested that proliferating macrophage clusters exerted multiple functional roles.
JOURNAL OF INFLAMMATION RESEARCH
(2023)
Article
Multidisciplinary Sciences
Jian Zhou, Zuoren Wu, Jie Hu, Dawei Yang, Xiaoyan Chen, Qin Wang, Jie Liu, Maosen Dou, Wenjun Peng, Yuanyuan Wu, Wenhao Wang, Chenjian Xie, Ming Wang, Yuanlin Song, Hengshan Zeng, Chunxue Bai
Article
Medicine, Research & Experimental
Lin Tong, Ning Ding, Xiaoling Tong, Jiamin Li, Yong Zhang, Xiaodan Wang, Xiaobo Xu, Maosong Ye, Chun Li, Xue Wu, Hairong Bao, Xin Zhang, Qunying Hong, Yuanlin Song, Yang W. Shao, Chunxue Bai, Jian Zhou, Jie Hu