Article
Plant Sciences
Ah-Won Kwak, Jin Woo Park, Seung-On Lee, Jin-Young Lee, Ji-hye Seo, Goo Yoon, Mee-Hyun Lee, Joon-Seok Choi, Jung-Hyun Shim
Summary: This study found that Isolinderalactone (ILL) can exert its anticancer effect in colorectal cancer (CRC) cells sensitive and resistant to oxaliplatin (Ox) by inducing ROS-mediated apoptosis through JNK/p38 MAPK signaling pathways. This provides a new insight into therapeutic strategies targeting drug-resistant CRC.
Article
Cell Biology
Fen Xiao, Chen-Yi Tang, Hao-Neng Tang, Hui-Xuan Wu, Nan Hu, Long Li, Hou-De Zhou
Summary: This study revealed that Lnc-FR332443 inhibits adipogenesis by regulating the expression of Runx1, suggesting it as a potential drug target for obesity prevention and treatment.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Cell Biology
Ling Liu, Yihao Xing, Mengyao Cao, Jinglei Xu, Jingjing Chen
Summary: JS-K induces apoptosis in hepatocellular carcinoma cells by activating JNK and p38 MAPK and inhibiting the Raf/MEK/ERK signaling pathway.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2021)
Article
Cell Biology
Yan Deng, Ling Li, Jia-Hui Zhu, Pei-Pei Li, Yi-Xuan Deng, Hong-Hong Luo, Yuan-Yuan Yang, Bai-Cheng He, Yuxi Su
Summary: This study demonstrates that overexpression of COX-2 enhances BMP9's osteogenic ability through upregulation of TGF-beta 1, resulting in the activation of p38 signaling pathway in MSCs.
Article
Medicine, Research & Experimental
Jingyuan Wen, Zhengsheng Bao, Lunxin Li, Yingquan Liu, Bing Wei, Xiaoang Ye, Huihui Xu, Longkang Cui, Xuefei Li, Gaobo Shen, Yuan Fang, Hanbing Zeng, Zhe Shen, Enping Guo, Hongting Jin, Lianguo Wu
Summary: Through network pharmacological analysis, this study found that Qiangguyin (QGY) can reduce fat accumulation in the chondro-osseous junction by activating the mitogen-activated protein kinase (MAPK) signaling pathway, thereby reducing decreased bone density and increased bone fragility in postmenopausal osteoporosis (PMOP) patients.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Biochemistry & Molecular Biology
Li Meng, Lichan Yuan, Jieli Ni, Mengru Fang, Shuyu Guo, Huayang Cai, Jinwei Qin, Qi Cai, Mengnan Zhang, Fang Hu, Junqing Ma, Yang Zhang
Summary: This study investigated the regulatory mechanism of Mir24-2-5p on Gnai3 expression regulation in osteoblast precursor cells, providing a new idea for improving prevention and treatment strategies for congenital mandibular defects and mandibular protrusion.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Michael A. Fawzy, Sherif A. Maher, Sally M. Bakkar, Mahmoud A. El-Rehany, Moustafa Fathy
Summary: This study demonstrated the protective effect of pantoprazole on renal ischemia/reperfusion injury in rats for the first time, by suppressing apoptosis, reducing pro-inflammatory cytokines levels, and impacting intracellular signaling pathways. Moreover, multiple doses of pantoprazole showed a greater therapeutic effect than a single dose.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Immunology
Tingting Tan, Tao Li, Cheng Xiang, Zhengxiao Ouyang
Summary: Disruption of osteoclasts and osteoblasts balance can lead to bone diseases like osteoporosis. The study showed that toosendanin (TSN) attenuated RANKL-induced osteoclastogenesis in vitro by inhibiting p38 signaling. In a mouse model, TSN effectively inhibited the formation of TRAP-positive osteoclasts and protected against bone loss. These findings suggest the potential therapeutic use of TSN in osteoporosis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Gastroenterology & Hepatology
Chenhong Lin, Huiqin He, John J. Kim, Xia Zheng, Zhihui Huang, Ning Dai
Summary: Upregulation of AQP8 and AQP3, as well as translocation of AQP8, were observed in colon tissues of patients with functional constipation. The Jun N-terminal kinase and p38 mitogen-activated protein kinase signaling pathways were found to be involved in the regulation of AQP8 in response to changes in osmotic pressure.
DIGESTIVE AND LIVER DISEASE
(2023)
Article
Cell Biology
Xi Chen, Weijie Ma, Ye Yao, Qi Zhang, Jinghua Li, Xiaoling Wu, Chengjie Mei, Xiang Jiang, Yiran Chen, Ganggang Wang, Kunlei Wang, Yingyi Liu, Yonghua Guo, Zhisu Liu, Yufeng Yuan
Summary: The study identified SDPR as a tumor suppressor in HCC by promoting apoptosis through the activation of the ASK1-JNK/p38 MAPK signaling pathways. This inhibits tumor growth and migration by enhancing cell apoptosis.
CELL DEATH & DISEASE
(2021)
Article
Immunology
Yue Xiong, Xiaochuan Cui, Yanjun Zhou, Gaoshang Chai, Xiufeng Jiang, Guizhi Ge, Yue Wang, Hongxu Sun, Huilian Che, Yunjuan Nie, Peng Zhao
Summary: DHL treatment effectively alleviated BLM-induced pulmonary fibrosis and inflammation by reducing pro-fibrotic mediators, inhibiting inflammatory cell infiltration, and downregulating IL-33 expression. The mechanism involved the JNK/p38 MAPK-mediated NF-kappa B signaling pathway to suppress macrophage activation and decrease IL-13 and TGF-beta levels.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Cell & Tissue Engineering
Yixuan Jiang, Na Xin, Yi Xiong, Yanjun Guo, Ying Yuan, Qin Zhang, Ping Gong
Summary: α-calcitonin gene-related peptide (αCGRP) plays a crucial role in regulating osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs) through the mitogen-activated protein kinase (MAPK) signaling pathway. Activation of αCGRP leads to increased phosphorylation of ERK1/2 and p38 MAPK, resulting in upregulated expression of osteogenic genes and enhanced formation of alkaline phosphatase and calcified nodules. Inhibition of this signaling pathway impairs BMSCs' osteogenic differentiation, proliferation, and apoptosis.
CELL TRANSPLANTATION
(2022)
Article
Biology
Yingyu Zhou, Tomohiro Takano, Xuyang Li, Yimei Wang, Rong Wang, Zhangliang Zhu, Masaru Tanokura, Takuya Miyakawa, Satoshi Hachimura
Summary: Beta-elemene regulates the balance of proinflammatory cytokines in mouse white adipose tissue through MAPK signaling, affecting the imbalance of M1-M2 macrophages and inhibiting the phosphorylation of MAPK pathways. These results suggest that beta-elemene may be a potential therapeutic medicine for macrophage-mediated chronic diseases.
COMMUNICATIONS BIOLOGY
(2022)
Article
Oncology
Kang Ding, Fengping Zhang, Gaoxiu Qi, Meng Lin, Min Chen, Yanchun Chen, Jie Zheng, Fenghua Zhou
Summary: This study found that the RNA-binding protein ZFP36L1 is overexpressed in gastric cancer tissues, and its overexpression is associated with poor prognosis. Further experiments showed that ZFP36L1 is also overexpressed in cell lines with higher malignancy, promoting cell proliferation, invasion, and migration. It was also demonstrated that ZFP36L1 promotes gastric cancer progression by inhibiting the JNK and p38 MAPK signaling pathways. Therefore, targeting the JNK and p38 MAPK signaling pathways could be a novel treatment strategy for gastric cancer.
RECENT PATENTS ON ANTI-CANCER DRUG DISCOVERY
(2023)
Article
Biochemistry & Molecular Biology
Jin Wook Hwang, Won-Jong Park, Younho Han
Summary: Asarylaldehyde is proposed for osteogenic differentiation of human periodontal ligament stem cells (hPDLSCs) to prevent bone loss. It promotes osteogenic differentiation of hPDLSCs by increasing the expression of osteoblast-specific markers through regulating the p38/ERK signaling pathway.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Review
Integrative & Complementary Medicine
Baocheng Xie, Qinghui Wang, Chenhui Zhou, Jiahuan Wu, Daohua Xu
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2018)
Review
Cell & Tissue Engineering
Baocheng Xie, Houlong Luo, Yusheng Zhang, Qinghui Wang, Chenhui Zhou, Daohua Xu
STEM CELLS INTERNATIONAL
(2018)
Article
Chemistry, Medicinal
Bao-Cheng Xie, Shu-Yong Song, Xiao-Yang Xie, Yu-Tong Sun, Xiao-Yuan Zhang, Dao-Hua Xu, Yun-Sheng Huang
ARCHIV DER PHARMAZIE
(2019)
Review
Integrative & Complementary Medicine
Shichun Chen, Baocheng Xie, Hao Tian, Shaobo Ding, Chengyu Lu
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2019)
Article
Pharmacology & Pharmacy
Baocheng Xie, Jiahuan Wu, Yongmei Li, Xuejun Wu, Zhanwei Zeng, Chenhui Zhou, Daohua Xu, Longhuo Wu
FRONTIERS IN PHARMACOLOGY
(2019)
Letter
Sport Sciences
Bao-Cheng Xie, Shi-Chun Chen, Jia-Huan Wu, Qing-Hui Wang, Chen-Hui Zhou, Dao-Hua Xu
JOURNAL OF SPORTS MEDICINE AND PHYSICAL FITNESS
(2019)
Review
Sport Sciences
Shi-Chun Chen, Shao-Bo Ding, Bao-Cheng Xie, Hao Tian, Cheng-Yu Lu
JOURNAL OF SPORTS MEDICINE AND PHYSICAL FITNESS
(2019)
Review
Cell & Tissue Engineering
Baocheng Xie, Minyi Chen, Runkai Hu, Weichao Han, Shaobo Ding
STEM CELLS INTERNATIONAL
(2020)
Review
Cell & Tissue Engineering
Baocheng Xie, Shichun Chen, Yongxiang Xu, Weichao Han, Runkai Hu, Minyi Chen, Ruirong He, Shaobo Ding
Summary: This study found through meta-analysis that MSC therapy can significantly reduce VAS and ODI scores in patients with DDD, providing a new therapeutic strategy for chronic low back pain and lumbar dysfunction caused by DDD.
STEM CELLS INTERNATIONAL
(2021)
Review
Pharmacology & Pharmacy
Baocheng Xie, Shichun Chen, Yongxiang Xu, Weichao Han, Runkai Hu, Minyi Chen, Yusheng Zhang, Shaobo Ding
Summary: Diabetes mellitus and osteoporosis are closely related, and GLP-1RAs may help in controlling blood sugar levels and promoting bone formation, but more research is needed to clarify their specific effects and mechanisms.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Endocrinology & Metabolism
Yu-Sheng Zhang, Yan-Dan Zheng, Yan Yuan, Shi-Chun Chen, Bao-Cheng Xie
Summary: The effects of anti-diabetic drugs on fracture risk in type 2 diabetes mellitus patients may vary. Specific drugs like trelagliptin may increase fracture risk, while voglibose and albiglutide may show benefits, with other drugs having comparable effects.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Medicine, Research & Experimental
Yuyun Li, Xiaoyang Xie, Shiyi Liao, Zhanwei Zeng, Siyan Li, Baocheng Xie, Qunfa Huang, Huan Zhou, Chenhui Zhou, Jiantao Lin, Yunsheng Huang, Daohua Xu
Summary: Breast cancer has become the most commonly diagnosed cancer in women worldwide. A011, a potential therapeutic agent for breast cancer, exerts its anticancer effects by inducing endoplasmic reticulum stress and cell apoptosis.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Pharmacology & Pharmacy
Yongxiang Xu, Shichun Chen, Linxuan Huang, Weichao Han, Yingying Shao, Minyi Chen, Yusheng Zhang, Ruirong He, Baocheng Xie
Summary: In this research, the protective impacts of epimedin C on the osteogenic inhibition impact of MC3T3-E1 cells and zebrafish larvae mediated by DEX were examined. The results showed that epimedin C could alleviate the suppressive impact of DEX on the osteogenesis of MC3T3-E1 cells and zebrafish larvae by triggering the PI3K and AKT signaling pathways. This suggests that epimedin C has significant potential in the development of innovative drugs for the treatment of glucocorticoid-mediated osteoporosis.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Cell Biology
June Wang, Shenlin Du, Chen Wang, Zinian Zhu, Baocheng Xie, Bashan Zhang
Summary: Our meta-analysis showed that elevated SNHG7 expression in cancers is associated with unfavorable overall survival, TNM stage, lymph node metastasis, and tumor differentiation. The correlation was verified through stratified analysis and TCGA dataset evaluation.